Sequence details NCBI ID: XM_004874029.1 (Coding sequence)   Best Hit

Details from NCBI annotation

Gene Symbol Top1
Gene Name topoisomerase (DNA) I, transcript variant X1
Entrez Gene ID 101704241

This gene is present in the GenAge database and has been identified as potentially important to ageing in humans.

Database interlinks

Part of NW_004624919.1 (Scaffold)

For more information consult the page for NW_004624919.1 (Scaffold)

Potential Gene Matches

The following genes have been identified as possible homologs of the naked mole-rat gene and compared to it.

TOP1 ENSCPOG00000009076 (Guinea pig)

Gene Details

topoisomerase (DNA) I

External Links

Gene Match (Ensembl Protein ID: ENSCPOP00000008149, Guinea pig)

Protein Percentage 98.44%
CDS Percentage 95.75%
Ka/Ks Ratio 0.03818 (Ka = 0.0069, Ks = 0.1801)

TOP1 ENSG00000198900 (Human)

Gene Details

topoisomerase (DNA) I

External Links

Gene Match (Ensembl Protein ID: ENSP00000354522, Human)

Protein Percentage 98.04%
CDS Percentage 93.55%
Ka/Ks Ratio 0.02551 (Ka = 0.0085, Ks = 0.332)

Top1 ENSMUSG00000070544 (Mouse)

Gene Details

topoisomerase (DNA) I

External Links

Gene Match (Ensembl Protein ID: ENSMUSP00000105094, Mouse)

Protein Percentage 97.65%
CDS Percentage 91.05%
Ka/Ks Ratio 0.01796 (Ka = 0.0101, Ks = 0.56)

Genome Location

Sequence Coding sequence

Length: 2307 bp    Location: 1669067..1756607   Strand: +
Raw sequence   
>XM_004874029.1
ATGAGTGGGGACCATCTCCACAACGATTCCCAGATCGAAGCGGATTTCCGATTGAATGATTCTCATAAACACAAAGATAAACACAAAGATCGAGAACACCGCCATAAAGAGCACAAGAAGGACAAGGAGAAGGACCGGGAAAAGTCCAAGCATAGCAACAGTGAACATAAAGATTCTGAAAAAAAACACAAAGAGAAAGAAAAAACCAAACACAAAGATGGAAGCTCAGAAAAGCATAAAGACAAACACAAAGACAGAGACAAGGAAAAACGGAAGGAGGAAAAGGTTAGAGCCTCTGGGGATGCAAAAATAAAGAAGGAGAAGGAAAATGGCTTCTCTAGCCCACCACGAATTAAAGATGAACCTGAAGATGATGGCTATTTTGCTCCTCCTCCTAAAGAGGATCTAAAACCATTGAAGAGACCTCGAGACGAGGATGATGCTGATTACAAACCTAAGAAAATTAAAACAGAAGATACCAAGAAGGAGAAAAAACGAAAACTAGAGGAAGAGGAGGATGGTAAATTGAAAAAACCCAAGAATAAAGATAAAGATAAAAAAGTTCCTGAGCCAGATAACAAGAAAAAGAAGCCGAAGAAAGAAGAGGAACAGAAGTGGAAATGGTGGGAAGAAGAACGGTATCCTGAAGGCATCAAGTGGAAATTCCTAGAACATAAAGGTCCTGTATTTGCTCCGCCATATGAGCCTCTTCCAGACAGTGTCAAGTTTTACTATGATGGTAAAGTCATGAAGCTGAGCTCTAAAGCAGAAGAAATAGCTACATTCTTTGCAAAAATGCTTGACCATGAATATACTACTAAGGAAATATTTAGGAAAAATTTCTTTAAAGATTGGAGAAAGGAAATGACTAATGAAGAGAAGAGTACTATCACCAACCTAAGCAAATGTGATTTTACTCAGATGAGCCAGTATTTCAAAGCCCAGTCGGAAGCTCGGAAACAGATGAGCAAGGAAGAAAAATTGAAAATCAAAGAGGAAAATGAAAAATTACTGAAAGAGTATGGCTTCTGTATTATGGATAACCACAGAGAGAGGATTGCTAACTTCAAGATAGAGCCCCCGGGGCTATTCCGTGGCCGGGGCAACCACCCCAAGATGGGCATGTTGAAGCGGAGGATCCTGCCCGAGGACATAATCATAAACTGCAGCAAAGATGCCAAGGTACCTTCTCCTCCTCCAGGACATAAGTGGAAAGAGGTCAGGCATGACAACAAAGTAACTTGGCTGGTCTCCTGGACAGAGAATATCCAAGGTTCCATTAAATACATCATGTTGAATCCCAGTTCAAGAATTAAGGGTGAAAAAGACTGGCAGAAATATGAGACTGCTCGGCGGCTAAAGAAGTGTGTGGACAAGATCCGAAACCAGTATCGAGAAGACTGGAAGTCCAAAGAGATGAAAGTCCGGCAGAGAGCTGTAGCACTGTACTTCATTGACAAGCTTGCTCTGAGAGCAGGAAATGAGAAGGAAGAAGGAGAAACAGCAGACACTGTGGGTTGCTGTTCGCTTCGTGTGGAGCACATCAACCTGCACCCAGAATTGGATGGTCAGGAATACGTGGTTGAGTTTGACTTCCCTGGGAAGGACTCAATTAGATACTATAACAAGGTCCCAGTTGAGAAACGAGTTTTTAAGAACTTGCAGCTATTTATGGAGAATAAGCAGCCCGAGGATGATCTTTTTGATAGACTTAATACTGGTATTCTAAATAAGCACCTTCAGGATCTCATGGAGGGCTTGACAGCCAAGGTATTCCGTACATACAATGCCTCCATCACGCTACAGCAGCAGCTAAAGGAACTCACAGCCCCGGATGAGAACATCCCAGCAAAGATTCTCTCTTACAACCGTGCCAATCGAGCAGTTGCGATTCTTTGTAACCATCAGAGGGCACCACCAAAAACTTTCGAGAAATCTATGATGAACTTGCAGTCTAAGATTGATGCCAAGAAGGATCAGCTTGCAGATGCTCGGAGGGACCTGAAAAGTGCAAAAGCTGATGCCAAAGTCATGAAGGATGCAAAGACCAAGAAGGTAGTAGAGTCAAAGAAGAAGGCTGTGCAGAGACTGGAGGAGCAGTTGATGAAGCTGGAAGTTCAGGCCACAGATCGTGAGGAGAATAAGCAAATTGCCTTGGGAACCTCCAAACTCAATTATCTGGATCCTCGGATCACAGTGGCTTGGTGCAAGAAGTGGGGGGTCCCAATTGAAAAAATTTACAACAAAACCCAGCGGGAGAAGTTTGCCTGGGCCATCGACATGGCTGATGAGGACTATGAATTTTAA

