CLUSTAL W(1.81) multiple sequence alignment ENSMUSP00000109067/1-1481 MEGAKGPRLRGFLSGSLATWALGLAGLVGEAEESAGGTEEEEEEEEEEGALCTEKRFLRL ENSRNOP00000033926/1-1477 MEGAKGPRLRDFLSGSLATWALGLAGLVGEAEESSG--TEEEEEEEEEGPLCTERRFLKL ENSP00000349238/1-1476 MEGGKGPRLRDFLSGSLATWALGLAGLVGEAEDSEG----EEEEEEEEPPLWLEKRFLRL ENSCPOP00000018836/1-1430 MEGGQGPRLGDFLSGSLATWALGLAELVGEAEELSG-------TEEEEGPLSPEKRFLRL XP_004852563.1/1-1484 MEGGQGHTLEDFLRGSLATWALGLAELVGEAEEPLR----TEEEEEEEGVLSLEKRFLWL ***.:* * .** *********** ******: **** * *:*** * ENSMUSP00000109067/1-1481 IDGALLLRVLGIIA----PSSRGGLRMVRGRDGPAACRMWNLCHLWGRLRDFYQEELQLL ENSRNOP00000033926/1-1477 ISGDLLLRVLGIIA----PSSRGRLQMVKGHDGPAACRIWNLYHLWGRLRDFYQEELQLL ENSP00000349238/1-1476 SDGALLLRVLGIIA----PSSRGGPRMLRGLDGPAAWRVWNLNHLWGRLRDFYQEELQLL ENSCPOP00000018836/1-1430 SDGALLLRVLGIMEVGPQPTSQGGPQRASGHDGPEARRVWNLNQLWTRLRDFYQEELQLL XP_004852563.1/1-1484 SDGALLLRVLGIIA----PISRWAHRMASSHDGPEACRVWNLSQLWIRLREFYQEELQLL .* ********: * *: : . *** * *:*** :** ***:********* ENSMUSP00000109067/1-1481 ILSPPPDLQTMGCDPFS-EEAVDELESILRLLLGASVQCEHRELFIRHIRGLSLDVQSEL ENSRNOP00000033926/1-1477 ILSPPPDLQTLGFDPFSAEEAVDELEGILRLLLGASVQCEHRELFIRHIQGLSLDVQSEL ENSP00000349238/1-1476 ILSPPPDLQTLGFDPLS-EEAVEQLEGVLRLLLGASVQCEHRELFIRHIQGLSLEVQSEL ENSCPOP00000018836/1-1430 VLWPPPDLQTLGFDPLS-EEAVEGLEGLLRLLLGASVQCEHRELFIRHIQGLSLDVQSDL XP_004852563.1/1-1484 VLLPPPDLQILGFDPLS-GEAMEGLGGLLRLLLGASVQCEHRELFIRHIQGLSLEVQSEL :* ****** :* **:* **:: * .:*********************:****:***:* ENSMUSP00000109067/1-1481 AGAIQEVTQPGAGVVLALAGPESGELVAEELEMQLRSLTGMMSRLARERDLGAQRLAELL ENSRNOP00000033926/1-1477 AAAIQEVTQPGAGVVLALTGPESAELVAEELEMQLRNLMGTMSRLVRERDLGAQRLAEVL ENSP00000349238/1-1476 AAAIQEVTQPGAGVVLALSGPDPGELAPAELEMLSRSLMGTLSKLARERDLGAQRLAELL ENSCPOP00000018836/1-1430 AAVIQEVTQPGAGVVLTLAGPEPGELAPSELEMLSRSLMGTLSRLARERDLGTQRLADLL XP_004852563.1/1-1484 AAAIQEVTQPGAGVVLTLAGPEPGELAPLELEMLSRSLMGTLSRLARERDLGTQRLADLL *..*************:*:**:..**.. **** *.* * :*:*.