CLUSTAL W(1.81) multiple sequence alignment ENSP00000396918/1-931 MASPGIEVELLGKGHSDLGEVAPEIKASERRTAVAIADLEWREMEGDDCEFRYGDGTNEA ENSMUSP00000091053/1-926 MASPGIEVELLVKGHSDLGEVAPEVKPSDSQTSVAIADLEWREMEGDDCGFHYGDGTNEA ENSRNOP00000016468/1-927 -RSPKIEVELLVKGHSDLGEVAPEVKPSDSQTSVAIADLEWREMEGDDCGFHYGDGTNEA ENSCPOP00000020954/1-932 LASSGCEGWHLQAGHSDLGEAAPEIKASERRAAVAIADLEWREMEGDDCGFHYGDGTNEA XP_004839998.1/1-931 MASPGIEVELLAKGHSDLGEAAPEIKASERRAAVAISDLEWREMEGDDCGFHYGDGTNEA *. * * *******.***:*.*: :::***:************ *:******** ENSP00000396918/1-931 QDNDFPTVERSRLQEMLSLLGLETYQVQKLSLQDSLQISFDSMKNWAPQVPKDLPWNFLR ENSMUSP00000091053/1-926 QDNDFPTVERSRLQEMLSLLGLETYQAQKLTLQDSLQISFDSMKNWAPQVPKDLPWHFLR ENSRNOP00000016468/1-927 QDNDFPTVERSRLQEMLSLLGLETYQVQKLTLQDSLQISFDSMKNWAPQAPKDLPWHFLR ENSCPOP00000020954/1-932 QDNDFPTVERSRLQEMLALLGLETYQGQRLSLQDSLQISFDSMKNWAPQVPKDLPWHFLR XP_004839998.1/1-931 QDNDFPTVERSRLQEMLSLLGLEAYQAQKLSLQDSLQISFDSMKNWAPQVPKDLPWHFLR *****************:*****:** *:*:******************.******:*** ENSP00000396918/1-931 KLQALNADARNTTMVLDVLPDARPVEKESQMEEEIIYWDPADDLAA-DIYSFSELPTPDT ENSMUSP00000091053/1-926 KLQALNAEARNTTMVLDVPPEAWPAEKESQAEEEMMYWDPAEDVAA-DIYSFSELPMPDT ENSRNOP00000016468/1-927 KLQALNAEARNTTMVLDSPPEAWPTEKGGQTEEGMMYWDPAEDVAA-DIYSFSELPMPDT ENSCPOP00000020954/1-932 KLQALNAEARNTTMVLDLPADARPAEKEGQMEEEIIYWDPAEDIAADDIYSFSELPTPDT XP_004839998.1/1-931 KLQALNAEARNTTMVLDMPADARPAEKESQMEEEMIYWDPAEDIAADDIYSFSELPTPDM *******:********* .:* *.** .* ** ::*****:*:** ********* ** ENSP00000396918/1-931 PVNPLDLLCALLLSSDSFLQQEIALKMALCQFALPLVLPDSENHYHTFLLWAMRGIVRTW ENSMUSP00000091053/1-926 PVNPLDLLCALLLSSDTFLQQEVLLKMSLCQFALPLVLPDSENHYHTFLLWALRGVVRTW ENSRNOP00000016468/1-927 PVNPLDLLCALLLSSDTFLQQEVLLKMSLCQFALPLVLPDSENHYHTFLLWALRGVVRTW ENSCPOP00000020954/1-932 PVNPLDLLCALLLSSDSFLQQEIILKMSLCQFALPLVLPDSENHYHTFLLWALRGVVRTW XP_004839998.1/1-931 PVNPLDLLCALLLSSDSFLQQEIVLKMSLCQFALPLVLPDSENHYHTFLLWALRGVVWTW ****************:*****: ***:************************:**:* ** ENSP00000396918/1-931 WSQPPRGMGSF-REDSVVLSRAPAFAFVRMDVSSNSKSQLLNAVLSPGHRQWDCFWHRDL ENSMUSP00000091053/1-926 WFQPLRSLGSF-REDSVVLSRVPTFAFVRMDVSSNSKSQLLNAVLSPARRQWDCFWHRDL ENSRNOP00000016468/1-927 WFQPPRGLGSFLREDSVVLSRVPTFAFVRMDVSSNSKSQLLNAVLSPARRQWDCFWHRDL ENSCPOP00000020954/1-932 WSQSPRGLGSF-REDSVVLSRVPTFAFVRMDVSSNSKSQLLNAILSPGHRQWDCFWHRDL XP_004839998.1/1-931 WSQTPRGLGSF-REDSVVLSRVPTFAFVRMDVSSNSKSQLLNAILSLGRRQWDCFWHRDL * *. *.:*** *********.