CLUSTAL W(1.81) multiple sequence alignment ENSCPOP00000019774/1-801 ------------------------------------------------------------ ENSMUSP00000016072/1-1464 MDIYDTQTLGVVVFGGFMVVSAIGIFLVSTFSMKETSYEEALANQRKEMAKTHHQKGEKK ENSRNOP00000052465/1-1582 MDIYDTQTLGVVVFGGFMVVSAIGIFLVSTFSMKETSYEEALANQRKEMAKTHHQKGEKK XP_004840914.1/1-967 MDIYDTQTLGVMVFGGFMVVSAIGIFLVSTFSMKETSYEEALANQRKEMAKIYYQKVEKK ENSP00000367044/1-1410 MDIYDTQTLGVVVFGGFMVVSAIGIFLVSTFSMKETSYEEALANQRKEMAKTHHQKVEKK ENSCPOP00000019774/1-801 -----------------------PE-----------------------PAPVQ------- ENSMUSP00000016072/1-1464 KKEKTVEKKGKTKKKEEKPNGKIPEHDLDPNVTIILKEPVRVSAVAVAPTSVHSSVGHTP ENSRNOP00000052465/1-1582 KKEKTVEKKGKTKKKEEKPNGKIPEHDLDPNVTIILKEPMRVPAVAVAPTSVHSSVGRTP XP_004840914.1/1-967 KKEKTVEKKGKTKKKDEKPNGKIPDHDLGPNVTVLLKEPTRTPALAVAPTPIQAPLVFTP ENSP00000367044/1-1410 KKEKTVEKKGKTKKKEEKPNGKIPDHDPAPNVTVLLREPVRAPAVAVAPTPVQPPIIVAP *: *:.:: ENSCPOP00000019774/1-801 ------------------------------------------------------------ ENSMUSP00000016072/1-1464 IATVPAMPQEKLASSPKDRKKKEKKVAKVEPAVSSIVNSIQVLASKSAILEATPKEVPMV ENSRNOP00000052465/1-1582 VATVPAMPQEKLASSPKDKKKKEKKVAKVEPAVSSIVNSIQVLASKSAILEASPKEVPMV XP_004840914.1/1-967 VAAVPAMPQEKLGSSPKDKKKKEKKVAKVEPAVSSVVNSIQVLASKSAILEAAPKE---- ENSP00000367044/1-1410 VATVPAMPQEKLASSPKDKKKKEKKVAKVEPAVSSVVNSIQVLTSKAAILETAPKEVPMV ENSCPOP00000019774/1-801 ------------------------------------------------------------ ENSMUSP00000016072/1-1464 AVPPVGSKASSPAT-SSQGKKGQGAQNQAKKGEGAQNQGKKGEGAQNQAKKGEGAQNQAK ENSRNOP00000052465/1-1582 AVPPVGSKASAPAT-SSQGKKGQGAQNQAKKGEGAQNQAKKGEGVQNQAKKGEGAQNQVK XP_004840914.1/1-967 ------------------------------------------------------------ ENSP00000367044/1-1410 VVPPVGAKGNTPATGTTQGKKAEGTQNQSKKAEGAPNQGRKAEGTPNQGKKTEGTPNQGK ENSCPOP00000019774/1-801 ------------------------------------------------------------ ENSMUSP00000016072/1-1464 KGEGAQNQGKKGEGAQNQAKKGEGGQNQAKKGEGAQNQGKKGEGAQNQGKKGEGAQNQAK ENSRNOP00000052465/1-1582 KGEGAQNQAKKGEGAQNQAKKGEGTQNQAKKGEGAQNQGKKGEGAQNQAKKGEGAQNQAK XP_004840914.1/1-967 ------------------------------------------------------------ ENSP00000367044/1-1410 KAEGTPNQGKKAEGTPNQGKKAEGAQNQGKKVDTTPNQGKKVEGAPTQGRKAEGAQNQAK ENSCPOP00000019774/1-801 ------------------------------------------------------------ ENSMUSP00000016072/1-1464 KGEGAQNQAKKGEGAQNQGKKGEGAQNQSKKGEGAQNQAKKGEGGQNQAKKGEGAQNQAK ENSRNOP00000052465/1-1582 KGEGAQNQAKKG--------------------EGAQNQAKKGEGGQNQAKKGEGAQNQAK XP_004840914.1/1-967 ------------------------------------------------------------ ENSP00000367044/1-1410 KVEGAQNQGKKA--------------------EGAQNQGKKGEGAQNQGKKAEGAQNQGK ENSCPOP00000019774/1-801 ------------------------------------------------------------ ENSMUSP00000016072/1-1464 KGEGAQNQAKKGEGVQNQAKKGVEGAQNQGKKGEANQNQAKKGEGGQNQTKKGEGPQNQG ENSRNOP00000052465/1-1582 KGEGAQNQAKKGEGVQNQAKKGVEGAQNQGKKGEANQNQAKKGEGGQNQTKKGEGLQNQG XP_004840914.1/1-967 ------------------------------------------------------------ ENSP00000367044/1-1410 KAEGAQNQGKKAEGA---------------------QNQGKKAEGAQNQGKKAEGAQNQG ENSCPOP00000019774/1-801 ------------------------------------------------------------ ENSMUSP00000016072/1-1464 KKGEAAQKQDKKIEGAQNQGKKPEGTSNQGKKGEGAQNQGKKGEGAQNQGKKGEGAQNQG ENSRNOP00000052465/1-1582 KKGEATQKQDKKIEGAQNQGKKPEGTPNQGKKGEGAQNQGKKGEGAQNQGKKGEGAQNQG XP_004840914.1/1-967 ------------------------------------------------------------ ENSP00000367044/1-1410 KKSEGAQNQGKKVEGAQNQGKKAEGAQNQGKKAEGAQNQGKKAEGAQNQGKKAEGAQNQG ENSCPOP00000019774/1-801 ------------------------------------------------------------ ENSMUSP00000016072/1-1464 KKGEGAQNQGKKGEGAQNQGKKGEGAQNQGKKGEGAQNQGKKGEGPQNQAKKGEGA---- ENSRNOP00000052465/1-1582 KKGEGAQNQGKKGEGAQNQGKKGEGAQNQGKKGEGAQNQGKKGEGAQNQGKKGEGSPSQN XP_004840914.1/1-967 ------------------------------------------------------------ ENSP00000367044/1-1410 KKAEGAQNQGKKAEGAQNQGKKAEGAQNQGKKVEGAQNQGKKAEGAQNQGKKAEGA---- ENSCPOP00000019774/1-801 ------------------------------------------------------------ ENSMUSP00000016072/1-1464 ------QNQGKKGEGAQNQGKKGEGAQNQGKKAEGVQSQSKKGEGTQNQGKKGDGNPNQG ENSRNOP00000052465/1-1582 IKVEGMQNQGRKAEGTPAQGKKMEAAQNQGKKAEGVQSQGKKGEGSQNQGKKGDGNPNQG XP_004840914.1/1-967 ------------------------------------------------------------ ENSP00000367044/1-1410 ------QNQGKKAEGAQNQGQKGEGAQNQGKKTEGA------------QGKKAERSPNQG ENSCPOP00000019774/1-801 ------------------------------------------------------------ ENSMUSP00000016072/1-1464 KKGEGASNQNRKTDTVANQGTKQEGVSNQVKKSEGSPNQGKKAEGAPNQGKKKDGSPSQA ENSRNOP00000052465/1-1582 KKGEGAPNQNRKTDTVANQGTKTEGVSNQVKKSEGSPNQGKKAEGAPNQGKKVEGSPNQA XP_004840914.1/1-967 ------------------------------------------------------------ ENSP00000367044/1-1410 KKGEGAPIQGKKADSVANQGTKVEGITNQGKKAEGSPSEGKKAEGSPNQG---------- ENSCPOP00000019774/1-801 -------------------GKSTVPVQSQETLKQEAPAKKKSGSKKKGES---------- ENSMUSP00000016072/1-1464 KKVDAAANQGKKSEMAPAQGQKASMVQSQEAPKQDAPAKKKSGSRKKGEP---------- ENSRNOP00000052465/1-1582 KKVDAAAGQGKKSEMTPAQGKNASMVQSQEAPKQEAPAKKK--SKKKGEPGAGEGPLSLG XP_004840914.1/1-967 -------------------SASADVVQSQEAPKLEAPAKKKSGSKKK------------- ENSP00000367044/1-1410 KKADAAANQGKKTESASVQGRNTDVAQSPEAPKQEAPAKKKSGSKKKGEP---------- . .: .