CLUSTAL W(1.81) multiple sequence alignment ENSMUSP00000024885/1-1052 MSADQEPVAFLAKQPWRPKQVTEDPDEEDEEDGDEGKNGFSLEEVLRLGGTKQDYLMLAT ENSRNOP00000006824/1-1045 MSADQEPLEFLAKNPWRPKEVTEDPDEEDEEDSDEAKNGFSLEEVLRLGGTKQDYLMLAT ENSP00000234170/1-1054 MAAVKEPLEFHAKRPWRPEEAVEDPDEEDEDNTSEAENGFSLEEVLRLGGTKQDYLMLAT ENSCPOP00000020612/1-1038 MAAAKEPLEFYAKRPRPQEDVFEDS---DEDDSGQTKDGFSLEEVLRLGGTKQDYLMLAT XP_004839355.1/1-1052 MAAAKEPLEFHAKRPWPRREVLEDSDEEDENDNGEAENGFSLEEVLRLGGTKQDYLMLAA *:* :**: * **.* .:. **. **:: .: ::*********************: ENSMUSP00000024885/1-1052 LDENEEVVDGGKKGTIDDLQQGELESFIQNLNLAKYSK-SLIEEDEPEKKENTSKKEAKL ENSRNOP00000006824/1-1045 LDENEEVVDGGKKGTIDDLQQGELEAFIQNLNLAKYSK-SLIEEDEPEKKENTSKKEAKL ENSP00000234170/1-1054 LDENEEVIDGGKKGAIDDLQQGELEAFIQNLNLAKYTKASLVEEDEPAEKENSSKKEVKI ENSCPOP00000020612/1-1038 LDENEEVVDGGKKGTIDDLQEGELKAFIQNLGLDKYSN-SFIEEDEPEK----------- XP_004839355.1/1-1052 LDENEEVLDGGKKGTIDDLQEGELKAFIQSLSLAKYAE-SFIEEDEPAKKENTSEKEAKV *******:******:*****:***::***.*.* **:: *::***** : ENSMUSP00000024885/1-1052 LKVENKKQKATEGKKTSEKKVKNKTVPEQRPE--SCPVSKAKKDKQPDVFEFLERQTMLL ENSRNOP00000006824/1-1045 PKVENKKQKAAEGKK------KNKSVPEQHPE--SSTVFKAKRDKQPDAFEFLERQALLL ENSP00000234170/1-1054 PKINN--KNTAESQRTSVNKVKNKNRPEPHSDENGSTTPKVKKDKQ-NIFEFFERQTLLL ENSCPOP00000020612/1-1038 -------QNEAENENVSMSKAKNKEMAGKHSAKKGSAVPKVPKEEQQDMFEFFERQTLLL XP_004839355.1/1-1052 SKIENKQQNAAESVRMSVNKVKNKDMPEKHSGKNSSAIPKVKKDKQQDVFEFFERETLLL :: :*. . *** . :. ... *. :::* : ***:**:::** ENSMUSP00000024885/1-1052 RPGGKWYDMEYSGEYSLELQPPDVVSKYKALAQKLYEHEVSLFKSKTNNQKGGSSTWMKA ENSRNOP00000006824/1-1045 KPGGKWYDMEYSGEFSLEPQPWDVVSKYKALAEKLYEQEVGLFKNKTSNQKGGSSTWMKA ENSP00000234170/1-1054 RPGGKWYDLEYSNEYSLKPQPQDVVSKYKTLAQKLYQHEINLFKSKTNSQKGASSTWMKA ENSCPOP00000020612/1-1038 KAGGKWYDLEYTSEYCFEPQPRDIVSKYKTLAQKLYECEVNLFKSKTNNQKGASSTWMKA XP_004839355.1/1-1052 KAGGKWYDLEYSNEYCLEPQPQDIVCKYKTLAQKLYECEIKLFKNKTNKQKGASSAWMKA :.******:**:.*:.:: ** *:*.***:**:***: *: ***.**..***.