CLUSTAL W(1.81) multiple sequence alignment ENSP00000299314/1-1256 MLFKLLQRQTYTCLSHRYGLYVCFLGVVVTIVSAFQFGEVVLEWSRDQYHVLFDSYRDNI ENSMUSP00000020251/1-1235 MLLKLLQRQTYTCLSHRYGLYVCFVGVVVTIVSAFQFGEVVLEWSRDQYHVLFDSYRDNI ENSRNOP00000006946/1-1228 MLLKLLQRQTYTCLSHRYGLYVCFVGVVVTIVSAFQFGEVVLEWSRDQYHVLFDSYRDNI XP_004844909.1/1-1208 MLLKLLQRQTYTCLSHRYGLYVCFVGVVVTLVSALQFGEVVLEWSRDQYHVLFDSYRDNV ENSCPOP00000018955/1-1209 MLLKLLQRQTYTCLSHRYGLYVCFVGVVVTLVSAFQFGEVVLEWSRDQYHVLFDSYRDNV **:*********************:*****:***:************************: ENSP00000299314/1-1256 AGKSFQNRLCLPMPIDVVYTWVNGTDLELLKELQQVREQMEEEQKAMREILGKNTTEPTK ENSMUSP00000020251/1-1235 AGKSFQNRLCLPMPIDVVYTWVNGTDLELLKELQQVREHMEEEQRAMRETLGKNTTEPTK ENSRNOP00000006946/1-1228 AGKSFQNRLCLPMPIDVVYTWVNGTDLELLKELQQVREHMEEEQKAMREILGKNTTEPTK XP_004844909.1/1-1208 AGRSFQSRLCLPVPIDVVYTWVNGTDLELLKELQQVRQQMEEEQKAMREILGKNTTEPMR ENSCPOP00000018955/1-1209 AGKSFQSRLCLPVPIDVVYTWVNGTDLELLRELRQVRAQMEEEQKAMREILGKNTTEPTK **:***.*****:*****************:**:*** :*****:**** ******** : ENSP00000299314/1-1256 KSEKQLECLLTHCIKVPMLVLDPALPANITLKDLPSLYPSFHSASDIFNVAKPKNPSTNV ENSMUSP00000020251/1-1235 KSEKQLECLLTHCIKVPMLVLDPPLPANCTLKDLPTLYPSFHAASDMFNVAKPKNPSTNV ENSRNOP00000006946/1-1228 KSERQLECLLTHCIKVPMLVLDPPLPANCTLKDLPALYPSFHAASDMFNIAKPKNPSTNV XP_004844909.1/1-1208 KSEQPLECLLTHCVKVPMLVLDPALPAHSSLKDLPALHPALRAASDLFHVAKPKNPSTNV ENSCPOP00000018955/1-1209 RSEQTLECLLTHCIKVPMLVLDPALPANSSLKDLPGLHPAFRTASDLFHVAKPKNPSTNV :**: ********:*********.***: :***** *:*::::***:*::********** ENSP00000299314/1-1256 SVVVFDSTKDVEDAHSGLLKGNSRQTVWRGYLTTDKEVPGLVLMQDLAFLSGFPPTFKET ENSMUSP00000020251/1-1235 SVVVFDTTKDVEDAHAGPFKGGSKQMVWRAYLTTDKEAPGLVLMQGLAFLSGFPPTFKET ENSRNOP00000006946/1-1228 SVVVFDTTKDVEDAHAGLFKGSSKQTVWRAYLTTDKEVPGLVLMQDLAFLSGFPPTFKET XP_004844909.1/1-1208 SVVVFDSTRDVEDAHAGLLRGSSKQTAWRGYLTTDREVPGLVLMQDLAFLSGFPPTFKET ENSCPOP00000018955/1-1209 SVVVFDNTRDVEDAHASLLKGSGKQTVWRGYLTTDREVPGLVLMQDLAFLSGFPPTFKET ******.*:******:. ::*..:* .**.*****:*.*******.