CLUSTAL W(1.81) multiple sequence alignment ENSP00000389803/1-1416 ------------------------------------------------------------ ENSMUSP00000101256/1-1501 MGGLAWGPSRAAGSSWVNASGTWEQPLR-GFSGLQGGRRRGRGEKGIPEEPLCQLTPQLG ENSRNOP00000034579/1-1500 MGGLAWGPSRAAGSSWVNASGTWEQSLGWGFRGLQGGRQRDRGEKEIPEEPPCQLPPQLG ENSCPOP00000018959/1-1415 ------------------------------------------------------------ XP_004863848.1/1-1420 ------------------------------------------------------------ ENSP00000389803/1-1416 ---------------MSGPWPSPDSRTKGTVAWLAEVLLWVGGSVVLSSEWQLGPLVERC ENSMUSP00000101256/1-1501 LSLRVPFGLGDYGLDMPGPQPSAASQTTGAVACLAEVLLWVGGSVVVSPRWQLSLVVERC ENSRNOP00000034579/1-1500 LSLRALSGSGDYHLDMPGSQLPAAIRTTGAVACLAEVLLWVGGSVVVSPRWQLSLLVERC ENSCPOP00000018959/1-1415 ---------------MPGPQLSTASRGTGAVTGLAEVLLWVGGSVAVSPEWQLGLLVERC XP_004863848.1/1-1420 ---------------MPGPQPSTTSXGTGAVACLAEALLWVGGSVVVSPWWQLGPGMERC *.*. .. .*:*: ***.********.:*. ***. :*** ENSP00000389803/1-1416 MGAMQEGMQMVKLRGGSKGLVRFYYLDEHRSCIRWRPSRKNEKAKISIDSIQEVSEGRQS ENSMUSP00000101256/1-1501 MSAMQEGTQMVKLRGSSKGLVRFYYLDEHRSCLRWRPSRKNEKAKISIDSIQEVSEGRQS ENSRNOP00000034579/1-1500 MSAMQEGTQMVKLRGSSKGLVRFYYLDEHRSCLRWRPSRKNEKAKISIDSIQEVSEGRQS ENSCPOP00000018959/1-1415 MSAMQEGTQMVKLRGSSKGLVRFYYLDEHRSCLRWRPSRKNEKAKISIDSIQEVSEGRQS XP_004863848.1/1-1420 MSAMQEGTQMVKLRGSSKGLVRFYYLDEHRSCLRWRPSRKNEKAKISIDSIQEVSEGRQS *.***** *******.****************:*************************** ENSP00000389803/1-1416 EVFQRYPDGSFDPNCCFSIYHGSHRESLDLVSTSSEVARTWVTGLRYLMAGISDEDSLAR ENSMUSP00000101256/1-1501 EIFQRYPDSSFDPNCCFSIYHGSHRESLDLVSPSSEEARTWVTGLRYLMAGISDEDSLAR ENSRNOP00000034579/1-1500 EIFQRYPDSSFDPNCCFSIYYGSHRESLDLVSPSSEEARTWVTGLRYLMAGISDEDSLAR ENSCPOP00000018959/1-1415 EIFQRYPDGSFDPNCCFSIYHGSHRESLDLVSPSGDEARTWVTGLRYLMAGISDEDSLAR XP_004863848.1/1-1420 EIFQRYPDGSFDPNCCFSIYHGSHRESLDLVSPSGDKARTWVTGLRYLMAGISDEDSLAR *:******.***********:***********.