*:*******************:** .:*********** ENSP00000396918/1-931 NLGTNAREISDGLVEISWFFPSGREDLDIFPEPVAFLNLRGDIGSHWLQFKLLTEISSAV ENSMUSP00000091053/1-926 NLGTNPREISDGLVEISWFFPSGKEDLDVFPEPMAFLNLRGDIGSHWLQFKLLTEVSSAV ENSRNOP00000016468/1-927 NLGTNPREIADGLVEISWFFPSGKEDLDVFPEPMAFLNLRGDIGSHWLQFKLLTEVSSAV ENSCPOP00000020954/1-932 SLGTNPREIADGLVEISWFFPSGREDLDVFPEPVAFLNLRGDIGSHWLQFKLLTEISSAV XP_004839998.1/1-931 SLGTNPREIADGLVEISWFFPSGRDDLDIFPEPVAFLNLRGDIGSHWLQFKLLTEISSAV .****.***:*************::***:****:*********************:**** ENSP00000396918/1-931 FILTDNISKKEYKLLYSMKESTTKYYFILSPYRGKRNTNLRFLNKLIPVLKIDHSHVLVK ENSMUSP00000091053/1-926 FILTDNISKKEYKLLYSMKESTTKYYFILSPYRGKRNTNLRFLNRLIPVLKIDHSHVLVK ENSRNOP00000016468/1-927 FILTDNISKKEYKLLYSMRESTTKYYFILSPYRGKRNTNLRFLNRLIPVLKIDHSHVLVK ENSCPOP00000020954/1-932 FILTDNISKKEYKLLYSMKESTTKYYFILSPYRGKRNTNLRFLNRLTPVLKIDHSHVLVK XP_004839998.1/1-931 FILTDNISKKEYKLLYSMKESTTKYYFILSPYRGKRNTNLRFLNRLTPVLKIDHSHVLVK ******************:*************************:* ************* ENSP00000396918/1-931 VSSTDSDSFVKRIRAIVGNVLRAPCRRVSVEDMAHAARKLGLKVDEDCEECQKAKDRMER ENSMUSP00000091053/1-926 VSSTDSEGFVRRIRAIMCSVARSPCRRVSVEDMAHAARKLGLRVDEDFEECQKAKDRMEK ENSRNOP00000016468/1-927 VSSTDGEGFLRRIRAIMCSVARSPCRRMSVEDMAHAARKLGLRVDEDFEECQKAKDRMEK ENSCPOP00000020954/1-932 VSSTDSEGFVRRLRAIVGGVARGPCRRVSVEDMAHAARKLGLRVDEDCEECQKAKDRMER XP_004839998.1/1-931 VSSTDSEGFVRRLRAIVASVVRAPCRRVSVEDMAHAARKLGLRVDEDFEECQKAKDRMER *****.:.*::*:***: .* *.****:**************:**** ***********: ENSP00000396918/1-931 ITRKIKDSDAYRRDELRLQGDPWRKAAQVEKEFCQLQWAVDPPEKHRAELRRRLLELRMQ ENSMUSP00000091053/1-926 ILRKIKDVDAYKRDELRLQGEPARRAAQAEREFCQLQWVPEPPEKHRAELRRRVLELRVQ ENSRNOP00000016468/1-927 IVRKIKDVDAYKRDELRLQGDPARKAAQAEREFCQLQWASEPPEKHRAELRRRALELRVQ ENSCPOP00000020954/1-932 ITRKIKDVDAYRRDELRLQGELGRKAAQAEREFCQLQWAPEPPEKYRVELRRRLLELRMQ XP_004839998.1/1-931 ITRKIKDVDAYRRDELRLQGDLGRKVAQVEREFCQLQWAPEPPEKHRVELRRRLLELRAQ * ***** ***:********: *:.**.*:*******. :****:*.***** **** * ENSP00000396918/1-931 QNGHDPSSGVQEFISGISSPSLSEKQYFLRWMEWGLARVAQPRLRQPPETLLTLRPKHGG ENSMUSP00000091053/1-926 QNGQEPTSGVQEFILGISSPSPSERQYFLRWMEWGLARLGQPRPRQPPETLLTLRPKLGG ENSRNOP00000016468/1-927 QNGQEPTSGVQEFILGVSSPSPSERQYFLRWMEWGLARLGQPRPRQPPETLLTLRPKLGG ENSCPOP00000020954/1-932 QSGQEPSTGLQDFVVGISSPSTSERQYFLRWMEWGLARVGHPRLRQPPETLLALRSKLGG XP_004839998.1/1-931 QSGQEPSMGLQDFIVGISSPSEGERQYFLRWMEWGLARVGHPRLRQPPETLLALRPKLGG *.*::*: *:*:*: *:**** .*:*************:.:** ********:**.