Sequence details NCBI ID: XM_004857887.1 (Coding sequence)   Best Hit

Details from NCBI annotation

Gene Symbol Mlh1
Gene Name mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli), transcript variant X1
Entrez Gene ID 101698546

This gene is present in the GenAge database and has been identified as potentially important to ageing in humans.

Database interlinks

Part of NW_004624788.1 (Scaffold)

For more information consult the page for NW_004624788.1 (Scaffold)

Potential Gene Matches

The following genes have been identified as possible homologs of the naked mole-rat gene and compared to it.

MLH1 ENSCPOG00000003928 (Guinea pig)

Gene Details

mutL homolog 1

External Links

Gene Match (Ensembl Protein ID: ENSCPOP00000003547, Guinea pig)

Protein Percentage 93.54%
CDS Percentage 92.74%
Ka/Ks Ratio 0.18025 (Ka = 0.0353, Ks = 0.1957)

MLH1 ENSG00000076242 (Human)

Gene Details

mutL homolog 1

External Links

Gene Match (Ensembl Protein ID: ENSP00000231790, Human)

Protein Percentage 90.61%
CDS Percentage 90.87%
Ka/Ks Ratio 0.20279 (Ka = 0.05, Ks = 0.2465)

Mlh1 ENSMUSG00000032498 (Mouse)

Gene Details

mutL homolog 1 (E. coli)

External Links

Gene Match (Ensembl Protein ID: ENSMUSP00000035079, Mouse)

Protein Percentage 88.26%
CDS Percentage 85.8%
Ka/Ks Ratio 0.14326 (Ka = 0.0695, Ks = 0.4851)

Mlh1 ENSRNOG00000033809 (Rat)

Gene Details

mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) (Mlh1), mRNA

External Links

Gene Match (Ensembl Protein ID: ENSRNOP00000061834, Rat)

Protein Percentage 87.85%
CDS Percentage 85.12%
Ka/Ks Ratio 0.14847 (Ka = 0.0756, Ks = 0.5094)

