CLUSTAL W(1.81) multiple sequence alignment ENSMUSP00000043953/1-1079 MAASGPAAAAPSGVLVTCGLEQVLEA----------------LKLLLSPG---GSGSSSL ENSRNOP00000033600/1-932 MAASVQAAAAPSGVLGTCGLEQILEA----------------LKLLLSPG---GSGSTSL ENSP00000261778/1-1094 -MAARQAVG--SGAQETCGLDRILEA----------------LKLLLSPG---GSGSSSL ENSCPOP00000017366/1-950 MAAPAQVVG--SGALQTCSLDQILEA----------------LKLLLSPGAQKGSSSSSL XP_004843289.1/1-1108 HISKNPFLH--LFFLPLSSIPLLERARHSTQRKSQFVCLICNLFLLLFSK---GSGSSSL : ..: : .* * *** . **.*:** ENSMUSP00000043953/1-1079 QNTKHDVLLQTLKSNLSALEAKFLKDAQWKKLKALRDELADKAEWPQSSEDITWSFTSQT ENSRNOP00000033600/1-932 QNTKHDVLLETLKSNLSALEAKFLKDAQWKKLKTLRDEIADKAEWPQSSEDITWSFTSQT ENSP00000261778/1-1094 QVTKHDVLLATLKSNLSALEDKFLKDPQWKNLKLLRDEIADKAEWPQNSVDVTWSFTSQT ENSCPOP00000017366/1-950 QITKRNVLLATLKSNLCALED-ILKDPHWKKLKLLRDEIGNQAEWPQNSVDITWSFTSQT XP_004843289.1/1-1108 QITKHDVLLATLKSNLSALEDKILRDPQWKTLKLLRDEIINQAEWPQNSVDITWSFTSQA * **::*** ******.*** :*:*.:**.** ****: ::*****.* *:*******: ENSMUSP00000043953/1-1079 LLLLLCLKEVLARLVADFNPGKPNPRTPEAAPALSPDTLSVSQQKTFQSVLQFVVTLGVC ENSRNOP00000033600/1-932 LLLLLCLKEIMTRLVAEFNPGKPNPRTPEAAPALSPDTLSVSQQKTFQSVLQFVVTLGVC ENSP00000261778/1-1094 LLLLLCLKETMIRLAANFNPGKPNPRTPEVAPALSPDALSISQQKTVQFVLQFVVTLGIC ENSCPOP00000017366/1-950 LLLLLCLKETMVRLAADFNPGKPNPRTPEVAPPLSPDTLSISQQKTVQSALQFVVTLGVC XP_004843289.1/1-1108 LLLLLCLKDTMIRLAADFNPGKPNPRTPEVAPALSPDVLSISQQKTVQSTLQFVVTLGVC ********: : **.*:************.**.****.**:*****.* .********:* ENSMUSP00000043953/1-1079 PYLIPGVGVPLRDRTEFGAVVQDVVRLEAAPHATRRLYICCRVLLDLAQHASLGSLIFCR ENSRNOP00000033600/1-932 PYLMPGVGVPLRDRTEFGAVVQGIVRLEAAPHATRRLYICCRVLLDLAQHASLGSLIFCR ENSP00000261778/1-1094 PYLMPGVGVPLRYRTEFGAVVQDVVCFDAAPDATRRLYTSCKALLNVAQHTSLGSLIFCH ENSCPOP00000017366/1-950 PYLMAGVGASLKHRTEFGAVVQDVVSLDATPHATRRLYTSCKVLLDVARHASLGSLIFCR XP_004843289.1/1-1108 PYLMAGVGVPLKYRTEFGAVVQDVVSLDAAPHAAQRLYTSCRVLLNVAQHASLGSLIFCR ***:.***..*: *********.:* ::*:*.*::*** .*:.**::*:*:********: ENSMUSP00000043953/1-1079 HFGDIAAGLCQLGFCPTKRKPPGPVEEVLTEEERTLSRRALRDILDQVYQPLAVRELLTL ENSRNOP00000033600/1-932 HFGDIAAGLCQLGFCPTKRKPPVPVEEVLTEEERTLSRQALRDILDQVYQPLAVRELLIL ENSP00000261778/1-1094 HFGDIAAGLCQLGFCPTKRKLLTPAEEVLTEEERTLSRGALRDMLDQVYQPLAVRELLIL ENSCPOP00000017366/1-950 HFGDIAAGLCQLGFCPTKGKPPTPAEEVLTEEERTLARGALRDILDQVYQPLAVRELLIL XP_004843289.1/1-1108 HFGDIAAGLCQLGFCPIKRKPLTPAEEVLTEEERTLSREALRDMLDQVYQPLAVRELLIL **************** * * *.