Providing databases and tools for the study of Heterocephalus glaber.
The naked mole-rat (Heterocephalus glaber) is a fascinating subterranean rodent that offers great promise as a biomedical model of resistance to disease, and diseases of ageing in particular. It is the longest-lived rodent and is exceptionally resistant to neoplasia, making it a unique model for research on ageing and cancer as well as other traits such as metabolic regulation, development, pain and behaviour.
You can search using either a gene name, Ensembl identifier (from Guinea pig, Human, Mouse, Rat) or Naked Mole-Rat sequence ID.
For more detailed queries you can use boolean (
NOT), wildcard (
*) and range searches (
[1 TO 2]). You can also search for specific terms by grouping them in quotes e.g. "growth hormone". Certain fields are also available for more detailed filtering: ka_ks_ratio, cdna_percentage and protein_percentage. These can be used by following the structure of the next example:
ka_ks_ratio:[0.75 TO 0.8] or
protein_percentage:98. When using filters wildcards are required to get partial matches.
A list of naked mole-rat genes also in the GenAge database is available to allow easy discovery of known ageing genes.
For searching sequences you can use our BLAST server to align a given sequence to scaffolds and genes/proteins.Go to BLAST search page »
This site aims to help researchers study the genome and genes of the naked mole-rat to better understand its extraordinary traits and foster further studies employing this unique organism. We develop genomic resources that facilitate studies on the naked mole-rat at various levels (e.g., cellular, molecular, genetic and biochemical). Specifically, we make available the benchmark naked mole-rat genome (HetGla_female_1.0; alias: hetGla2) sequenced at the Broad Institute and annotated by the NCBI. Scaffolds, genes (coding sequences) and proteins can be searched, BLASTed and downloaded. We also developed a pipeline for gene expression profiling.
We welcome opportunities to collaborate with other researchers. Since our aim is to encourage studies in this emerging biomedical model, we are happy to work with the research community and the public to increase awareness and information of the naked mole-rat as a model of healthy ageing and cancer resistance. Please contact us if you have any questions or comments.
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