CLUSTAL W(1.81) multiple sequence alignment ENSP00000382492/1-1075 -----------------------------MFYGTHFIMSPPTKSKLKRQSQLLSSMLSRT ENSMUSP00000082910/1-1099 MGSSIFLGLQPSPSHWLKSSVVIHEDAPTMFYGTQLIMSPPTKNKLKRQSQLLSTMLSRT ENSRNOP00000033795/1-1071 -----------------------------MFYGTQFIMSPPTKNKLKRQSQLLSSMLSRT ENSCPOP00000018124/1-1052 -----------------------------MFYGTHFVMSPPTKSKLKRQGQLLSSMLSRT XP_004840461.1/1-1072 -----------------------------MLYGTHFVMSPPTKSKLKRQGQLLSNMLSRT *:***:::******.*****.****.***** ENSP00000382492/1-1075 LSYKYRDLDSTFSSLGASDDPAELSTQLSAPGVLKVFGDSVCTGTHYKSVLATGTSSARE ENSMUSP00000082910/1-1099 LSYKYRDLDSTFCSLGASDDPSELSTQLSAPGVLKVFGDSVCTGTHYKSVLATGSSSAQE ENSRNOP00000033795/1-1071 LSYKYRDLDSTFCSLGASDDPSELSTQLSAPGVLKVFGDSVCTGTHYKSVLATGASSAQE ENSCPOP00000018124/1-1052 LSHKYRDLDSTPCSLGSSDDPAELSTQLSAPGVLKVFGDSVCTGTHYKSVLATGMSSARE XP_004840461.1/1-1072 LSHKYRDLDSALCSLGARDDPAELSTQLSAPGVLKVFGDSVCLGTHYKSVLATGMSSAQE **:*******: .***: ***:******************** *********** ***:* ENSP00000382492/1-1075 LVKEALERYALDPRQAGQYVLCDVVGQAGDAGQRWQARCFRVFGDSEKPLLIQELWKPRE ENSMUSP00000082910/1-1099 LVKEALERYALDPECAGQYVLCDVVGQAGDSGQRWQAQCFRVFGDNEKPLLIQELWKPRE ENSRNOP00000033795/1-1071 LVKEALERYALDPECASQYVLCDVVGQAGDSGQRWQAQCFRVFGDNEKPLLIQELWKPRE ENSCPOP00000018124/1-1052 LVKEALERYALDPTCADQYVLCDVVGQAGDPGQRWQAQCFRVFGDNEKPLLIQELWKPRE XP_004840461.1/1-1072 LVKEALERYALDPECASQYVLCDVVGQAGDPGKQWQAQCFRVFGDNEKPLLIQELWKPRE ************* *.*************.*::***:*******.************** ENSP00000382492/1-1075 GLSRRFELRKRSDVEELAAKEVDTITAGINAQARRLQRSRAKGTPTPALGDARSSPPPRL ENSMUSP00000082910/1-1099 GLSRRFELRKKSDVEELASRDVDTTTAGINAQARRLQRIRAKGTPALTSEAAQSSPPTRL ENSRNOP00000033795/1-1071 GLSRRFELRKKSDVEELAARDVDTTTAGINAQARRLQRIRAKGTPALTSETAQSSPPTGL ENSCPOP00000018124/1-1052 GLFRRFELRKKSDVEELAAKDVDTITAGINAQARRLQRIRAKGTPSLAPGTVCGSPPPQL XP_004840461.1/1-1072 GLSRRFELRKRSDVEELAAKDVDTLTAGINAQARRLQRIRAKGTSGLAPGAACSSPPPRL ** *******:*******:::*** ************* *****. : . .***. * ENSP00000382492/1-1075 RRTVSETSLSPVNALPAAAQGPEEPGPDAMRYSLYQSPHLLLLQGYSQQHDSLVYVLNRD ENSMUSP00000082910/1-1099 RRTVSETSLSPAPSLPEAAQRPEEPVPEAMRYSLYQCPHLLLLQGYSQQHDSLVYVLSKE ENSRNOP00000033795/1-1071 RRTVSETSLSPTPTLPEAAQRPEEPLPDSMRYSLYQCPHLLLLQGYNQQHDSLVYVLSRE ENSCPOP00000018124/1-1052 RRTVSET---------------EEPARDTMRCSLFQAPHLLLLQGYSQQHDSLVYVLNRE XP_004840461.1/1-1072 RRTVSETSLSPATAPPEAAQGPEEPARDAMRCSLFQAPHLLLLQGYSQQHDSLVYVLNQE ******* *** ::** **:*.