CLUSTAL W(1.81) multiple sequence alignment ENSMUSP00000092735/1-1232 MCLPSHLLSTWVLFMVTLPAAQSLGKTWLPNHCRSPIKAVCNFVCDCGDCSDETQCGFHG ENSRNOP00000022390/1-1215 MCLPSCLLSIWVLFM----AAQSLGKTWVPDHCRSPTEATCNFVCDCGDCSDEAQCGFHG ENSP00000411339/1-1216 MPLSSHLLPALVLFL-----AGSSGWAWVPNHCRSPGQAVCNFVCDCRDCSDEAQCGYHG ENSCPOP00000018261/1-1130 MLLPAYLLPALVLLT-----AQSLGRAWNPGPCQSPIEAQCNFLCDCSDCSDESQCGYNG XP_004848894.1/1-1140 MWLPAYLLPALVLLM-----AQALGRAWASSPCQSPVEAQCDFLCNCRDCSDETQCGYRV * *.: **. **: * : * :* .. *:** :* *:*:*:* *****:***:. ENSMUSP00000092735/1-1232 ASTIPSTSFTCNFEQDSCGWQDISTSGYRWLRDRAGAVLHGPGPHSDHTHGTDLGWYMAV ENSRNOP00000022390/1-1215 ASTTPNTPFTCNFEQDPCGWQDISTSGYRWLRDRAGAGLDSSGPHSDHTRGTDLGWYMAV ENSP00000411339/1-1216 ASPTLGAPFACDFEQDPCGWRDISTSGYSWLRDRAGAALEGPGPHSDHTLGTDLGWYMAV ENSCPOP00000018261/1-1130 APPGPGAPFTCDFEQDPCGWQDISTSGYSWVRNRAGAQAEGPVAHTDHTRGTDLGWYIGV XP_004848894.1/1-1140 ASPSLGTPFTCDFEQDSCGWQDISTSGYSWVRDRAGAQPEGPVAHADHTRGTDLGWYMAV *.. .:.*:*:****.***:******* *:*:**** ... .*:*** *******:.* ENSMUSP00000092735/1-1232 GTHSGKEPSTATLRSPVMREAAPTCELRLWYHIASRDVAELRLDLTHGVETLTLWQTSGP ENSRNOP00000022390/1-1215 GTHSGKEPSTATLRSPVMREAAPTCELRLWYHTDSRDVAELRLDLTHGMETLTLWQSSGP ENSP00000411339/1-1216 GTHRGKEASTAALRSPTLREAASSCKLRLWYHAASGDVAELRVELTHGAETLTLWQSTGP ENSCPOP00000018261/1-1130 GTHRGTESSSAVLRSPVLRNAGPACELRLWYHTASGDVAELQLELTHSAETLTLWQSLGP XP_004848894.1/1-1140 GTHLGTEASIAALRSPVLREAGPACELRLWYQAASGDVAELQLELTHRAETLTLWRSSGP *** *.*.* *.****.:*:*..:*:*****: * *****:::*** ******:: ** ENSMUSP00000092735/1-1232 WGPGWQELAVNTGRIQGDFKVTFSATRNATHRGAVALDDVEFRDCGLPIPQARCPLGHHH ENSRNOP00000022390/1-1215 WGPGWQELAVNTGRIQGDFKVTFSATRNATHRGAVALDDMEFWDCGLPIPQARCPLGHHH ENSP00000411339/1-1216 WGPGWQELAVTTGRIRGDFRVTFSATRNATHRGAVALDDLEFWDCGLPTPQANCPPGHHH ENSCPOP00000018261/1-1130 WGRGWQELAVTTGRIQGDFQVTFSVTRNATHRSAVALDDVEFWDCGLPTSQAICPQGYHH XP_004848894.1/1-1140 WRPGWQALAVTTGRIQGDFRVTFSATRNATHRGAVALDDVEFWDCGLPTPQATCPVGHHH * *** ***.****:***:****.*******.******:** ***** .