Sequence details NCBI ID: XM_004857895.1 (Coding sequence)   Best Hit

Details from NCBI annotation

Gene Symbol Top2b
Gene Name topoisomerase (DNA) II beta 180kDa
Entrez Gene ID 101704972

This gene is present in the GenAge database and has been identified as potentially important to ageing in humans.

Database interlinks

Part of NW_004624788.1 (Scaffold)

For more information consult the page for NW_004624788.1 (Scaffold)

Potential Gene Matches

The following genes have been identified as possible homologs of the naked mole-rat gene and compared to it.

TOP2B ENSCPOG00000015416 (Guinea pig)

Gene Details

topoisomerase (DNA) II beta 180kDa

External Links

Gene Match (Ensembl Protein ID: ENSCPOP00000013900, Guinea pig)

Protein Percentage 97.55%
CDS Percentage 96.2%
Ka/Ks Ratio 0.07913 (Ka = 0.0122, Ks = 0.1539)

TOP2B ENSG00000077097 (Human)

Gene Details

topoisomerase (DNA) II beta 180kDa

External Links

Gene Match (Ensembl Protein ID: ENSP00000396704, Human)

Protein Percentage 96.66%
CDS Percentage 94.31%
Ka/Ks Ratio 0.0715 (Ka = 0.0174, Ks = 0.2428)

Top2b ENSMUSG00000017485 (Mouse)

Gene Details

topoisomerase (DNA) II beta

External Links

Gene Match (Ensembl Protein ID: ENSMUSP00000017629, Mouse)

Protein Percentage 95.93%
CDS Percentage 91.72%
Ka/Ks Ratio 0.04959 (Ka = 0.0207, Ks = 0.4183)