*.: *********************** ENSP00000389803/1-1416 RQRTRDQWLKQTFDEADKNGDGSLSIGEVLQLLHKLNVNLPRQRVKQMFREADTDDHQGT ENSMUSP00000101256/1-1501 RQRTRDQWLKQTFDEADKNGDGSLSISEVLQLLHKLNVNLPRQRVKQMFREADTDDHQGT ENSRNOP00000034579/1-1500 RQRTRDQWLKQTFDEADKNGDGSLSISEVLQLLHKLNVNLPRQRVKQMFREADTDDHQGT ENSCPOP00000018959/1-1415 RQRTRDQWLKQTFDEADKNGDGSLSMGEVLQLLHKLNVKLPRQRVKQMFREADTDDRQGT XP_004863848.1/1-1420 RQRTRDQWLKQTFDEADKNGDGSLSIGEVLQLLHKLNVNLPRQRVKQMFREADTDDRQGT *************************:.***********:*****************:*** ENSP00000389803/1-1416 LGFEEFCAFYKMMSTRRDLYLLMLTYSNHKDHLDAASLQRFLQVEQKMAGVTLESCQDII ENSMUSP00000101256/1-1501 LGFEEFCAFYKMMSTRRDLYLLMLTYSNHKDHLDASDLQRFLEVEQKMNGVTLESCQNII ENSRNOP00000034579/1-1500 LGFEEFCAFYKMMSTRRDLYLLMLTYSNHKDHLDASDLQRFLEVEQKMSGVTLESCQSII ENSCPOP00000018959/1-1415 LGFEEFCAFYKMMSTRRDLYLLLLTYSNHKDHLDAADLQRFLEVEQKMQGVTLERCRDII XP_004863848.1/1-1420 LGFEEFCAFYKMMSTRRDLYLLLLTYSNHKDHLDAADLQRFLEVEQKVQAVTLQSCLDII **********************:************:.*****:****: .***: * .** ENSP00000389803/1-1416 EQFEPCPENKSKGLLGIDGFTNYTRSPAGDIFNPEHHHVHQDMTQPLSHYFITSSHNTYL ENSMUSP00000101256/1-1501 EQFEPCLENKSKGMLGIDGFTNYTRSPAGDIFNPEHNRVHQDMTQPLSHYFITSSHNTYL ENSRNOP00000034579/1-1500 EQFEPCLENKSKGVLGIDGFTNYTRSPAGDIFNPEHHRVHQDMTQPLSHYFITSSHNTYL ENSCPOP00000018959/1-1415 QQFEPCPENRSKGVLGIDGFTNYTRSPAGDIFNPEHHGVHQDMTRPLSHYFITSSHNTYL XP_004863848.1/1-1420 QQFEPCPENQSKGVLGIDGFTNYTRSPAGDIFNPKHHGVHQDMTRPLSHYFITSSHNTYL :***** **:***:********************:*: ******:*************** ENSP00000389803/1-1416 VGDQLMSQSRVDMYAWVLQAGCRCVEVDCWDGPDGEPIVHHGYTLTSKILFKDVIETINK ENSMUSP00000101256/1-1501 VGDQLMSQSRVDMYAWVLQAGCRCVEVDCWDGPDGEPIVHHGYTLTSKILFKDVIETINK ENSRNOP00000034579/1-1500 VGDQLMSQSRVDMYAWVLQAGCRCVEVDCWDGPDGEPIVHHGYTLTSKILFKDVIETINK ENSCPOP00000018959/1-1415 VGDQLTSQSRADMYAWVLQAGCRCVEVDCWDGPDGEPIVHHGYTLTSKILFRDVIETINK XP_004863848.1/1-1420 VGDQLMSQSRADMYARVLQAGCRCVEVDCWDGPDGEPIVHHGYTLTSKILFRDVIETINK ***** ****.**** ***********************************:******** ENSP00000389803/1-1416 YAFIKNEYPVILSIENHCSVIQQKKMAQYLTDILGDKLDLSSVSSEDATTLPSPQMLKGK ENSMUSP00000101256/1-1501 YAFIKNEYPVILSIENHCSVVQQKKMAQYLTDILGDKLDLSSVSSEDATMLPSPQMLKGK ENSRNOP00000034579/1-1500 YAFIKNEYPVILSIENHCSVVQQKKMAQYLTDILGDKLDLSSVSGEDATMLPSPQMLKGK ENSCPOP00000018959/1-1415 YAFLKNEYPVILSIENHCCVVQQKKMAQYLTDILGDKLDLSAVSSEDASTLPSPQMLRGK XP_004863848.1/1-1420 YAFLKNEYPVILSIENHCSVIQQKKMAQYLTDILGDKLDLSAVSSEDATMLPSPQMLKGK ***:**************.