CLUSTAL W(1.81) multiple sequence alignment ENSMUSP00000107262/1-1132 MADAQMQVAPTPTIQMRTEEDLSLPHPSAPEGLPPPPPKETFSKFQQQRQASELRRLYKH ENSRNOP00000052739/1-1127 MADAQMQVVHTPTIQMRTGEDLPLPPPSALEGLPPPPPKESFSKFQQQRQANELRRLYKH ENSP00000343140/1-1843 MADTQTQVAPTPTMRMATAEDLPLPPPPALEDLPLPPPKESFSKFHQQRQASELRRLYRH ENSCPOP00000020129/1-1088 -AETQMQVAPTSTIPMATAKDLSLPPPSALEDLPALPPKESFSKFHQQRQASELRRLYRH XP_004835289.1/1-1127 MAETQAQATPKPTVPMATAEGLSLPPPSTLGHLPPPPPKESFSKFHQQRQASELRRLYKH *::* *.. ..*: * * :.*.** *.: ** ****:****:*****.******:* ENSMUSP00000107262/1-1132 IHPELRKNLEEAVAEDLAEVLGSEEPTEGDVQCMRWIFENWRLDAIGDHERPAAREPVSG ENSRNOP00000052739/1-1127 IHPELRKNLEEAVAEDLAKVLGSEEPTEGDVQCMRWIFENWSLDAIGDHERPAGKEPVSG ENSP00000343140/1-1843 IHPELRKNLAEAVAEDLAEVLGSEEPTEGDVQCMRWIFENWRLDAIGEHERPAAKEPVLC ENSCPOP00000020129/1-1088 IHPELRKNLAEAVAEDLAEVLGSEEPTEGDVQCMRWIFENWRLDTIGDRQQPAAKEPVTG XP_004835289.1/1-1127 IHPELRKNLAEAVAEDLAEVLGSEEPTEGDVQCMRWIFENWQLDAIGDREQPAAKEPVPG ********* ********:********************** **:**::::**.:*** ENSMUSP00000107262/1-1132 GNVQATSRKFEEGSFTNSSDQEPEGLRPSGGDVQAARQMFETKPLDALRGQEEATQTTMR ENSRNOP00000052739/1-1127 GNVQATSRKFEEGSFTNSSDLEP-GPQLSGGDVRATRQLFETKSLDALTGQEEATQMTMK ENSP00000343140/1-1843 GDVQATSRKFEEGSFANSTDQEPTRPQPGGGDVRAARWLFETKPLDELTGQAKELEATVR ENSCPOP00000020129/1-1088 GDVQATSRKFEEGSFANSVGPQLAGTQPAGGDVRAARWLFETKPLDELTGRTEVTEAPAR XP_004835289.1/1-1127 GDVQATSRKFEEGSFANSVDPQPPGPQPSGGDVRAARWLFETKPLDELTGQAEATEAPGR *:*************:** . : : .****:*:* :****.** * *: : : . : ENSMUSP00000107262/1-1132 EPAATGDVQGTRKLFETRPLDRLGSRPSIQEQSPLELRSEIQELKGDVKKTVKLFQTEPL ENSRNOP00000052739/1-1127 EPAVSGDVQGTRKLFETKPLDMLGSCPSIQDQSPLELRSEIQELKGDVKKTVKLFQTEPL ENSP00000343140/1-1843 EPAASGDVQGTRMLFETRPLDRLGSRPSLQEQSPLELRSEIQELKGDVKKTVKLFQTEPL ENSCPOP00000020129/1-1088 EPAASGDVQGTRMLFETRPLDRLGSRPSMQEQSLLELRSEIQELRGDVKKTVKLFQTEPL XP_004835289.1/1-1127 EPVASGDVQGTRMLFETRPLDRLGSRPSMQEQSPLELRSEIQELKGDVKKTVKLFQTEPL **..:******* ****:*** *** **:*:** **********:*************** ENSMUSP00000107262/1-1132 CAIQDAEGTIHEVKAACREEIQSNAVRSARWLFETRPLDAFNQDPSQVRVIRGISLEEGA ENSRNOP00000052739/1-1127 CAIQDAEGAIHEVKAACREEIQSNAVRSARWLFETRPLDAFNQDPSQVRVIRGISLEEGA ENSP00000343140/1-1843 CAIQDAEGAIHEVKAACREEIQSNAVRSARWLFETRPLDAINQDPSQVRVIRGISLEEGA ENSCPOP00000020129/1-1088 CAIQDPEGAIHEVKAACREEIQSNAVRCGRWLFETRPLDAFNQDPSQVRVIRGISLEEGS XP_004835289.1/1-1127 CAIQDAEGAIHEVKAACREEIQSNAVRSARWLFETRPLDEFNQDPSQVRVIRGISLEEGS *****.