*********.**********.:: ENSP00000382492/1-1075 RHTVGQRTPSSKPSISLSAPDILPLHCTIRRQPLPDSGQAAGRLVLEPIPGAHISVNFSE ENSMUSP00000082910/1-1099 RHTVGQRTPSSKPSISLSAPDILPLHCTIRRHQSPEGGPAGTRLVLEPITGASVSVNFSE ENSRNOP00000033795/1-1071 RHTVGQRTPSSKPSISLSAPDILPLHCTIRRHQSPDGGPAGTRLVLEPIAGAPVSVNFSE ENSCPOP00000018124/1-1052 QHTVGQRTPSSKPSISLAAPDILPLHCTIRRRPAPDGSPEAARLVLEPIAGAPVAVNFSA XP_004840461.1/1-1072 RHTVGQRTPSSKPSISLVAPDILPLHCTIRRCPAPDGSPGVARLVLEPIAGAPMAVNFSA :**************** ************* *:.. *******.** ::**** ENSP00000382492/1-1075 VGHRTVVLHHGDLLSLGLYYLLLFKDPAQAQPLPARALARLRAVPQSCRLCGAALGARGA ENSMUSP00000082910/1-1099 VGRNPVVLQHGDLLSLGLYYLLLFKDPGQAQPLPACALARLGAAPQSCRMCGAVLRARGA ENSRNOP00000033795/1-1071 VGRNPVVLQHGDLLSLGLYYLLLFKDPGQAQPLPACALARLGAAPQSCRMCGAALKARGP ENSCPOP00000018124/1-1052 VGRGAVVLRHGDLLSLGLYYLLLFKDPAQAQLLPAGALAHLRP-PQSCRTCGAALRARGT XP_004840461.1/1-1072 VGRGPVVLQHGDLLSLGLYYLLLFKDPAQAQLLPAGALAHLRP-PQSCRTCGAALRAHDG **: .***:******************.*** *** ***:* . ***** ***.* *:. ENSP00000382492/1-1075 ASPTQAALPRRQQLLLEFEPHLEDTLLQRIMTLIEPGGDDHKLTPAFLLCLCIQHSATHF ENSMUSP00000082910/1-1099 PSLP-AAVVRRRSLLLEFEPDVEDTLLQRIMTLIEPGGDDHKLTPAFLLCLCIQHSAMHF ENSRNOP00000033795/1-1071 ASLP-AAVVRRRSLFLEFEPDVEDTLLQRIMTLIEPGGDDHKLTPAFLLCLCIQHSATHF ENSCPOP00000018124/1-1052 ASCSLAALPRRRQLLLEFEPDMEDALLQRIMTLIEPGGNDYKLTPAFLLCLCIQHSAMHF XP_004840461.1/1-1072 ASCSLVDVPRRRQLLLEFEPDVEDTLLQRIMTLIEPGSDDYKLTPAFLLCLCIQHSATHF .* . . : **:.*:*****.:**:************.:*:**************** ** ENSP00000382492/1-1075 QPGTFGQLLLKIARLIRETVWEKTKELAEKQAQLQEPISLASCAMADLVPDLQPILFWMS ENSMUSP00000082910/1-1099 QPGTFRHLLLKISKRVRDTVWEKTKELAEKQAQLQEPISWASFPMADLVPDLQHILFWMS ENSRNOP00000033795/1-1071 QPGTFRHLLLKIAKRIRDTVWEKTKELAEKQAQLQEPISWASFPMADLVPDLQHILFWMS ENSCPOP00000018124/1-1052 EPGTFGRLLLKIARRIRDTVWEKTKELAEKQAQLQEPISWASFTMADLVPDLQHILFWMS XP_004840461.1/1-1072 EQGTFGRLLLKVARRIRDTVWEKTKELAEKQAQLQEPISWASFTMADLVPDLQHILFWMS : *** :****::: :*:********************* ** .