***********:* ****:************** * ENSMUSP00000043953/1-1079 QGGPRQPCTDVKTQLRCRAQAPAWLRRLCGQLLSERLMRPNGVQAVVRGILEGAGAGAAG ENSRNOP00000033600/1-932 QGGSPQSCTDVKTKLRCP--APAWLRRLCGQLLSERLMRPNGVQAVVRGILEGAGAGAAG ENSP00000261778/1-1094 QGGPPQSCTDVKTQMRCR--APAWLRRLCGQLLSERLMRPNGVQAVVRGILEGAGAGAAG ENSCPOP00000017366/1-950 QGGPPQSCTSAKTQLRCQ--TPAWLRRLCGQLLSERLMRPSGVQAVVRGILEGAGAGAAG XP_004843289.1/1-1108 QGGPPQSCTDVKTQLRCR--TPAWLRHLCGQLLSERLMRPSGVQAVVRGILEGAGAGAAG ***. *.**..**::** :*****:*************.******************* ENSMUSP00000043953/1-1079 GSDAEATAADWRKCDLIAKILASCPQQSLSPESYYKDICPQILDLFHLQDKLTARQFQRV ENSRNOP00000033600/1-932 GSDAEATAADWKKCDLIAKILASCPQQSLSPESYYKDICPQILDLFHLQDKLTARQFQRV ENSP00000261778/1-1094 GSDAEVTAADWKKCDLIAKILASCPQQSLSPENYYRDICPQVLDLFHFQDKLTARQFQRV ENSCPOP00000017366/1-950 GSDAEATAADWKKCDLIAKILASCPQQSLSPEDYYRDICPQILDLFHFQDKLTARQFQRV XP_004843289.1/1-1108 GSDAEATAADWKKCDLIAKILASCPQQSLSPEDYYRDICPQILDLFHFQDKLTVRQFQRV *****.*****:********************.**:*****:*****:*****.****** ENSMUSP00000043953/1-1079 ATTTFITLSRERPELAAKYLLQPMLAPLQRCLSTAEIPESDMVPGAILVTEEELSRCVED ENSRNOP00000033600/1-932 ATTTFTTMLRERPELAPKYLLQPMLAPLHRCSTTAEIPESDMVPGTVLVTEEELSRCVED ENSP00000261778/1-1094 ATTTFITLSRERPHLAAKYLLQPVLAPLHRCLNTAELSESDMVPGTILVTEEELSRCIED ENSCPOP00000017366/1-950 ATTTFITMSREHPQLAANYLLQPLLAPLRRCLNIAEIPESDMVPGTILVTEEELSRCIED XP_004843289.1/1-1108 ATTTFITMSREHPQLAANYLLQPLLAPLQRCLNTAEIPESDMVPGTILVTEEELSRCIED ***** *: **:*.**.:*****:****:** . **:.*******::**********:** ENSMUSP00000043953/1-1079 VFKVYVVANEPVPVLLDSLLPLLRVFFSLYCFTQQSVSHIRSLCQEILLWILVKLERKKA ENSRNOP00000033600/1-932 VFKVYVVANEPLPVLLDSLLPLLGVFFSLYCFTQQSASHIRSLCQEILLWALVKLERKRA ENSP00000261778/1-1094 VFKVYVVGNEPLTVLMDSLLPVLGVLFLLYCFTKQSVSHIRSLCQEILLWILGKLERKKA ENSCPOP00000017366/1-950 VYKVYVVGNELLTVLVDSLLPVLRMLFALYCFTKQLVRCIESLCQEILLWILQKLERKIA XP_004843289.1/1-1108 VYKVYVVGNEPLTVLLDSLLPVLRMLFALYCFTKQSVSHIRSFCQEILLWILEKLERKIA *:*****.** :.**:*****:* ::* *****:* . *.