CLUSTAL W(1.81) multiple sequence alignment ENSMUSP00000110202/1-1348 MMSRTVRLVLLALA--CTVDLSQASGFTENGLSLLSYQLCSYPVTRSVQKLQAVQTSHTA ENSRNOP00000045256/1-1310 -MSRALGLALLALT--CTVDLGQTSGFTENGLSLLSYQLCSYPMTRSVQKLQAVQTSYTA ENSP00000386126/1-1446 -MLRTSGLALLALV--SAVGPSQASGFTEKGLSLLGYQLCSHRVTHTVQKVEAVQTSYTS ENSCPOP00000016881/1-1337 TMSRMLGLALLALAGTTTVGLSWASGFTETGLSLLSYQLCSYQETRTVQRLEAVQTSHVT XP_004842647.1/1-1370 ----MLRLVLLALA--SAVGHSWASGLTETGLSLLSYQLCSYQETRTEQRVEAVQSSHVT *.****. :*. . :**:**.*****.*****: *:: *:::***:*:.: ENSMUSP00000110202/1-1348 YVYCGGWIPWKKCPKTVYRTQYLAMDVPESRNVTDCCAGFEQLGLYCVLSLNRSREFASR ENSRNOP00000045256/1-1310 YVYCGGWIPWKKCPKTVYRTQYLEMNVPESRNVTDCCAGFEQLGLYCVLSRNRSREFASR ENSP00000386126/1-1446 YVSCGGWIPWRRCPKMVYRTQYLVVEVPESRNVTDCCEGYEQLGLYCVLPLNQSGQFTSR ENSCPOP00000016881/1-1337 HVACGGWILWRWCPKTIYRTQYLTVEVPESRNITDCCKGYEQLGLYCVLPLNWSMEFTSR XP_004842647.1/1-1370 YVACGGWIPWRRCPKTVYRTQYLTVEAPEARNVTACCEGYEQLGVYCVLPLNRSAEFASR :* ***** *: *** :****** ::.**:**:* ** *:****:****. * * :*:** ENSMUSP00000110202/1-1348 PGVCPTAEAEPLSPSCSLDTDCSGLQKCCSWPGGRHCVSPTPT----------------- ENSRNOP00000045256/1-1310 PGVCPTAEPGPFTSSCSLDTDCPGLQKCCAWPGGHRCVSPTPT----------------- ENSP00000386126/1-1446 PGACPAEGPEPSTSPCSLDIDCPGLEKCCPWSGGRYCMAPAPQ----------------- ENSCPOP00000016881/1-1337 PGVCPTANPETPISPCSSDNDCPGLQKCCPRPEGHHCVAPVSQ----------------- XP_004842647.1/1-1370 PGLCPTAALEAPVSSCSSDTDCPGLQKCCPQQGGHLCMAPALQGLQDNWPLYLRTVPCTI ** **: . ..** * **.**:***. *: *::*. ENSMUSP00000110202/1-1348 ------------------------------GTEKSMVS-WYNVTVLVKVGFEDLQREDPG ENSRNOP00000045256/1-1310 ------------------------------GTERSIVG-WYNVTVLVKMGFEDLQREDPG ENSP00000386126/1-1446 ------------------------------APERDPVGSWYNVTILVKMDFKELQQVDPR ENSCPOP00000016881/1-1337 --------------------------DAGAVAEGRPTS-WYNVTVRVKMDFTDLSRVDPE XP_004842647.1/1-1370 IDGPTGLVAIGREEGTAAWGPSPPLADAGATAEGSLVS-WYNVTMRVKTDFKDLRGADPE .* .. *****: ** .