**:**** ENSMUSP00000024885/1-1052 IVSSGTLADRMAAMILLIQDDAVHTLQFVETLMSLVKKKGSKQQCLMALDTFKELLITDL ENSRNOP00000006824/1-1045 IVSSGTLADRMAAMILLIQDDAVHTLQFVETLLSLVRKKGSKQQCLMALDTFKELLITDL ENSP00000234170/1-1054 IVSSGTLGDRMAAMILLIQDDAVHTLQFVETLVNLVKKKGSKQQCLMALDTFKELLITDL ENSCPOP00000020612/1-1038 IVSSGTLGDRMAAMILLIQDDAVHTLQFVETLLSLVKKKGSKQQCLMALDTFKELLITDL XP_004839355.1/1-1052 IVSSGTLGDRMAAMILLIQDDAVHTLQFVETLLNLVKKKGSKQQCFMALDTFKELLITDL *******.************************:.**:********:************** ENSMUSP00000024885/1-1052 LPDSRKLRVFSQHPFHKLEELSSGNKDSRDRRLILWYYEHQLKHLVAEFVQVLETLSHDS ENSRNOP00000006824/1-1045 LPDSRKLRLFSQRPLHKLEELSSGNKDSRDRRLILWYYEHQLKHLVAEFVQVLETLSHDS ENSP00000234170/1-1054 LPDNRKLRIFSQRPFDKLEQLSSGNKDSRDRRLILWYFEHQLKHLVAEFVQVLETLSHDT ENSCPOP00000020612/1-1038 LPDNRKLRVFSQHPFNKLEQVSSGNKDSRDRRLILWYFEHQLKHLVAEFVQVLETLSRDS XP_004839355.1/1-1052 LPDNRKLRVFSQHPFNKLEQLSSGNKDSRDRRLILWYFEHQLKHLVAEFVQILETLSQDS ***.****:***:*:.***::****************:*************:*****:*: ENSMUSP00000024885/1-1052 LVTTKTRALVAAHELLCDKPEEEKALLVQVINKLGDPQNRIATKASHLLEVLLRKHPNMK ENSRNOP00000006824/1-1045 LVTTKTRALVAAHELLCDKPEEEKALLVQVINKLGDPQNRIATKASHLLEVLLRKHPNMK ENSP00000234170/1-1054 LVTTKTRALTVAHELLCNKPEEEKALLVQVVNKLGDPQNRIATKASHLLETLLCKHPNMK ENSCPOP00000020612/1-1038 LEATKTRALLAAHELLCNKPEEEKALLMQVVNKLGDPQNRIATKASHLLETLLCKHPNMK XP_004839355.1/1-1052 LAASKIRALTAAHELLCNKPEEEKALLVQVVNKLGDPQNRIATKASHLLETLLCKHPNMK * ::* *** .******:*********:**:*******************.** ****** ENSMUSP00000024885/1-1052 GVVCAEIERLLFRSNISPKAQYYAICFLNQMVLSHEESELANKLITLYFCFFRTCIKKKD ENSRNOP00000006824/1-1045 GVVCGELERLLFRSNISPKAQYYAICFLNQMVLSHEESELANKLITLYFCFFRTCIKKKD ENSP00000234170/1-1054 GVVSGEVERLLFRSNISSKAQYYAICFLNQMALSHEESELANKLITVYFCFFRTCVKKKD ENSCPOP00000020612/1-1038 GVVCGEIERLLFRSNISPKAQYYAICFLNQIVLSHEESELANKLITI-----RTCIKKKD XP_004839355.1/1-1052 GVVCGEIERLLFRSNISPKAQYYSICFLNQIALSHEESELANKLITIYFCFFRTCVKKKD ***..*:**********.*****:******:.**************: ***:**** ENSMUSP00000024885/1-1052 IESKMLSAILTGVNRAYPYSQIGDDKVREQVDTLFKVLHVVNFNTSVQALMLLFQVMNSQ ENSRNOP00000006824/1-1045 IESKMLSAILTGVNRAYPYSQIGDDRVREQVDTLFKVLHVVNFNTSVQALMLLFQVMNSQ ENSP00000234170/1-1054 VESKMLSALLTGVNRAYPYSQTGDDKVREQIDTLFKVLHIVNFNTSVQALMLLFQVMNSQ ENSCPOP00000020612/1-1038 IESKMLSALLSGVNRAYPYSQSGDEKVREQVDTLFRVLHVVNFNTSVQALMLLFQVMNSQ XP_004839355.1/1-1052 IESKMX-----GVNRGYPYSQSGDDKVREQVDTLFKVLHLVNFNTSVQALMLLFQVMNSQ :**** ****.