CLUSTAL W(1.81) multiple sequence alignment ENSP00000393539/1-1491 MNGVAFCLVGIPPRPE-------PRPPQLPLGPRDGCSPRRPFPWQGPRTLLLYKSPQDG ENSMUSP00000112999/1-1488 MNGVAFCLVGIPPRPE-------PRPPQLPLGPRDGCSSGRPLPWPGPRTLLLRKSLQDG ENSRNOP00000032436/1-1477 MNGVAFCLVGIPPRPE-------PRPPQLPLGSRDGCSSGRPLPWQGPRTLLLHKNLQDG ENSCPOP00000021054/1-1404 LSPAVLCL-GEPGVPATCRSPCLPVSPQLPLGPKDGCSPGRPLHWQGPRTLLLRKSLQDG XP_004859607.1/1-1446 MNGVAFCLVGIPPRPE-------PRPPQLPLGPRDGCSPGRPLPWQGPRTLLLHKSLQDG :. ..:** * * * * .******.:****. **: * ******* *. *** ENSP00000393539/1-1491 FGFTLRHFIVYPPESAVHCSLKEEENGGRGG-----GPSPRYRLEPMDTIFVKNVKEDGP ENSMUSP00000112999/1-1488 FGFTLRHFIVYPPESAVHCILKEEENGGRGGRGGGGGPSPRHRLEPMDTIFVKNVKDGGP ENSRNOP00000032436/1-1477 FGFTLRHFIVYPPESAVHCSLKEEENGSRGG-----RPSPRHRLEPMDTIFVKNVKEGGP ENSCPOP00000021054/1-1404 FGFTLRHFIVYPPESAVHCNLKRVFNLGRGV-----GASPRHRLEPMDTIFVKSVRDGGP XP_004859607.1/1-1446 FGFTLRHFIVYPPESAVHCSLKEEENGGRGG------PSPRHRLEPMDTIFVKNIKDDGP ******************* **. * .** .***:***********.:::.** ENSP00000393539/1-1491 AHRAGLRTGDRLVKVNGESVIGKTYSQVIALIQNSDDTLELSIMPKDEDILQLAYSQDAY ENSMUSP00000112999/1-1488 AHRAGLRTGDRLVKVNGESIIGKTYSQVIGLIQNSDDTLELSIMPKDEDILQLAYSQDAY ENSRNOP00000032436/1-1477 AHRAGLRTGDRLVKVNGESVIGKTYSQVIGLIQNSDDTLELSIMPKDEDILQLAYSQDAY ENSCPOP00000021054/1-1404 AHRAGLRTGDRLVKVNGESVIGKTYSQVIALIQDSDDTLELSIMPKDEDILQLAYSQDAY XP_004859607.1/1-1446 AHRAGLRTGDRLVKVNGESVIGKTYSQVIALIQNSDDNLELTIMPKDEDVLQLAYSQDAY *******************:*********.***:***.***:*******:********** ENSP00000393539/1-1491 LKGNEPYSGEARSIPEPPPICYPRKTYAPPARASTRATMVPEPTSALPSDPRSPAAWSDP ENSMUSP00000112999/1-1488 LKGNEPYSGEARSIPEPPPLCYPRKTYAPPTRAPAWATMVPEPISALPPDPRSPAAWSDP ENSRNOP00000032436/1-1477 LKGNEPYSGEARSIPEPPPLCYPRKTYAPPTRAPAWATMVPEPISALPTDPRSPAAWSDP ENSCPOP00000021054/1-1404 LKGNEPYSGEARSIPEPPRLCYPRKTYALPARLSAWATMVPEPASALPSDPRSPAAWSDP XP_004859607.1/1-1446 LKGNEPYSGEARSIPEPPPLCYPRKTYAPPARLSAWATMVPEPTSALLSDPRSPAAWSDP ****************** :******** *:* .: ******* *** .