******:****::* ENSMUSP00000109067/1-1481 LEREPAHLLLPEAPANASAEGVSHHLALQLTNAKAQLRRLRQEVEEKAEQLLDSQAEVQG ENSRNOP00000033926/1-1477 LEREPAHLLLPEASANASAEGPSHHLALQLTNAKAQLRRLRQEVEEKAELLLDSQAEVQG ENSP00000349238/1-1476 LEREPLCLR-PEAPSRAPAEGPSHHLALQLANAKAQLRRLRQELEEKAELLLDSQAEVQG ENSCPOP00000018836/1-1430 LQPRWAPLL-PEAPVRAPTEGPSHHLALQLANAKAHLRRLRQELEEKAELLLDSQEEVQG XP_004852563.1/1-1484 LQREQVPLL-SEAPGRAPAEGPSHHLALQLANAKAQLRRLRQELEEKAELLLDSQAEVQG *: . * .**. .*.:** ********:****:*******:***** ***** **** ENSMUSP00000109067/1-1481 LEAEIRRLRQETQALSAQAKRAELYREEAEALRERAGRLPRLQEELRRCREKLQAAEVFK ENSRNOP00000033926/1-1477 LESEIRRLRQETQALSGQAKRAELYREEAEALRERAGRLPRLQEELRRCRERLHAAVKCV ENSP00000349238/1-1476 LEAEIRRLRQEAQALSGQAKRAELYREEAEALRERAGRLPRLQEELRRCRERLQAAEAYK ENSCPOP00000018836/1-1430 LEAEIRRLRQEAQALSGQAKRAELYREEVEALRQRVGRLSRLQEELGRCRERLQAAEACK XP_004852563.1/1-1484 LEAEIRRLRQEAQGLSGQAKRAELYREEVEALRQRTGRLSRLQEDLGRCRQRLQAAEACK **:********:*.**.***********.****:*.***.****:* ***::*:** ENSMUSP00000109067/1-1481 GQLEEERVLSEALEASKVLLEEQLEVARERSARLHETQRENLLLRTRLGEAHADLDSLRH ENSRNOP00000033926/1-1477 RIQQEERVLSGALEASKVLLEEQLEIARERSARLHETQRENLLLRTRLGEAHADLDSLRH ENSP00000349238/1-1476 SQLEEERVLSGVLEASKALLEEQLEAARERCARLHETQRENLLLRTRLGEAHAELDSLRH ENSCPOP00000018836/1-1430 SQLEEERVLSGALEASKALLEEQLEAARERCARLHEVQRENLLLRTRLGEAHAELDSLRH XP_004852563.1/1-1484 SQLEEERALSGALEASKALLEEQLEAARERCARLHETQRENLLLRTRLGEAHAELDSLRH :***.** .*****.******* ****.*****.****************:****** ENSMUSP00000109067/1-1481 QLEQLVEENVELELELQRSLEPPPGSPGEASLPGAAPSLQDEVREAEAGRLRAVERENRE ENSRNOP00000033926/1-1477 QLEQLVEENVELELELQRSLEPPPGSPGETSLPGAAPSLQDEVREAEAGRLRTVEQENRT ENSP00000349238/1-1476 QVDQLAEENVELELELQRSLEPPPGSPGEAPLAGAAPSLQDEVREAEAGRLRTLERENRE ENSCPOP00000018836/1-1430 QVNQLADENVELELELCRSLEPPLDSPVEAPLPAAAPSLQDEVREAEAGQLRTLERENQE XP_004852563.1/1-1484 QVNQLAEENVELELELCRSLEPPPDSPAEAPLPRTAPSLQDEVREAEAGQLRTLERENQE *::**.:********* ****** .** *:.