************** ENSP00000299314/1-1256 NQLKTKLPENLSSKVKLLQLYSEASVALLKLNNPKDFQELNKQTKKNMTIDGKELTISPA ENSMUSP00000020251/1-1235 SQLKTKLPEKLSSKIKLLRLYSEASVALLKLNNPKGFQELNKQTKKNMTIDGKELTISPA ENSRNOP00000006946/1-1228 IQLKTKLPENLSSKIKLLQLYSEASVALLKLNNPKGFPELNKQTKKNMSISGKELAISPA XP_004844909.1/1-1208 SQLRTKLPESLAARIRLLQLYSEASVALLQLHNPKGFQELSKQTKKNMTIDGKELTLSPA ENSCPOP00000018955/1-1209 SQLRTKLPEGLAAKIRLLQLYSEASVALLHLHNPRDFQELNKQTKKNMTIQGKELTLSPA **:***** *:::::**:**********:*:**:.* **.*******:*.****::*** ENSP00000299314/1-1256 YLLWDLSAISQSKQDEDISASRFEDNEELRYSLRSIERHAPWVRNIFIVTNGQIPSWLNL ENSMUSP00000020251/1-1235 YLLWDLSAISQSKQDEDVSASRFEDNEELRYSLRSIERHAPWVRNIFIVTNGQIPSWLNL ENSRNOP00000006946/1-1228 YLLWDLSAISQSKQDEDVSASRFEDNEELRYSLRSIERHAPWVRNIFIVTNGQIPSWLNL XP_004844909.1/1-1208 YLLWDLSTISQSKQDEDISASRFEDNEELRYSLRSIERHAPWVRNIFIVTNGQIPSWLNL ENSCPOP00000018955/1-1209 YLLWDLGAISQSKQDEDVSASRFEDNEELRYSLRSVERHAPWVRNIFIVTNGQIPSWLNL ******.:*********:*****************:************************ ENSP00000299314/1-1256 DNPRVTIVTHQDVFRNLSHLPTFSSPAIESHIHRIEGLSQKFIYLNDDVMFGKDVWPDDF ENSMUSP00000020251/1-1235 DNPRVTIVTHQDIFQNLSHLPTFSSPAIESHIHRIEGLSQKFIYLNDDVMFGKDVWPDDF ENSRNOP00000006946/1-1228 DNPRVTIVTHQDIFQNLSHLPTFSSPAIESHIHRIEGLSQKFIYLNDDVMFGKDVWPDDF XP_004844909.1/1-1208 DNPRVAIVTHQEVFRNLSHLPSFSSPAIESHIHRIEGLSQKFIYLNDDVMFGKDVWPDDF ENSCPOP00000018955/1-1209 DNPRVKVVTHQEVFRNLSHLPTFSSPAIESHIHRIEGLSQKFIYLNDDVMFGKDVWPDDF ***** :****::*:******:************************************** ENSP00000299314/1-1256 YSHSKGQKVYLTWPVPNCAEGCPGSWIKDGYCDKACNNSACDWDGGDCSGNSGGSRYIAG ENSMUSP00000020251/1-1235 YSHSKGQKVYLTWPVPNCAEGCPGSWIKDGYCDKACNNSACDWDGGDCSGNTAGNRFVAG ENSRNOP00000006946/1-1228 YSHSKGQKVYLTWPVPNCAEGCPGSWIKDGYCDKACNNSACDWDGGDCSGNSAGSRYVAG XP_004844909.1/1-1208 YSHSKGQKVYLTWPVPNCAEGCPGSWVKDGYCDKACNNSACDWDGGDCSGSSGGSRYAGG ENSCPOP00000018955/1-1209 YSHSKGQKVYLTWPVPNCAEGCPGSWIKDGYCDKACNNSACDWDGGDCAGSSGGSRYVGG **************************:*********************:*.:.*.*: .