**:******************..********** :******************: ENSMUSP00000107262/1-1132 LPDVSATRWIFETQPLDAIREIEVDEKDFQPSPDLIPPGPDVQHQRHLFETCSLDTLKG- ENSRNOP00000052739/1-1127 LPDVSATRWIFETQPLDAIREILVDEKDFQPSPDLIPPGPDVQHQRHLFETCALDTLKG- ENSP00000343140/1-1843 RPDVSATRWIFETQPLDAIREILVDEKDFQPSPDLIPPGPDVQQQQHLFETRALDTLKG- ENSCPOP00000020129/1-1088 LPDVSATRWIFETQPLDAIREIVVDEKDFQPSPDLVPPGPDVQQQRHLFETRALSTLKGE XP_004835289.1/1-1127 RPDVSATRWIFETQPLDAIREILVDEKDFQPSPDLVPPGPDVQQQRHLFETRALDTLKG- ********************* ************:*******:*:***** :*.**** ENSMUSP00000107262/1-1132 ERETEAEVPPKEEVIPGDVRSTLWLFETKPLDAFRDQVQVGHLQRVGHQEGEGLVTECLP ENSRNOP00000052739/1-1127 ERETEAEAPAKEEVIPGDVRSTLWLFETKPLDAFRDQVQVGHLQRVDHQKGEGPVIECLS ENSP00000343140/1-1843 DEEAGAEAPPKEEVVPGDVRSTLWLFETKPLDAFRDKVQVGHLQRVDPQDGEG----HLS ENSCPOP00000020129/1-1088 EEEATAKTLPKEEVVPGNVQSTLWLFETKPLDTLRDQIQVGHLQRVGHQESEG-----LT XP_004835289.1/1-1127 EEEAAAEAPPKEEVVPGNVRSTLWLFETKPLDTLGDQVQVGHLQRVGHQEDEG-----LM :.*: *:. .****:**:*:************:: *::********. *..** * ENSMUSP00000107262/1-1132 SNGTSVLPLSQGVPQNDGLKGDVKTFKNLFETLPLDSIGQGEPSAYGNINRGQNTDSAEQ ENSRNOP00000052739/1-1127 SNGTSALPLSQGVPQNNGPKGDVKTFKNLFETLPLDSIGQGEPSACGNINRGQRTDSTGL ENSP00000343140/1-1843 SDSSSALPFSQSAPQRDELKGDVKTFKNLFETLPLDSIGQGEVLAHGSPSREEGTDSAGQ ENSCPOP00000020129/1-1088 SDSSLALPTSQGAPQRDGVKGDVKTFKNLFETLPLDSIGQGEASACGSVSTAGITDCAGQ XP_004835289.1/1-1127 CAGSSPLPAFLGAPQRDGVKGDVKNFKNLFETLPLDSIRQGEASVPGSVNPAGTTDFAGQ . .: ** ..**.: *****.************* *** . *. . ** : ENSMUSP00000107262/1-1132 SQGSDAPVYAMQDSRGQLHALTSVSREQVVGGDVQGYKWMFETQPLDTLGRSPSTIDVVR ENSRNOP00000052739/1-1127 SEGADAPVYAMQDSRGQLHALTSVSREQVVGGDVQGYKWMFETQPLDRLGRSPSTVDVVR ENSP00000343140/1-1843 AQGIGSPVYAMQDSKGRLHALTSVSREQIVGGDVQGYRWMFETQPLDQLGRSPSTIDVVR ENSCPOP00000020129/1-1088 SQAAGPPVYAMQDSKGQLHALTSVSREQVVGGDVQGYRWMFETQPLDQLGRSPSTIDVVQ XP_004835289.1/1-1127 SQAAGSPVYAVQDSEGQLHALTSVSREQVVGGDVQGYRWMFETQPLDQLGRSPSTIDVVR ::. ..****:***.*:***********:********:********* *******:***: ENSMUSP00000107262/1-1132 GITRQEVVAGDVGTTRWLFETQPLEMIHQQEQQKPEEEEGKGPGGPPPELPKKGDVQTIR ENSRNOP00000052739/1-1127 GITRQEVVAGDVGTTRWLFETQPLEMIHQQEQQKREEEEGRGPGGPPPELPQKGDVQTIR ENSP00000343140/1-1843 GITRQEVVAGDVGTARWLFETQPLEMIHQREQQERQKEEGKSQGDPQPEAPPKGDVQTIR ENSCPOP00000020129/1-1088 GITRQEVVAGDVGTTRWLFETQPLEMIHQREQQERQEEEGKRQEGLQPEAPAKGDVQTIR XP_004835289.1/1-1127 