*********** ENSP00000393539/1-1491 GLRVPPAARAHLDNSSLGMSQPRPSPGAFPHLSSEPRTPRAFPEPGSRVPPSRLECQQAL ENSMUSP00000112999/1-1488 GSRVPSATRAHLDNSSLGMSQPRPSPGAFPHLPSESRTPRAFPEPGSRVLPSRLECQQAL ENSRNOP00000032436/1-1477 GSRVTSATRAHLDNSSLGMSQPRPSPGAFPHLPSESRTPRAFLESGSRVLPSRLECQQAL ENSCPOP00000021054/1-1404 GPRVPPATRTPSEPSS-GMSQPRPSPGAFLHLPSEPRTPQAFPEPSGRVLPSRLECQQAL XP_004859607.1/1-1446 GPCVPPATLTHPESSSLGMSQPRPSPGAFPHLPEEPRTSRAFPEPGSRALPSRLECQQAL * *..*: : : ** ************ **..*.**.:** *...*. ********** ENSP00000393539/1-1491 SHWLSNQVPRRAGERRCPAMAPRARSASQDRLEEVAAPRPWPCSTSQDALSQLGQEGWHR ENSMUSP00000112999/1-1488 SHWLSNQIPRRAGERRCPAMPPRARSASQDRLEDVTTHHPWPCSTSQDALSQLGQEGWHR ENSRNOP00000032436/1-1477 SHWLSNQIPRRAGERRCPAMPPRARSASQDRLEDVTTHHPWPCSTSQDALSQLGQEGWHR ENSCPOP00000021054/1-1404 SHWLSKQVPRRAGESRCPAMPPRTRSASQDRLEDVTAHRVWPCSTSQDALSQLGQESWHQ XP_004859607.1/1-1446 SNWLSKQVPRRAGESRCPAMPPRARSASQDRLEEVTAHRAWPCSTSQDALSQLGRESWHR *:***:*:****** *****.**:*********:*:: : **************:*.**: ENSP00000393539/1-1491 ARSDDYLSRATRSAEALGPGALVSPRFERCGWASQRSSARTPACPTRDLPGPQAPPPSGL ENSMUSP00000112999/1-1488 ARSDDYLSRATRSAEALGPGALVSPRLERCGWASQRPSARTSACPSRDL--TQAPPPSGL ENSRNOP00000032436/1-1477 ARSDDYLSRATRSAEALGPGALVSPRLERCGWASQRSSARTSACPSRDLPGPQAPPASGL ENSCPOP00000021054/1-1404 ARSEDYLGRATRSAEALGPGALGSPRFERCGWASQRPTARTVTCPARDLPGPQAPPVPGL XP_004859607.1/1-1446 ARSEDYLGRATRSAEALGPGLLGSPRFERCSWASQHPAAHTTACPARDLPGPQALPAPGL ***:***.************ * ***:***.****:.:*:* :**:*** .** * .** ENSP00000393539/1-1491 QGLDDLGYIGYRSYSPSFQRRTGLLHALSFRDSPFGGLPTFNLAQSPASFPPEASEPPRV ENSMUSP00000112999/1-1488 QGLDDIGYIGYRSYSPSFQRRTGLLHALSFRDSPFGGLPTFSLAQSPASFPPEASEPPRV ENSRNOP00000032436/1-1477 QGLDDIGYIGYRSYSPSFQRRTGLLHALSFRDSPFGGLPTFSLAQSPASFPPEASEPPRV ENSCPOP00000021054/1-1404 QGLDDTGYVGYRSYSPSFQRRTGLLHALSFRDSPFGGLPTFSLAQTPTPFPPEASEPPKV XP_004859607.1/1-1446 QGLDDIGYMGYRSYSPSFQRRTGLLHALSFRDSPFGGLPSFSLAQTATPFPPEASEPPRV ***** **:******************************:*.***:.:.