Genome Location

Sequence Coding sequence

Length: 4590 bp    Location: 3590143..3493180   Strand: -
Raw sequence   
>XM_004857895.1
ATGGCCAAGTCCGGCGGCTGCGGCGCGGGAGCCGGCAATGGGGCGCTGACCTGGGTGAACAATGCTGCAAAAAAAGAAGAGTTAGAAGCTGCAAACAAAAATGATTCTTCAAAGAAGTTGTCTGTTGAGAGAGTGTATCAGAAGAAGACACAACTTGAACACATTCTGCTTCGTCCTGATACATATATTGGATCAGTGGAGCCCCTAACACAGTTGATGTGGGTATATGATGAAGATGTAGGAATGAATTGCAGAGAGGTTACTTTTGTTCCAGGTTTATACAAGATCTTTGATGAAATTTTGGTTAACGCTGCTGACAATAAGCAGAGGGATAAGAATATGACCTGTATTAAGATTTCTATTGATCCTGAATCTAATATTATAAGCATTTGGAATAATGGAAAAGGCATTCCAGTAGTAGAACACAAAGTAGAGAAAGTTTATGTTCCAGCTTTAATATTTGGACAGCTTTTAACATCCAGTAACTATGATGATGATGAAAAAAAAGTTACAGGTGGCCGCAATGGTTATGGTGCAAAACTTTGTAATATTTTCAGTACAAAGTTTACAGTAGAAACAGCTTGCAAAGAATACAAACATAGTTTTAAACAGACATGGATGAATAATATGATGAAGACTTCTGAAGCCAAAATTAAACATTTTGATGGTGAAGATTACACATGCATAACATTCCAACCAGATCTGTCTAAATTTAAGATGGAAAAACTTGACAAGGATATTGTGGCCCTCATGACCAGAAGAGCATATGATTTGGCTGGTTCATGTAAAGGGGTTAAAGTTATGTTTAATGGAAAGAAATTGCCAGTAAATGGATTTCGCAGTTATGTAGATCTTTATGTGAAAGACAAATTGGATGAAACTGGGGTAGCCCTGAAAGTTATTCATGAACTTGCAAATGAAAGATGGGATGTTTGTCTTACATTGAGTGAAAAAGGATTCCAGCAAATCAGCTTTGTAAATAGTATTGCAACTACAAAAGGTGGACGACATGTGGATTATGTAGTAGATCAAGTTGTTGGTAAACTGATTGAAGTAGTTAAGAAAAAGAACAAAGCTGGTGTATCAGTGAAACCATTTCAAGTAAAAAACCATATATGGGTTTTTATTAATTGTCTTATTGAAAATCCAACTTTTGATTCTCAGACTAAGGAAAACATGACTCTGCAGCCCAAAAGTTTTGGGTCCAAATGCCAACTATCAGAAAAATTTTTTAAAGCAGCCTCTAATTGTGGCATTGTAGAAAGTATCCTGAACTGGGTGAAATTTAAAGCTCAGACTCAGCTGAATAAGAAATGTTCATCTGTAAAATATAGTAAAATCAAAGGTATTCCCAAACTGGATGATGCTAACGATGCTGGTGGCAAACATTCCCTGGAGTGTACCCTGATATTAACAGAAGGAGACTCTGCCAAATCACTGGCAGTGTCTGGATTAGGTGTAATTGGGCGAGACAGATATGGAGTCTTTCCCCTAAGGGGTAAAATTCTTAATGTAAGAGAAGCTTCTCATAAACAGATCATGGAAAATGCAGAAATAAACAATATTATTAAAATAGTTGGTCTACAGTACAAGAAAAGTTATGATGATGCAGAGTCTCTAAAAACATTACGTTATGGGAAGATTATGATTATGACTGATCAGGATCAAGATGGTTCTCACATAAAAGGCCTGCTTATTAATTTCATCCATCACAATTGGCCATCACTTCTGAAACATGGTTTTCTTGAAGAATTTATTACTCCCATTGTAAAGGCAAGCAAAAATAAGCAGGAACTTTCCTTCTACAGTATTCCTGAATTTGATGAGTGGAAAAAACATATAGAAAACCAAAAAGCCTGGAAAATAAAATACTACAAACATTTGACTTATAATGATTTCATCAACAAGGAATTGATCCTGTTCTCAAACTCAGATAATGAAAGATCTATACCATCTCTTGTTGATGGCTTTAAACCAGGCCAACGTAAAGTTTTATTTACCTGTTTCAAGAGGAATGATAAACGAGAAGTTAAAGTCGCCCAGTTGGCTGGATCTGTTGCTGAAATGTCTGCTTATCATCATGGAGAACAAGCATTGATGATGACTATTGTGAATTTGGCTCAGAATTTTGTGGGAAGTAACAATATTAACTTGCTTCAGCCCATTGGTCAATTTGGAACTCGGCTTCATGGTGGCAAAGATGCTGCAAGCCCTCGTTATATTTTCACAATGTTAAGCTCTCTAGCAAGACTACTTTTTCCTGCTGTGGATGACAACCTGCTTAAGTTCCTTTATGATGATAATCAGCGTGTAGAGCCTGAGTGGTATATTCCCATAATTCCCATGGTTTTAATAAATGGTGCTGAGGGCATTGGTACTGGATGGGCTTGTAAACTGCCCAACTATGATGCTAGGGTAAGATCCTGTTATTTCCTTTTTTCTCTTCAGCTTCCAAATTACAAAAATTTTAAAGGTACAATCCAGGAACTTGGTCAAAACCAGTATGCAGTCAGTGGTGAAATATTTGTGGTGGATAGAAACACAGTGGAAATTACAGAGCTTCCAGTTAGAACTTGGACACAGGTATACAAGGAACAGGTTTTAGAACCTATGCTAAATGGAACAGATAAAACACCAGCACTAATTTCTGATTATAAAGAATATCATACTGATACAACTGTGAAATTTGTGGTGAAAATGACAGAAGAGAAACTAGCACAAGCAGAAGCTGCTGGATTACATAAAGTTTTTAAACTTCAAACTACTCTTACTTGTAATTCCATGGTACTTTTTGATCATATGGGATGTCTGAAGAAGTATGAAACTGTGCAAGACATTCTGAAAGAATTCTTTGATTTACGATTAAGTTATTATGGTTTACGTAAGGAATGGCTTGTAGGAATGCTGGGAGCAGAATCTACAAAACTTAACAATCAAGCCCGTTTCATTTTAGAGAAGATACAAGGGAAAATTACTATAGAGAATAGGTCAAAGAAAGATTTGATTCAAATGTTAGTCCAGAGAGGTTATGAATCTGACCCAGTGAAAGCCTGGAAAGAAGCACAAGAAAAGGCAGCAGAAGAGGAAGAAACACAAAACCAACATGATGATAGTTCCTCTGATTCAGGAACTCCTTCAGGCCCTGATTTTAATTATATTTTAAATATGTCTCTGTGGTCTCTTACTAAAGAAAAAGTTGAAGAACTGATTAAACAGAGAGATGCAAAAGGCCGAGAGGTCAATGATCTTAAAAGAAAATCACCTTCAGATCTTTGGAAAGAAGATTTAGCAGCATTTGTTGAAGAACTGGATGTATTGGAAGCACAAGAACGAGAAGATATTCTGGCAGGAATGTCTGGGAAAGCAATAAAAGGTAAAGTTGGCAAACCTAAGGTGAAGAAACTTCAGTTGGAAGAGACAATGCCTTCACCTTATGGGAGAAGAGTAGTTCCTGAAATTACTGCTATGAAGGCAGATGCCAGCAAAAAGTTGTTGAAGAAGAAGAAGGGTGATCTTGATACTACAGTAGTAAAAGTGGAATTTGATGAAGAATTCAGTGGAACACCAGCAGAAGGTACAGGAGAAGAGGCATTGGTCCCATCAGCTCCTATAAATAAAGGTCCAAAGCCCAAAAGGGAAAAAAAGGAGCCTGGTACCAGGGTTAGAAAAACACCTACAGCATCTGGTAAACCTAGTGCAAAAAAAGTGAAGAAACGGAATCCTTGGTCGGATGATGAATCCAAGTCAGAGAGTGACTTGGAAGAAACAGAACCTGTGGTTATTCCAAGAGATTCTTTGCTTAGGAGAGCAGCAGCTGAAAGACCTAAGTACACATTTGATTTCTCAGAAGAGGAAGATGATGATGCCGATGATGATGATGATGACAATAATGATTTAGAGGAATTGCAAGTTAAAGCATCTCCCATAATAAATGATGGGGAAGATGAATTTATTCCTTCAGATGGCTTGGATAAAGATGAATATACATTTTCTCCCAGCAAATCTACTCCAGAAAAATCTTTGCATGACAAAAAAAATCAGGATTTTGGGAATCTCTTTTCATTTCCTTCATACTCTCAGAAGTCAGAAGATGATTCAGCTAAATTTGACAGTAATGAAGAAGATACTGCTTCTGTTTTTTCACCATCATTTGGTCTGAAGCAAACAGACAAAGTTCCAAGTAAAACAGTAGCCGCTAAAAAGGGAAAGCCACCTTTGGATACAGCTTCTAAATCCAAGAGAGCCCCCAAGCAGAAGAAAGTAGTGGAAACTATAAACTCTGACTCAGATTCAGAATTTGGCGTTCCAAAGAAGACTGCAACACCAAAAGGTAAAGGCCGAGGGGCAAAGAAAAGGAAAGCATCTAGCTCTGAAAATGAAGGTGATTATAACCCTGGCAGGAAATCATCCAAAACAACAAGCAAGAAACCGAAGAAAACATCTTTTGATCAGGATTCAGATGTGGACATCTTCCCCTCAGACTTCACTTCTGACCCACCTTCTCTGCCACGGACTGGTCGGGCTAGGAAAGAAGTAAAATATTTTGCAGAGTCTGATGAAGAAGATGTTGATTTTGCAATGTTTAATTAA