GITRQEVMAGDVGTARWLFETQPLEVIHQREQQERREEEGKTQEGPQPEAPPKGDVQTIR *******:******:**********:***:***: .:***: . ** * ******** ENSMUSP00000107262/1-1132 WLFETYPMSELAEKRESEVTDPVSKAETQSCTWMFGPQSLNPAEGSGEQHLQTSQVPAGD ENSRNOP00000052739/1-1127 WLFETYPMSELAEKQESEVTGPVSKAEAQSCTWMFGSQSLNQAEGSGEQHLQTSQVQAGD ENSP00000343140/1-1843 WLFETCPMSELAEKQGSEVTDPTAKAEAQSCTWMFKPQPVDRPVGSREQHLQVSQVPAGE ENSCPOP00000020129/1-1088 WLFETCPMSELAEKQSSEVTDATVKAQARSCTWMFKPQPLDPAEDSREKHLQVSQVQARE XP_004835289.1/1-1127 WLFETCPMSEVAEKQSSEVTDPTAKAQARSSTWMFKPQPLDPAEDSREKHLQVSQVQAGE ***** ****:***: ****... **:::*.**** .*.:: . .* *:***.*** * : ENSMUSP00000107262/1-1132 RQTDRHVFETESLPASNQSSGRK-PVRYCSRVEIPSGQVSRQKEVFQALEAGKKEVPE-- ENSRNOP00000052739/1-1127 RQTDSHVFETESLSAQGQSSGRK-PVRYCSRVEIPSGQVSRQKEVFQALEAGKRGVQE-- ENSP00000343140/1-1843 RQTDRHVFETEPLQASGRPCGRR-PVRYCSRVEIPSGQVSRQKEVFQALEAGKKEEQE-- ENSCPOP00000020129/1-1088 RQTDGHVFEVEPLQDMAHPCGRGPPVRYSSRVEIPSGQVSRQKEVFQALEAGKREEEGQG XP_004835289.1/1-1127 RQTNGHIFETEPLQASGRPCGRG-PVRYCSRVEIPSGQVSRQKEVFQALEASKREEQEQD ***: *:**.*.* :..** ****.**********************.*: ENSMUSP00000107262/1-1132 TTINLGSIPTGSVHKFTWLFENCPMGSLAAESIRGDNLQEEQPKGSAGHGTPERQETAAE ENSRNOP00000052739/1-1127 TVLSPGSIPTGSVHKFTWLFENCPMGSLAAESVSGGNLQEEQPKVSADPGTPERQETAAE ENSP00000343140/1-1843 PRVIAGSIPAGSVHKFTWLFENCPMGSLAAESIQGGNLLEEQPMSPSGNRMQESQETAAE ENSCPOP00000020129/1-1088 SRITPGPTPSGSVRKFTWLFENCPMGSLAAESIRGGDLQEEQPRKLSSNEAPEKQKTATE XP_004835289.1/1-1127 SRTAPGPIATGSVHKFTWLFENCPMGSLTAESIQGGDLEEEQPRKPSSNGTPEKQETAAE . *. .:***:**************:***: *.:* **** :. * *:**:* ENSMUSP00000107262/1-1132 RTLRTLHATPGILHHGGILMEARGPGELCLAKYVLPSPGQGRPYIRKEELVCGELPRIVR ENSRNOP00000052739/1-1127 RTLRTLHATPGILHHGGILMEARGPGELCLAKYVLPSPGQGRPCVQKEELVCGELPRIVR ENSP00000343140/1-1843 GTLRTLHATPGILHHGGILMEARGPGELCLAKYVLSGTGQGHPYIRKEELVSGELPRIIC ENSCPOP00000020129/1-1088 GTLQTLHATPGILHHGGILMEVQGPGELCLAKYVLPGPAQGRPYVQKEELVFGELPRIVR XP_004835289.1/1-1127 GTLRTLHATPGILHHRGILMEVRGPGELCLAKYVLPGPGQGRPYVQKEELVSGELPRIVR **:*********** *****.:************....**:* ::***** ******: ENSMUSP00000107262/1-1132 QVLRRTDVDQQGLLVQEDTAGQLQLHPLTLPGPGDPGNIEDMDPELQQLLACGLGVSVSK ENSRNOP00000052739/1-1127 QVLGRTDVDQQGLLVQEDTAGQLRLHPLKLPGPGDPENIEDMDPELQQLLACGLGVSMAK ENSP00000343140/1-1843 QVLRRPDVDQQGLLVQEDPTGQLQLKPLRLPTPGSSGNIEDMDPELQQLLACGLGTSVAR ENSCPOP00000020129/1-1088 QVLRRPDVDPQGLLVQEDPTGHLWLHPLKLPAPSNNGSIEDLDPELQQLLACSLGASVSR XP_004835289.1/1-1127 QVLRRPDVDQRGLLVQEDQTGQLWLHALRLPAPGNSGNIEDMDPELQQLLACGLGTSVAR *** *.