* ENSP00000299314/1-1256 GGGTGSIGVGQPWQFGGGINSVSYCNQGCANSWLADKFCDQACNVLSCGFDAGDCGQDHF ENSMUSP00000020251/1-1235 GGGTGNIGAGQHWQFGGGINTISYCNQGCANSWLADKFCDQACNVLSCGFDAGDCGQDHF ENSRNOP00000006946/1-1228 GGGTGNIGVGQRWQFGGGINTISYCNQGCANSWLADKFCDQACNVLSCGFDAGDCGQDHF XP_004844909.1/1-1208 GAGAGSVGGGQPWQFGGGLSSISYCNQGCANSWLADKFCDQACNVLACGFDAGDCGQDHF ENSCPOP00000018955/1-1209 GGGAGSVAGGQPWQFSGGLSSVSYCSQGCANSWLADKFCDQACNVLACGFDAGDCGQDHF *.*:*.:. ** ***.**:.::***.********************:************* ENSP00000299314/1-1256 HELYKVILLPNQTHYIIPKGECLPYFSFAEVAKRGVEGAYSDNPIIRHASIANKWKTIHL ENSMUSP00000020251/1-1235 HELYKVTLLPNQTHYVVPKGEYLSYFSFANIARRGVEGTYSDNPIIRHASIANKWKTIHL ENSRNOP00000006946/1-1228 HELYKVTLLPNQTHYVVPKGEYLSYFSFANIAKRGVEGTYSDNPIVRHASIANKWKTIHL XP_004844909.1/1-1208 HELYKVSLLPNRTHYALPKGERLPYFSFAEIAKRAVEGSYGDSPVVRHASIANKWKTVHL ENSCPOP00000018955/1-1209 HELYKVVLRPNQTRYVLPRGERQPYFSFAEIAKRGVEGSYSDSPVIRHASVANKWKTVHL ****** * **:*:* :*:** .*****::*:*.***:*.*.*::****:******:** ENSP00000299314/1-1256 IMHSGMNATTIHFNLTFQNTNDEEFKMQITVEVDTREGPKLNSTAQKGYENLVSPITLLP ENSMUSP00000020251/1-1235 IMHSGMNATTIYFNLTLQNANDEEFKIQIAVEVDTREAPKLNSTTQKAYESLVSPVTPLP ENSRNOP00000006946/1-1228 IMHSGMNATTIYFNLTLQNSNDEEFKIQIAVEVDTREVPKPNSTTQKTYDNLVSPVTPLP XP_004844909.1/1-1208 LLHGGMNATTLYLNLTLQSATDREFRLQLEVEVDTREGLRPNATTQRPPEP-GSPATPLP ENSCPOP00000018955/1-1209 LLHGGMNATTLQLNLTLQDAAEREFRLQLAIEVDTREGPRPNA----------------- ::*.******: :***:*.: :.**::*: :****** : *: ENSP00000299314/1-1256 EAEILFEDIPKEKRFPKFKRHDVNSTRRAQEEVKIPLVNISLLPKDAQLSLNTLDLQLEH ENSMUSP00000020251/1-1235 QADVPFEDVPKEKRFPKIRRHDVNATGRFQEEVKIPRVNISLLPKEAQVRLSNLDLQLER ENSRNOP00000006946/1-1228 QADVPFEDVPKEKRFPRVRRPDVNATGKVQEEVKIPRVNISLLPKEAQVRLSNLDSQLER XP_004844909.1/1-1208 EAEVLFEDIPEEKRFPKVRRHGGDTAERPQEP-SVPRANLSLLPREAQARLRLLDTQLAQ ENSCPOP00000018955/1-1209 KAEVLFEDVPEEKRFPRVRR-----LGTPHEPLPMPQVNVSLLPREAQARLRVLDLQLAQ :*:: ***:*:*****:.:* :* :* .*:****::** * ** ** : ENSP00000299314/1-1256 GDITLKGYNLSKSALLRSFLMNSQHAKIKNQAIITDETNDSLVAPQEKQVHKSILPNSLG ENSMUSP00000020251/1-1235 GDITLKGYNLSKSALLRSFLGNSLDTKIKPQA-RTDETKGNLEVPQENPSHRR--PHGFA ENSRNOP00000006946/1-1228 GDITLKGYNLSKSALLRPFLRNSLDTKGKPQA-GTDETKDNLEVPQEDPSHQR--PRGFA XP_004844909.1/1-1208 