Sequence details NCBI ID: XM_004843327.1 (Coding sequence)   Best Hit

Details from NCBI annotation

Gene Symbol Top3b
Gene Name topoisomerase (DNA) III beta, transcript variant X2
Entrez Gene ID 101708161

This gene is present in the GenAge database and has been identified as potentially important to ageing in humans.

Database interlinks

Part of NW_004624747.1 (Scaffold)

For more information consult the page for NW_004624747.1 (Scaffold)

Potential Gene Matches

The following genes have been identified as possible homologs of the naked mole-rat gene and compared to it.

TOP3B ENSCPOG00000001812 (Guinea pig)

Gene Details

topoisomerase (DNA) III beta

External Links

Gene Match (Ensembl Protein ID: ENSCPOP00000001640, Guinea pig)

Protein Percentage 98.14%
CDS Percentage 93.5%
Ka/Ks Ratio 0.02883 (Ka = 0.0084, Ks = 0.2917)

TOP3B ENSG00000100038 (Human)

Gene Details

topoisomerase (DNA) III beta

External Links

Gene Match (Ensembl Protein ID: ENSP00000381773, Human)

Protein Percentage 96.98%
CDS Percentage 89.91%
Ka/Ks Ratio 0.02189 (Ka = 0.0138, Ks = 0.631)

Top3b ENSMUSG00000022779 (Mouse)

Gene Details

topoisomerase (DNA) III beta

External Links

Gene Match (Ensembl Protein ID: ENSMUSP00000023465, Mouse)

Protein Percentage 96.06%
CDS Percentage 87.78%
Ka/Ks Ratio 0.02886 (Ka = 0.0195, Ks = 0.674)

Top3b ENSRNOG00000001845 (Rat)

Gene Details

topoisomerase (DNA) III beta (Top3b), mRNA

External Links

Gene Match (Ensembl Protein ID: ENSRNOP00000002524, Rat)

Protein Percentage 95.36%
CDS Percentage 87.66%
Ka/Ks Ratio 0.03404 (Ka = 0.0235, Ks = 0.6917)

Genome Location

Sequence Coding sequence

Length: 2589 bp    Location: 1473268..1450238   Strand: -
Raw sequence   
>XM_004843327.1
ATGAAGACTGTGCTCATGGTTGCTGAGAAGCCTTCCCTGGCACAGTCCATTGCCAAAATCCTCTCTCGAGGGAGCATGTCTTCACACAAAGGACTGAATGGGGCGTGCTCAGTCCATGAGTACACGGGAACCTTCGACAGCCAGCCAGTCCGCTTCAAGATGACCTCTGTCTGTGGTCATGTGATGACCCTGGATTTCCTGGGAAAGTACAACAAGTGGGACAAAGTGGACCCTGCAGAACTGTTCAGTCAAGCTCCAACAGAGAAGAAGGAAGCGAACCCCAAGCTGAACATGGTGAAGTTCTTGCAGGTGGAGGGCAGAGGCTGCGACTATATCGTGCTGTGGCTGGACTGTGACAAAGAAGGGGAGAACATTTGCTTTGAGGTCCTTGATGCCGTTCTGCCCGTCATGAATAAGGCCCACAGCGGTGAGAAGACAGTATTCCGGGCCAGGTTCAGCTCCATCACTGACACAGACATCTGTAATGCCATGGCCCGCCTGGGTGAGCCAGATCACAACGAGGCACTATCGGTGGATGCCCGTCAGGAGCTGGACCTACGCATCGGCTGTGCTTTCACCAGGTTTCAGACAAAATATTTCCAGGGGAAGTATGGTGATTTGGATAGTTCTCTCATCTCCTTTGGGCCGTGTCAGACTCCTACCCTGGGATTCTGCGTGGAGAGACATGATAAAATCCAGTCCTTCAAGCCAGAGACCTATTGGGTGCTGCAGGCCAAGGTTAATGCTGACAAAGACAAATCTCTCCTTTTGGACTGGGACCGAGTGAGAGTGTTCGATCGGGAGATTGCACAGATGTTTTTAAACATGACAAAGCTGGAGAAGGAAGCCCAGGTGGAGGCCACAAGCAGGAAAGAAAAAGCCAAGCAGAGGCCGCTGGCCCTGAACACTGTGGAGATGCTACGTGTAGCCAGTTCAGCTCTAGGCATGGGACCTCAGCACGCCATGCAGACAGCCGAGCGGCTGTACACACAGGGCTACATCAGCTACCCACGGACAGAAACCACCCACTACCCTGAGAACTTTGACTTGAAGGGTTCTCTGCGACAACAGGCCAACCACCCCTACTGGGCAGACACGGTGAAGCAGTTGTTAACGGAAGGTATCAACCGTCCGCGGAAAGGACATGATGCTGGTGACCATCCTCCCATCACCCCGATGAGGTCTGCCACAGAGGACGAATTAGGAGGTGATGCATGGCGGCTCTATGAGTACATCACCAGACACTTCATTGCCACAGTTAGCCATGACTGCAAGTACCTCCAGAGCACCATTTCCTTCCAGATCGGGCCTGAGCTCTTCACTTGCTCAGGGAAGACTGTTATCTCGCCAGGCTTCACAGAGATCATGCCCTGGCAGAGTGTGCCCTTGGAGGAGAGCCTGCCCACCTGCCAGAGGGGTGACACCTTCACAGTGGGGGAGGTGAAGATGCTGGAGAAGCAAACGAGCCCACCTGACTACCTGACTGAAGCCGAGCTCATCACACTCATGGAGAAGCATGGCATTGGAACTGATGCCAGCATCCCTGTGCACATCAACAATATCTGCCAGCGCAACTACGTCACTGTGGAGAGTGGCCGCCGGCTTAAGCCTACCAACCTTGGCATCGTCCTGGTGCATGGTTACTACAAGATTGATGCAGAGCTGGTGCTCCCCACCATCCGCAGTGCAGTGGAAAAGCAACTGAACCTGATTGCCCAGGGCAAGGCAGACTACCGCCAGGTCCTGGGCCACACCTTGGATGTCTTCAAGAGGAAGTTCCACTATTTTGTCGATTCCATCGCAGGAATGGATGAGTTGATGGAGGTGTCTTTTTCACCCCTGGCAGCCACAGGCAAGCCTCTGTCACGTTGTGGAAAGTGCCACCGGTTCATGAAATACATCCAGGCCAAGCCGAGCCGCCTGCACTGTTCCCACTGCGATGAGACCTACACCCTCCCTCAGAATGGCACCATCAAGCTCTATAAGGAGCTACGGTGCCCACTGGACGACTTCGAGCTGGTCCTATGGTCATCGGGCTCCCGGGGCAAGAGCTACCCACTGTGCCCCTATTGCTACAACCACCCACCCTTCCGAGACATGAAGAAAGGCATGGGCTGCAACGAGTGCACACACCCCACCTGCCAGCACTCACTGAGCATGCTGGGCATTGGCCAGTGTATAGAGTGCGAGAGCGGCATCCTGGTGCTGGACCCCACTTCAGGCCCCAAGTGGAAGGTGGCCTGCAACAAGTGCAACGTGGTGGCCCACTGCTTCGAGAATGCCCACCGTGTACGGGTGTCTGCCGACACCTGCAATACCTGTGAGGCTGCCCTGCTGGACGTGGACTTCAACAAGGCCAAGTCTCCATTGCCAGGTGACGAGACACAGCATACAGGCTGTGTTTTCTGCGACCCTGTCTTCCAGGAGCTGGTGGAGTTGAAACATGCAGCCTCCTGTCACCCTATGCACCGTGGCGGTCCCGGGAGGAGGCAGGGCCGAGGGCGGGCTCGGGGCCGGCGGCCACCAGGGAAGCCCAACCCCAGGAGGCCAAAGGACAAGATGTCAGCCCTGGCGGCCTACTTCGTATGA