***** **::****:****:***:******************** ENSMUSP00000024885/1-1052 QTISDRYYTALYRKMLDPGLTTCSKQAMFLNLIYKSLKADIMLRRVKAFVKRLLQVTCTQ ENSRNOP00000006824/1-1045 QTISDRYYTALYKKMLDPGLTTCSKQAMFLNLIYKSLKADIMLRRVKAFVKRLLQVTCTQ ENSP00000234170/1-1054 QTISDRYYTALYRKMLDPGLMTCSKQAMFLNLVYKSLKADIVLRRVKAFVKRLLQVTCQQ ENSCPOP00000020612/1-1038 QTISDRYYTALYRKILDPGLLMCSKQAMFLNLVYKSLKADIVLRRVKAFVKRLLQVTCTQ XP_004839355.1/1-1052 QTISDRYYSALYRKMLDPGLMMCSKQAMFLNLVYKSLKADIVLRRVKAFVKRLLEITCAQ ********:***:*:***** **********:********:************::** * ENSMUSP00000024885/1-1052 MPPFICGALYLVSEILKAKPDLRSQLDDHPES-DEENFVDVGDDSDDEKFTDADKETATD ENSRNOP00000006824/1-1045 MPPFICGALYLVSEILKAKPDLRSQLDDHPES-DEENFVDVGDDSDDEKFTDADRETATD ENSP00000234170/1-1054 MPPFICGALYLVSEILKAKPGLRSQLDDHPESDDEENFIDANDDEDMEKFTDADKETEI- ENSCPOP00000020612/1-1038 TPPFICGALYLVSEILKAKPDLRSQLNNHVESDDEEKFVDAADDDGIEKFTDADKETEVD XP_004839355.1/1-1052 MPPFICGALYLVSEILKAKPDLRSQLDDHVETDDEEKFVDIGDDEDTEEFTDADKETEID *******************.*****::* *: ***:*:* **.. *:*****:** ENSMUSP00000024885/1-1052 AVKEVESKETEPESSAEAEKPKAASWVHFDNLKGGKQIKTYDPFSRNPLFCGAENTTLWE ENSRNOP00000006824/1-1045 AVEEVEAKEAEPESSTETEKPKAASWVHFDNLKGGKQIKTYDPFGRNPLFCGAEHTNLWE ENSP00000234170/1-1054 -VKKLETEETVPETDVETKKPEVASWVHFDNLKGGKQLNKYDPFSRNPLFCGAENTSLWE ENSCPOP00000020612/1-1038 TVKKVETEETV--SDTETKNPKTASWVHLNNLKGVKHLNTYDPFSRNPLFCGAENTSFWE XP_004839355.1/1-1052 TVGKVETEETG--SDTKTKNPKTASWVHVDNLRGVKQLNTYDPLSRNPLFCGAENTSLWE * ::*::*: :..::::*:.*****.:**:* *:::.***:.*********:*.:** ENSMUSP00000024885/1-1052 LKKLSEHFHPSVALFAKTILEGNCIQYSGDPLQDFTLMRFLDRFVYRNPKLHKGKENTDS ENSRNOP00000006824/1-1045 LRKLSQHFHPSVALFAKTILEGNHIQYSGDPLQDFTLMRFLDRFVYRNPKLHKGKENTDS ENSP00000234170/1-1054 LKKLSVHFHPSVALFAKTILQGNYIQYSGDPLQDFTLMRFLDRFVYRNPKPHKGKENTDS ENSCPOP00000020612/1-1038 LKKLSEHFHPSVALFAKTILQGNYIQYSGDPLQDFTLMRFLDRFVYRNPKPHRGKENTDS XP_004839355.1/1-1052 LKKLSEHFHPSVALFAKTILQGNYIQYSGDPLQDFTLMRFLDRFVYRNPKPHKGKENTDS *:*** **************:** ************************** *:******* ENSMUSP00000024885/1-1052 VVMQPKRKHFMKNVRDLAVNSKEFLAKEESQIPVDEVFFYRYYKKVAVVKDKQKRSADEE ENSRNOP00000006824/1-1045 VVMQPKRKHFMKNVRDLAVNSKEFLAKEESQIPVDEVFFYRYYKKVAVTKDKQKRNADED ENSP00000234170/1-1054 VVMQPKRKHFIKDIRHLPVNSKEFLAKEESQIPVDEVFFHRYYKKVAV-KEKQKRDADEE ENSCPOP00000020612/1-1038 VVMQPKRKHFIKDIRSLAVNSKEFLAKEESQIPVDEVFFHRYYKKVAVVKEKQKPNTDEE XP_004839355.1/1-1052 VVMQPKWKHFIKDIRSLAVNSKEFLAKEESQIPVDEVFFHRYYKKAAIIKEKQKRNADEE ****** ***:*::* *.