*. :**************:**::*:**: ENSMUSP00000109067/1-1481 LRGQLQMLQAQLGSQHPLLEEQRENSRQPPVPNRDPATPSALHHSPQSPAC-QIGGEGSE ENSRNOP00000033926/1-1477 LRGQLQMLREQLDSQRPLLEEQSKDS-MLPVTNGAPAAPLALDHSPKSLAC-QIGGEGPG ENSP00000349238/1-1476 LRGLLQVLQGQPGGQHPLLEAPREDP-VLPVLEEAPQTPVAFDHSPQGLVQ-KARDGGPQ ENSCPOP00000018836/1-1430 LRGLLQALQRQQGDQPPLLEEQSGKS-VLLVPDGAPQASLGSGHSPQSLLCPQVGDQD-- XP_004852563.1/1-1484 LRALLQVLQRQRGGQLPLLEEQSRES-VLLVLDGTSRTPLASDLNPQGFFC-QVGDQDPQ **. ** *: * ..* **** .. * : . :. . .*:. : . . ENSMUSP00000109067/1-1481 SLDLPSPASYSDITRSPKCSQAPDSHPEL-ESPLQMVSQDPQTSDQALQESDPTVETHQC ENSRNOP00000033926/1-1477 SLDLPSPASYSGITRLSECLQAPDSHPEL-DSPFQMVSQDPQTSDQT-QESDPTGEAHQS ENSP00000349238/1-1476 ALDLAPPALDSVLEASAECPQAPDSDPQEAESPLQAAAMDPQASDWSPQESGSPVETQES ENSCPOP00000018836/1-1430 -LQLTPPASDLCPEGSAESPQASDSSREVTEKPFQAA----------------GIETQEA XP_004852563.1/1-1484 Q---AHPASDSGLEGSAENTQASDSHRAVTERPFQAAAPASQTSHLTPQESHAGVEAQRS . ** .: **.** : *:* . *::.. ENSMUSP00000109067/1-1481 LEKSGHRVPLQSPIVWDPPQGPEVRIEVQELL-GETGSREAPQGELVHKAQVLKQESPKC ENSRNOP00000033926/1-1477 LEKSGHRVSVQSPIVWDPPQGAEIRIDVQEL--GETGSREASEGESVPEAQVLKQENPEC ENSP00000349238/1-1476 PEKAGRRSSLQSPASVAPPQGPGTKIQAPQLLGGETEGREAPQGELVPEAWGLRQEGPEH ENSCPOP00000018836/1-1430 LEEPSPRATLQSSTCVAPCQNPEIKTEVLQLPGGETGKIQAPQKELMLEVQGLREEGPEC XP_004852563.1/1-1484 LEKPTSGAPLQSPISLAPYQGPEIKIEKQQLLEGETGEMQPPQKELMPEAQGLRKEHPEH *:. .:**. * *.. : : :* *** :..: * : :. *::* *: ENSMUSP00000109067/1-1481 RPRSAELTLREPLKDQKALDRELELSKQQKETGRHEQRPKGLESKLGPQKPQQTSEGVPD ENSRNOP00000033926/1-1477 RPRSAEFILLEPLKDQKTLEPELELSKQQTETGGHEQRPKGLVNKLVLQKPQQTSEGPPD ENSP00000349238/1-1476 KPGPSEPSSVQ-LEEQEGPNQGLDLATGQAEAREHDQRLEGTVRDPAWQKPQQKSEGALE ENSCPOP00000018836/1-1430 KRGSSEPSHCELLEKPVTMGQELNAPTRPPGARGHELRLIGMVRELAPLSPQQTSEGAPN XP_004852563.1/1-1484 KQGSSELSLCVLLEK-ETVGQPLDESTKWTEAQGHEWRLERMVGGPAPPLPEQTSKDAPD : .:* *:. *: .. : *: * *:*.*:. : ENSMUSP00000109067/1-1481 AWSREEPTPGETLVSAIPEEQALRDEVAQLRREVAGLEVKLQAQAQRLEARSAEALCLSE ENSRNOP00000033926/1-1477 AWSREEPIPGETLATAIPEEQALRDEVAQLRREVVSLEAKLQAQAQRLEARSAEAVSLSE ENSP00000349238/1-1476 VQVWEGPIPGESLASGVAEQEALREEVAQLRRKAEALGDELEAQARKLEAQNTEAARLSK ENSCPOP00000018836/1-1430 ARALEGQILGETLEGGVSEQEALREEVARLRTEAVALEAKLEAQARRLEARGAEVARLSE XP_004852563.1/1-1484 ARAWEGPISEEALGSGVSEQDALREELALLRTEAVALEAELEAQARRLEARGAEVARLSE . * *:* .:.