*********:* ENSP00000393539/1-1491 VRPEPSTRALEPPAEDRGDEVVLRQKPPTGRKVQLTPARQMNLGFGDESPEPEASGRGER ENSMUSP00000112999/1-1488 VRPDPSTRALEPPAEDHRDEVVLRQKPPTGRKVQLTPARQMNLGFGDESPEPEA--RGER ENSRNOP00000032436/1-1477 ARPDPSTRALEPPAEDHRDEVVLRQKPPTGRKVQLTPARQVNLGFGDESLEPEA--RGER ENSCPOP00000021054/1-1404 SKPEPSTRALEPPTDDHREEVVLRQKPPTGRKGPPGPTRQMNLGFGEETLEPEAGGRGER XP_004859607.1/1-1446 TRPEPNALALEPPAEDPREEVILRQKPPTGRKGPLGPARQMNLGLGDETPEPEAGGRGER :*:*.: *****::* :**:********** *:**:***:*:*: **** **** ENSP00000393539/1-1491 LGRKVAPLATTEDSLASIPFIDEPTSPSIDLQAKHVPASAVVSSAMNSAPVLGTSPSSPT ENSMUSP00000112999/1-1488 LGRKVAPLATTEDSLASIPFIDEPTSPSIDLQAKHVPASAVVSSAMNSAPVLGTSPSSPT ENSRNOP00000032436/1-1477 PGRKVAPLATTEDSLASIPFIDEPTSPSIDLQAKHVPASAVVSSAMNSAPVLGTSPSSPT ENSCPOP00000021054/1-1404 PGRRVAPLATTEDSLASIPFIDEPTSPSIDLQAKHVPASAVVSSAMNSAPVLGTSPTSPT XP_004859607.1/1-1446 LGRRVTPLATTEDSLASIPFIDEPTSPSIDLQAKHVPASAVVSSAMNSAPVLGTSPSSPT **:*:**************************************************:*** ENSP00000393539/1-1491 FTFTLGRHYSQDCSSIKAGRRSSYLLAITTERSKSCDDGLNTFRDEGRVLRRLPNRIPSL ENSMUSP00000112999/1-1488 FTFALSRHYSQDCSSIKAGRRSSYLLAITTERSKSCDDGLNTFRDEGRVLRRLPSRVPSL ENSRNOP00000032436/1-1477 FTFALSRHYSQDCSSIKAGRRSSYLLAITTERSKSCDDGLNTFRDEGRVLRRLPNRVPSL ENSCPOP00000021054/1-1404 FTFALSRHYSQDCSSIRAGRRSSYLLAVTTERSKSCDDGLNSFRDEGRALRRLPSRVPSL XP_004859607.1/1-1446 FTFALSRHYAKDCSSIKAGRRSSYLLAITTERSKSCDDGLNTFRDEGRALRRLPSRVPSL ***:*.***::*****:**********:*************:******.*****.*:*** ENSP00000393539/1-1491 RMLRSFFTDGSLDSWGTSEDADAPSKRHSTSDLSDATFSDIRREGWLYYKQILTKKGKKA ENSMUSP00000112999/1-1488 RVLRSFFTDGSLDSWGTSEDADAPSKRHSTSDLSDATFSDIRREGWLYYKQILTKKGKKA ENSRNOP00000032436/1-1477 RMLRSFFTDGSLDSWGTSEDAEAPSKRHSTSDLSDATFSDIRREGWLYYKQILTKKGKKA ENSCPOP00000021054/1-1404 RVLRSFFTDGSLDSWGTSEDADAPSKRHSTSDLSDTAFSDIRREGWLSYKQVLTKKGKKA XP_004859607.1/1-1446 RVLRSFFTDGSLDSWGTSEDADAPSKRHSTSDLSDSAFSDVRREGWLSYKQVLTRKGKKA *:*******************:*************::***:****** ***:**:***** ENSP00000393539/1-1491 GSGLRQWKRVYAALRARSLSLSKERREPGPAAAGAAAAGAGEDEAAPVCIGSCLVDISYS ENSMUSP00000112999/1-1488 GGGLRQWKRVYAVLRARSLSLSKERREPGPAAAGAAAAGAGEDEAAPVCIGSCLVDISYS ENSRNOP00000032436/1-1477 GGGLRQWKRVYAVLRARSLSLSKERREPGPAAAGAAAAGAGEDEAAPVCIGSCLVDISYS ENSCPOP00000021054/1-1404 GGGLRQWKRVYATLRARSLCLSK--------------AGEGEGGRPPSCIAPCLVDISYS XP_004859607.1/1-1446 GSGLRQWKRVYATLRARSLCLSKERREPGP-AAGAAAAGAGEEEAAPVCIGSCLVDISYS *.