Related Sequences

XP_004857952.1 Protein

Top2b PREDICTED: DNA topoisomerase 2-beta [Heterocephalus glaber]

Length: 1529 aa      View alignments
>XP_004857952.1
MAKSGGCGAGAGNGALTWVNNAAKKEELEAANKNDSSKKLSVERVYQKKTQLEHILLRPDTYIGSVEPLTQLMWVYDEDVGMNCREVTFVPGLYKIFDEILVNAADNKQRDKNMTCIKISIDPESNIISIWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETACKEYKHSFKQTWMNNMMKTSEAKIKHFDGEDYTCITFQPDLSKFKMEKLDKDIVALMTRRAYDLAGSCKGVKVMFNGKKLPVNGFRSYVDLYVKDKLDETGVALKVIHELANERWDVCLTLSEKGFQQISFVNSIATTKGGRHVDYVVDQVVGKLIEVVKKKNKAGVSVKPFQVKNHIWVFINCLIENPTFDSQTKENMTLQPKSFGSKCQLSEKFFKAASNCGIVESILNWVKFKAQTQLNKKCSSVKYSKIKGIPKLDDANDAGGKHSLECTLILTEGDSAKSLAVSGLGVIGRDRYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKSYDDAESLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLKHGFLEEFITPIVKASKNKQELSFYSIPEFDEWKKHIENQKAWKIKYYKHLTYNDFINKELILFSNSDNERSIPSLVDGFKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSAYHHGEQALMMTIVNLAQNFVGSNNINLLQPIGQFGTRLHGGKDAASPRYIFTMLSSLARLLFPAVDDNLLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWACKLPNYDARVRSCYFLFSLQLPNYKNFKGTIQELGQNQYAVSGEIFVVDRNTVEITELPVRTWTQVYKEQVLEPMLNGTDKTPALISDYKEYHTDTTVKFVVKMTEEKLAQAEAAGLHKVFKLQTTLTCNSMVLFDHMGCLKKYETVQDILKEFFDLRLSYYGLRKEWLVGMLGAESTKLNNQARFILEKIQGKITIENRSKKDLIQMLVQRGYESDPVKAWKEAQEKAAEEEETQNQHDDSSSDSGTPSGPDFNYILNMSLWSLTKEKVEELIKQRDAKGREVNDLKRKSPSDLWKEDLAAFVEELDVLEAQEREDILAGMSGKAIKGKVGKPKVKKLQLEETMPSPYGRRVVPEITAMKADASKKLLKKKKGDLDTTVVKVEFDEEFSGTPAEGTGEEALVPSAPINKGPKPKREKKEPGTRVRKTPTASGKPSAKKVKKRNPWSDDESKSESDLEETEPVVIPRDSLLRRAAAERPKYTFDFSEEEDDDADDDDDDNNDLEELQVKASPIINDGEDEFIPSDGLDKDEYTFSPSKSTPEKSLHDKKNQDFGNLFSFPSYSQKSEDDSAKFDSNEEDTASVFSPSFGLKQTDKVPSKTVAAKKGKPPLDTASKSKRAPKQKKVVETINSDSDSEFGVPKKTATPKGKGRGAKKRKASSSENEGDYNPGRKSSKTTSKKPKKTSFDQDSDVDIFPSDFTSDPPSLPRTGRARKEVKYFAESDEEDVDFAMFN