*::***:*:* ** :. .* :*:***::***:.:*. **: ENSMUSP00000109067/1-1481 ELAQARRTEAEAHQEAEAQAREQARLREAVDTASLELEAASREREALAEALAAAGRERRQ ENSRNOP00000033926/1-1477 ELAQARRTEAEAHLEVEARAREQARLREAVDAASLELEAASREREALAEALAAAGRERRQ ENSP00000349238/1-1476 ELAQARRAEAEAHREAEAQAWEQARLREAVEAAGQELESASQEREALVEALAAAGRERRQ ENSCPOP00000018836/1-1430 ELAHARRAEAEAHREVEAHAQEQTQLREAVEAAGRELEAASREREALAEALAAAGRERRQ XP_004852563.1/1-1484 ELSHACRAEAEAHREVEAQVQEQARLQEAVEAAGRELEALSREREALAEALAAAGRERRQ **::* *:***** *.**:. **::*:***::*. ***: *:*****.************ ENSMUSP00000109067/1-1481 WERDGPRLRAQVEAAEQQVQALESQVRCHLEEAEREHAEKQALREELEKAVLRGQELGDR ENSRNOP00000033926/1-1477 WEREGPRLRAQVEAAEQQVQALESQVRCHLEEAEREHLEKQALREELEKAVVRGQELGDR ENSP00000349238/1-1476 WEREGSRLRAQSEAAEERMQVLESEGRQHLEEAERERREKEALQAELEKAVVRGKELGDR ENSCPOP00000018836/1-1430 WEREGPRLRAWAEAAEERVQALESQRQGCLQEAEQERREKQALSEELEKATARGLELGSR XP_004852563.1/1-1484 WEREGPRLRARAEAAEERVQALESQGQDRLEEAERERQEKQALSEELEKAMLRGQELGSR ***:*.**** ****:::*.***: : *:***:*: **:** ***** ** ***.* ENSMUSP00000109067/1-1481 LEHLQEELEQAALERQKFLQEQENQHQRYRHLEQRLEAELQAASTSKEEALMELKARALQ ENSRNOP00000033926/1-1477 LEHLQRELEQAALERQKFLQERESQHQRYQHLEQRLEAELQAASTNKEEALMKLKARALQ ENSP00000349238/1-1476 LEHLQRELEQAALERQEFLREKESQHQRYQGLEQRLEAELQAAATSKEEALMELKTRALQ ENSCPOP00000018836/1-1430 L---------------KFLQEQENQQQRYQGLEQRLETELQAVATSKEAALMELKSRALK XP_004852563.1/1-1484 LEHLQQDLEQAAQERQKFLREQENQQQRYQGLEQRLEAELQAAATSKEEALMELKSRALK * :**:*:*.*:***: ******:****.:*.** ***:**:***: ENSMUSP00000109067/1-1481 LEEELIQLRQYPVDLATGARAGPRTVETQNGRLIEVERNNATLVAEKAALQGQLQHLEGQ ENSRNOP00000033926/1-1477 LEEELIQLRQYPVDQATEVRAEPRTVETQNGRLIEVERNNATLVAEKAALQGQLQHLEGQ ENSP00000349238/1-1476 LEEELFQLRQGPAGLGPKKRAEPQLVETQNVRLIEVERSNAMLVAEKAALQGQLQHLEGQ ENSCPOP00000018836/1-1430 LEEELLQLRQGPMGV-----SEPQVAAAQGSRLIEVERSNATLVAEKAALQGQLQHLEGQ XP_004852563.1/1-1484 LEEELLQLRQGPVGLASEGHSESQIAAAQGSRLIEVERSNATLVAEKAALQGQLQHLEGK *****:**** * . : .: . :*. *******.