GDITLKGYNASKAALLRSLLLSLPEAAVSAAA-TTARAKDNVEALEEKL------ARSVG ENSCPOP00000018955/1-1209 GDITVKGYNLSKSALLQAFLTSVPVTAISPAT-----------VTEGRRGHRS--LDSSR ****:**** **:***:.:* . : . : . : . ENSP00000299314/1-1256 VSERLQRLTFPAVSVKVNGHDQ--GQNPPLDLETTARFRVETHTQKTIGGNVTKEKPPSL ENSMUSP00000020251/1-1235 GEHRSERWTAPAETVTVKGRDH--ALNPPPVLETNARL-----AQPTLGVTVSKENLSPL ENSRNOP00000006946/1-1228 AARRPERWTTPAETATVNGRDH--GLNPPP-------------TQP-----VPKENLSPL XP_004844909.1/1-1208 GVQNPRRPTFPAGTAQGVRHSP--DSSPPLVSGTKARFK----SEPQAPSVFLEKPAPPD ENSCPOP00000018955/1-1209 GLQQPLWPALPAGIAEGHRLHRLLGASPSPVPEARAA------ASPAPG--LRRKHPPP- .. : ** . .*. :. . .: .. ENSP00000299314/1-1256 IVPLESQMTKEKKITGKEKENSRMEENAENHIGVTEVLLGRKLQHYTDS-YLGFLPWEKK ENSMUSP00000020251/1-1235 IVPPESHLP-------KEEESDRAEGNA---VPVKELVPGRRLQQN----YPGFLPWEKK ENSRNOP00000006946/1-1228 IIPPEGRMP-------KEGDRDRAEGNADSHVPVNELVPGRRLQQHIPS-YPGFLPWEKN XP_004844909.1/1-1208 ILPENRVME--EKRAAQEEGESQKEAHPEDPIDTKGVVPGRKLHQHAGS-DLGFLPWEKR ENSCPOP00000018955/1-1209 -AQGERNVA--------VEKEPQVEAGAADPRDPAAPLPGRRLQQELSGSYLGFLPWEKT : : : * . : **:*:: ******* ENSP00000299314/1-1256 KYFQDLLDEEESLKTQLAYFTDSKNTGRQLKDTFADSLRYVNKILNSKFGFTSRKVPAHM ENSMUSP00000020251/1-1235 KYFQDLLDEEESLKTQLAYFTDSKHTGRQLKDTFADSLRYVNKILNSKFGFTSRKVPAHM ENSRNOP00000006946/1-1228 KYFQDLLDEEESLKKQLAYFTDSRHAGRQLKDTFADSLRYVNKILNSKFGFTSRKVPAHM XP_004844909.1/1-1208 KYFQDLLEEEAALKTQLAYLTDGSHTGRQLKDTFADSLRYVNRILNSKFGFASRKVPAHM ENSCPOP00000018955/1-1209 KYFQDLLEEEAALKTQLAYLTDSSHAGRRLQDTFADSLRYVNKILNSKFGFASRKVPAHM *******:** :**.****:**. ::**:*:***********:********:******** ENSP00000299314/1-1256 PHMIDRIVMQELQDMFPEEFDKTSFHKVRHSEDMQFAFSYFYYLMSAVQPLNISQVFDEV ENSMUSP00000020251/1-1235 PHMIDRIVMQELQDMFPEEFDKTSFHKVRHSEDMQFAFSYFYYLMSAVQPLNISQVFHEV ENSRNOP00000006946/1-1228 PHMIDRIVMQELQDMFPEEFDKTSFHKVRHSEDMQFAFSYFYYLMSAVQPLNLSQVFDEV XP_004844909.1/1-1208 PHMIDRLVMQELQDMFPEEFDKTSFHKVRHSEDMQFAFSYFYYLMSAVRPLNVSQVFDEV ENSCPOP00000018955/1-1209 PHMIDRVVMQELQDMFPEEFDRTSLHKVRHSEDMQFAFSYFYYLMSALQPLNVAQVFDEV ******:**************:**:**********************::***::***.