**********.******.*** ** ** .* **..******** ENSP00000393539/1-1491 ETKRRHVFRLTTADFCEYLFQAEDRDDMLGWIRAIRENSRAEGEDPGCANQALISKKLND ENSMUSP00000112999/1-1488 ETKRRHVFRLTTADFCEYLFQAEDRDDMLGWIRAIRENSRAEGEDPGCANQALISKKLND ENSRNOP00000032436/1-1477 ETKRRHVFRLTTADFCEYLFQAEDRDDMLGWIRAIRENSRAEGEDPGCANQALISKKLND ENSCPOP00000021054/1-1404 DTKRNH--RLT---FCENLFQAEDRDDMLGWIRAIRE-SRAEGEDPGCANQALISKKLNN XP_004859607.1/1-1446 DTKRRHVFRLTTADFCEYLFQAEDRDDMLGWIRAIRENSRAEGEDPGWANQALISKKLND :***.* *** *** ******************* ********* ***********: ENSP00000393539/1-1491 YRKVSHSSGPKADSSPKGSRGLGGLKSEFLKQSAARGLRTQDLPAGSKDDSAAAPKTPWG ENSMUSP00000112999/1-1488 YRKVSHSSGPKADSSPKGSRGLGGLKSEFLKQTAVRGLRTQEQPPGSKEDSVAAPKTPWG ENSRNOP00000032436/1-1477 YRKVSHSSGPKADSSPKGSRGLGGLKSEFLKQTAVRGLRTQDQPAGSKEDSVTTPKTPWG ENSCPOP00000021054/1-1404 YRKVSHGSGPKAEASPKVS-----LKPEFLRQSAARALRTQEQPAGSKDDSAAAPKTPWG XP_004859607.1/1-1446 YRKVSHGSGPKADASPKVSRGLGGLKSEFLKQSAVRGLRTQEQSPGSKDDTTAAPKTPWG ******.*****::*** * **.***:*:*.*.****: ..***:*:.::****** ENSP00000393539/1-1491 INIIKKNKKAAPRAFGVRLEECQPATENQRVPLIVAACCRIVEARGLESTGIYRVPGNNA ENSMUSP00000112999/1-1488 INIIKKNKKAAPRAFGIRLEECQPATENQRVPLIVAACCRIVEARGLESTGIYRVPGNNA ENSRNOP00000032436/1-1477 INIIKKNKKAAPRAFGIRLEDCQPATENQRVPLIVAACCRIVEARGLESTGIYRVPGNNA ENSCPOP00000021054/1-1404 INIIKKNKKAAPRAFGVRLEECQPATENQHVPLIVATCCRIVEARGLESTGIYRVPGNNA XP_004859607.1/1-1446 INIIKKNKKATPRAFGVRLEECQPAPENQRVPLIVAACCRIVEARGLESTGIYRVPGNNA **********:*****:***:****.***:******:*********************** ENSP00000393539/1-1491 VVSSLQEQLNRGPGDINLQDERWQDLNVISSLLKSFFRKLPEPLFTDDKYNDFIEANRIE ENSMUSP00000112999/1-1488 VVSSLQEQLNRGPSDINLQDERWQDLNVISSLLKAFFRKLPEPLFTDDKYNDFIEANRIE ENSRNOP00000032436/1-1477 VVSSLQEQLNRGPSDINLQDERWQDLNVISSLLKAFFRKLPEPLFTDDKYNDFIEANRIE ENSCPOP00000021054/1-1404 VVCSLQEQLNRGLGDINPQDERWQDLNVISSLLKSFFRKLPEPLFTNDKYNDFIEANRIE XP_004859607.1/1-1446 VVSSLQEQLNRGPGDINLQDERWQDLNVISSLLKSFFRKLPEPLFTNDKYNDFIEANRIE **.