*********************:*****.*: *:*** .:**: ENSMUSP00000024885/1-1052 SIEDIDDEEFENMIDTFEDDNCFPPGKDDIDFASNMKK-AKGAKADL--EDSESSDGELG ENSRNOP00000006824/1-1045 SIEDVDDEEFENMIDTFEDDNCFTPGKDDMDFASNMKK-IKGAKDDL--EDSESSDDELG ENSP00000234170/1-1054 SIEDVDDEEFEELIDTFEDDNCFSSGKDDMDFAGNVKKRTKGAKDNTLDEDSEGSDDELG ENSCPOP00000020612/1-1038 SIEDVDDEEFEKMIDTFEDDNCYTPGKGDLDFVSNMKKTKKRAKDNLEDEDSEGSDDEFG XP_004839355.1/1-1052 SIEDVDDEEFEKMIDTFEDDNYYTGGTDDLDFVSNVKKKTKRAKDNCEDEDSEGSDDEFA ****:******::******** :. *..*:**..*:** * ** : ****.**.*:. ENSMUSP00000024885/1-1052 DLDDDEVSLGSMNDEDF-EIDEDGGTFMDVSDDESEDAPEFADANPKANTKKSKRKSEDD ENSRNOP00000006824/1-1045 DLDDDEVSLGSMNDEDF-EIDEDGGTFMDVSDDESDHVPEFGEASPKASTKKSKRKSEDD ENSP00000234170/1-1054 NLDDDEVSLGSMDDEEFAEVDEDGGTFMDVLDDESESVPEL-EVHSKVSTKKSKRKGTDD ENSCPOP00000020612/1-1038 NLDDEEVSLGSM-NEDFDELDDDGGTFMDVSDEGSEGAPELDDDNSKDNTKKNKRKSTGD XP_004839355.1/1-1052 NLDDEEVSLGSM-DEEFAEIDEDAGTFMDVSDDESEGIPELDEVNSKDSAKRNKRRGTGD :***:******* :*:* *:*:*.****** *: *: **: : .* .:*:.**:. .* ENSMUSP00000024885/1-1052 FDFAGSFQGQ-KKKKKSFNDSSLFVSAEEFGHLLDENMGSKFDTIGMNAMANRDNASFKQ ENSRNOP00000006824/1-1045 FDFAGSFQGQ-KKKKKSFNDSSLFVSAEEFGHLLDENMGSKFDTTGMNAMANKDNASFKQ ENSP00000234170/1-1054 FDFAGSFQGP-RKKKRNLNDSSLFVSAEEFGHLLDENMGSKFDNIGMNAMANKDNASLKQ ENSCPOP00000020612/1-1038 VDFAGSFLGPKKKKKRSLHDSSLFVSAEEFGHLLDENMGSKFDNIGMNAMANKDNASLKQ XP_004839355.1/1-1052 FDFAGSFEGPKKKKKRNLNNSSLFVSAEEFGHLLDENMGSRFDNIGMNAMANKDNASLKQ .****** * :***:.:::********************:**. *******:****:** ENSMUSP00000024885/1-1052 LKWEAERDDWLHNRDVKSIIKKK-KNFR-----KKMK-APQKPKRQRK ENSRNOP00000006824/1-1045 LKWEAERDDWLHNRDVKSIIKKK-KNFR-----KKK--APQKPKRQRK ENSP00000234170/1-1054 LRWEAERDDWLHNRDAKSIIKKK-KHFK-----KKRIKTTQKTKKQRK ENSCPOP00000020612/1-1038 LRWEAERDDWLHNRDVSPLVMKKLLQFKKLVMIKKRSVSTHKPRFRAL XP_004839355.1/1-1052 LRWEAERDDWIHNRDVRSIIKKK-KNFK-----KKRP-NTQKAKKQRK *:********:****. .:: ** :*: ** .:*.: :