Details from NCBI annotation

Gene Symbol Hmgcr
Gene Name 3-hydroxy-3-methylglutaryl-CoA reductase, transcript variant X1
Entrez Gene ID 101717005

Database interlinks

Part of NW_004624951.1 (Scaffold)

For more information consult the page for NW_004624951.1 (Scaffold)

Potential Gene Matches

The following genes have been identified as possible homologs of the naked mole-rat gene and compared to it.

HMGCR ENSCPOG00000004276 (Guinea pig)

Gene Details

3-hydroxy-3-methylglutaryl-CoA reductase

External Links

Gene Match (Ensembl Protein ID: ENSCPOP00000003857, Guinea pig)

Protein Percentage 96.51%
CDS Percentage 93.84%
Ka/Ks Ratio 0.08166 (Ka = 0.0173, Ks = 0.2115)

HMGCR ENSG00000113161 (Human)

Gene Details

3-hydroxy-3-methylglutaryl-CoA reductase

External Links

Gene Match (Ensembl Protein ID: ENSP00000287936, Human)

Protein Percentage 95.16%
CDS Percentage 91.25%
Ka/Ks Ratio 0.07355 (Ka = 0.025, Ks = 0.3406)

Hmgcr ENSMUSG00000021670 (Mouse)

Gene Details

3-hydroxy-3-methylglutaryl-Coenzyme A reductase

External Links

Gene Match (Ensembl Protein ID: ENSMUSP00000022176, Mouse)

Protein Percentage 93.35%
CDS Percentage 85.83%
Ka/Ks Ratio 0.05564 (Ka = 0.037, Ks = 0.6653)

Hmgcr ENSRNOG00000016122 (Rat)

Gene Details

3-hydroxy-3-methylglutaryl-CoA reductase (Hmgcr), mRNA

External Links

Gene Match (Ensembl Protein ID: ENSRNOP00000022055, Rat)

Protein Percentage 92.9%
CDS Percentage 85.42%
Ka/Ks Ratio 0.05927 (Ka = 0.0398, Ks = 0.672)

Genome Location

Sequence Coding sequence

Length: 2667 bp    Location: 681486..711482   Strand: +
>XM_004875067.1
ATGCTGTCAAGACTCTTCCGCATGCATGGCCTCTTTGTGGCCTCCCACCCCTGGGAAGTCATCGTGGGGACAGTCACACTGACCATCTGCATGATGTCCATGAACATGTTCACTGGTGACAACAAGGTCTGTGGCTGGAATTATGAATGTCCAAAATTTGAAGAGGAAGTTTTGAGCAGTGACATCATAATTCTAACAATAACACGATGCATAGCAATCCTGTATATTTACTTCCAGTTCCAGAATTTACGTCAACTTGGATCAAAATATATTTTGGGTATTGCTGGTCTCTTCACAATTTTCTCAAGTTTTGTGTTTAGTACAGTTGTCATTCACTTCTTAGATAAAGAGTTGACAGGCTTAAATGAAGCATTGCCCTTTTTCCTGCTTTTGATTGACCTCTCCAGAGCCAGCGCATTAGCCAAGTTTGCCCTAAGTTCAAATTCACAGGATGAAGTCAGGGAAAACATTGCTCGTGGAATGGCCATTTTAGGTCCCACATTCACCCTCGATGCTCTTGTGGAATGTCTTGTCATTGGAGTTGGTACCATGTCAGGGGTACGTCAACTCGAAATCATGTGCTGCTTTGGGTGCATGTCAGTTCTTGCCAACTACTTCGTATTTATGACTTTTTTCCCAGCTTGTGTGTCCTTGGTATTGGAGCTTTCTCGGGAAAGCCGTGAGGGTCGTCCAATTTGGCAGCTCAGCCATTTTGCTCGAGTTTTAGAAGAAGAAGAAAATAAACCAAATCCTGTAACTCAGAGGGTCAAGATGATTATGTCATTAGGCTTGGTCCTTGTTCATGCTCACAGTCGCTGGATAGCTGATTCTTCGCCTCAAAACAGTACTACAGAACAGTCTAAGGTTTCTTTAGGACTGGATGAAAATGTGTCCAAGAGAATTGAACCAAGTGTTTCCCTCTGGCAGTTTTATCTCTCCAAAATGATCAGCATGGATATTGAGCAAGTTATTACCCTAAGTTTAGCTCTCCTTCTGGCTGTCAAGTACATTTTCTTTGAACAAGCAGAGACAGAATCTACACTTTCATTAAAAAATCCTATCACATCTCCTGTGGTGACCCAAAAGAAAGTCCCTGACAATTGTTGTAGACGTGAACCTATGCTTGTCAGAAACAACCAGAAATTCCAGGCAGTTGAAGAAGAAACAGGGATAAACCAAGAAAGAAAAGTTGAAGTTATAAAACCCTTAGTGGCTGAAACCGACACCTCAAACAGAGCTACATTTATTGTTGGTGGCCCCTGCTCGCCTGATACTCCATCAGACCTGGTGACACAGGAGCCTAAAATTCAACTTCCCACAGACCCTCGGCCTGCTGAAGAATGTTTGCAGATACTTGGGAATGCAGAGAAAGGTGCAAAGTTCCTTAGTGATGCTGAAATCATCCAATTGGTTAATGCGAAGCACATCCCAGCTTATAAATTAGAGACTCTGATGGAAACCCATGAACGAGGTGTATCTATTCGCCGACAGTTACTTTCCAAAAAGCTTCCAGAGCCTTCCTCTTTGCAGTATTTACCTTACAGGGATTATAATTACTCCTTGGTGATGGGAGCTTGTTGTGAGAATGTTATTGGGTACATGCCCATCCCTGTTGGAGTGGCAGGACCTTTGTGCTTGGATGGAAAAGAATTTCAAGTTCCAATGGCAACAACAGAAGGTTGTCTTGTGGCCAGCACTAATAGAGGTTGCAGAGCAATCAGTCTTGGTGGAGGAGCCAGCAGCCGAGTCCTTGCGGACGGGATGACTCGTGGCCCAGTGGTGCGTCTTCCCCGTGCTTGTGACTCTGCAGAAGTGAAGGCCTGGCTTGAAACCCCTGAAGGGTTTGCAGTGATAAAGGAGGCCTTTGATAGCACCAGCAGATTTGCACGTCTACAGAAACTTCACACCAGTATGGCTGGACGAAACCTTTATATCCGTTTCCAGTCTAAGACAGGGGATGCCATGGGGATGAACATGATTTCAAAGGGCACCGAGAAAGCACTTTCAAAACTTCATGAATATTTCCCTGAAATGCAAATTCTAGCAGTGAGTGGTAACTATTGTACGGACAAGAAACCTGCTGCCATAAACTGGATCGAGGGAAGAGGGAAGACTGTTGTTTGTGAAGCTGTCATTCCAGCCAAGGTTGTCAGAGAAGTATTAAAAACGACTACGGAAGCGCTAATTGATGTGAACATTAATAAGAATCTGGTGGGCTCTGCCATGGCTGGGAGTATAGGGGGCTACAATGCCCATGCAGCCAACATTGTCACTGCTATCTACATTGCTTGTGGACAGGATGCAGCACAGAATGTTGGAAGTTCAAACTGTATTACTTTAATGGAAGCAAGTGGTCCAACAAATGAAGATTTGTACATTAGTTGCACCATGCCATCTGTAGAAATAGGAACTGTGGGCGGTGGGACCAGCCTCTTACCTCAGCAAGCCTGTCTACAGATGCTAGGTGTCCAAGGAGCATGCATAGACAATCCTGGGGAAAATGCCCGGCAGCTTGCCCGAATAGTGTGTGGTACAGTAATGGCTGGGGAATTGTCACTGATGGCAGCATTGGCAGCAGGGCATCTTGTCAAAAGTCACATGATTCACAACAGGTCAAAGATAAATTTACAAGACCTTCAAGGAACATGCACCAAGAAAGCATCTTGA

