CLUSTAL W(1.81) multiple sequence alignment ENSCPOP00000017376/1-1234 MELYFGEYRRVQQEYGVHLRLAGDQAAKPRDVARSRPSSYGVSIRVQGIDGHPYIVLNNE ENSMUSP00000112479/1-1297 MELYFGEYQHVQQEYGVHLRLASGDTPKPRNSQPSKAGSYGVSIRVQGIDGHPYIVLNNT ENSRNOP00000023458/1-1292 MELYFGEYQHVQQEYGVHLRLASDGTPKPRNSQPSKAGSYGVSIRVQGIDGHPYIVLNNT ENSP00000281282/1-1302 MELYFGEYQHVQQEYGVHLRLASDDTQKSRSSQNSKAGSYGVSIRVQGIDGHPYIVLNNT XP_004855803.1/1-1290 MELYFGEYRHVQQEYGVHLRLASEATKKTRSSPHSKTGSYGVSIRVQGIDGHPYIVLNNT ********::************. : *.*. *:..********************* ENSCPOP00000017376/1-1234 EHCVPGAAFPGNRPPFPSPVMQGRS--------------KDAPLPPE-----DPLGDLQR ENSMUSP00000112479/1-1297 ERCLAGTPFPENAPSFPSSVINNLSLHPSNGTVLKENTPEELQLPENPYLQTSPLRGQKQ ENSRNOP00000023458/1-1292 ERCLAGIPFPENRP-FPSPMINNLSLHPSNGTVLKENTPEELQLPENPYLQASPVSGQKQ ENSP00000281282/1-1302 ERCLAGTSFSENGPPFPPPVINNLPLHSSNGSVPKENS-EELQLPENPYAQPSPIRNLKQ XP_004855803.1/1-1290 EHCLAGRPFSENGPSFPSSMISDLP--GCSGSVPKESSMEEPPHPENSYAQPSPPRNPKQ *:*:.* .*. * * **..::.. . :: * : .* . :: ENSCPOP00000017376/1-1234 TSPLGVRAGVPEQKDIPGKSPQLLNFQRHPELLQPYDPGKHEPVLQTPRAPEGEGFDCSP ENSMUSP00000112479/1-1297 FSLHEGRNGVLERKDGPTKLPHVLNFQRHPELLQPYDPEKNEVNAKKHHPPESPWLRNAT ENSRNOP00000023458/1-1292 FSFHEGRNGVLERKDGPTKLPHVLNFQRHPELLQPYDPEKNEVNSKKHHPPESPWLRNAT ENSP00000281282/1-1302 PLLHEGKNGVLDRKDGSVKPSHLLNFQRHPELLQPYDPEKNELNLQNHQPSESNWLKTLT XP_004855803.1/1-1290 PSLHEGRNSVLERKDIPGKSSHLLNFQRHPELLQPYDPDKNDLNLHNLQAPESDGLNGLA : .* ::** . * .::*************** *:: :. :..*. : . ENSCPOP00000017376/1-1234 EDAVEEKTPPRTCIPSPG----------------LEAVRLCGSVVIADPGQRTSVRVSVQ ENSMUSP00000112479/1-1297 EDGTNCKK-SRNCFPKSYGSQPNSPTSEDLAKTNMTAIRLCSSVVIEDPQKQTSVCVNVQ ENSRNOP00000023458/1-1292 EEGTNCKM-SRNCFPKPCGSQPNSPTPEDLAKTNMTAIRLCSSVVIEDPQKQTSVCVNVQ ENSP00000281282/1-1302 EEGINNKK-PWTCFPKPSNSQPTSPSLEDPAKSGVTAIRLCSSVVIEDPKKQTSVCVNVQ XP_004855803.1/1-1290 EEGANNKKQPWACSSKPGNPPPTSPS--------LESTRLCSSVVTEEPEKQTSVCVNVQ *:. : * . * ... : : ***.*** :* ::*** *.** ENSCPOP00000017376/1-1234 SCTRDGPAEEEEDEDPARSGRSPAPRNPQPHVETQRARPDVLPFWRQDSAGPVLDGARSR ENSMUSP00000112479/1-1297 RCAKEG-VGEET---LSPRRKSPTAPSPQAYSETKKNRPDVLPFRRQDSAGPILDGARSR ENSRNOP00000023458/1-1292 RCAKEG-VGEET---LSPRRKSPTAPSPQAYSETKKSRPDVLPFRRQDSAGPILDGARSR ENSP00000281282/1-1302 SCTKER-VGEEA---LFTSGRPLTAHSPHAHPETKKTRPDVLPFRRQDSAGPVLDGARSR XP_004855803.1/1-1290 SCMKEGRVGDA----LSPSRRSLSTLSPQAHGEIKKTRPDVLPFRRQDSAGPILDGARSR * :: . : :. :. .*:.: * :: ******* *******:******* ENSCPOP00000017376/1-1234 RSSSSCTTPTSATSLYRFLLDGPEAAIHADSVNRHENRRYIPFLPGTGRDIDTGSLPAVD ENSMUSP00000112479/1-1297 RSSSSSTTPTSATSLYKFLLDDQECAIHADSVNRHENRRYIPFLPGTGRDIDTCSIPGVD ENSRNOP00000023458/1-1292 RSSSSSTTPTSATSLYKFLLDDQECAIHADSVNRHENRRYIPFLPGTGRDIDTCSIPGVD ENSP00000281282/1-1302 RSSSSSTTPTSANSLYRFLLDDQECAIHADNVNRHENRRYIPFLPGTGRDIDTGSIPGVD XP_004855803.1/1-1290 RSSSSSTTPTSANSLYRFLLDDQECAIHADNVNRHENRRYIPFFPGTGRDIDTGSIPGVD *****.