*** :******* :*:* *:.* ** *.. .***:**********.**.*::: ENSMUSP00000107262/1-1132 TGLVMQETGQGLVALTAYSLQPQLTSRAPERSSVQLLASCIDKGDLHSLHSLRWEPPTDP ENSRNOP00000052739/1-1127 TGLVMQETGQGLVALTAYSLQPQPTSRGPERSSVQLLASCIDKGELHSLPSLRWEPPTDS ENSP00000343140/1-1843 TGLVMQETEQGLVALTAYSLQPRLTSKASERSSVQLLASCIDKGDLSGLHSLRWEPPADP ENSCPOP00000020129/1-1088 TGLVMQETEQGLVALTAYSLQPRLTSRVPERGSVQLVASCIDKGDLSGLHSLHWEPPADP XP_004835289.1/1-1127 TGLVMQETEQGLVSLTAYSLQPQLTSRVPERSSVQLLASCIDKGDLSGLHSLRWEPPADP ******** ****:********: **: .**.****:*******:* .* **:****:*. ENSMUSP00000107262/1-1132 SSGPATEESQRVPQTESIIHVTPLDSTMEMGQLRISGSTPCPPPSRAAGKVVLPNGKPVA ENSRNOP00000052739/1-1127 SSVPVTEETQRLPPTESIIRVTPLDSTMKMGHLRVSGSTPCPPLPRAAGKVVLPNGRPG- ENSP00000343140/1-1843 SPVPASEGAQSLHPTESIIHVPPLDPSMGMGHLRASGATPCPP--QAIGKAVPLAGEAAA ENSCPOP00000020129/1-1088 SPGPATEGTQRFLPTESTIHVSPLDPSLGVGNLRGPGATSCPP--QAPAKAVPLAGQGAA XP_004835289.1/1-1127 SPGPATEGTQRLLPTESIIHVPPLDTSLGMGHLRGPGATSCLP--QAIAKAVPLAGQAAP *. *.:* :* . *** *:*.***.:: :*:** .*:*.* * :* .*.* *. ENSMUSP00000107262/1-1132 QAPLQEARKKTDISHAGQKGKAASGRPEGTIASPLGSGAPDLQEAMQNLRLATAEAQSLH ENSRNOP00000052739/1-1127 -APLQEARKQVDISHAGQKGKAASGRPEGTIAPPLGSGAPNLQEAMQNLRLATAEAQSLH ENSP00000343140/1-1843 PAQLQNTEKQED-SHSGQKGMAVLGKSEGATTTPPGPGAPDLLAAMQSLRMATAEAQSLH ENSCPOP00000020129/1-1088 SAPWQNTKKQ---------GAAALGKSEGAMATPTDSRAPDLQEALQNLQTATTEAQSLH XP_004835289.1/1-1127 PAPLQDTEKQEDSSHTGQKRTAALGRSEGTMATHAESRAPDLQAALQSLQMATAEAQSLH * *::.*: *. *:.**: :. . **:* *:*.*: **:****** ENSMUSP00000107262/1-1132 QQVLSRHPQGSDPVATSMPVQDVLQASTPATGVTQGSIRPVAGSEARIPAFPRKLL---- ENSRNOP00000052739/1-1127 QQVLSRHAQGSDPAATSISAQDVLQVPTPTT--TQGSIMPVAGRDARITAVPRKLL---- ENSP00000343140/1-1843 QQVLNKHKQGPTPTATSNPIQDGLR----KAGATQSNIRPGGGSDPRIPAAPRKVSREEQ ENSCPOP00000020129/1-1088 QHILSKHKQSSASVATAVSVQDALQ----------------------------------- XP_004835289.1/1-1127 QQVLSRHKQGSTPAATAVPVQDGLPAPAPATAATQSNSRRVAAGDSRTPAAPRKLL---- *::*.:* *.. ..