** *: * :****** *:** ENSCPOP00000019774/1-801 ------------------------------------------------------------ ENSMUSP00000016072/1-1464 ------------------------------------------------------------ ENSRNOP00000052465/1-1582 LPEFCEPPSSACGSASFWRISTTSIPDSVTLQQQFSALLPVSMISVSQGQRASQSCSRGG XP_004840914.1/1-967 ------------------------------------------------------------ ENSP00000367044/1-1410 ------------------------------------------------------------ ENSCPOP00000019774/1-801 -----------------------------------------------------------G ENSMUSP00000016072/1-1464 -----------------------------------------------------------G ENSRNOP00000052465/1-1582 KSCEWSPDKVQSTHHVSSEGLHSEMEEQCRQSSLANFLEHLAISLPLGNKEGAAPSLGSG XP_004840914.1/1-967 -----------------------------------------------------------R ENSP00000367044/1-1410 -----------------------------------------------------------G ENSCPOP00000019774/1-801 PSDADSPLCLPYKSLVSMVGSMALNEGEAQRLIEILSEKAGVLQDTWHKATQKGDPVAIL ENSMUSP00000016072/1-1464 PPDCDGPLFLPYKTLVSTVGSMVFSEGEAQRLIEILSEKTGVIQDTWHKATQKGDPVAIL ENSRNOP00000052465/1-1582 PPDCDSPLFLPYKTLVSTVGSMVFSEGEAQRLIEILSEKTGVIQDTWHKATQKGDPVAVL XP_004840914.1/1-967 PPDANSPLYLPYKTLVSMVGTMAFNEGEAQRLIEILSEKAGVIQDTWHKATQKGDPVVIL ENSP00000367044/1-1410 PPDADGPLYLPYKTLVSTVGSMVFNEGEAQRLIEILSEKAGIIQDTWHKATQKGDPVAIL *.*.:.** ****:*** **:*.:.**************:*::**************.:* ENSCPOP00000019774/1-801 KRQLEEKEKLLATEQEDAAVAKSKLRELNKEMAAEKAKAAAGEAKVKRQLVAREQEIAAV ENSMUSP00000016072/1-1464 KRQLEEKEKLLATEQEDAAVAKSKLRELNKEMASEKAKAAAGEAKVKKQLVAREQEIAAV ENSRNOP00000052465/1-1582 KRQLEEKEKLLATEQEDAAVAKSKLRELNKEMASEKAKAAAGEAKVKKQLVAREQEIAAV XP_004840914.1/1-967 KRQLEEKEKLLATEQEDAAVAKSKLRELNKEMAAEKAKAAAGEAKVKKQLVAREQEIAAV ENSP00000367044/1-1410 KRQLEEKEKLLATEQEDAAVAKSKLRELNKEMAAEKAKAAAGEAKVKKQLVAREQEITAV *********************************:*************:*********:** ENSCPOP00000019774/1-801 QARMQASYREHVQEVQQLQGKIRTLQEQLENGPNTQLARLQQENSILRDALNQATSQVES ENSMUSP00000016072/1-1464 QARMQASYRDHVKEVQQLQGKIRTLQEQLENGPNTQLARLQQENSILRDALNQATSQVES ENSRNOP00000052465/1-1582 QARMQASYQDHVKEVQQLQGKIRTLQEQLENGPNTQLARLQQENSILRDALNQATSQVES XP_004840914.1/1-967 QARMQASYREHVKEVQQLQGKIRTLQEQLENGPNTQLARLQQENSILRDALNQATSQVES ENSP00000367044/1-1410 