********* .*** ****************:***********:************* ENSP00000393539/1-1491 DARERMRTLRKLIRDLPGHYYETLKFLVGHLKTIADHSEKNKMEPRNLALVFGPTLVRTS ENSMUSP00000112999/1-1488 DSRERMKTLRKLIRDLPGHYYETLKFLVGHLKTIADHSEKNKMEPRNLALVFGPTLVRTS ENSRNOP00000032436/1-1477 DSRERMKTLRKLIRDLPGHYYETLKFLVGHLKTIADHSEKNKMEPRNLALVFGPTLVRTS ENSCPOP00000021054/1-1404 DARERMKTLRKLIRDLPGHYYETLKFLVGHLKTIADHSEQNKMEPRNLALVFGPTLVRTS XP_004859607.1/1-1446 DARERMKTLRKLIRDLPGHYYETLKFLVGHLKTIADHSEQNKMEPRNLALVFGPTLVRTS *:****:********************************:******************** ENSP00000393539/1-1491 EDNMTDMVTHMPDRYKIVETLIQHSDWFFSDEEDKGERTPVGDKEPQAVPNIEYLLPNIG ENSMUSP00000112999/1-1488 EDNMTDMVTHMPDRYKIVETLIQHSDWFFSDDEDKGERTPVDDKEPQSVPNIEYLLPNIG ENSRNOP00000032436/1-1477 EDNMTDMVTHMPDRYKIVETLIQHSDWFFSDDEDKGERTPVDDKEPQSVPNIEYLLPNIG ENSCPOP00000021054/1-1404 EDNMTDMVTHMPDRYKIVETLIQHSDWFFSDDQDKGERTPVDDKEPQAVPNIEYLLPNIG XP_004859607.1/1-1446 EDNMTDMVTHMPDRYKIVETLIQHSDWFFSDDKDKGERTPVDDKEPQSVPNIEYLLPNIG *******************************::********.*****:************ ENSP00000393539/1-1491 RTVPPGDPGS-DSTTCSSAKSKGSWAPKKEPYAREMLAISFISAVNRKRKKRREARGLGS ENSMUSP00000112999/1-1488 RTVPPSDPGS-DSTTCSSAKSKGSWVPKKEPYAREMLAISFISAVNRKRKKRREARGLGS ENSRNOP00000032436/1-1477 RTVPPSDPGSADSTTCSSAKSKGSWVPKKEPYAREMLAISFISAVNRKRKKRREARGLGS ENSCPOP00000021054/1-1404 RTGPPGDSGS-DFTTCNSAKSKAPWAPRKEPCTREMLAISFISAVNRKRKKRREARGLGS XP_004859607.1/1-1446 RTVPPGDPGP-DFATCSSAKSKASWAPRKEPYAREMLAISFISAVNRKRKKRREARGLGS ** **.*.*. * :**.*****..*.*:*** :*************************** ENSP00000393539/1-1491 STDDDSEQEAHKPGAGATAPGTQERPQGPLPGAVAPEAPGRLSPPAAPEERPAADTRSIV ENSMUSP00000112999/1-1488 STDDDSEQEAHKAAV-----GTQEPPEGQLPGPAAEEAPGRLSPPTAPDERPAADTRSIV ENSRNOP00000032436/1-1477 STDDDSEQEAHKAAV-----GTQEPPEGQLPGPSAEEAPGRLSPSTAPDERPAADTRSIV ENSCPOP00000021054/1-1404 STDDDSEHEAAQAGV----PGGPDPADG--------------SPTTL-----APDARYVV XP_004859607.1/1-1446 STDDDSEHEAARGGA----PGAPEPPPR--------------APSPTPPAAPAPDARSVA *******:** : .. * : . :*.. *.