** ** *:** ENSMUSP00000092735/1-1232 CQNKACVEPHQLCDGEDNCGDRSDEDPLICSHHMATDFETGLGPWNQLEGWTRNHSAGSM ENSRNOP00000022390/1-1215 CQNKACVEPHQLCDGEDNCGDSSDEDPLICSHHMATDFETGLGPWTQLEGWTRNFSAGSM ENSP00000411339/1-1216 CQNKVCVEPQQLCDGEDNCGDLSDENPLTCGRHIATDFETGLGPWNRSEGWSRNHRAGGP ENSCPOP00000018261/1-1130 CKNAACIEPHQLCDGEDNCGDGSDEDPLTCSHHTGTDFETGLGPWSHSEGPAWNLSTGLP XP_004848894.1/1-1140 CQNAACIESHQLCDREDNCGDGSDEDLLTCSHHTATDFETGLGLWTHSEGPAWNHSTGSP *:* .*:*.:**** ****** ***: * *.:* .******** *.: ** : * :* ENSMUSP00000092735/1-1232 VSPAWPHRDHSRNSAYGFFLISVAKPGTTAVLYSPEFQGSVSNNCSFTFYYYLHGSEASH ENSRNOP00000022390/1-1215 VSPAWPHRDHSRNSAYGFFLVSVAKPGTTAVLYSPEFQGSVSYNCSFTFYYYLHGSEANQ ENSP00000411339/1-1216 ERPSWPRRDHSRNSAQGSFLVSVAEPGTPAILSSPEFQASGTSNCSLVFYQYLSGSEAGC ENSCPOP00000018261/1-1130 KGSAWPHRDHSRNSAKGSFLVTTAKPGNPAILLSPQLQASNSHNCSLIFYHYLHGSEAAR XP_004848894.1/1-1140 KGSAWPSRDHSRNSAQGSFLVSTAKPGSPAVLLSPQLQASGSHNCSLIFYHYLHGSEDGR .:** ******** * **::.*:**..*:* **::*.* : ***: ** ** *** ENSMUSP00000092735/1-1232 FQLFLQAQGLNTPQVPVLLRSRHGELGTAWVRDRVDIQSAHPFRILLAGETGPGGVVGLD ENSRNOP00000022390/1-1215 FQLFVQAQGLNTTQPPVLLRSRHGELGTAWVRDRVNIQSAHPFRILLAGETGPGGFVGLD ENSP00000411339/1-1216 LQLFLQTLGPGAPRAPVLLRRRRGELGTAWVRDRVDIQSAYPFQILLAGQTGPGGVVGLD ENSCPOP00000018261/1-1130 LELFLQTEGP---RAPVLLRQRYGELGAAWVRDRVDIQSAHPFRILLTGEVGPGGVVGLD XP_004848894.1/1-1140 LQLLLHTQGPRASQAPVLLRQRQGELGAAWVRDQVDVRSAQPFWILLTGETGPGGVVGLD ::*:::: * : ***** * ****:*****:*:::** ** ***:*:.****.**** ENSMUSP00000092735/1-1232 DLIMSSHCMLVPAMSTLQS----SLSGPVPLALY---PQTSIKLPQQTCEPGHLSCGDLC ENSRNOP00000022390/1-1215 DLIMSNHCILVPGMSTLQS----SLSGPVPLALY---PQTSI---KRTCEPGHLSCDELC ENSP00000411339/1-1216 DLILSDHCRPVSEVSTLQP----LPPGPRAPAPQPLPPSSRL---QDSCKQGHLACGDLC ENSCPOP00000018261/1-1130 DLILSDHCMMDPG--DLLS----LPPVPWLKAPH--AQQSSL---QGSCKPGQLACGELC XP_004848894.1/1-1140 DLILSDHC--TPHVTSLCPTGAVLTPAAWPKAPW--PQQSSL---QGSCQPGQLACGDLC ***:*.