*:********************:**.***: *******:** ENSP00000389803/1-1416 ILVKGKKLPANISEDAEEGEVSDEDSADEIDDDCKLLNGDASTNRKRVENTAKRKLDSLI ENSMUSP00000101256/1-1501 ILVKGKKLPANISEDAEEGEVSDEDSADEMEDDCKLLNGDASTNRKRVENIAKKKLDSLI ENSRNOP00000034579/1-1500 ILVKGKKLPANISEDAEEGEVSDEDSADEIEDDCKLLNGDASTNRKRVENIAKKKLDSLI ENSCPOP00000018959/1-1415 ILVKGKKLPANISEDAEEGEVSDEDSADEIDEDCKLLNGDASTNRKRVENMAKKKLDSLI XP_004863848.1/1-1420 ILVKGKKLPANISEDVEEGEVSDEDSADEIDEDCKLLNGDVSTNRKRVENIAKKKLDSLI ***************.*************:::********.********* **:****** ENSP00000389803/1-1416 KESKIRDCEDPNNFSVSTLSPSGKLGRK-------SKAEEDVESGEDAGASRRNGRLVVG ENSMUSP00000101256/1-1501 KESKIRDCEDPNDFSVSTLSPSGKLGRKAEAKKGQSKVEEDVEAGEDSGVSRQNSRLFMS ENSRNOP00000034579/1-1500 KESKIRDCEDPNDFTVSTLSPSGKLGHKAEAKKAQSKAEEDVESGEDTGVSRRNSRLLMS ENSCPOP00000018959/1-1415 KESKARDCEDPDDFTISTMSPTGRPGHRADANK--SKAEEDTESGEDAGVSRRNSRLLMS XP_004863848.1/1-1420 KESKIRDCEDPNDFTVSTMFPLGKPGPRAEARKGQSKAEEDVESRADTRASRRDGRLLVS **** ******::*::**: * *: * : **.***.*: *: .**::.**.:. ENSP00000389803/1-1416 SFSRRKKKGSKLKKAASVEEGDEGQDSPGGQSRGATRQKKTMKLSRALSDLVKYTKSVAT ENSMUSP00000101256/1-1501 SFSKRKKKGSKIKKVASVEEGDETLDSPGSQSRGTARQKKTMKLSRALSDLVKYTKSVGT ENSRNOP00000034579/1-1500 SFSKRKKKGSKIKKVASVEEGDESLDSPGSQSRGTARQKKTMKLSRALSDLVKYTKSVGT ENSCPOP00000018959/1-1415 SFSKRKKKGSKLKKVASTEEGDEDPDSPGSQSRGTARQKKTVKLSRALSDLVKYTKSVGS XP_004863848.1/1-1420 SFSKRKRKGSKLKKVASMEEGVEDPDSAGSHPRGTVRQKKTMKLSRALSDLVKYTKSVGT ***:**:****:**.** *** * **.*.:.**:.*****:****************.: ENSP00000389803/1-1416 HDIEMEAASSWQVSSFSETKAHQILQQKPAQYLRFNQQQLSRIYPSSYRVDSSNYNPQPF ENSMUSP00000101256/1-1501 HDVEIEVVSSWQVSSFSETKAHQILQQKPTQYLRFNQHQLSRIYPSSYRVDSSNYNPQPF ENSRNOP00000034579/1-1500 HDVEMEVVSSWQVSSFSETKAHQILQQKPAQYLRFNQHQLSRIYPSSYRVDSSNYNPQPF ENSCPOP00000018959/1-1415 HDVEMEVASSWQVSSFSETKAHQILQQKPAQYLRFNQHQLSRIYPSSYRVDSSNYNPQPF XP_004863848.1/1-1420 HDVDTEVASSWQVSSFSETKAHQILQQRPVRYLHFNQQQLSRVYPSPYRVDSSNYDPQPF **:: *..