* :* ** ENSMUSP00000110202/1-1348 LRNHTRLLYSLVTSALQPLNPAVHYLTSTGGKDTFTTVSWLLMGFPRLMTVANVSVMLDD ENSRNOP00000045256/1-1310 LRNHTRLLYSLVTSALQPLNPAVHYLTSTGGKDTFTTVSWLLLGFPQRMTVANVSTMLDD ENSP00000386126/1-1446 LLNHMRLLHSLVTSALQPMASTVHHLHSAPG-NASTTVSRLLLGLPRPLPVADVSTLLGD ENSCPOP00000016881/1-1337 LQNHTRLLCSLVASALQPLDSSVHYLDSASG-GPSSTVSRLLLGLPRPLVVVNVSTVLDD XP_004842647.1/1-1370 LRSHSRLLCSLVTSALQPLDSAVHYLGSASG-DSSTTVSQLLLGLAQPLSVANVSALLDD * .* *** ***:*****: .:**:* *: * .. :*** **:*:.: : *.:**.:*.* ENSMUSP00000110202/1-1348 MVNRVYEVVSIQVQDVNECLHSELQACSVREQCRNLEGSYQCVS--------SQRLNHTD ENSRNOP00000045256/1-1310 MVNRVYEVISIQVQDVNECLHSELQACSEGKQCWNLEGSYQCVS--------PQQLNHTD ENSP00000386126/1-1446 IAKRVYEVISVQVQDVNECFYEELNACSGRELCANLEGSYWCVCHQEAPATSPRKLNLEW ENSCPOP00000016881/1-1337 IPRRVCEVTSIQVQDVDECAHRALHACSMGQQCLNLEGSYRCVS-AEDPTSSPQPLNHTG XP_004842647.1/1-1370 IMKRVCEVMGIQVKDVDECVYAGLHTCSQRQRCLNLEGSYQCIS-PQALTLPPPMLSHTR : .** ** .:**:**:** : *::** : * ****** *:. . *. ENSMUSP00000110202/1-1348 EDCPPIRDFVALNVTSSSFHVSWSLNSTQNYNFHIQVYKGKEILRSAWTRGHTMAVSDLE ENSRNOP00000045256/1-1310 KDCPPIRDFVALDVTSSSFHVSWSLNSTQNHTFHVQVYKGREILRSTWTGDRTLAVPDLE ENSP00000386126/1-1446 EDCPPVSDYVVLNVTSDSFQVSWRLNSTQNHTFHVRVYRGMELLRSARTQSQALAVAGLE ENSCPOP00000016881/1-1337 EDCPPILDHVALNVTSSSFQVSWSVDPPRSRDFHVQVFRGEQLLQSAWTSGLALQVSGLD XP_004842647.1/1-1370 EACLPIRDHVALNVTSSSFRVSWSVSPSRSQDFLVQVYRGEQLLQGAWRSGPGLWVTGLE : * *: *.*.*:***.**:*** :...:. * ::*::* ::*:.: . : *..*: ENSMUSP00000110202/1-1348 AGVLYRVRTSYLGCGANVSATLVVKT-----DAQVFQVTIRIMDRNLTEQILDCSSGEFW ENSRNOP00000045256/1-1310 AGVLYRVRTSYQGCRANISATLVVKT-----DARVFQVTIRIMNRNLTEQILNCSSREFW ENSP00000386126/1-1446 AGVLYRVKTSYQGCGADVSTTLTIKT-----NAQVFEVTIKIVNHNLTEKLLNRSSVEYQ ENSCPOP00000016881/1-1337 AGELYVVRTSYQGCSANISTMLTVKT-----DARVFEVIIRITNHNLTEQLLDGGSEERR XP_004842647.1/1-1370 AGQLYTVRTSYQGCGANVSTALSIKTGKAGQNTRVFEVVIRITDRNLTDQLLDGSSEEHR ** ** *:*** ** *::*: * :** :::**:* *:* ::***:::*: .