** . * . . . * .: : : :*: *:*:*.:** ENSMUSP00000092735/1-1232 VPPEQLCDFQKHCAEGEDEHKCGTTDFESASAGGWEDISVGKLQWQWVEAQEKSKPAGDA ENSRNOP00000022390/1-1215 VPPEQLCDFQQHCAEGEDEEKCGTTDFESASAGGWEDISIGKLQWQRAEAQESGKPARDT ENSP00000411339/1-1216 VPPEQLCDFEEQCAGGEDEQACGTTDFESPEAGGWEDASVGRLQWRRVSAQESQGSS--- ENSCPOP00000018261/1-1130 VPLEQLCDFQPQCALGEDELKCGTTDFESTTVGGWEDASIGRLQWRQWAAPESSWPG--- XP_004848894.1/1-1140 VPLEQLCDFQPQCAQGEDEQECGTTDFESATAGGWEDASVGRLQWVRLAAQERGGPG--- ** ******: :** **** ********. .***** *:*:*** * * .. ENSMUSP00000092735/1-1232 NRDAPGHFLSLQKAWGQLRSEARALTPALGPSGPHCELHMAYYFQSHPQGFLALVVVENG ENSRNOP00000022390/1-1215 NRNAPGHFLSLRKAWGQLRSEARALTPALGPSGPHCELHMTYYFHSHPQGFLALAVVENG ENSP00000411339/1-1216 -AAAAGHFLSLQRAWGQLGAEARVLTPLLGPSGPSCELHLAYYLQSQPRGFLALVVVDNG ENSCPOP00000018261/1-1130 -RPAAGHFLSLQRAWGQLRPEARARTPVLGPSGLHCELHMAYYFHSHP------------ XP_004848894.1/1-1140 -RTAAGHFLSVQRAWGQLRAEARALTPVLGPSGPHCELHMAYYFHSRP------------ *.*****:::***** .***. ** ***** ****::**::*:* ENSMUSP00000092735/1-1232 FRELLWQAPGGGSGSWTEEKIILGARRRPFQLEFVSLVDLDGPGQQGAGVDNVTLRDCNP ENSRNOP00000022390/1-1215 FRELLWQAPSSSSGGWTLQKILLGARRRPFQLEFVSLVDLDGPGQQGAGVDNVTLRDCNP ENSP00000411339/1-1216 SRELAWQALSSSAGIWKVDKVLLGARRRPFRLEFVGLVDLDGPDQQGAGVDNVTLRDCSP ENSCPOP00000018261/1-1130 ------------------------------------------------------------ XP_004848894.1/1-1140 ------------------------------------------------------------ ENSMUSP00000092735/1-1232 MVTTESDQELSCNFERDSCSWHTGHLTDAHWHRIKSHGSQLDHTTGQGFFMFLDPTDPPA ENSRNOP00000022390/1-1215 MVTTESDQEVSCNFERDSCSWHTGHLTDAHWHRVKSHGSQYDHTTGQGFFMFLDPMDPPA ENSP00000411339/1-1216 TVTTERDREVSCNFERDTCSWYPGHLSDTHWRWVESRGPDHDHTTGQGHFVLLDPTDPLA ENSCPOP00000018261/1-1130 -------REVTCNFERDMCGWHQSHLTDVHWRRVESHNSGYDHTTGQGFFMLLDPTEPLT XP_004848894.1/1-1140 -------REVTCNFERDACGWHLSHLTDVHWHRVESHSSGYDHTTGQGFFMLLDPTNPLS :*::****** *.*: .**:*.**: ::*:.. *******.*::*** :* : ENSMUSP00000092735/1-1232 RGQGALLLTRPQVPVVPKECLSFWYRLYGPQIGTLCLAMRREREEDILLWSRSGTHGNRW ENSRNOP00000022390/1-1215 RGQGALLLTRPQVPVVPKECLSFWYHLHGPQIGTLCLAMRREGEEDTLLWSRSGTHGNRW ENSP00000411339/1-1216 WGHSAHLLSRPQVPAAPTECLSFWYHLHGPQIGTLRLAMRRE-GEETHLWSRSGTQGNRW ENSCPOP00000018261/1-1130 HGHHAYLLTGPQVPTAPEQCLSFWFYLHGPQIGTLQLALRRD-GQDIKLWSESGTHGNRW XP_004848894.1/1-1140 RDHHAHLLTEPQVPAALDQCLGFWFLLHGPQIGTLRLAMRRNKEEEVQLWSGSGTHGNRW .: * **: ****.. :**.