*:* :. ENSP00000393539/1-1491 SGYSTLSTMDRSVCSGASGRRAGAGDEADDERSELSHVETDTEGAAGAGPGGRLTRRPSF ENSMUSP00000112999/1-1488 SGYSTLSTMDRSVCSGTGGRRAGAGDEADDERSELSHVETDTEG--GAGPGGRLSRRPSF ENSRNOP00000032436/1-1477 SGYSTLSTMDRSVCSGTGGRRAGAGDEADDERSELSHVETDTEG--GAGPGGRLARRPSF ENSCPOP00000021054/1-1404 SGYSTL-----------GTRRAGAGDEADDERSEPSLAGTDTE---GAGAG------PSF XP_004859607.1/1-1446 SGYSTLSS------AGRGARRAGAGDEADDERSEPSLAGTDTEG--GAGARG---RRPSF ****** . *************** * . **** ***. *** ENSP00000393539/1-1491 SSHHLMPCDTLARRRLARGRPDGEGAGRGG----PRAPEPPGSASSSSQESLRPPAAA-- ENSMUSP00000112999/1-1488 SSHHLMPCDTLARRRLSRSRAEAEGPGAGTARACPRGPEPPGSASSSSQESLRPPAAAPA ENSRNOP00000032436/1-1477 SSHHLMPCDTLARRRLSRSRADAEG---------PRGPEPLGSASSSSQESLRPPAAAPV ENSCPOP00000021054/1-1404 SSHRLMAGDTLARRRLSRGRANPED---------DRAPAP-GSASSSSQES--------- XP_004859607.1/1-1446 SSHRLMPCDTLARRRLARGRADPEG---------PRAPAP-GSASSSSQESLRPPGAAEA ***:**. ********:*.*.: *. *.* * ********** ENSP00000393539/1-1491 LASRPSRMEALRLRLRGTADDMLAVRLRRPLSPETRRRRSSWRRHTVVVQSPLTDLNFNE ENSMUSP00000112999/1-1488 LGSRPSRVEALRLRLRGTADDMLAVRLRRPLSPETRRRRSSWRRHTVVVQSPLTDLNFNE ENSRNOP00000032436/1-1477 LGSRPSRVEALRLRLRGTADDMLAVRLRRPLSPETRRRRSSWRRHTVVVQSPLTDLNFNE ENSCPOP00000021054/1-1404 ----PSRLETLRLRLRGTADDM-AVRLRRPLSPETRRRRSSWRRHTVVVQSPLTDLNFNE XP_004859607.1/1-1446 LGARPSRLETLRLRLRGTADDM-AVRLRRPLSPETRRRRSSWRRHTVVVQSPLTDLNFNE ***:*:************ ************************************* ENSP00000393539/1-1491 WKELGGGGPPEPAGARAHSDNKDSGLSSLESTKARAPSSAASQPPAPGDTGSLQSQPPRR ENSMUSP00000112999/1-1488 WKELGGGGPQESVGVRPHSDNKDSGLSSLESTKARA-SSAASLP--SGDLGALQGLPQRR ENSRNOP00000032436/1-1477 WKELDGGGPPESAGVRPHSDNKDSGLSSLESTKARA-SSAASLP--SGDLGALQGLPARR ENSCPOP00000021054/1-1404 WKE---AGAQDTTGARAHSDNKDSGLSSLESTKARASSSAASLP--P-DLGTLQGVAPRL XP_004859607.1/1-1446 WKE---RGAQGAAGARAHSDNKDSGLSSLESTKARASSSAASLP--PGDLGTLQAV---- *** *. ..*.*.******************* ***** * . * *:**. ENSP00000393539/1-1491 SAASRLHQCL ENSMUSP00000112999/1-1488 SAAARLHQCL ENSRNOP00000032436/1-1477 SAAARLHQCL ENSCPOP00000021054/1-1404 ASTSHLHPCL XP_004859607.1/1-1446 ATASRLHPCL :::::** **