** *****************: ENSMUSP00000109067/1-1481 LGSLQGRAQELL----LQSQRAQEHSSRLQAEKSMMEMQGQELHRKLGVLEEEVRAARRA ENSRNOP00000033926/1-1477 LGSLQGRAQELL----LQSQRAQEHSSRLQAEKSMMEIQGQELHRKLGVLEEEVRVARRA ENSP00000349238/1-1476 LGSLQGRAQELL----LQSQRAQEHSSRLQAEKSVLEIQGQELHRKLEVLEEEVRAARQS ENSCPOP00000018836/1-1430 LGSLQGRAQELLSQLPLSSDPSHPSLCPFSAEKSALELQGQELHQKLGVLEEEVRAARQA XP_004852563.1/1-1484 LGSLQDRAQELL----LQSQRAQEHSSHLQAEKSVLELQGQELHQKLGVLEAEVRAARQA *****.****** *.*: :: . :.**** :*:******:** *** ***.**:: ENSMUSP00000109067/1-1481 QEETRGQQQALLRDHEALVQLQRRQETELEGLLVRHRDLKANMRALELAHRELQGRHEQL ENSRNOP00000033926/1-1477 QEETRGQQQALLRDHEALVQLQRRQETELEGLLVRHRDLKANMRALELAHRELQGRHEQL ENSP00000349238/1-1476 QEETRGQQQALLRDHKALAQLQRRQEAELEGLLVRHRDLKANMRALELAHRELQGRHEQL ENSCPOP00000018836/1-1430 HEEARGQQQALLRDHEALVQLQRRQEAELEGLLGRHRDLKANMRALELAHRELQGRHEQL XP_004852563.1/1-1484 HEEARGQQQALLRDHQALVQLQRRQEAELERLLGRHRDLKAKMRTLELAHRELQGRHDQL :**:***********:**.*******:*** ** *******:**:************:** ENSMUSP00000109067/1-1481 QAQRANVEAQEVALLAERERLMQDGHRQRGLEEELRRLQNEHERAQMLLAEVSRERGELQ ENSRNOP00000033926/1-1477 QAQRASVEAQEVALLAERERLMQDGHRQRGLEEELRRLQNEHQRAQMLLAEVSRERGELQ ENSP00000349238/1-1476 QAQRASVEAQEVALLAERERLMQDGHRQRGLEEELRRLQSEHDRAQMLLAELSRERGELQ ENSCPOP00000018836/1-1430 QAQRASVEAQEVALLVERERLMKDGHRQRGMEDELRRLQNEHDRAQMLLAEVSR------ XP_004852563.1/1-1484 QAQRANVEAQEVALLAERERLMQDGHRQWGMEEELRRLQSEHDRAQVLLAEVSRERGELQ *****.*********.******:***** *:*:******.**:***:****:** ENSMUSP00000109067/1-1481 GERGELRSRLARLELERAQLEIQSQQLRESNQQLDLSACRLTTQCELLTQLRSAQEEENR ENSRNOP00000033926/1-1477 GERGELRSRLARLELERAQLEIQSQKLRESNQQLDLSACRLTTQCELLTQLRSAQEEENR ENSP00000349238/1-1476 GERGELRGRLARLELERAQLEMQSQQLRESNQQLDLSACRLTTQCELLTQLRSAQEEENR ENSCPOP00000018836/1-1430 --------RLARLELERAQLEVQSQKLRESNQQLDLSACRLATQCELLTELRSAQEEENR XP_004852563.1/1-1484 GERGELKGRLARLELERAQLEVQSQQLRESNQQLDLSACRLATQCELLTELRSAQEEENR *************:***:***************:*******:********** ENSMUSP00000109067/1-1481 