Genome Location

Sequence Coding sequence

Length: 2277 bp    Location: 15110455..15157161   Strand: +
Raw sequence   
>XM_004857887.1
ATGTCGCTCGTGGCTGGGGTTATTCGGCGGCTGGATGAGACCGTGGTGAACCGCATCGCAGCGGGAGAAGTTATCCAGCGGCCTGCTAATGCCATCAAAGAGATGATTGAAAACTGTTTAGATGCAAAGTCCACAAGTATTCAAGTGGTCGTTAAAGAGGGAGGTCTAAAGTTAATTCAGATCCAAGACAATGGCACTGGAATCAGGAAAGAAGATCTGGAAATTGTGTGCGAGAGATTCACAACAAGTAAACTGCAATCCTTTGAGGATTTAGCCACTATTTCTACTTATGGCTTTCGGGGTGAGGCTTTGGCCAGCATAAGCCATGTGGCTCACGTTACCATTACAACCAAAACAGCTGATGGAAAGTGTGCATACAGAGCAAGTTACTCAGATGGAAAGATGAAAGCTTCTCCTAAACCATGTGCAGGCAATCAGGGGACCCAGATCACGGTGGAGGACCTTTTTTATAACATAACCACAAGAAGGAAAGCTTTAAAAAATCCAAGTGAAGAGTATGGGAAAATTTTGGAAGTTGTTGGCAGGTATTCAATACACAACTCAGGCGTTAGTTTCTCAGTTAAGAAACAAGGCGAGACAGTTGCTGACATCAGAACACTATCCAGTGCCACAATTGTGGACAATATTCGCTCCATCTTTGGAAATGCTGTTAGCCGAGAACTGATAGAAGTTGGATGTGAGGATAAAACCCTGGCTTTCAAAATGAATGGCTACATATCTAATGCAAACTACTCAGTGAAGAAGTGCATTTTCTTACTCTTCATCAACCATCGTCTGGTAGAATCAACTTCATTGAGAAAAGCCATAGAAACGGTGTATGCAGCATATTTGCCCAAAAACACACACCCATTCCTATACCTCAGTTTAGAAATCAGCCCCCAGAATGTGGATGTCAATGTGCACCCTACAAAACATGAAGTTCACTTCCTGCATGAGGAGAGCATCCTGGAGCGGGTGCAGCAACACATTGAGAGCAAGCTCCTGGGTGCCAACTCGTCCAGGATGTACTTCACTCAGACTTTGCTACCAGGACTTGCCGGTTCCTCTGGGGAGATAGTTAAATCTACACCAGGTGTGACCCCCTCATCTACTTCTGGAAGTGGTGACAAGGTCTATGCTTATCAGATGGTCCGTACAGATTCCCGGGAACAGAAGCTCGATGCCTTTCTGCAGCCTGTGAGCAAGGCCCTGCCCAGTCAGCCCCAGGCTGTTGACCCAGGGGATAAAACAGATGGTTCTAGTTGCAAAGCTGGGCAGCAAGATGAAGACATGCTTGAAATCCCAGCCCTTGGTGAAGTGGCTGCCAAGAGTCAGAACACAGAGGGGGATGCAAACAAGGGTGCTTTAGAAACAGCAGAAAAGAGAGCACCCACTTCTAGCCCAGGCAACCCCAGAAAGAGACATCGGGAAGACTCTGATGTGGAAATGATGGAAAGTGGTTCCCAGAAGGAAATGACAGCAGCTTGTACCCCTCGGAGAAGGATCATTAACCTCACTAGTGTTTTGAGTCTCCAGGAAGAAATTAATGAGCGGCGACATGAGACTCTCCGGGAGATGCTCCAAAACCACTCCTTTGTGGGCTGTGTGAATCCTCAGTGGGCCTTGGCCCAGCATCAGACCAAGTTGTATCTTCTCAACACCACCAAGCTTAGTGAAGAACTGTTCTACCAGATACTCATTTATGACTTTGCCAATTTTGGTGTTCTAAGGTTATCGGAGCCAGCACCACTCTTTGACCTTGCCATGCTTGCCTTAGGAAGTCCTGAGAGTGGCTGGACTGAGGAAGATGGTCCCAAAGAAGGACTTGCTGAATACATAGTTGAGTTTCTGAAAAAGAAAGCTGAAATGCTGGCAGACTATTTCTCTTTGGAAATTGATGAGGAAGGGAACCTGATTGGATTACCCCTTCTGATTGACAACTATGTGCCCCCTTTGGAAGGATTGCCTATCTTTATTCTTCGACTAGCCACAGAGGTAAATTGGGATGAAGAAAAGGAATGTTTTGAAAGCCTCAGTAAAGAATGTGCTATGTTTTACTCCATCCGGAAGCAGTATGTATCAGAGGAGTCGACCCTCTCAAGCCAGCAGAGTGAAGTGTCTGGCTCTACTCTAAACCCCTGGAAGTGGACTGTGGAACACATCATCTACAAAGCCTTCCGCTTACACCTAACGCCTCCAAAACATTTCACAGAAGATGGAAATGTCCTGCAACTTGCTAACCTGCCAGATTTATACAAAGTCTTTGAAAGGTGTTAA

Related Sequences

XP_004857944.1 Protein

Mlh1 PREDICTED: DNA mismatch repair protein Mlh1 isoform X1 [Heterocephalus glaber]

Length: 758 aa      View alignments
>XP_004857944.1
MSLVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVVVKEGGLKLIQIQDNGTGIRKEDLEIVCERFTTSKLQSFEDLATISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKMKASPKPCAGNQGTQITVEDLFYNITTRRKALKNPSEEYGKILEVVGRYSIHNSGVSFSVKKQGETVADIRTLSSATIVDNIRSIFGNAVSRELIEVGCEDKTLAFKMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGANSSRMYFTQTLLPGLAGSSGEIVKSTPGVTPSSTSGSGDKVYAYQMVRTDSREQKLDAFLQPVSKALPSQPQAVDPGDKTDGSSCKAGQQDEDMLEIPALGEVAAKSQNTEGDANKGALETAEKRAPTSSPGNPRKRHREDSDVEMMESGSQKEMTAACTPRRRIINLTSVLSLQEEINERRHETLREMLQNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALGSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYVSEESTLSSQQSEVSGSTLNPWKWTVEHIIYKAFRLHLTPPKHFTEDGNVLQLANLPDLYKVFERC