Details from NCBI annotation

Gene Symbol Irs1
Gene Name insulin receptor substrate 1, transcript variant X3
Entrez Gene ID 101708189

This gene is present in the GenAge database and has been identified as potentially important to ageing in humans.

Database interlinks

Part of NW_004624843.1 (Scaffold)

For more information consult the page for NW_004624843.1 (Scaffold)

Potential Gene Matches

The following genes have been identified as possible homologs of the naked mole-rat gene and compared to it.

IRS1 ENSCPOG00000005422 (Guinea pig)

Gene Details

insulin receptor substrate 1

External Links

Gene Match (Ensembl Protein ID: ENSCPOP00000004880, Guinea pig)

Protein Percentage 94.74%
CDS Percentage 91.05%
Ka/Ks Ratio 0.06607 (Ka = 0.0247, Ks = 0.3731)

IRS1 ENSG00000169047 (Human)

Gene Details

insulin receptor substrate 1

External Links

Gene Match (Ensembl Protein ID: ENSP00000304895, Human)

Protein Percentage 92.23%
CDS Percentage 88.89%
Ka/Ks Ratio 0.07275 (Ka = 0.0377, Ks = 0.5184)

Irs1 ENSMUSG00000055980 (Mouse)

Gene Details

insulin receptor substrate 1

External Links

Gene Match (Ensembl Protein ID: ENSMUSP00000063795, Mouse)

Protein Percentage 89.95%
CDS Percentage 84.75%
Ka/Ks Ratio 0.06869 (Ka = 0.0525, Ks = 0.7644)

Irs1 ENSRNOG00000014597 (Rat)

Gene Details

insulin receptor substrate 1 (Irs1), mRNA

External Links

Gene Match (Ensembl Protein ID: ENSRNOP00000019579, Rat)

Protein Percentage 90.6%
CDS Percentage 85.05%
Ka/Ks Ratio 0.06264 (Ka = 0.0489, Ks = 0.7807)