QLLAEVQALSRENRELLERSLESRDHLHREQREYLDQLNALRREKQKLVEKIMDQYRVLE ENSRNOP00000033926/1-1477 QLLAEVQALSRENRELLERSLESRDHLHREQREYLDQLNALRREKQKLVEKIMDQYRVLE ENSP00000349238/1-1476 QLLAEVQALSRENRELLERSLESRDHLHREQREYLDQLNALRREKQKLVEKIMDQYRVLE ENSCPOP00000018836/1-1430 QLLAEVQALSRENRELLERSLESRDHLHREQREYLDQLNALRREKQKLVEKIMDQYRVLE XP_004852563.1/1-1484 QLLAKVQALSRENRELLERSLESRDHLHREQREYLDQLNALRREKQKLVEKIMDQYRVLE ****:******************************************************* ENSMUSP00000109067/1-1481 PGPLPRTKKGSWLADKVKRLIRPRREGALHGGPRLGADGAGSTESL------GGPLETEL ENSRNOP00000033926/1-1477 PGPLPRTKKGSWLADKVKRLIRPRREGALHGGPRLGADGAGSTESL------GGPLETEL ENSP00000349238/1-1476 PVPLPRTKKGSWLADKVKRLMRPRREGGPPGGLRLGADGAGSTESL------GGPPETEL ENSCPOP00000018836/1-1430 PGPLPRTKKGSWLADKVKRLMRPRREGGLHGVPRLGADGAGSTESL------GGIPETEL XP_004852563.1/1-1484 PGPLPRTKKGSWLADKVKRLMRPRREGGPHGGPRLGADGAGSTESLGGPPEMGGPPETEL * ******************:******. * ************* ** **** ENSMUSP00000109067/1-1481 PEGREADGTGSSSPAPMRRVQSSLCLGDETLAGGQRRRLSSRFPGGRSSASFSPGDTPRQ ENSRNOP00000033926/1-1477 PEGREADGTGSSSPAPMRRAQSSLCLGDENLAGGQRRRLSSRFPAGRSSASFSPGDTPRQ ENSP00000349238/1-1476 PEGREADGTGSPSPAPMRRAQSSLCLRDETLAGGQRRKLSSRFPVGRSSESFSPGDTPRQ ENSCPOP00000018836/1-1430 PEGREADGTGASSPAPVRRAQSSLCLRETLASSGQRRKLSSRFPTVRSSESFSPGDTPRQ XP_004852563.1/1-1484 PEGREADGTGVPSPAPMRRAQSSLCLRETLAGSGQRRKLSSRLPTGRSSESFSPGDTPRQ ********** .****:**.****** : ..****:****:* *** ********** ENSMUSP00000109067/1-1481 RFRQRRPGPLGAPSTHSKGS-----GVEWDGSIKTLSEHEADDTREAFQEQKPEKQFLTP ENSRNOP00000033926/1-1477 RFRQRRPGPLGAPSSHSKGS-----GVEWDGSIETLSEHEADATGEALQEQKPEKQFLTS ENSP00000349238/1-1476 RFRQRHPGPLGAPVSHSKGP-----GVGWENSAETLQEHETDANREGPEVQEPEKRPLTP ENSCPOP00000018836/1-1430 RFRQRRPGPLGAPSTHGKGS-----GVEWDGSTKTAQEHEADASRESLQEQELEKRPLAT XP_004852563.1/1-1484 RFRQRRPGPLGAPSTHSKGSALCPSGVEWDGSAETLQEHEADANRESLKEQEPEKHPLAT *****:******* :*.**. ** *:.* :* .***:* . *. : *: **: *:. ENSMUSP00000109067/1-1481 SLSQ ENSRNOP00000033926/1-1477 SLSQ ENSP00000349238/1-1476 SLSQ ENSCPOP00000018836/1-1430 SLSQ XP_004852563.1/1-1484 SLSQ ****