*******************:*.:**:***:****:***.********:**** ENSP00000389803/1-1416 WNAGCQMVALNYQSEGRMLQLNRAKFSANGGCGYVLKPGCMCQGVFNPNSEDPLPGQLKK ENSMUSP00000101256/1-1501 WNAGCQMVALNYQSEGRMLQLNRAKFSANGDCGYVLKPQCMCQGVFNPNSEDPLPGQLKK ENSRNOP00000034579/1-1500 WNAGCQMVALNYQSEGRMLQLNRAKFSANGGCGYVLKPQCMCQGK-GPELGYPIPGELRH ENSCPOP00000018959/1-1415 WNAGCQMVALNYQSEGRMLQLNRAKFSANGNCGYVLKPPCMCQGVFNPNSEDPLPGQLRK XP_004863848.1/1-1420 WNAGCQMVALNYQSEGRMLQLNRAKFSANGNCGYVLKPPCMCQGVFNPNSEDPLPGQLKK ******************************.******* ***** .*: *:**:*:: ENSP00000389803/1-1416 QLVLRIISGQQLPKPRDSMLGDRGEIIDPFVEVEIIGLPVDCSREQTRVVDDNGFNPTWE ENSMUSP00000101256/1-1501 QLALRIISGQQLPKPRDSVLGDRGEIIDPFVEVEVIGLPVDCSKEQTRVVDDNGFNPMWE ENSRNOP00000034579/1-1500 LAHTRILPGVFNPNSEDPLPGQL-KIIDPFVEVEVIGLPVDCSKEQTRVVDDNGFNPMWE ENSCPOP00000018959/1-1415 QLALRIISGQQLPKPRDSMLGDRGEIIDPFVEVEVIGLPVDCSKEQTRVVDDNGFNPMWE XP_004863848.1/1-1420 QLALRIISGQQLPKPRDSMLGDRGEIIDPFVEVEVIGLPVDCGKEQTRVVDDNGFNPMWE **:.* *:..*.: *: :*********:*******.:************* ** ENSP00000389803/1-1416 ETLVFMVHMPEIALVRFLVWDHDPIGRDFIGQRTLAFSSMMPGYRHVYLEGMEEASIFVH ENSMUSP00000101256/1-1501 ETLVFTVHMPEIALVRFLVWDHDPIGRDFIGQRTLAFSSIMPGYRHVYLEGMEEASIFVH ENSRNOP00000034579/1-1500 ETLVFTVHMPEIALVRFLVWDHDPIGRDFIGQRTLAFSSMMPGYRHVYLEGMEEASIFVH ENSCPOP00000018959/1-1415 ETLVFTVHMPELALVRFLVWDHDPIGRDFIGQRTLAFSSMMPGYRHVYLEGMEEASIFVH XP_004863848.1/1-1420 ETLVFTVHMPEIALVRFLVWDHDPIGRDFIGQRTLAFSSMMPGYRHVYLEGMEEASIFVH ***** *****:***************************:******************** ENSP00000389803/1-1416 VAVSDISGKVKQALGLKGLFLRGPK---PGSLDSHAAGRPPARPSVSQRILRRTASAPTK ENSMUSP00000101256/1-1501 VAVSDISGKVKQTLGLKGLFLRGTK---PGSLDSHAAGQPLPRPSVSQRLLRRTASAPTK ENSRNOP00000034579/1-1500 VAVSDISGKVKQTLGLKGLFLRGPK---PGSLDSHAAGQPLPRPSVSQRLLRRTASAPTK ENSCPOP00000018959/1-1415 VAISDISGKAKQALGLKGLFLRGAKARLPG--QSMPAGQPPP-PSVSQRFLRRTASAPTK XP_004863848.1/1-1420 VAISDISGKARQALGLKGLFLRAAK---PGSLDSHAAGQPPPRPSVSQRLLRRTASAPTK **:******.:*:*********..