Genome Location

Sequence Coding sequence

Length: 3711 bp    Location: 1178407..1144362   Strand: -
>XM_004867977.1
ATGGCGAGCCCTCCAGATACCGATGGCTTCTCGGACGTGCGCAAGGTTGGCTACCTGCGCAAACCCAAGAGCATGCACAAGCGCTTCTTCGTGCTGCGGGCTGCCAGCGAGGCCGGGGGCCCGGCGCGCCTGGAGTACTACGAGAATGAGAAGAAGTGGCGGCACAAGTCGAGCGCCCCCAAACGCTCTATCCCCCTGGAGACCTGCTTCAACATCAACAAGCGGGCTGACTCCAAGAACAAGCACCTGGTGGCTCTCTACACCCGGGACGAGCACTTTGCCATTGCGGCGGACAGCGAGGCCGAGCAAGACAGCTGGTACCAGGCTCTCCTGCAGCTGCACAACCGAGCCAAGGGCCACCACGATGGGGCCGCAGTCCCCGGGGCCGGAGGCGGCGGGGGCAGCTGCAGCGGCAGCTCTGGCGTTGGCGAGGCCGGGGAGGACCTGAGCTACGGAGATGTGCCCCCCGGACCTGCGTTCAAGGAGGTCTGGCAGGTGATCCTGAAACCCAAGGGCTTGGGTCAGACAAAGAACCTGATCGGCATCTACCGCCTCTGCCTGACCAGCAAGACCATCAGCTTCGTGAAGCTGAACTCGGAGGCGGCGGCCGTGGTGCTGCAGCTGATGAACATCAGGCGCTGCGGCCACTCAGAGAACTTCTTCTTCATTGAGGTGGGCCGCTCCGCTGTGACAGGGCCCGGGGAGTTCTGGATGCAGGTGGACGACTCGGTGGTGGCCCAGAACATGCACGAGACCATCCTGGAAGCCATGCGGGCTATGAGCGACGAGTTTCGCCCCCGCAGCAAGAGTCAGTCCTCATCCAACTGCTCCAACCCCATCAGCGTTCCCCTGCGCAGGCACCATCTCAACAACCCCCCGCCCAGCCAGGTGGGACTGACCCGCCGGTCCCGCACCGAGAGCATCACCGCCACCTCTCCGGCCAGCATGGTGGGCGGGAAGCCCGGGTCTTTCCGCGTGCGCGCCTCCAGCGACGGTGAGGGCACCATGTCCCGGCCAGCCTCGGTGGATGGCAGTCCTGTGAGTCCCAGTACTAACAGGACCCATGCCCACCGGCATCGGGGCAGCTCCCGGCTGCACCCCCCACTCAACCACAGCCGCTCCATCCCCATGCCGTCTTCTCGCTGCTCACCCTCGGCCACCAGCCCCGTGAGCCTGTCCTCCAGCAGCACCAGCGGCCACGGCTCCACCTCAGACTGCCTCTTTCCCAGGCGCTCCAGTGCTTCGGTTTCAGGCTCCCCCAGCGATGGCGGTTTCATCTCTTCTGATGAGTACGGCTCGAGTCCCTGTGATTTCCGAAGTTCTTTCCGCAGTGTCACCCCGGACTCCCTGGGCCACACCCCACCAGCCCGTGGAGAGGAGGAGCTGAGCAACTACATCTGCATGGGCGGCAAGGGGGCCTCCACCCTGACGGCTCCCAATGGTCACTACATTTTGTCCCGGGGTGGCAATGGCCACCGCTACCTCCCCGGAGCTGGCTTGGGCACCAGCCCGGCGTTGGCTGGGGAGGAAGCCGCCAGTGCTGCGGACCTGGAGAATCGGTTCCGGAAGAGGACTCACTCAGCAGGGACGTCCCCGACCATCTCCCACCAGAAGACGCCCTCGCAGTCCTCCGTGGCGTCCATTGAGGAGTACACGGAGATGATGCCTGCCTACCCGCCAGGAGGTGGCAGTGGAGGCCGACTGCCCAGCTACCGGCACTCCGCCTTTGTGCCCACCCACTCCTACCCTGAGGAGGGCCTGGAGATGCACCCGATGGAGCAGCGTGGGGGCCACCCCCGCCCAGACAGCTCCGGCCTGCACACCGATGACGGCTACATGCCCATGTCTCCAGGGGTGGCCCCAGTGCCTGGCAGCCGAAAGGGCAGCGGGGACTATATGCCCATGAGTCCCAAGAGCGTGTCGGCCCCTCAGCAGATCATCAACCCTATCCGCCGCCATCCCCAGAGGGTCGACCCCAACGGCTACATGATGATGTCTCCCAGCGGCAGCTGCTCCCCGGACATCGGAGGCGGGTCCAGCAGCAGCAGCAGCATTAGCGCCGCCCCTTCCGGGAGTAGCTATGGGAAGCTGTGGACGAATGGAGTTGGGGGCCACCACTCTCATGCCCTGTCTCACCCCAGGCCCCCTGTGGAGAGCGGTGGCAGCAAGCTCCTGCCTTGTACCAGCGACTACATGAACATGTCGCCAGTTGGGGACTCCAACACCAGCAGCCCCTCTGACTGCTATTACGGCTCCGAGGACCCCCAGCACAAGCCCGTCCTCTCCTATTACTCATTGCCAAGGTCCTTTAAGCATACCCAGCGGCCTGGGGAGCCGGAGGAAGGTGCCCGGCACCAGCACCTCCGCCTCTCCTCCAGCTCTGGTCGTCTTCTCTACGCTGCAGCGGCGGAAGATTCTTCGTCCTCCACCAGCAGCGACAGTCTGGGTGGAGGTTACTGCGGGGCGAGGCCGGAGGCCGGTCCCCCGCATCCCCACCATCACGTCCTGCAGCCCCGTCTGCCTCGAAAGGTGGACACAGCTGCGCAGAGCAACAGCCGCCTGGCCCGGCCCACCAGGCTGTCCCTGGGGGATCCCAAGGCCAGCACCTTACCTCGGGCTCGGGAGCAGCAGCAGCCGCCCCTGGTGCACCCTCCAGAGCCCAAGAGCCCAGGAGAATATGTGAATATTGAATTTGGGAGCGGCCAGCCTGGCTACTTCTCTGGTCCCATGGCTTCCCGCAGTTTCCCTTCTGTCCGGTGTCAGCTCCAGCCGGCTCCCAGGGAGGAAGAGACTGGCACCGAGGAGTACATGAACATGGACCTGGGGCCTGGCCGGAGGGCAGCCTGGCAGGAGAGTAGTGGGGCAGAGACGGGCAGAGCGGGCCCTGCTCCCCCGGGGGCTGCCAGCGTTTGCAGGCCTACCCGGGCAGTGCCCAGCAGCCGGGGGGACTACATGACCATGCAGATGGGTTGTCCTCGCCAGAACTACGTGGACACCTCACCAGTCACGCCCGTCAGCTATGCTGACATGCGGACAGGCATTGCAGAGGAGGTGAGCCTGCCCAGGGCCACCGTGGCTGCCCCCTCTTCATCTTCGGCAGCCCCTGCTTCCCCCACAGCACCTCAAGGAGCAGCTGAGCTGGCGGCCCACTCCTCCCTGCTGGGGGGCCCACAGGGACCTGGGGGCGTGAGCGCCTTCACCAGGGTGAACCTCAGTCCCAACCGCAACCAGAGTGCCAAAGTGATCCGCGCGGACGCACCAGGGTGTCGGCGGAGGCATAGCTCCGAAACCTTCTCCTCAACACCTGCCGCCACCCGTGCGGGCAACACGGTGCCCTTTGGAGGGGGGGCTGCAGTAGGGGGCAGTGGTGGCAGCAGCAGCAGCAGCGAGGATGTGAAACGCCACAGTTCTGCTTCGTTTGAGAACGTGTGGCCAAGACCTGGGGAGCAAGGGGGTGCCCCCAAGGACACGGCCCAAGCTTGTGCAGCAGCTGGGGGTTTGGAAAATGGTCTTCACTACATAGACCTGGATTTGGTCAAAGACTTGAAACAGCGCCCTCAGGAGCGCCCCTCTCAGCTGCAGGCTCCTCTTCCCCCACCCCCTCATCATCCCCTGGGCAGCAGTGAGAGCAGCTCGACCAGCCGCTCCAGTGAGGATTTAAGCGCCTATGCCAGCATCAGTTTCCAGAAGCAGCCAGAGGACCGCCAGTAG