**: *:******* **:**: :: *** ***:**** ENSMUSP00000092735/1-1232 HQAWVTLHHQPEASTKYQLLFEGLRNGYHGTMALDDIAVRPGPCWAPKSCSFEDSDCGFS ENSRNOP00000022390/1-1215 HQAWVTLHHQLQPSTKYQLLFEGLRDGYHGTMGLDDMAVRPGPCWAAKRCSFEDSDCGFS ENSP00000411339/1-1216 HEAWATLSHQPGSHAQYQLLFEGLRDGYHGTMALDDVAVRPGPCWAPNYCSFEDSDCGFS ENSCPOP00000018261/1-1130 HQAWATLHHQMEPGSKYQLLFQGLRDGYEGIMALDDVTIRPGTCPPPWRCSFEDSACSFS XP_004848894.1/1-1140 HQAWATLNHQLEPSTKYQLLFQGLRDGYHGIMALDDVTLQPGTCPAPQRCSFEESACSFS *:**.** ** . ::*****:***:**.* *.***::::**.* .. ****:* *.** ENSMUSP00000092735/1-1232 PGGWGLWTHQSNASGLASWGPWIDHTTGTAQGHYMVVDTSPNVLPKGHVAALTSEEHQPL ENSRNOP00000022390/1-1215 PGGWGLWTRQNNASGLGPWGPWIDHTTGTAQGHYMVVDTSPNLLPKGHVASLTSEEHPPL ENSP00000411339/1-1216 PGGQGLWRRQANASGHAAWGPPTDHTTETAQGHYMVVDTSPDALPRGQTASLTSKEHRPL ENSCPOP00000018261/1-1130 SGGQGLWRRQANALGHSAQGPWTDHTTETAQGHYMVVDTSPDVLPQGHMASLTSEEHWPL XP_004848894.1/1-1140 SGGQGLWRRQASAWGHAARGPWTDHTTETAQGHYMVVDTSPDVLPRGHMASLTSEEHWAL .** *** :* .* * .. ** **** *************: **:*: *:***:** .* ENSMUSP00000092735/1-1232 SQPACLTFWYHMSVPNPGTLRVHVEESTRRQELSISAHGRSAWRLGSVNVQAEQAWKVVF ENSRNOP00000022390/1-1215 SRPACLTFWYHLSFHNPGTLRVFVEESTRRQELSISGHGGFAWRLGSVNVQAEQAWKVVF ENSP00000411339/1-1216 AQPACLTFWYHGSLRSPGTLRVYLEERGRHQVLSLSAHGGLAWRLGSMDVQAERAWRVVF ENSCPOP00000018261/1-1130 LHPACLTFWYHLSARSPGTLQVRVEEAKWRQTLSISEPGGPAWRLGSMDVRAKQAWRVVF XP_004848894.1/1-1140 PRPACLTFWYHLSLQSPGTLQVRVEEGGRHQTLSISEHGALAWRLGSMDVHAEQAWRVVF :********* * .****:* :** :* **:* * ******::*:*::**:*** ENSMUSP00000092735/1-1232 EAVAAGVEYSYMALDDISLQDGPCPQPGSCDFETGLCGWSHLPWPSLGGYSWDWSSGATP ENSRNOP00000022390/1-1215 EAMASGVEHSYMALDDISLQDGPCAQPGSCDFESGLCGWSHLPWPGLGGYSWDWSSGATP ENSP00000411339/1-1216 EAVAAGVAHSYVALDDLLLQDGPCPQPGSCDFESGLCGWSHLAWPGLGGYSWDWGGGATP ENSCPOP00000018261/1-1130 EAVATGMQHSYIALDDVLLQDGPCPQPGSCDFESGLCGWSHLPWPGLGGYSWDWSSGAAP XP_004848894.1/1-1140 EAVAAGVEHSYIALDDVFLQDGPCPQPGSCDFESGLCGWSHLAWPGLGGYSWDWSSGAAP **:*:*: :**:****: ******.