* ** :* .**:* . ******:********** ENSP00000389803/1-1416 SQKPGRRGFPELVLGTRDTGSKGVADDVVPPGPGPAPEAPAQEGPGSGSPRDTRPLSTQR ENSMUSP00000101256/1-1501 SQKPSRKGFPELALGTQDAGSEGAADDVAPSSPNPALEAPTQERSGSSSPRDTRLFPLQR ENSRNOP00000034579/1-1500 SQKPSRKGFPELALGTQDAGSEGAADDVAPPSPNPALEAPTQERSGSSSPRDTRLFPLQR ENSCPOP00000018959/1-1415 SQKPGR-GFPELVLGTRDVGSEGAADDVVPPSPGPTPETPAHDGPGSSISRDPRPFSTQR XP_004863848.1/1-1420 SQKPGRKGFPELALGTQDVGSERAADDVVSPSPGPTPETPARDAPGSSIPRDACPLSTQR ****.* *****.***:*.**: .****....*.*: *:*::: .**. .**. :. ** ENSP00000389803/1-1416 PLPPLCSLETIAEEPAPGPGPPPPAAVPTSSSQGRPPYPTGPGANVASP----------- ENSMUSP00000101256/1-1501 PISPLCSLEPIAEEPALGPGLPLQAAAPTGPSQEGSQCPVGLGAKVTSSQQTSLGAFGTL ENSRNOP00000034579/1-1500 PISPLCSLEPIAEEPALGPGLPLQAAVPTGPSQEGPQCPVGQGAKVTGPQQTSLGASGTL ENSCPOP00000018959/1-1415 PISPLCSLEPIAEEPALGPGAPAQAATPTSPPRVRPPCSTGPAAKAASPP---------- XP_004863848.1/1-1420 SVSPLCSLEPIMEEPAVGPGAPAQAATPSSPPGERSPHFPGPVAKAASPPQTARGPPGPL .:.******.* **** *** * **.*:... . * *:.:.. ENSP00000389803/1-1416 ---LEDTEEPRDSRPRPCNGEGAGGAYERAPGSQTDGRSQPRTLGHLPVIRRVKSEGQVP ENSMUSP00000101256/1-1501 QLRIGGGRENEEPPLRPHNGGISSGPREGTSGRQTDSKSRSRVPGHLPVVRRAKSEGQV- ENSRNOP00000034579/1-1500 QLRTGGDREKEEPPLRPHNGGIPHGPREGTSGRQTDSKSRSWAPGHLPVVRRAKSEGQV- ENSCPOP00000018959/1-1415 ---TGGQEDNENSPRKLLNGGGPSGACEGAAGSQTDSRSQPRALGLLPVVRRAKSEGQVP XP_004863848.1/1-1420 QLRTGGHGDDKQAPRRLLDGGGPTGACEGASGSQQDSGSQPRVLGLLPSVRRAKSESQVS . : .:. : :* . *. * :.* * *. *:. . * ** :**.***.** ENSP00000389803/1-1416 TEPLGGWRPLAAPFPAPAVYSDATGSDPLWQRLEPCGHRDSVSSSSSMSSSDTVIDLSLP ENSMUSP00000101256/1-1501 ---------LSELSPTPAVYSDATGTDRLWQRLEPGSHRDSVSSSSSMSSNDTVIDLSLP ENSRNOP00000034579/1-1500 ---------LSELSPTPAVYSDATGSDRLWQRLEPGSHRDSVSSSSSMSSNDTVIDLSLP ENSCPOP00000018959/1-1415 SEPPGVWRPLAGPSPTPAIYSDATGSDRIWQRLEPGSHRDSVSSSSSMSSSDTVIDLSLT XP_004863848.1/1-1420 LEPPGTWRPLAGPTPSPAVHSDATGSDRIWQRLEPGSHRDSVSSSSSMSSSDTVIDLSLT *: *:**::*****:* :****** .*************.