********* ****** ENSP00000382492/1-1075 NSIELLYFIQQKCPLYMQSMEEQLDITGSKESLFSCTLTASEEAMAVLEEVVLYAFQQCV ENSMUSP00000082910/1-1099 NSIELLYFIQQKSPLYVQSMEEELDVTGSKESLFSCTLTASEEAMAALEEVVLYAFQQCV ENSRNOP00000033795/1-1071 NCIELLYFIQQKSPLYVQSMEEELDVTGSKESLFSCTLTASEEAMAALEEVVLYAFQQCV ENSCPOP00000018124/1-1052 NSIELLYFIQQKCPFYMQSMEEELDVTGSKESLFSCTLTASEEAMAALEEVVLYAFQQCV XP_004840461.1/1-1072 NSIELLYFIQQKCPLYMQSMEEELDVTGSKESVFSCTLTASEEAMAVLEEVVLYAFQQCV *.**********.*:*:*****:**:******:*************.************* ENSP00000382492/1-1075 YYVSKSLYICLPALLECPPFQTERRESWSSAPELPEELRRVVSVYQAALDLLRQLQVHPE ENSMUSP00000082910/1-1099 YYLSKCLYVCLPALLECPPFQTERRESWRSGPALPEELRRVVSVFQATLDLLQQLQMHPE ENSRNOP00000033795/1-1071 YYLSKCLYVCLPALLECPPFQTERRESWRSGPALPEELRRVVSVFQATMDLLQQLQMHPE ENSCPOP00000018124/1-1052 YYLSKCLYVCLPALLECPPFQTERRESWHGGPVLPEELRRVVAVYQAALDLLRQLRVHPE XP_004840461.1/1-1072 YYLSKCLYVCLPALLECPPFQPEHQESWRGGPALPEELHRVVAVYQAALDLLRQLQVHPE **:**.**:************.*::*** ..* *****:***:*:**::***:**::*** ENSP00000382492/1-1075 VASQMLAYLFFFSGTLLLNQLLDRGPSLSCFHWPRGVQACARLQQLLEWMRSAGFGAAGE ENSMUSP00000082910/1-1099 VASQMLAYLFFFSGTLLLNQVLDKGPSLSCFHWPRGVQVCARLQQFLEWARSAGLGAPAE ENSRNOP00000033795/1-1071 VASQMLAYLFFFSGTLLLNQVLDKGPSLSCFHWPRGVQVCARLQQFLEWARSAGLGAPAE ENSCPOP00000018124/1-1052 VASQMLAYLFFFSGTLLLNQLLDR---VSCFHWPRGVQACTRLQQLLEWARSAGLGAAGE XP_004840461.1/1-1072 VASQMLAYLFFFSGTLLLNQLLDRGPSLSCFHWPRGVQACARLQQLLEWARSAGLGVSGE ********************:**: :**********.*:****:*** ****:*...* ENSP00000382492/1-1075 HFFQKLSCTLNLLATPRAQLIQMSWTALRAAFPALSPAQLHRLLTHYQLASAMGPMSTWE ENSMUSP00000082910/1-1099 RFFRKLSCTLHLLATPRAQLIQMSWATLRVTFPALNPAQLHRLLTQYQLASAMGPVSAWE ENSRNOP00000033795/1-1071 RFFRKLSCTLHLLATPRAQLVQMSWATLRATFPALNPAQLHRLLTQYQLASAMGPVSAWD ENSCPOP00000018124/1-1052 RFFRKLSCTLHLLATPSAQLVQMSWATLRATFPALSPAQLHRLLTQYQLASAMGPMSAWE XP_004840461.1/1-1072 HFFRKLSCTLHLLATPSAQLVQMSWATLRATFPALSPAQLHRLLTQYQLASAMGPMSAWE :**:******:***** ***:****::**.:****.*********:*********:*:*: ENSP00000382492/1-1075 PGAQDSPEAFRSEDVLESYENPPPIVLPSDGFQVDLEANCLDDSIYQHLLYVRHFLWGLR ENSMUSP00000082910/1-1099 PGAPDGPEAFQSEDILESYENPPPIVLPSQGFQVDLEADCVEDSIYQHLLYIRHFLWGLR ENSRNOP00000033795/1-1071 PGAQESPEAFQTEDILESYENPPPIVLPSQGFQVDLEADCPEDSIYQHLLYIRHFLWGLR ENSCPOP00000018124/1-1052 PGAQDCPDAFQSDHVLESYEKPPPIVLPSEGFQVDLEADCP-DGVYQHLIYIRHFLWGLR XP_004840461.1/1-1072 PGPQDCPDAFQSEHVLESYEKPPPIVLPSEGFQVDLEADCPDDSIYQHLLYIRNFLWGLR **. : *:**:::.:*****:********:********:* *.:****:*:*:****** ENSP00000382492/1-1075 SRASPGSPGRPGSGASQPVCPEGMHHVVLDGHLEAPSCPLAPRDPGPAAREVAPERTLPL ENSMUSP00000082910/1-1099 GQASPDS------GPAQPESIEGLYHTIPEGHLEGHGCPLANRDPGRVAVETAPPHSLPV ENSRNOP00000033795/1-1071 GQASPES------GPAQPDSIEGLYHTIPEGHLEGHGCPLTNREQGRGAVETAPGHSLPV ENSCPOP00000018124/1-1052 GPTSPDR------GVIQPASLEGLYHTIPEGPLEDQGCPLAARNPSGGALEAAPAHSVPG XP_004840461.1/1-1072 GPASPGR-----GGPMQLASLEGLYHTVPEGHPEGQGCPLAARDPSGGPLKATPAHSVPG . :** * * . **::*.: :* * .***: *: . . :.:* :::* ENSP00000382492/1-1075 RGAPWAQAPP-GRQPSRG---GSQAGPPHTDSSCLLTPPSTPLGPEPGDPDWPESGGPCG ENSMUSP00000082910/1-1099 TGAPRAQGPP-GRQPTRGDRRGSQAGSLHTDSSCMLTPPSTPLGLEPAGPSWPEPSGLCG ENSRNOP00000033795/1-1071 PGAPRAQGPP-GRQPPRGDRRGSQAGSLHTDSSCLLTPPSTPLGLEPGGPTWPEPSGLCG ENSCPOP00000018124/1-1052 AGTSGAQEPPGGRQPGRGGHRGSQAGLLHTDSSCLLTPPGTPLGLEPGGPSWPEPGSLCG XP_004840461.1/1-1072 AGAPRAQEPPEGQHPNRGGHRGSQAGLLHTDSSCLLTPPGTPLGLKPGGPSWSEPRGPCG *:. ** ** *::* ** ***** ******:****.**** :*..* *.*. . ** ENSP00000382492/1-1075 KALPERQRNGLSGLRGAAPEGDSAALAEESPPAPSSRSSSTEDFCYVFTVELERGPSGLG ENSMUSP00000082910/1-1099 RAVLDGQRNGPGGLPGAVLEGDAIQDA-EPPAEASSPSSSAEDFCYVFMVELERGPSGLG ENSRNOP00000033795/1-1071 KALLEGQRNGPGGLPGAVLEGDAVQAAAEPPAEASSPSSSTEDFCYVFMVELERGPSGLG ENSCPOP00000018124/1-1052 KILPELQRNGLGPL-GAALEGDTVAPMDESPVDPSNGSSSTEDFCYVFSVELERGPLGLG XP_004840461.1/1-1072 KILPKGQRNGLDSL-GAVLEGDTVAPVDESPLDPSSGSSSTEDFCYIFSVELERGPLGLG : : . **** . * **. ***: *.* .*. ***:*****:* ******* *** ENSP00000382492/1-1075 MGLIDGMHTHLGAPGLYIQTLLPGSPAAADGRLSLGDRILEVNGSSLLGLGYLRAVDLIR ENSMUSP00000082910/1-1099 MGLIDGMHTPLGAQGLYIQTLLPGSPAASDGRLSLGDQILEVNGSSLRGVSYMRAVDLIR ENSRNOP00000033795/1-1071 MGLIDGMHTPLEAPGLYIQTLLPGSPAASDGRLSLGDQILEVNGSSLMGVSYMRAVDLIR ENSCPOP00000018124/1-1052 MGLIDGMHTALGSPGLYIQTLLPGSPAAANGRLSLGDRILEVNGTSLMGVSYMRAVDLIR XP_004840461.1/1-1072 MGLIDGMHTPLGSPGLYIQTLVPGSPAAADGRLSLGDRILEVNSISLMGISYMRAVDLIR ********* * : *******:******::*******:*****. ** *:.*:******* ENSP00000382492/1-1075 HGGKKMRFLVAKSDVETAKKIHFRTPPL ENSMUSP00000082910/1-1099 HGGKKMRFLVAKSDMETAKKIRFRNPPS ENSRNOP00000033795/1-1071 HGGKKMRFLVAKSDMETAKKIRFRKPPS ENSCPOP00000018124/1-1052 HGGKKMQFLVAKSDVETAKKIHFRTPPP XP_004840461.1/1-1072 HGGKKMRFLVAKSDVETAKKIRYHMPPP ******:*******:******::: **