********:********.**.********..**:* ENSMUSP00000092735/1-1232 SRYPQPSVDHTLGTEAGHFAFFETSVLGPGGQAAWLRSEPLPATTVSCLRFWYYMGFPEH ENSRNOP00000022390/1-1215 SRYPRPSVDHTVGTEAGHFAFFETSVLGPGGQAAWLRSEPLPATAVSCLHFWYYMGFPAH ENSP00000411339/1-1216 SRYPQPPVDHTLGTEAGHFAFFETGVLGPGGRAAWLRSEPLPATPASCLRFWYHMGFPEH ENSCPOP00000018261/1-1130 SRYPRPPVDHTLGTEAGHFIFFETGVLGPGGRAAWLRSEPLPATKVSCLRFWYYMGFPEH XP_004848894.1/1-1140 SPYARPPVDHTLGTEAGHFAFFETGVLGAGGRAAWLRSEPLPATAASCLRFWYLMGFPEH * *.:*.****:******* ****.***.**:************ .***:*** **** * ENSMUSP00000092735/1-1232 FYKGELRVLLSSARGQLAVWYQGGHLRDQWLQVQIELSNSEEFQIVFEATLGGQPALGPI ENSRNOP00000022390/1-1215 FYKGELRVLLSSTQGQLAVWHRGGHLRDQWLQVQIEVSSSEEFQIVFEATLGGQPALGPI ENSP00000411339/1-1216 FYKGELKVLLHSAQGQLAVWGAGGHRRHQWLEAQVEVASAKEFQIVFEATLGGQPALGPI ENSCPOP00000018261/1-1130 FYKGELHVLLVSIRGQLAVWAKGGRLRHQWLEAQVEVASTEEFQVVFEATLGSQPAQGPI XP_004848894.1/1-1140 FYKGELHVLLASSRGRLEVWAAGGRLRHQWLEAQVEVASDEEFQVVFEATLGGQPVQGPI ******:*** * :*:* ** **: *.***:.*:*::. :***:*******.**. *** ENSMUSP00000092735/1-1232 AIDDVQYLAGQQCKQPSPSQGEVAAPVSVPVAVGGALLFFMFLVLMGLGGWHWLQKQ--- ENSRNOP00000022390/1-1215 ALDDVEYLAGQHCKQPTPSQGGVAAPVSVPVAVGGALLLFLL--LLGLGGWHWLQKQ--- ENSP00000411339/1-1216 ALDDVEYLAGQHCQQPAPSPGNTAAPGSVPAVVGSALLLLMLLVLLGLGGRRWLQKKG-- ENSCPOP00000018261/1-1130 ALDDIEYLSGQRCQRPTLSPEDTAVPVSVEATVSGALIFLMLLVLLGLAGWHWLQKGG-- XP_004848894.1/1-1140 ALDDIEYLAGQHCQWPAPSPEDTAAHVSVLAAVSGALVFLVLLVLLGLAGRHWLQKSGGW *:**::**:**:*: *: * .*. ** ..*..**::::: *:**.* :**** ENSMUSP00000092735/1-1232 HCPGQRSTDAAASGFANILFNADHVTLPESITSNPQSPPDLA ENSRNOP00000022390/1-1215 HLPCQ-STDAAASGFDNILFNADQVTLPESITSNP------- ENSP00000411339/1-1216 SCPFQSNTEATAPGFDNILFNADGVTLPASVTSDP------- ENSCPOP00000018261/1-1130 GWPSWRSRDSAPSSFDNILFNADQVTLPAAVTRDP------- XP_004848894.1/1-1140 GWPFQRDKDLAAPGFDNILFSADQVTLPAAVTSDP------- * . : :...* ****.** **** ::* :*