Details from NCBI annotation

Gene Symbol Hmgcl
Gene Name 3-hydroxymethyl-3-methylglutaryl-CoA lyase, transcript variant X1
Entrez Gene ID 101716848

Database interlinks

Part of NW_004624764.1 (Scaffold)

For more information consult the page for NW_004624764.1 (Scaffold)

Potential Gene Matches

The following genes have been identified as possible homologs of the naked mole-rat gene and compared to it.

HMGCL ENSCPOG00000008645 (Guinea pig)

Gene Details

3-hydroxymethyl-3-methylglutaryl-CoA lyase

External Links

Gene Match (Ensembl Protein ID: ENSCPOP00000007766, Guinea pig)

Protein Percentage 93.23%
CDS Percentage 91.69%
Ka/Ks Ratio 0.14794 (Ka = 0.0375, Ks = 0.2536)

HMGCL ENSG00000117305 (Human)

Gene Details

3-hydroxymethyl-3-methylglutaryl-CoA lyase

External Links

Gene Match (Ensembl Protein ID: ENSP00000363614, Human)

Protein Percentage 86.77%
CDS Percentage 86.67%
Ka/Ks Ratio 0.20969 (Ka = 0.0802, Ks = 0.3824)

Hmgcl ENSMUSG00000028672 (Mouse)

Gene Details

3-hydroxy-3-methylglutaryl-Coenzyme A lyase

External Links

Gene Match (Ensembl Protein ID: ENSMUSP00000030432, Mouse)

Protein Percentage 88.0%
CDS Percentage 85.23%
Ka/Ks Ratio 0.12104 (Ka = 0.0682, Ks = 0.5636)

Hmgcl ENSRNOG00000009422 (Rat)

Gene Details

3-hydroxymethyl-3-methylglutaryl-CoA lyase (Hmgcl), mRNA

External Links

Gene Match (Ensembl Protein ID: ENSRNOP00000012853, Rat)

Protein Percentage 87.69%
CDS Percentage 85.54%
Ka/Ks Ratio 0.11541 (Ka = 0.065, Ks = 0.5629)

Genome Location

Sequence Coding sequence

Length: 978 bp    Location: 8363178..8349268   Strand: -
>XM_004850573.1
ATGGCGAGCGTCAGGAATTTGGTGCCGCGACGGCTGGTGGGCTTGGCGTCCCTCCGGGCTGTCAGCACCTCATCTATGGACACTTTCCCAAAGCGGGTGAAAATTGTGGAAGTTGGTCCCCGAGATGGTCTACAAAATGAAAAGAATGTTGTTCCTACTCCAGTGAAAATCAAGCTAATAGACATGCTTTCGGAAGCAGGACTTCCTGTTATAGAAGCCACCAGCTTTGTGTCTCCCAAGTGGGTTCCCCAGATGGCTGACCACACCGAAGTCTTAAAGGGCATTCGGAAGTTTCCTGGCATCAACTACCCGGTCCTGGTCCCAAACATGAAAGGCTTCGAGGCAGCGGTGGCTGCTGGCGCCAAGGAAGTGAGCGTCTTCGGAGCTGCCTCAGAGCTGTTCTCCAAGAAGAACATCAACTGCTCCATAGAGGAGAGCTTCCAGCACATGGGTGGGGTTCTGCAGGCTGCAAAGGCCACCGGGATTCCTGTGCGAGGGTATGTCTCCTGTGTGCTCGGATGTCCCTACGAAGGGAAGATCTCCCCGGCTAAAGTAGCTGAGGTCGCCAAGAAGTTGTACACCATGGGCTGCTACGAGATCTCCCTGGGGGACACCATTGGTGTAGGCACCCCAGGGCTCATGAAGGACATGCTGTCAGCTGTCATGCGTGAGGTGCCTGTGACCACGCTGGCTGTGCACTGCCATGATACCTATGGCCAAGCCCTGGCCAACACCCTGATGGCTCTGCAGATGGGAGTGAGTGTTGTGGACACCTCAGTGGCAGGACTTGGAGGCTGCCCCTATGCACAGGGGGCATCAGGGAACCTGGCCACCGAGGACCTGGTTTACATGCTGACTGGTTTGGGGATTCACACGGGTGTGAATCTCCAGAAGCTCCTGGAAGCTGGGGACTTCATCTGTCAAGTCTTGAACAGAAAAACCAGTTCCAAAGTGGCACAAGCTAGCTGTAAACTCTGA

Related Sequences

XP_004850630.1 Protein

Hmgcl PREDICTED: hydroxymethylglutaryl-CoA lyase, mitochondrial isoform X1 [Heterocephalus glaber]

Length: 325 aa      View alignments
>XP_004850630.1
MASVRNLVPRRLVGLASLRAVSTSSMDTFPKRVKIVEVGPRDGLQNEKNVVPTPVKIKLIDMLSEAGLPVIEATSFVSPKWVPQMADHTEVLKGIRKFPGINYPVLVPNMKGFEAAVAAGAKEVSVFGAASELFSKKNINCSIEESFQHMGGVLQAAKATGIPVRGYVSCVLGCPYEGKISPAKVAEVAKKLYTMGCYEISLGDTIGVGTPGLMKDMLSAVMREVPVTTLAVHCHDTYGQALANTLMALQMGVSVVDTSVAGLGGCPYAQGASGNLATEDLVYMLTGLGIHTGVNLQKLLEAGDFICQVLNRKTSSKVAQASCKL