** ENSP00000299314/1-1256 DTDQSGVLSDREIRTLATRIHELPLSLQDLTGLEHMLINCSKMLPADITQLNNIPPTQES ENSMUSP00000020251/1-1235 DTDQSGVLSDREIRTLATRIHDLPLSLQDLTGLEHMLINCSKMLPANITQLNNIPPTQEA ENSRNOP00000006946/1-1228 DTDQSGVLSDREIRTLATRVHDLPLSLQDLTGLEHMLINCSKLLPANITQLSNIPPTQEA XP_004844909.1/1-1208 DTDHSGVLSDREIRTLATRVHDLPLSLQDLTGLEHMFINCSKVLPANITRLPSVPPTQES ENSCPOP00000018955/1-1209 DTDHSGVLSDREIRTLATRVHELPLSLQDLTGLEHMLINCSKMLPANVTQLHAVPPTQEA ***:***************:*:**************:*****:***::*:* :*****: ENSP00000299314/1-1256 YYDPNLPPVTKSLVTNCKPVTDKIHKAYKDKNKY---RFEIMGEEEIAFKMIRTNVSHVV ENSMUSP00000020251/1-1235 YYDPNLPPVTKSLVTNCKPVTDKIHKAYKDKNKY---RFEIMGEEEIAFKMIRTNVSHVV ENSRNOP00000006946/1-1228 YYDPNLPPVTKSLVTNCKPVTDKIHKAYKDKNKY---RFEIMGEEEIAFKMIRTNVSHVV XP_004844909.1/1-1208 YYDPNLPPVTKSLVTNCKPVTDKIHKAYKDKNKY-------------------------- ENSCPOP00000018955/1-1209 YYDPNLPPVTKSLVTNCKPVTDKIHKAYKDRNKYRTTRFEIMGEEEIAFKMIRTNVSHVV ******************************:*** ENSP00000299314/1-1256 GQLDDIRKNPRKFVCLNDNIDHNHKDAQTVKAVLRDFYESMFPIPSQFELPREYRNRFLH ENSMUSP00000020251/1-1235 GQLDDIRKNPRKFVCLNDNIDHNHKDARTVKAVLRDFYESMFPIPSQFELPREYRNRFLH ENSRNOP00000006946/1-1228 GQLDDIRKNPRKFVCLNDNIDHNHKDAQTVKAVLRDFYESMFPIPSQFELPREYRNRFLH XP_004844909.1/1-1208 ----------RKFVCLNDNIDHTHRDAQTVKAVLRDFYESMFPVPSQFELPREYRNRFLH ENSCPOP00000018955/1-1209 GQLDDIRKNPRKFVCLNDNIDHNHKDAQTVKAVLRDFYESMFPLPSQFELPREYRNRFLH ************.*:**:***************:**************** ENSP00000299314/1-1256 MHELQEWRAYRDKLKFWTHCVLATLIMFTIFSFFAEQLIALKRKIFPRRRIHKEASPNRI ENSMUSP00000020251/1-1235 MHELQEWRAYRDKLKFWTHCVLATLIIFTIFSFFAEQIIALKRKIFPRRRIHKEASPDRI ENSRNOP00000006946/1-1228 MHELQEWRAYRDKLKFWTHCVLATLIIFTVFSFFAEQIIALKRKIFPRRRTHKEASPDQI XP_004844909.1/1-1208 VHELREWRAYRDKLKFWTHCVLATLILFTVVSFFAEQLIALRRKVLPRRRVCQEASPDRI ENSCPOP00000018955/1-1209 VRELREWRAYRDKLKFWTHCVLATLIIFTVFSFFAEQLIALKRKVFPRRRTHKEASPDRI ::**:*********************:**:.******:***:**::**** :****::* ENSP00000299314/1-1256 RV ENSMUSP00000020251/1-1235 RV ENSRNOP00000006946/1-1228 RV XP_004844909.1/1-1208 KV ENSCPOP00000018955/1-1209 KV :*