**: . ** * ENSMUSP00000107262/1-1132 ------------------------------------------------------------ ENSRNOP00000052739/1-1127 ------------------------------------------------------------ ENSP00000343140/1-1843 ALPRGLPGGWVTIQDGIYTAHPVRTFDPPGGVQLSQREPQSRHRETALSVQAPRPLQGGP ENSCPOP00000020129/1-1088 ------------------------------------------------------------ XP_004835289.1/1-1127 ------------------------------------------------------------ ENSMUSP00000107262/1-1132 ------------------------------------------------------------ ENSRNOP00000052739/1-1127 ------------------------------------------------------------ ENSP00000343140/1-1843 GQSTGPGREEPGGCTQMAWGPPGKAMAEVCPGGLQAAETTLKTAPLGRHILASGPQAAGA ENSCPOP00000020129/1-1088 ------------------------------------------------------------ XP_004835289.1/1-1127 ------------------------------------------------------------ ENSMUSP00000107262/1-1132 ------------------------------------------------------------ ENSRNOP00000052739/1-1127 ------------------------------------------------------------ ENSP00000343140/1-1843 SPHPHNAFVPPPPTLPAAVTGPDFPAGAHRAEDSIQQASEPLKDPLLHSHSSPAGQRTPG ENSCPOP00000020129/1-1088 ------------------------------------------------------------ XP_004835289.1/1-1127 ------------------------------------------------------------ ENSMUSP00000107262/1-1132 ------------------------------------------------------------ ENSRNOP00000052739/1-1127 ------------------------------------------------------------ ENSP00000343140/1-1843 GSQTKTPKLDPTMPPKKKPQLPPKPAHLTQSHPPQRLPKPLPLSPSFSSEVGQREHQRGE ENSCPOP00000020129/1-1088 ------------------------------------------------------------ XP_004835289.1/1-1127 ------------------------------------------------------------ ENSMUSP00000107262/1-1132 ------------------------------------------------------------ ENSRNOP00000052739/1-1127 ------------------------------------------------------------ ENSP00000343140/1-1843 RDTAIPQPAKVPTTVDQGHIPLARCPSGHSQPSLQHGLSTTAPRPTKNQATGSNAQSSEP ENSCPOP00000020129/1-1088 ------------------------------------------------------------ XP_004835289.1/1-1127 ------------------------------------------------------------ ENSMUSP00000107262/1-1132 ------------------------------------------------------------ ENSRNOP00000052739/1-1127 ------------------------------------------------------------ ENSP00000343140/1-1843 PKLNALNHDPTSPQWGPGPSGEQPMEGSHQGAPESPDSLQRNQKELQGLLNQVQALEKEA ENSCPOP00000020129/1-1088 ------------------------------------------------------------ XP_004835289.1/1-1127 ------------------------------------------------------------ ENSMUSP00000107262/1-1132 ------------------------------------------------------------ ENSRNOP00000052739/1-1127 ------------------------------------------------------------ ENSP00000343140/1-1843 ASSVDVQALRRLFEAVPQLGGAAPQAPAAHQKPEASVEQAFGELTRVSTEVAQLKEQTLA ENSCPOP00000020129/1-1088 ------------------------------------------------------------ XP_004835289.1/1-1127 ------------------------------------------------------------ ENSMUSP00000107262/1-1132 ------------------------------------------------------------ ENSRNOP00000052739/1-1127 ------------------------------------------------------------ ENSP00000343140/1-1843 RLLDIEEAVHKALSSMSSLQPEASARGHFQGPPKDHSAHKISVTVSSSARPSGSGQEVGG ENSCPOP00000020129/1-1088 ------------------------------------------------------------ XP_004835289.1/1-1127 ------------------------------------------------------------ ENSMUSP00000107262/1-1132 ------------------------------------------------------------ ENSRNOP00000052739/1-1127 ------------------------------------------------------------ ENSP00000343140/1-1843 QTAVKNQAKVECHTEAQSQVKIRNHTEARGHTASTAPSTRRQETSREYLCPPRVLPSSRD ENSCPOP00000020129/1-1088 ------------------------------------------------------------ XP_004835289.1/1-1127 ------------------------------------------------------------ ENSMUSP00000107262/1-1132 ------------------------------------------------------------ ENSRNOP00000052739/1-1127 ------------------------------------------------------------ ENSP00000343140/1-1843 SPSSPTFISIQSATRKPLETPSFKGNPDVSVKSTQLAQDIGQALLHQKGVQDKTGKKDIT ENSCPOP00000020129/1-1088 ------------------------------------------------------------ XP_004835289.1/1-1127 ------------------------------------------------------------ ENSMUSP00000107262/1-1132 ------------------------------------------------------------ ENSRNOP00000052739/1-1127 ------------------------------------------------------------ ENSP00000343140/1-1843 QCSVQPEPAPPSASPLPRGWQKSVLELQTGPGSSQHYGAMRTVTEQYEEVDQFGNTVLMS ENSCPOP00000020129/1-1088 ------------------------------------------------------------ XP_004835289.1/1-1127 ------------------------------------------------------------ ENSMUSP00000107262/1-1132 ---------------------------------------------------------- ENSRNOP00000052739/1-1127 ---------------------------------------------------------- ENSP00000343140/1-1843 STTVTEQAEPPRNPGSHLGLHASPLLRQFLHSPAGFSSDLTEAETVQVSCSYSQPAAQ ENSCPOP00000020129/1-1088 ---------------------------------------------------------- XP_004835289.1/1-1127 ----------------------------------------------------------