Related Sequences

XP_004868034.1 Protein

Irs1 PREDICTED: insulin receptor substrate 1 isoform X3 [Heterocephalus glaber]

Length: 1236 aa      View alignments
>XP_004868034.1
MASPPDTDGFSDVRKVGYLRKPKSMHKRFFVLRAASEAGGPARLEYYENEKKWRHKSSAPKRSIPLETCFNINKRADSKNKHLVALYTRDEHFAIAADSEAEQDSWYQALLQLHNRAKGHHDGAAVPGAGGGGGSCSGSSGVGEAGEDLSYGDVPPGPAFKEVWQVILKPKGLGQTKNLIGIYRLCLTSKTISFVKLNSEAAAVVLQLMNIRRCGHSENFFFIEVGRSAVTGPGEFWMQVDDSVVAQNMHETILEAMRAMSDEFRPRSKSQSSSNCSNPISVPLRRHHLNNPPPSQVGLTRRSRTESITATSPASMVGGKPGSFRVRASSDGEGTMSRPASVDGSPVSPSTNRTHAHRHRGSSRLHPPLNHSRSIPMPSSRCSPSATSPVSLSSSSTSGHGSTSDCLFPRRSSASVSGSPSDGGFISSDEYGSSPCDFRSSFRSVTPDSLGHTPPARGEEELSNYICMGGKGASTLTAPNGHYILSRGGNGHRYLPGAGLGTSPALAGEEAASAADLENRFRKRTHSAGTSPTISHQKTPSQSSVASIEEYTEMMPAYPPGGGSGGRLPSYRHSAFVPTHSYPEEGLEMHPMEQRGGHPRPDSSGLHTDDGYMPMSPGVAPVPGSRKGSGDYMPMSPKSVSAPQQIINPIRRHPQRVDPNGYMMMSPSGSCSPDIGGGSSSSSSISAAPSGSSYGKLWTNGVGGHHSHALSHPRPPVESGGSKLLPCTSDYMNMSPVGDSNTSSPSDCYYGSEDPQHKPVLSYYSLPRSFKHTQRPGEPEEGARHQHLRLSSSSGRLLYAAAAEDSSSSTSSDSLGGGYCGARPEAGPPHPHHHVLQPRLPRKVDTAAQSNSRLARPTRLSLGDPKASTLPRAREQQQPPLVHPPEPKSPGEYVNIEFGSGQPGYFSGPMASRSFPSVRCQLQPAPREEETGTEEYMNMDLGPGRRAAWQESSGAETGRAGPAPPGAASVCRPTRAVPSSRGDYMTMQMGCPRQNYVDTSPVTPVSYADMRTGIAEEVSLPRATVAAPSSSSAAPASPTAPQGAAELAAHSSLLGGPQGPGGVSAFTRVNLSPNRNQSAKVIRADAPGCRRRHSSETFSSTPAATRAGNTVPFGGGAAVGGSGGSSSSSEDVKRHSSASFENVWPRPGEQGGAPKDTAQACAAAGGLENGLHYIDLDLVKDLKQRPQERPSQLQAPLPPPPHHPLGSSESSSTSRSSEDLSAYASISFQKQPEDRQ