******.***:****. *.*****.************:********* *:*.** ENSCPOP00000017376/1-1234 QLIEKFDQKPGPQRRGRSGRRHRIHPEDRQRSRSVDSALPFGLQGNAEYLAEFSRSRGKA ENSMUSP00000112479/1-1297 QLIEKFDQKPGLQRRGRSGKRNRINPDDRKRSRSVDSAFPFGLQGNTEYLTEFSRNLGKS ENSRNOP00000023458/1-1292 QLIEKFDQKPG-QRRGRSGRRNRINADDRKRSRSVDSAFPFGLQGNTEYLTEFSRNLGKS ENSP00000281282/1-1302 QLIEKFDQKPGLQRRGRSGKRNRINTDDRKRSRSVDSAFPFGLQGNSEYLIEFSRNLGKS XP_004855803.1/1-1290 QLIEKFDQKPGLQRRGRSGKRNRINPDDRKRSRSVDSAFPFGLQGNSEYLTEFSRNLGKS *********** *******:*:**:.:**:********:*******:*** ****. **: ENSCPOP00000017376/1-1234 CERLLRPSQLCPPRT-------------PLA-------GPQGA-----SQGKDGPAPRGS ENSMUSP00000112479/1-1297 SEHLLRPSQVFPQRSVAQEHRGKHSPSSPPAKLQ----GAQGAHPKPPLQNKDGKVL-NK ENSRNOP00000023458/1-1292 SEHLLRPSQVFLQRSVAQEHRGKHSPISTLAKL-------QGAHPKPPLQNKDGKVL-NK ENSP00000281282/1-1302 SEHLLRPSQVCPQRPLSQERRGKQSVGRTFAKLQGAAHGASCAHSRPPQPNIDGKVLETE XP_004855803.1/1-1290 SERLLRPSQLCPQRSLAQEYLGKQGMGRAFAKLQGAMHGAQGA-----PQNKDGKVPENK .*:******: *. . * . * . ** . . ENSCPOP00000017376/1-1234 AGQEGAAVAAGCASSLALPAKAGKQEETKTATATLMLQSHRAAATSPESGAKKISVKTFP ENSMUSP00000112479/1-1297 GRQEST-GA--CAPS--LPAPNKKEEEIKIATATLMLQN-RAVAATSDSGAKKISVKTFP ENSRNOP00000023458/1-1292 GSQESI-GA--GAPS--LPAQNKKEEEIKIATATLMLQN-RAVAATSDSGAKKISVKTFP ENSP00000281282/1-1302 GSQEST-VI--RAPS--LGAQSKKEEEVKTATATLMLQN-RATATSPDSGAKKISVKTFP XP_004855803.1/1-1290 GGREGTVVV--CAPS--LPAQARKEDEIKTATATLMLQN-RAVATSPDSGAKKISMKTFS . :*. *.* * * *::* * ********. **.*::.:*******:***. ENSCPOP00000017376/1-1234 SVSNPQATPDLLKGQQELSQRANEETAKQILYNYLKEGSSDNEDATKRKVNLVFEKIQTL ENSMUSP00000112479/1-1297 SDSSTQATPDLLKGQQELTQQTNEETAKQILYNYLKEGGTDNEDATKRKVNLVFEKIQTL ENSRNOP00000023458/1-1292 SDSSTQATPDLLKGQQELTQQTNEETAKQILYNYLREGGTDNEDATKRKVNLVFEKIQTL ENSP00000281282/1-1302 SASNTQATPDLLKGQQELTQQTNEETAKQILYNYLKEGSTDNDDATKRKVNLVFEKIQTL XP_004855803.1/1-1290 SNSNTQATPDLLKGQQELNQQANEETAKQILYNYLKEGSSDNEDATKRKVNLVFEKIQTL * *..*************.*::*************:**.:**:***************** ENSCPOP00000017376/1-1234 KSRAAGSAPGNHQTTSSSSEVKDLLEQKNKLTSEVAELQQRLQLETKNQQNIQEERARLR ENSMUSP00000112479/1-1297 KSRAAGSAQGSNQAPNSPSEGNSLLDQKNKLILEVSELQQQLQLEMKNQQNIKEERERMR ENSRNOP00000023458/1-1292 KSRATGSAQGNNQAPNSSSEGNDLLDQKNKLILEVSELQQQLQLEMKNHQNIKEERERMR ENSP00000281282/1-1302 KSRAAGSAQGNNQACNSTSEVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMR XP_004855803.1/1-1290 KSRAAGSAQGNPQTSSSSSEVKDLLEQKNKLTSEVAELQRQLQLEVKNQQNIQEERERLR ****:*** *. *: .*.** :.**:**.