* * ENSMUSP00000110202/1-1348 NFSRQLFHEVQNSFPQAISDLYRQGRLRMQIVSLQAGSLVVTLRLTLQDPDFSVGVHTLT ENSRNOP00000045256/1-1310 NFSRQLFQEVENSFPQVISNMYRQGRLKMQIVSLKAGSLVVTLRLTLQDPDFLVNVGTLK ENSP00000386126/1-1446 DFSRQLLHEVESSFPPVVSDLYRSGKLRMQIVSLQAGSVVVRLKLTVQDPGFPMGISTLA ENSCPOP00000016881/1-1337 TFSRQLLREVENSFPPAVSELHRMGKLRLEITSLQAGSVVATLRVMVLDPESPVGVSTLA XP_004842647.1/1-1370 NFSQQLLREVENSFPPAVSDLHRRGKLKLQIASLRAGSLVVSLRVTVRDPESPVGVSTLA **:**::**:.*** .:*:::* *:*:::*.**:***:*. *:: : ** :.: ** ENSMUSP00000110202/1-1348 PMLPVLSVSNVFQVDQQRTFVQDWDECAHSSEHDCHPSARCINLEGSYTCQCLTARDASP ENSRNOP00000045256/1-1310 PMLQPLSMSTVFQVDQQGTRVQDWDECAHSSEHDCHPAARCINLEGSYTCQCLTARDANP ENSP00000386126/1-1446 PILQPLLASTVFQIDRQGTRVQDWDECVDSAEHDCSPAAWCINLEGSYTCQCRTTRDATP ENSCPOP00000016881/1-1337 PMLQLLRASTMFQIDPQGSRVQDRDECAHASEHDCSPAARCVNLEGSYTCQCHTARDASP XP_004842647.1/1-1370 PMLQPLCASSVFQIDPQGTQVQDWDECAHSSEHDCLPAARCVNLEGSYTCQCREAKDASP *:* * *.:**:* * : *** ***..::**** *:* *:********** ::**.* ENSMUSP00000110202/1-1348 SRAGRVCEGDMVIPTGDELSV-TTKVTVPAASTGITTFGPETLTESLSSKHPRSTPARSQ ENSRNOP00000045256/1-1310 SRAGRVCEGDMVTPTGGGLSVETTKVKAAAVSMGITTFGPETLTLSPSSEHLRSTPAEGQ ENSP00000386126/1-1446 SRAGRACEGDLVSPMGGGLSA-ATGVTVPGLGTGTAALGLENFTLSPSPGYPQGTPAAGQ ENSCPOP00000016881/1-1337 TRPGRACEGDVVSPTGRGLSA-ALGVTALVLTTRNTALVPEPPTLSPNPRNLECTPTAAQ XP_004842647.1/1-1370 GRAGQACEGDEVSPSGRALSA-ATGVTAPALGTGTTALVPEPPTLSLSPRNLGGSPTAAQ *.*:.**** * * * **. : *.. ::: * * * .. :*: .* ENSMUSP00000110202/1-1348 TWTPVPPSVRDGGSIVRQDRNSTGQGM--EVPNVTPNLGKTHRSTSGV------------ ENSRNOP00000045256/1-1310 ASTLGPPSRRDGGSTARQDRNSTGQDV--EVPNV-------------------------- ENSP00000386126/1-1446 AWTPEPSPRRGGSNVVGYDRNNTGKGVEQEVPSTAPGLGMDQGSPSQVNPSQGSPSQGSL ENSCPOP00000016881/1-1337 VPTPGPLPKRGADGTVGQHRNSGG-------PRPSPG----------------------- XP_004842647.1/1-1370 AQTPGSPPTRGAGGTVGHGGNSTG-------P---------------------------- . * . . *.... . *. * * ENSMUSP00000110202/1-1348 ------------------------------------------------------------ ENSRNOP00000045256/1-1310 ------------------------------------------------------------ ENSP00000386126/1-1446 RQESTSQASPSQRSTSQGSPSQVNPSQRSTSHANSSQGSPSQGSPSQESPSQGSTSQASP ENSCPOP00000016881/1-1337 ------------------------------------------------------------ XP_004842647.1/1-1370 ------------------------------------------------------------ ENSMUSP00000110202/1-1348 ----------TSSVPWAPGQTHGTHQGTTDAPLHTTRESQELITKDPPFLTATT---TGY ENSRNOP00000045256/1-1310 ----------------------------TQNP-HTTRESQEHMTKGPPFLTARS---TGY ENSP00000386126/1-1446 SHRNTIGVIGTTSSPKATGSTHSFPPGATDGPLALPGQLQGNSIMEPPSWPSPTEDPTGH ENSCPOP00000016881/1-1337 -------------SSW----------GTTDGPVHSRGQLLGNITTEPPTLPAPTSSPTGH XP_004842647.1/1-1370 -------------GRW------------DKGP----RQSRGNITMELPPLPASPTGPPGH . * : * .: . .*: ENSMUSP00000110202/1-1348 VVWHSS-PTWKTPPNSTRLQNEDPRSSSFPGPPSAPTDVTPESPACVPGPIGKVTVSNVT ENSRNOP00000045256/1-1310 VVWHPS-PTWETPLKSTRPQNEDPPPSSFPGPPSTLVAVTPETPACVPGPIGKVTISNVT ENSP00000386126/1-1446 FLWHATRSTRETLLNPTWLRNEDSGPSGSVDLPLTSTLTALKTPACVPVSIGRIMVSNVT ENSCPOP00000016881/1-1337 VEWHPSLPTQGTPLQSTTLWQEDPGPSASQGSLTVPTTVALETPACAPVPIRKVTVSNVT XP_004842647.1/1-1370 VEWHSSRPTTGTPLSSVGLRHEDPGPSPFPDSPTVPTPVALKTPGCGPVPIRKVTISNVT . **.: .* * ... :**. .* . . . .: ::*.* * .* :: :**** ENSMUSP00000110202/1-1348 STSFSLEWPADIRLSPAFHLTLVSPRGPAMTMETQNNNVTLSGLEWGTLYLVEIVAKVCG ENSRNOP00000045256/1-1310 STSFSLKWSADLHLSPAFCLTLVSPRGPAKTMETQHNNVTLSGLELGTLYLVEIMAKVCG ENSP00000386126/1-1446 STGFHLAWEADLAMDSTFQLTLTSMWSPAVVLETWNTSVTLSGLEPGVLHLVEIMAKACG ENSCPOP00000016881/1-1337 STGFHLMWEADVTLRPTFHLSATAPKGPAVALETREHNAKLSGLEPGVSYLVELTAKACG XP_004842647.1/1-1370 STSFHLAWVADVALHPTFHLAAVSPRSPAVGLDTQEPSATLSGLDPGVLYLVHITAKACG **.* * * **: : .:* *: .: .** ::* . ...****: *. :**.: **.** ENSMUSP00000110202/1-1348 KEGARTQLKVRTVAQKLAGNVRITSMQYSESFLNTSSREHREFVELFFRTVRDSLPATLR ENSRNOP00000045256/1-1310 KEGARTQLKVRTTAHKLTGKVRIPSMQYSESFRNASSREHQEFVQMFFRTVRDSLPATLR ENSP00000386126/1-1446 KEGARAHLKVRTAARKLIGKVRIKNVRYSESFRNASSQEYRDFLELFFRMVRGSLPATMC ENSCPOP00000016881/1-1337 EEGAGTRLKVRTAAQKLSGKVRIANVRFSESFRNASSTEYRAFVDLFSRTVRDSLPATLR XP_004842647.1/1-1370 KEGARMQLKVRTAAQKLRGRVRISSIRYSESFQDASSEQYRDFLGLFSRAVRDSLAAALP :*** :*****.*:** *.*** .:::**** ::** ::: *: :* * **.