********. ENSP00000389803/1-1416 --SLGLGRSRENLAGAHMGRLPPRPHSASAARPDLPPVTKSKSNPNLRATGQRPPIPDEL ENSMUSP00000101256/1-1501 --SLGLCRSRESIPGVSLGRLTSRPCLASAARPDLPPVTKSKSNPNLRVAGGLPTAPDEL ENSRNOP00000034579/1-1500 --SLGLCRSRESIPGVSLGRLTPRPCLASAARPDLPPVTKSKSNPNLRVAGGLPLAPDEL ENSCPOP00000018959/1-1415 SLSLGLGRSRESLAGTPLGRLPPRPCSASTVRPDLPPVTKSKSNPNLRAAGQLPPAPDVL XP_004863848.1/1-1420 -----------SLAGTPLGRLPSRPCSAPTAHPDLPPVAKSKSNPNLWAAGQLPPAPDAP .:.*. :***..** *.:.:******:******** .:* * ** ENSP00000389803/1-1416 QPRSLAPRMAGLPFRPPWGCLSLVGVQDCPVAAKSKSLGDLTADDFAPSFEGGSRRLSHS ENSMUSP00000101256/1-1501 QPRPLAPRLTGHHPRPPWHHLTLVGLRDCPVSAKSKSLGDLTADDFAPSFQGSTSSLSCG ENSRNOP00000034579/1-1500 QPRPLAPRLTGLHSRPPWHHLTLVGLRDCPVSAKSKSLGDLTADDFGPSFQGSTGSLSCG ENSCPOP00000018959/1-1415 RPRPLAPRLPGPRPRPSWGGLALLGLPDCPVAAKSKSLGDLTADDFSSGFEGSSRSLGRG XP_004863848.1/1-1420 QPRPLAPRLPGPRPRPSWGRLAPGCLQDCPVAAKSKSLGDLTADDFAPSFQGSSRSLGQG :**.****:.* **.* *: : ****:**************...*:*.: *. . ENSP00000389803/1-1416 LGLPGGTRRVSGPGVRRDTLTEQLRWLTVFQQAGDITSPTSLGPAGEGVAGGPGFVRRSS ENSMUSP00000101256/1-1501 LGSLGVAHQVLEPGIRRDALTEQLRWLTGFQQAGDITSPTSLGPAGDGSVGGPSFLRRSS ENSRNOP00000034579/1-1500 LSPLGVVHQVLEPGRRRDALTEQLRWLTGFQHAGDITSPTSLGPAADGSVGGPSFLRRSS ENSCPOP00000018959/1-1415 LGPPG--------GTRRDALTEQLRWLTGFQQAGDITSPTSLGPAGDGALGGPGFLRRSS XP_004863848.1/1-1420 PGPRG--------SARQDTLTEQLRWLTGFQQAGDITSPTSLGPAGDRAEGGPGFLRRPS . * . *:*:********* **:*************.: ***.*:**.* ENSP00000389803/1-1416 SRSHSRVRAIASRARQAQERQQRLQGLGRQGPPEEERGTPEGACSVGHEGSVDAPAPSKG ENSMUSP00000101256/1-1501 SRSQSRVRAIASRARQAQERQQRLRGQDSRGPPEEERGTPEGACSVGHEGCVDVPMPAKG ENSRNOP00000034579/1-1500 SRSQSRVRAIASRARQAQERQQRLRGLDSRGPPEEERGTPEGACSVGHEGCVDVPMPAKG ENSCPOP00000018959/1-1415 SRSQSRVRAIASRARQAQERQQRLRGLDPRAPPEEERGTPEGACSVGLEGCVDAAGPPKG XP_004863848.1/1-1420 SRSQSRVRAIASRARQAQERQQRLRGLDPQDPPEEERGTPEGACSVGLEGCVDATGLPKG ***:********************:* . : **************** **.**.. .** ENSP00000389803/1-1416 ALGPASAAAENLVLLRL ENSMUSP00000101256/1-1501 APEQVCGAADGQLLLRL ENSRNOP00000034579/1-1500 APEQVCGAADDQLLLRL ENSCPOP00000018959/1-1415 TPEQVPGAADGLLLLRL XP_004863848.1/1-1420 APEQVPHAADSLLLLRL : . **:. :****