** **:***::**** **:***:*** *:* ENSCPOP00000017376/1-1234 ADLEELRSQLDRRVEDDAGLQQRLKESEAELRKSLEELFQVKMEREQHQTEIRDLQDQLS ENSMUSP00000112479/1-1297 EDLEELRVRHQSQVEETATLQRRLEESEGELRKSLEELFQVKMEREQHQTEIRDLQDQLS ENSRNOP00000023458/1-1292 EDLEELRVRHQSQVEETATLQRRLEESEEELRKNLEELFQVKIEREQHQTEIRDLQDQLS ENSP00000281282/1-1302 ANLEELRSQHNEKVEENSTLQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLS XP_004855803.1/1-1290 ADLEEVRSQLDRRVEDSAALQQRLEDSEAELRKSLEELFQVKMEREQHQTEIRDLQDQLS :***:* : : :**: : **:**::** ****.********:***************** ENSCPOP00000017376/1-1234 EMHDELDSAKRSEDREKAALIEELLQAKRDLHDLLIAKEGLEELLRKRERELTALRGALK ENSMUSP00000112479/1-1297 EMHDELDSTKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALK ENSRNOP00000023458/1-1292 EMHDELDSTKRSEDQEKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALK ENSP00000281282/1-1302 EMHDELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALK XP_004855803.1/1-1290 EMHDELDSAKHSEDREKAALIEELLQAKRDLHDLLIAKEELEDLLRKRERELTALKGALK ********:*:***:**.**********:**:******* *:************:**** ENSCPOP00000017376/1-1234 EEVSSHDHEMDRLKAQYDAELQALRESVEEATKNVEVLASRSNASEQSQVGAEMREKALK ENSMUSP00000112479/1-1297 EEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNSSEQSQAEADLREKVLK ENSRNOP00000023458/1-1292 EEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSHSSEQTQAEADLREKALK ENSP00000281282/1-1302 EEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQ XP_004855803.1/1-1290 EEVSSHDQEMDRLKEQYDMELQALRESVEEATKNVEVLASWSNTSEQTQVGAEMREKALK *******:***:** *** ********************* *::*** *. :::* * *: ENSCPOP00000017376/1-1234 E--------------------AQIEDGKGNEARAEEALRKYEGEVRQLEEALVQARKEQK ENSMUSP00000112479/1-1297 EENEKLQGRIAELERRAAQLQRQMEDVKGDEAQAKETLRKCESEVQQLEEALVHARKEEK ENSRNOP00000023458/1-1292 EENEKLQGRIVELERRAAQLQRQMEDVKGDEAQAKETLRKCESEVQQLEEALVCARNEEK ENSP00000281282/1-1302 EENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEK XP_004855803.1/1-1290 EEMEKLQGRAEELECRVAELQAQLEDGKGGEAQAEEALRKCKGEVWQLEEALVHARKGEE * *:** **.**:*:*:*:* :.*: ******* **: :: ENSCPOP00000017376/1-1234 EAVSVRWTLESELAGVQRELSRTIQEQKQLSEKLQDETEQKEQLKRLKNEMDSERRHLSE ENSMUSP00000112479/1-1297 EATCARRALEKELEQARRELSQVSQEQKELLEKLRDEAEQKEQLRKLKNEMESERWHLDK ENSRNOP00000023458/1-1292 EAACARTAVERELEQAQRELSQISQEQKELLEKLQEEVEQKEQLRKLKNEMESERWHLDK ENSP00000281282/1-1302 EAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGK XP_004855803.1/1-1290 EAVSARRALESELADAQQELSRTIQEQKQLSKKLQDETEQKEQLRRLKNEMDSERRHLGE **...* ::* ** .: :**: ****:* :**::* ******::*****:.** **.: ENSCPOP00000017376/1-1234 TIEKLQKEMADIVEASRTSTLELQNQLDEYKDKNRRELAEMQRQLKEKTLDAEKARLTAT ENSMUSP00000112479/1-1297 TIEKLQKEMADIAEASRTSSLELQKQLGEYKEKNRRELAEMQTQLKEKCLEVEKARLAAS ENSRNOP00000023458/1-1292 TIEKLQKEMADIAEASRTSSLELQKQLDEYKEKNRRELAEMQTQLKEKSLEVEKARLAAS ENSP00000281282/1-1302 TIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAM XP_004855803.1/1-1290 TIEKLQKEMADIVEASRTSTLELQNQLDEYKDKNRRELAEVQRQLKEKTVEAENSHLAAM ************.