**.*:: ENSMUSP00000110202/1-1348 QHMDAGRIRVDIINITN--GSIVVEFNLLMTADLDVREVSAGFLNALQNTSMLEVVRGKT ENSRNOP00000045256/1-1310 QHMDEGRIQVDIINITN--GSVVVEFNLLMTADLDVREVSAGFLSAFQNTSMLEVVRGKT ENSP00000386126/1-1446 QHMDAGGVRMEVVSVTN--GSIVVEFHLLIIADVDVQEVSAAFLTAFQTVPLLEVIRGDT ENSCPOP00000016881/1-1337 QHMDTGGIRMSITCVTN--GSIVVEFDLLITVAVDVGVVSATFLDALGNMSQLEVVRNDT XP_004842647.1/1-1370 QHVDTGGIRMSVTSITNSSGSVVVEFDLLITVALDVREASAVFLDALGNVSRLEVVRSDA **:* * :::.: :** **:****.**: . :** .** ** *: . . ***:*..: ENSMUSP00000110202/1-1348 FMQDYNECDMKEDDCAPGT---CRNTFGSFTCSCDEGGPDSQVEYSGRSCDGDPSGNMTQ ENSRNOP00000045256/1-1310 IIQGGL-CSML---ICPGQSQLCASWLGRCALSLLEGIPRSCLKHGMDSLSVEPSKSLGD ENSP00000386126/1-1446 FIQDYDECERKEDDCVPGTS--CRNTLGSFTCSCEGGAPDFPVEYSERPCEGDSPGNETW ENSCPOP00000016881/1-1337 FIWDYDECGRGEDDCVPGTS--CHNTLGTFTCSCEGGAPDSRVEYSGRACAGGSPDSFTL XP_004842647.1/1-1370 VIWDYDECERMEDDCVPGAA--CRNILGSFTCSCEGGAPDSHVEYSGRACVGGSADSSTL .: . * ** * . :* : * * * :::. . .. . ENSMUSP00000110202/1-1348 TPGSEWSPTPAGTRGVPVPIASSTAQ-DLPLRLNLMDAVSVSCEIETVIITIQK-RFLQQ ENSRNOP00000045256/1-1310 VSQSSWVWGMPREKGTPLLDTAWHDQIQVDPRTH--DAHICDWKAGTLLVSLQQVTWGRG ENSP00000386126/1-1446 ATSPERPLTTAGTKAAFVQGTSPTPQ-GLPQRLNLTGAVRVLCEIEKVVVAIQK-RFLQQ ENSCPOP00000016881/1-1337 TPSPEHRPAGAETSAALPPGTNPEPQ-GTQPRLNLTGAVRVLCEMERVGIAIQK-HFLQQ XP_004842647.1/1-1370 TPGPEQRPTRAGTSAALLPDTSPVAQ-GPPPRLTLTDAVRVLCEVERVAIAIQK-RFLWQ .. .. . .. : * * .* : : :::*: : ENSMUSP00000110202/1-1348 AAIPEASLYLGEPSCNVSRSNSTHVFLVAG-WGECGTILQSNMTTTVVTTTLRNNLSPEG ENSRNOP00000045256/1-1310 GTLVRIFPFWGQ-----SYSPWNIAAFGAGAPSGPGVHLHPNMTTTVVKTTLRNDLSPEG ENSP00000386126/1-1446 ESIPESSLYLSHPSCNVSHSNGTHVLLEAG-WSECGTLMQSNMTNTVVRTTLRNDLSQEG ENSCPOP00000016881/1-1337 ELIPESSLYLGQPACNASVSNDSHVLLAVG-WGECGTLVQSNKTSTVVKTVLRNDRSPDG XP_004842647.1/1-1370 EAIPEASLYLGQPACNVSLSNASHVLLAVS-WAECGTLVQSNKTSTVVKTVLRNDQSPDG : . : .. * * . . : .. . *. ::.* *.*** *.