*:******* * ***** * ENSMUSP00000043953/1-1079 IASLKGFSGLDKTVPTLHPQCQFRAATHGGIVITAKEAISD-DEDEALYQKVSSEQSQVE ENSRNOP00000033600/1-932 IASLRGFSGLDKAVPALHPQCQFRAATHGGIVITVKEALSD-DEDEALYQKVSSEQSQME ENSP00000261778/1-1094 IASLKGFAGLDKAVPSLHSLCQFRVATQGGIMITIKEAISDEDEDEALYQKVSSEQGRVE ENSCPOP00000017366/1-950 IASLKGFAGLDKAVPSLHPLCQFRAATQGGVMITIREAISDEDEDEALYQKLSSEQSQVE XP_004843289.1/1-1108 IASLKGFAGLDKAVPSLHPLCQFRTATKGGSMITIREAISDEDEDEALYQKVSSEQSQVE ****:**:****:**:**. ****.**:** :** :**:** *********:****.::* ENSMUSP00000043953/1-1079 HLGDLLLHCQQCGLAGDFFIFCLKELSHLLEDREAEFTPKPSCYASLLELEHHQTLLIED ENSRNOP00000033600/1-932 HLGDLLLHCQPCGLAGDFFIFCLKELSHLLEENEAEFTPKPPCSTSLLELEQHQTLLIED ENSP00000261778/1-1094 HLGDLLSHCQECGLAGDFFIFCLKELTHVASENETELKTEPFSSKSLLELEQHQTLLVEG ENSCPOP00000017366/1-950 HLGDLLTHCQECGLAGDFFIFCLKELTHLTVENEVELKPKPLSSKSLLELE-HQAHLVEG XP_004843289.1/1-1108 HLGDLLTHCQECGLAGDFFIFCLKELTHLAVENEAELKSEPFFSKSLLELE-HQALLVEG ****** *** ***************:*: :.*.*:..:* ****** **: *:*. ENSMUSP00000043953/1-1079 QERKLQVLQLLAVLCEKMSEQIFTHVTQVVDFVAATLQRACAGLAHEAESAVGSQTLSMS ENSRNOP00000033600/1-932 QERKLLVLQLLAVLCEKMSEQIFTHITQVVDFVAATLQRACAGLAHEAESTVGSQTLSMA ENSP00000261778/1-1094 QERKLLVLQLMAVLCERMSEQIFTNVTQVVDFVAATLQRACASLAHQAESTVESQTLSMS ENSCPOP00000017366/1-950 QERRLLVLQLLAVLCEKMSEQIFTNITQVVDFVAATLQRACASLAHEAESTVESQTLSMS XP_004843289.1/1-1108 QEHRLLVLQLLAVLCEKMSEQIFTNITQVVDFVAATLQRACASLAHEAKSTVESQTLSMS **::* ****:*****:*******::****************.***:*:*:* ******: ENSMUSP00000043953/1-1079 MGLVAVMLGGAVQLKSSDFAVLKQLLPLLERVSNTYPDPVIQELAADLRITISTHGAFST ENSRNOP00000033600/1-932 MGLVAAMLGGAVQLKSSDFVVLKQLLPLLEKVSNTYPDPVIQELAVDLRITISTHGAFST ENSP00000261778/1-1094 MGLVAVMLGGAVQLKSSDFAVLKQLLPLLEKVSNTYPDPVIQELAVDLRITISTHGAFAT ENSCPOP00000017366/1-950 MGLVAVMLGGAVQLKSSDFAVMKQLLPLLEKVSNTYPDPVIQELAVDLRITISTHGAFAT XP_004843289.1/1-1108 MGLVAVMLGGAVQLKSSDFAIMKQLLPLLEKVSNTYPDAVIQELALDLQITISTHGAFAT *****.*************.::********:*******.****** **:*********:* ENSMUSP00000043953/1-1079 DAVSTAAQSTLNQKDPGQKIEEQRQTSPDISTEGAQKP----------PRTG-------- ENSRNOP00000033600/1-932 EAVSTAAQSTLNKKDPEQKIKEQRQTSYDASTEGTQNR----------PETG-------- ENSP00000261778/1-1094 EAVSMAAQSTLNRKDLEGKIEEQQQTSHERPTDVAHSHLEQQQSHETAPQTGLQSNAPII ENSCPOP00000017366/1-950 QAVSVAAQSTLNKKGPEERMEEKQQASND--TQAPQSRLEQQPSNEKSPQTGLESDVAFI XP_004843289.1/1-1108 QAVSVAAQSTLNKKSPEGKTEEEQQSHHD--TQVAQSHLEQQQSREKSPQTGQESVAPFI :*** *******:*. : :*::*: : *: .:. *.