QARMQASYREHVKEVQQLQGKIRTLQEQLENGPNTQLARLQQENSILRDALNQATSQVES ********::**:*********************************************** ENSCPOP00000019774/1-801 KQNAELAKLRQELGKASKELVEKAEISRQEEQQRKALEAKVAASEKQMLQLQVSHKESEE ENSMUSP00000016072/1-1464 KQNTELAKLRQELSKVNKELVEKSEASRQEEQQRKALEAKAATFEKQVLQLQASHKESEE ENSRNOP00000052465/1-1582 KQNTELAKLRQELSKVNKELVEKSEASRQEEQQRKALEAKAATFEKQILQLQASHKESEE XP_004840914.1/1-967 KQNAELAKLRQELGKASKELMEKAEASRQEEQQRKALEAKAAAFEKQVLQLQVSYRESEE ENSP00000367044/1-1410 KQNAELAKLRQELSKVSKELVEKSEAVRQDEQQRKALEAKAAAFEKQVLQLQASHRESEE ***:*********.*..***:**:* **:**********.*: ***:****.*::**** ENSCPOP00000019774/1-801 ALQKRLDELSRELCRTQSSHASLRADAEKAQEQQQRAAELHSKLQASEAEVKSKCEELRG ENSMUSP00000016072/1-1464 ALQKRLEEVTRELCRAQTSHANLRADAEKAQEQQQRVAELHSKLQSSEVEVKSKCEELSS ENSRNOP00000052465/1-1582 ALQKRLEEVTRELCRAQTSHANLRADAEKAQEQQQRVAELHSKLQSSEVEVKSKCEELSD XP_004840914.1/1-967 ALQKRLDELSRELCRTQSSHASLRADAEKAQEQQQRVAELHSKLQSSEAEVKSKCEELRG ENSP00000367044/1-1410 ALQKRLDEVSRELCHTQSSHASLRADAEKAQEQQQQMAELHSKLQSSEAEVRSKCEELSG ******:*::****::*:***.*************: ********:**.**:****** . ENSCPOP00000019774/1-801 LHSRLQEAQAENTQLAERMHSIEALLEAGQAHST---QVSQVEAERQQTQLVELESQVLR ENSMUSP00000016072/1-1464 LHGQLKEARAENSQLTERIRSIEALLEAGQAQDT---QASHAEANQQQTRLKELESQVSC ENSRNOP00000052465/1-1582 LHGQLKEARAENSQLTERIRSIEALLEAGQAQDS---QASRAEADQQQTRLKELESQVSC XP_004840914.1/1-967 LHGQLQEARAENTQLAERMHSIEALLEAGQTRDT---QASQAEAEQQQTRLKELESQVSC ENSP00000367044/1-1410 LHGQLQEARAENSQLTERIRSIEALLEAGQARDAQDVQASQAEADQQQTRLKELESQVSG **.:*:**:***:**:**::**********::.: *.*:.**::***:* ****** ENSCPOP00000019774/1-801 LEKEATELREAMEQQKGKNNDLREKNWKAMEALALAERTCAEKLHVLTRAKEDSEKQLQQ ENSMUSP00000016072/1-1464 LEKETSELKEAMEQQKGKNNDLREKNWKAMEALALAERACEEKLRSLTQAKEESEKQLHL ENSRNOP00000052465/1-1582 LEKETSELKEAMEQQKGKNNDLREKNWKAMEALALAERACEEKLRSLTQAKEESEKQLHL XP_004840914.1/1-967 LEKEAIELREAVEQQKGKNNDLREKNWKAMEALALAERTCAEKLQTLTQAKEDSEKQLHL ENSP00000367044/1-1410 LEKEAIELREAVEQQKVKNNDLREKNWKAMEALATAEQACKEKLLSLTQAKEESEKQLCL ****: **:**:**** ***************** **::* *** **:***:***** ENSCPOP00000019774/1-801 VQAQTREALQVLLPELSASAHQSYTEWLQELRERGPELLKTLLASTEPPPDVASKLREAE ENSMUSP00000016072/1-1464 AEAQTKETLLALLPGLSISAHQNYAEWLQEFKEKGSELLKKPP-TLEPSMDIVLKLREAE ENSRNOP00000052465/1-1582 AEAQTKEVLLALLPELSIPAHQNYADWLQEVKEKGSELLKKPPVSVEPSLDIVSKLREAE XP_004840914.1/1-967 TEAQTREALLALLPELSALAHQSYAEWLQELRVRGPELLKIPS---EPPQDVTSKLREAE ENSP00000367044/1-1410 IEAQTMEALLALLPELSVLAQQNYTEWLQDLKEKGPTLLKHPPAPAEPSSDLASKLREAE :*** *.