***: * :* ENSMUSP00000110202/1-1348 VIHHPQFLSPIHCAFQNDVLTSSGYTPQWGVYTVIEDLHGTGNFVTEMQLYIGDSPIPQN ENSRNOP00000045256/1-1310 VIHHLQILSPIHCAFQNDLLTSSGYTPQWGVYTVIEDLHGTGNFVTEMQLFIGDSPIPQN ENSP00000386126/1-1446 IIHHLKILSPIYCAFQNDLLTSSGFTLEWGVYTIIEDLHGAGNFVTEMQLFIGDSPIPQN ENSCPOP00000016881/1-1337 IIHHPTILSPIRCIFRNDLLTSLGYTPKWGVYTVMEDLHGAGTFVTEMQLFVGDSPIPQN XP_004842647.1/1-1370 VIHHPTILSPIRCVFRNDLLTSLGYTPKWGVPSLVEDLHGAGTFVTEMQLFVGDSPIPQN :*** :**** * *:**:*** *:* :*** :::*****:*.*******::******** ENSMUSP00000110202/1-1348 YSVSASDEIKIEVGLHRQKSSLKVVLTECWATPSSNAKDPVTFSFINNSCPVPNTYTSVI ENSRNOP00000045256/1-1310 YSVSASDEIKIEVELHRQKSNLKVVLTECWATPSSNAKDPVTFGFINNSCPVPNTYTSVI ENSP00000386126/1-1446 YSVSASDDVRIEVGLYRQKSNLKVVLTECWATPSSNARDPITFSFINNSCPVPNTYTNVI ENSCPOP00000016881/1-1337 YSVSASDEVKVQVGLHRQKSSLKVVLVRCWATPSRDAQDPVTFGFINNSCPVPNTYTSVI XP_004842647.1/1-1370 HSVSASDDVKIQVGLDGQNS-LKVVLMECWATPSSDARDPVTFGFINNSCPIPNTHTRVI :******:::::* * *:* ***** .****** :*:**:**.*******:***:* ** ENSMUSP00000110202/1-1348 QNGHSSKAQFKLRIFSFINNSIVYLHCKLRVCMENPRNSCRISCNDFRSLRSSE--ALHQ ENSRNOP00000045256/1-1310 QNGNSSKAQFKLRIFSFINNSIVYLHCKLRVCMENPRNSCRINCNDFRLLRSSE--AIHQ ENSP00000386126/1-1446 ENGNSNKAQFKLRIFSFINDSIVYLHCKLRVCMESPGATCKINCNNFRLLQNSETSATHQ ENSCPOP00000016881/1-1337 QNGDSSKAQFKLRIFSFINNSIVYLHCKLRVCMESPGATCKINCNDFRVLRSRDGARMLE XP_004842647.1/1-1370 QNGDSSKAQFKLRIFSFINNSIVYLHCKLRVCMESPGTTCKINCNDFRFLKSNQGSAVLQ :**.*.*************:**************.* :*:*.**:** *:. : : ENSMUSP00000110202/1-1348 MTWGPLHRTEGAQACTKPVLGTGYIILLAAAALLVVAGATTLLILRYQRVRQKYNLRIQT ENSRNOP00000045256/1-1310 MTWGPLHRSEGAQACTKPGLGTGYIILIAAAVLVVVAGAATLLILRYQRVKQKYNLRIQS ENSP00000386126/1-1446 MSWGPLIRSEGEPPHAEAGLGAGYVVLIVVAIFVLVAGTATLLIVRYQRMNGRYNFKIQS ENSCPOP00000016881/1-1337 VSWGPLLRS-AVSPGTRPHLTTSYVALIVVTALVVVAGAVALLILRYQRTTGKYSFRMQP XP_004842647.1/1-1370 ATWGPLFRSDGVYPRAKPHVGAGYVTLTVVAALALVAGAVTLLILRYQRSTGKYSFRMQP :**** *: . . :.. : :.*: * ..: : :***:.:***:**** :*.:::*. ENSMUSP00000110202/1-1348 DDFSYQVFSQ ENSRNOP00000045256/1-1310 DDFSYQVFSQ ENSP00000386126/1-1446 NNFSYQVFYE ENSCPOP00000016881/1-1337 DNFSYRVFSG XP_004842647.1/1-1370 GSFGYQVFSG ..*.*:**