** ENSMUSP00000043953/1-1079 -QGSSGPCTATSQPPGSITTQQFREVLLSACDPEVPTRAAALRTLARWVEQREARALEEQ ENSRNOP00000033600/1-932 -QGSSEPCTATSQPPGNITTEQFREVLLSACDPQVPTRAAALRTLSRWVEQREGRALEEQ ENSP00000261778/1-1094 PQGVNEPSTTTSQKSGSVTTEQLQEVLLSAYDPQIPTRAAALRTLSHWIEQREAKALEMQ ENSCPOP00000017366/1-950 PKGVSEPSTTTNQKSGSITTEQLQEVLLSAYDPQIPTRAAALRTLSRWIEQREAKALERQ XP_004843289.1/1-1108 PKGVSEPSITTNQKSGSITTEQLQEVLLSAYDPQIPLRAAALRTLSRWIEQREAKALERQ :* . *. :*.* .*.:**:*::****** **::* ********::*:****.:*** * ENSMUSP00000043953/1-1079 KKLLQIFLENLEHEDSFVYLSAIQGIALLSDVYPEEILVDLLAKYDSGKDKHTPETRMKV ENSRNOP00000033600/1-932 KKLLQIFLENLEHEDSFVYLSAIQGVALLSDVYPEEILVDLLARYDSSKDKHTPETRMKV ENSP00000261778/1-1094 EKLLKIFLENLEHEDTFVYLSAIQGVALLSDVYPEKILPDLLAQYDSSKDKHTPETRMKV ENSCPOP00000017366/1-950 EKLLKVFLENLEHEDTFVYLSAIQGVALLSDVYPEKILVDLLAQYDSSKGKHTPETRMKV XP_004843289.1/1-1108 EKLLKIFLENLEHEDTFVYLSAIQGVALLSDVYPEKILLDLLAQYDSSKDKHTPETRMKV :***::*********:*********:*********:** ****:***.*.********** ENSMUSP00000043953/1-1079 GEVLMRVVRALGDMVSKYREPLIHTFLRGVRDPDAAHRASSLANLGELCQCLHFLLGPVV ENSRNOP00000033600/1-932 GEVLMRIVRALGE----------------------------------------------- ENSP00000261778/1-1094 GEVLMRIVRALGDMVSKYREPLIHTFLRGVRDPDGAHRASSLANLGELCQRLDFLLGSVV ENSCPOP00000017366/1-950 GEVLMRIVRALGEF---------------------------------------------- XP_004843289.1/1-1108 GEVLIRIVRALGDMVSKYRDPLIHTFLRGVRDPDGAHRASSLANLGELCQHLDFLLGPVV ****:*:*****: ENSMUSP00000043953/1-1079 HEVTACLIAVAKTDNDVQVRRAAVHVVVLLLRGLSQKATEVLSDVLRDLYHLLKHVVRLE ENSRNOP00000033600/1-932 ------------------------------------------------------------ ENSP00000261778/1-1094 HEVTACLIAVAKTDGEVQVRRAAIHVVVLLLRGLSQKATEVLSAVLKDLYHLLKHVVCLE ENSCPOP00000017366/1-950 ------------------------------------------------------------ XP_004843289.1/1-1108 HEVTACLITVAKTDSEVQVRRAAIHVIVLLLRGLSQKATEVLRDVLKDLYHLLKHVVLLE ENSMUSP00000043953/1-1079 PDDVAKLHAQLALEELDEIMRNFLFPPQKLEKKIVVLP ENSRNOP00000033600/1-932 -------------------------------------- ENSP00000261778/1-1094 PDDVAKLHAQLALEELDDIMKNFLFPPQKLEKKIMVLP ENSCPOP00000017366/1-950 -------------------------------------- XP_004843289.1/1-1108 PDDVAKLHAQLALEELDEIMRNFLFPQQKLEKKIVVLP