Related Sequences

XP_004875124.1 Protein

Hmgcr PREDICTED: 3-hydroxy-3-methylglutaryl-coenzyme A reductase isoform X1 [Heterocephalus glaber]

Length: 888 aa      View alignments
>XP_004875124.1
MLSRLFRMHGLFVASHPWEVIVGTVTLTICMMSMNMFTGDNKVCGWNYECPKFEEEVLSSDIIILTITRCIAILYIYFQFQNLRQLGSKYILGIAGLFTIFSSFVFSTVVIHFLDKELTGLNEALPFFLLLIDLSRASALAKFALSSNSQDEVRENIARGMAILGPTFTLDALVECLVIGVGTMSGVRQLEIMCCFGCMSVLANYFVFMTFFPACVSLVLELSRESREGRPIWQLSHFARVLEEEENKPNPVTQRVKMIMSLGLVLVHAHSRWIADSSPQNSTTEQSKVSLGLDENVSKRIEPSVSLWQFYLSKMISMDIEQVITLSLALLLAVKYIFFEQAETESTLSLKNPITSPVVTQKKVPDNCCRREPMLVRNNQKFQAVEEETGINQERKVEVIKPLVAETDTSNRATFIVGGPCSPDTPSDLVTQEPKIQLPTDPRPAEECLQILGNAEKGAKFLSDAEIIQLVNAKHIPAYKLETLMETHERGVSIRRQLLSKKLPEPSSLQYLPYRDYNYSLVMGACCENVIGYMPIPVGVAGPLCLDGKEFQVPMATTEGCLVASTNRGCRAISLGGGASSRVLADGMTRGPVVRLPRACDSAEVKAWLETPEGFAVIKEAFDSTSRFARLQKLHTSMAGRNLYIRFQSKTGDAMGMNMISKGTEKALSKLHEYFPEMQILAVSGNYCTDKKPAAINWIEGRGKTVVCEAVIPAKVVREVLKTTTEALIDVNINKNLVGSAMAGSIGGYNAHAANIVTAIYIACGQDAAQNVGSSNCITLMEASGPTNEDLYISCTMPSVEIGTVGGGTSLLPQQACLQMLGVQGACIDNPGENARQLARIVCGTVMAGELSLMAALAAGHLVKSHMIHNRSKINLQDLQGTCTKKAS