Related Sequences

XP_004843384.1 Protein

Top3b PREDICTED: DNA topoisomerase 3-beta-1 isoform X2 [Heterocephalus glaber]

Length: 862 aa      View alignments
>XP_004843384.1
MKTVLMVAEKPSLAQSIAKILSRGSMSSHKGLNGACSVHEYTGTFDSQPVRFKMTSVCGHVMTLDFLGKYNKWDKVDPAELFSQAPTEKKEANPKLNMVKFLQVEGRGCDYIVLWLDCDKEGENICFEVLDAVLPVMNKAHSGEKTVFRARFSSITDTDICNAMARLGEPDHNEALSVDARQELDLRIGCAFTRFQTKYFQGKYGDLDSSLISFGPCQTPTLGFCVERHDKIQSFKPETYWVLQAKVNADKDKSLLLDWDRVRVFDREIAQMFLNMTKLEKEAQVEATSRKEKAKQRPLALNTVEMLRVASSALGMGPQHAMQTAERLYTQGYISYPRTETTHYPENFDLKGSLRQQANHPYWADTVKQLLTEGINRPRKGHDAGDHPPITPMRSATEDELGGDAWRLYEYITRHFIATVSHDCKYLQSTISFQIGPELFTCSGKTVISPGFTEIMPWQSVPLEESLPTCQRGDTFTVGEVKMLEKQTSPPDYLTEAELITLMEKHGIGTDASIPVHINNICQRNYVTVESGRRLKPTNLGIVLVHGYYKIDAELVLPTIRSAVEKQLNLIAQGKADYRQVLGHTLDVFKRKFHYFVDSIAGMDELMEVSFSPLAATGKPLSRCGKCHRFMKYIQAKPSRLHCSHCDETYTLPQNGTIKLYKELRCPLDDFELVLWSSGSRGKSYPLCPYCYNHPPFRDMKKGMGCNECTHPTCQHSLSMLGIGQCIECESGILVLDPTSGPKWKVACNKCNVVAHCFENAHRVRVSADTCNTCEAALLDVDFNKAKSPLPGDETQHTGCVFCDPVFQELVELKHAASCHPMHRGGPGRRQGRGRARGRRPPGKPNPRRPKDKMSALAAYFV