* .*** ** *:*.*::***:.: :*. *** **. *:. ****** ENSCPOP00000019774/1-801 EAQSSLQAECDQYRTILAETEGMLKDLQKSVEKEDQVWKAKVGAKEEELQKSQVTVKHLE ENSMUSP00000016072/1-1464 ETQNSLQAECDQYRTILAETEGMLKDLQKSVEEEERVWKAKVGAAEEELHKSRVTVKHLE ENSRNOP00000052465/1-1582 ETQNSLQAECDQYRTILAETEGMLKDLQKSVEEEERVWKAKVGAAEEELQKSRFTVKHLE XP_004840914.1/1-967 EAQSTLQAECDQYRAILAETEGMLKDLQKSVEEEEQVWKAKVGTKEEELQKSQVTVKHLE ENSP00000367044/1-1410 ETQSTLQAECDQYRSILAETEGMLRDLQKSVEEEEQVWRAKVGAAEEELQKSRVTVKHLE *:*.:*********:*********:*******:*::**:****: ****:**:.****** ENSCPOP00000019774/1-801 DTIAKLKGELESSDQVWKHTLHLEAELEKYLEQDASSHLFFLFSCPQLRQLLLDSQSQLD ENSMUSP00000016072/1-1464 DIVEKLKGELESSDQVREHTSHLEAELEKHMAAASAECQNYAKEVAGLRQLLLESQSQLD ENSRNOP00000052465/1-1582 DLVEKLRGELESSDQVREHTSHLEAELEKHMAAASAECQNYAKEVAGLRQLLLDSQSQLE XP_004840914.1/1-967 DTIEKLKGELESSDQVRKHTLHLEAELEKHMAAASAECQSYAKEVAGLRQLLLDSQSQLD ENSP00000367044/1-1410 EIVEKLKGELESSDQVREHTSHLEAELEKHMAAASAECQNYAKEVAGLRQLLLESQSQLD : : **:********* :** ********:: ::. : . . ******:*****: ENSCPOP00000019774/1-801 ATKREAQKQSQELDLLRQQMSEMKSRMLDTDVAGSPGV----PSAEPDSLKLRAQLERTE ENSMUSP00000016072/1-1464 EAKSEAQKQSDELALVRQQLSDMRSHVEDGDVAGSPAV----PPAEQDPMKLKTQLERTE ENSRNOP00000052465/1-1582 EAKSEAQKQSNELALVRQQLSDMRSHVEDGDVAGSPAV----PPAEQDPVKLKTQLERTE XP_004840914.1/1-967 ATKSEAQKQSQELALVRRQLSEMKSHVADGDVAGSPGV----PSAKQDPVKLQAQLERME ENSP00000367044/1-1410 AAKSEAQKQSDELALVRQQLSEMKSHVEDGDIAGAPASSPEAPPAEQDPVQLKTQLEWTE :* ******:** *:*:*:*:*:*:: * *:**:*. *.*: *.::*::*** * ENSCPOP00000019774/1-801 LALEEEQAQRRKLKAEFEEAQSTVCQLRKELEMLRATGPLSTGA--EVAQLKERLE-EQQ ENSMUSP00000016072/1-1464 ATLEAEQTRRQKLTAEFEEAQRTACRIQEELEKLRAAGPLESSGKEEITQLKERLEKEKR ENSRNOP00000052465/1-1582 ATLEDEQTRRQKLTAEFEEAQSTACRLQEELEKLRAAGPLESSGIEEVTQLKERLEKEKR XP_004840914.1/1-967 LALEEEQVQRQKLTAEFQEARSTVCQLQEELEMLRATGPPASLGTEEVAQLKERLEKEKK ENSP00000367044/1-1410 AILEDEQTQRQKLTAEFEEAQTSACRLQEELEKLRTAGPLESSETEEASQLKERLEKEKK ** **.:*:**.***:**: :.*::::*** **::** : * :******* *:: ENSCPOP00000019774/1-801 LTGDLGCTTSTLQGLLGTTQGQLVGEQTKVEQLQEQPGRVEDGSGPKEGTSV ENSMUSP00000016072/1-1464 LTSDLGRAAIKLQELLKTTQEQLTKEKDTVKKLQEQLGKAEDGSSSKEGTSV ENSRNOP00000052465/1-1582 LTSDLGRAATKLQELLKTTQEQLTKEKDTVKKLQEQLGKAEDGSSSKEGTSV XP_004840914.1/1-967 LTSDLGRAASKLQELLKTTQEQLAEEKDKVKQLQEQLEKVEDGSGPKEGTSV ENSP00000367044/1-1410 LTSDLGRAATRLQELLKTTQEQLAREKDTVKKLQEQLEKAEDGSSSKEGTSV **.*** :: ** ** *** **. *: .*::**** :.****..******