Related Sequences

XP_004874086.1 Protein

Top1 PREDICTED: DNA topoisomerase 1 isoform X1 [Heterocephalus glaber]

Length: 768 aa      
>XP_004874086.1
MSGDHLHNDSQIEADFRLNDSHKHKDKHKDREHRHKEHKKDKEKDREKSKHSNSEHKDSEKKHKEKEKTKHKDGSSEKHKDKHKDRDKEKRKEEKVRASGDAKIKKEKENGFSSPPRIKDEPEDDGYFAPPPKEDLKPLKRPRDEDDADYKPKKIKTEDTKKEKKRKLEEEEDGKLKKPKNKDKDKKVPEPDNKKKKPKKEEEQKWKWWEEERYPEGIKWKFLEHKGPVFAPPYEPLPDSVKFYYDGKVMKLSSKAEEIATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTNEEKSTITNLSKCDFTQMSQYFKAQSEARKQMSKEEKLKIKEENEKLLKEYGFCIMDNHRERIANFKIEPPGLFRGRGNHPKMGMLKRRILPEDIIINCSKDAKVPSPPPGHKWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYETARRLKKCVDKIRNQYREDWKSKEMKVRQRAVALYFIDKLALRAGNEKEEGETADTVGCCSLRVEHINLHPELDGQEYVVEFDFPGKDSIRYYNKVPVEKRVFKNLQLFMENKQPEDDLFDRLNTGILNKHLQDLMEGLTAKVFRTYNASITLQQQLKELTAPDENIPAKILSYNRANRAVAILCNHQRAPPKTFEKSMMNLQSKIDAKKDQLADARRDLKSAKADAKVMKDAKTKKVVESKKKAVQRLEEQLMKLEVQATDREENKQIALGTSKLNYLDPRITVAWCKKWGVPIEKIYNKTQREKFAWAIDMADEDYEF