* ** ENSP00000396918/1-931 TTDVGEPLWPEPLGVEHFLREMGQFYEAESCLVEAGRLPAGQRRFAHFPGLASELLLTGL ENSMUSP00000091053/1-926 PSDLTEPLWPEPLGVEHFLREMGQFYEAESCLIEAGRLPAGQRRFAHFPGVAVELLLGGL ENSRNOP00000016468/1-927 PSDLNEPLWPEPLGVEHFLREMGQFYEAESCLVEAGRLPAGQRRFAHFPGLAVDLLLGGL ENSCPOP00000020954/1-932 ASDFSEPFWPEPLGVEHFLREMGQFYEAESCLVEAGRLSAGQRRFAHFPGLAAELLLAGQ XP_004839998.1/1-931 ASDFSEPLWPEPLGIEHFLREMGQFYESESCLVEAGRLPAGQRRFAHFPGLATELLLAGL .:*. **:******:************:****:*****.***********:* :*** * ENSP00000396918/1-931 PLELIDGSTLSMPVRWVTGLLKELHVRLERRSRLVVLSTVGVPGTGKSTLLNTMFGLRFA ENSMUSP00000091053/1-926 PLELVDGATLSIPVRWVTGLLKELHTRLDRRSRLVVLSALGVPGTGKSTLLNTMFGLKFA ENSRNOP00000016468/1-927 PLELVDGATLSIPVRWVTGLLKELHVRLDRRSRLVVLSALGVPGTGKSTLLNTMFGLKFA ENSCPOP00000020954/1-932 PLELVDGGTLSIPVRWVTGLLKELHVRLDRRSRLVVLSALGVPGTGKSTLLNTMFGLRFA XP_004839998.1/1-931 PLELVDGGTLSIPIHWVTGLLKELHIRLDRRSRLVVLSTLGVPGTGKSTLLNTMFGLRFA ****:**.***:*::********** **:*********::*****************:** ENSP00000396918/1-931 TGKSCGPRGAFMQLITVAEGFSQDLGCDHILVIDSGGLIGGALTSAGDRFELEASLATLL ENSMUSP00000091053/1-926 TGRSCSPRGAFMQLLPVAEGFSQDLGCDQILVIDSGGLISGALASAGDRFELEASLATLL ENSRNOP00000016468/1-927 TGRSCSARGAFMQLLPVAEGFSQDLGCDQILVIDSGGLISGALASAGDRFELEASLATLL ENSCPOP00000020954/1-932 TGRSCSPRGAFMQLITVAEGFSQDLGCDHILAIDSGALISGASTSAGDRFELEASLATLL XP_004839998.1/1-931 TGRSCRPRGAFMQLITVAEGFSQDLGCDHILAIDSGALISGALVSAGDRFELEASLATLL **:** .*******:.************:**.****.**.** .**************** ENSP00000396918/1-931 MGLSNVTVISLAETKDIPAAILHAFLRLEKTGHMPNYQFVYQNLHDVSVPGPRPRDKRQL ENSMUSP00000091053/1-926 MGLSNVTVVSLAETKDIPPAVLHAFLRLEKMGHMPNYQFVYQNLHDLPVPSPKPRDRRQL ENSRNOP00000016468/1-927 MGLSNVTVVSLAETKDIPPAVLHAFLRLEKMGHMPNYQFVYQNLHDLPVPSPKPRDRRQL ENSCPOP00000020954/1-932 MGLSNVTVVSLAETRDIPPAILHAFLRLEKTGHMPNCQFVYQSLHDVPAPSPKPRERRQV XP_004839998.1/1-931 MGLSNVTVVSLAETRDIPPAILHAFLRLEKRGHMPNCQFVYQSLHDVPAPSPKPRERRQL ********:*****:***.*:********* ***** *****.***:..*.*:**::**: ENSP00000396918/1-931 LDPPGDLSRAAAQMEKQGDGFRALAGLAFCDPEKQHIWHIPGLWHGAPPMAAVSLAYSEA ENSMUSP00000091053/1-926 LDPPSDLSR-ATHLEKQGGGFRTLAGLA----ERQHVWHIPALWHGAPPMAAVSLGYSEA ENSRNOP00000016468/1-927 LDPPSDLSRAATHLEKQGGGFRTLAGLT----ERQHVWHIPALWHGAPPMAAVSLGYSEA ENSCPOP00000020954/1-932 LDPPSDLSRAAAHIEKQSGGFRTLAGLAFCDPERQHVWHVPGLWHGAPPMAAVSLGYSEA XP_004839998.1/1-931 LDPPGDLGR-AAQVEKQSGSFRTLAGLAFCDPERQHVWHVPGLWHGAPPMAAVSLGYSEA ****.**.* *:::***...**:****: *:**:**:*.*************.**** ENSP00000396918/1-931 IFELKRCLLENIRNGLSNQNKNIQQLIELVRRL ENSMUSP00000091053/1-926 IFELKRCLLENIRNGLSNQNQNIQQLIELLRRL ENSRNOP00000016468/1-927 IFELKRCLLENIRNGLSNQNKNIQQLIDLVRRL ENSCPOP00000020954/1-932 IFELKRCLLENIRNGLSNQNKNIQQLIELVRRL XP_004839998.1/1-931 IFELKRCLLENIRNGLSNQNKNIQQLIELVRRL ********************:******:*:***