******:****:**.***:********:* ***** ::.*:::*:* ENSCPOP00000017376/1-1234 KLQDEVRLREEEIRDHQRAQDEALTKKQLLEQTLKDLEHELEARSHLRDDRSRLVKQMED ENSMUSP00000112479/1-1297 KMQDELRLKEEELQDYQRAEEEALTKRQLLEQSLKDLEYELEAKSHLKDDRSRLIKQMED ENSRNOP00000023458/1-1292 KMQDELRLKEEELRDYQRAEEEALTKRQLLEQSLKDLEYQLEAKSHLKDDRSRLVKQMED ENSP00000281282/1-1302 KMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMED XP_004855803.1/1-1290 KLQDEMRLMEEEIRDHQRAQDEALTKKQLLEQTLKDLEHELEARSHLRDDRSRLVKQMED *:***:** ***::*:***::*****:*****:*****::***:***:******:***** ENSCPOP00000017376/1-1234 KVSQLETELEEERSNSDLLSERIAWSRDQMEQMRNELLQERTVRQDLECDKISLERQNKD ENSMUSP00000112479/1-1297 KVSQLEIELEEERTNADLLSERITWSREQMEQMRSELLQEKAAKQDLECDKISLERQNKD ENSRNOP00000023458/1-1292 KVSQLEIELEEERTNADLLSERITWSREQMEQMRSELLQEKAAKQDLECDKISLERQNKD ENSP00000281282/1-1302 KVSQLEMELEEERNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKD XP_004855803.1/1-1290 KVSQLEMELEEERNNSDLLSERITRSREQMEQMRNELLQERAVRQDLECDKISLERQNKD ****** ******.*:*******: **:****:*.*****::.:**************** ENSCPOP00000017376/1-1234 LKSRLVHLEGSYRSSKEGLVVQMEARIMELEDRLESEERDRTSLQLSNRRLERKVKELLM ENSMUSP00000112479/1-1297 LKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLENEERDRANLQLSNRRLERKVKELVM ENSRNOP00000023458/1-1292 LKSRITHLEGSYRSSKEGLVVQMEARIAELEDRLENEERDRANLQLNNRRLERKVKELVM ENSP00000281282/1-1302 LKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVM XP_004855803.1/1-1290 LKSRIGHLEGSYRSSKEGLVVQMEARIVELEDRLESEERDRASLQLSNRRLERKVKELVM ****: ********************* *******.*****:.***.***********:* ENSCPOP00000017376/1-1234 QVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQLDVNEHLQG ENSMUSP00000112479/1-1297 QVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMGVNEQLQG ENSRNOP00000023458/1-1292 QVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQIGVNEQLQG ENSP00000281282/1-1302 QVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQG XP_004855803.1/1-1290 QVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQVDVNEQLQG ***************************************************:.:**:*** ENSCPOP00000017376/1-1234 QLNSMKKDLRLKKLPSKVLDDVDDDDDLSTDGGSLCEAPLSFAFPRDSTMISQI ENSMUSP00000112479/1-1297 QLNSLKKGLRLKTLSSKVLDD-SDDDDLSSDAGSLYEAPLSYAFPKDSTIASQI ENSRNOP00000023458/1-1292 QLNSMKKGLRLKTLSSKVLDD-SDDDDLSSDAGSLYEAPLSYPFPKDSTITSQI ENSP00000281282/1-1302 QLNSMKKDLRLKKLPSKVLDDMDDDDDLSTDGGSLYEAPVSYTFSKDSTVASQI XP_004855803.1/1-1290 QLSSLKKDLRLKKLPSKVLDDMDDDDDLSTDGGSLYEAPLSFTFPRDSAVVSQI **.*:**.****.*.****** .******:*.*** ***:*:.*.:**:: ***