CLUSTAL W(1.81) multiple sequence alignment ENSMUSP00000027040/1-1588 -----------------------------MKLYVFLVNTGTTLTFDTELTVQTVADLKHA ENSRNOP00000060201/1-1588 -----------------------------MKLYVFLVNTGTTLTFDTELTVQTVADLKHA ENSP00000025008/1-1594 -----------------------------MKLYVFLVNTGTTLTFDTELTVQTVADLKHA XP_004838144.1/1-1552 MVPGAAGGGGGAAGNYQKVRLKLTESREIMKLYVFLVNTGTTLTFDTELTVQTVADLKHA ENSCPOP00000016880/1-1482 -----------------------------MKLYVFLVNTGTTLTFDTELTVQTVADLKHA ******************************* ENSMUSP00000027040/1-1588 IQSKYKIAIQHQVLVVNGGECMAADRRVCTYSAGTDTNPIFLFNKEMILCDRAPAIPKAT ENSRNOP00000060201/1-1588 IQSKYKIAVQHQVLVVNGGECMTADRRVCTYSAGTDTNPIFLFNKEMILCDRAPAIPKTT ENSP00000025008/1-1594 IQSKYKIAIQHQVLVVNGGECMAADRRVCTYSAGTDTNPIFLFNKEMILCDRPPAIPKTT XP_004838144.1/1-1552 IQSKYKIAIQHQVLVVNGGECMSADRRVCTYSAGTDTNPIFLFNKEMILCDRAPAIPKTT ENSCPOP00000016880/1-1482 IQSKYKIAIQHQVLVVNGGECMAADRRVCTYSAGTDTNPIFLFNKEMILCDRAPAIPKTT ********:*************:*****************************.*****:* ENSMUSP00000027040/1-1588 FSTENDMEIKVEESLMMPAVFHTVASRTQLAVEMYDVAKKLCSFCEGLVHDEHLQHQGWA ENSRNOP00000060201/1-1588 FSTENDMEIKVEESLMMPAVFHTVASRTQLAVEMYEVAKKLCSFCEGLVHDEHLQHQGWA ENSP00000025008/1-1594 FSTENDMEIKVEESLMMPAVFHTVASRTQLALEMYEVAKKLCSFCEGLVHDEHLQHQGWA XP_004838144.1/1-1552 FSTENDMEIKVEESLMMPAVFHTVASRTQLAVEMYEVAKKLCSFCEGLVHDEHLQHQGWA ENSCPOP00000016880/1-1482 FSTENDMEIKVEESLMMPAVFHTVASRTQLAVEMYEVAKKLCSFCEGLVHDEHLQHQGWA *******************************:***:************************ ENSMUSP00000027040/1-1588 AIMANLEDCSNSYQKLLFKFESIYSDYLQSIEDIKLKLTHLGTAVSVMAKIPLLECLTRH ENSRNOP00000060201/1-1588 AIMANLEDCSTSYQKLLFKFESIYSDYLQSIEDIKLKLTHLGTAVSVMAKIPLLECLTRH ENSP00000025008/1-1594 AIMANLEDCSNSYQKLLFKFESIYSNYLQSIEDIKLKLTHLGTAVSVMAKIPLLECLTRH XP_004838144.1/1-1552 AIMANLEDCSNSYQKLLFKFESIYSNYLQSIEDIKLKLTHLGTAVSVMAKIPLLECLTRH ENSCPOP00000016880/1-1482 AIMANLEDCSNSYQKLLFKFESIYSNYLQSIEDIKLKLTHLGTAVSVMAKIPLLECLTRH **********.**************:********************************** ENSMUSP00000027040/1-1588 SYRECLGRPDSLNEHEGSEKAEMKRSTELVLSPDMPRTTNTSLVTSFHKSMEHVAPDPTG ENSRNOP00000060201/1-1588 SYRECLGRPDSLNEHEGSEKADMKRSTELVLSPDMPRTTNTSLLTSFHKSVEHVAPDVTD ENSP00000025008/1-1594 SYRECLGRLDSLPEHEDSEKAEMKRSTELVLSPDMPRTTNESLLTSFPKSVEHVSPDTAD XP_004838144.1/1-1552 SYRECLGRLDSLNELEGSEKAEMKQSSELVLSPDMPRTTDTSLLTSFHKSVEHVAPDSTD ENSCPOP00000016880/1-1482 SYRECLGRLDSLNDHEGSEKAEMKRSTELVLSPDMPRTTNTSLLTSFHKSMEPVAPDTTD ******** *** : *.****:**:*:************: **:*** **:* *:** :. ENSMUSP00000027040/1-1588 TERGKELRESCQSTV-QQEEASVDAKDSDLPFFNVSLLDWINVQDRPNDVESLVRKCFDS ENSRNOP00000060201/1-1588 AEQGKELRESCQSTV-QQEDAPVDAKDSDLPFFNVSLLDWINVQDRPNDVESLVRKCFDS ENSP00000025008/1-1594 AESGKEIRESCQSTVHQQDETTIDTKDGDLPFFNVSLLDWINVQDRPNDVESLVRKCFDS XP_004838144.1/1-1552 AESGKEIRESNQSTA-PQDETSVDAKDSDLPFFNVSLLDWINVQDRPNDVESLVRKCFDS ENSCPOP00000016880/1-1482 AESGKEIRESCQSSV-QQDETSVDAKDSDLPFFNVSLLDWINVQDRPNDVESLVRKCFDS :* ***:*** **:. *:::.:*:**.******************************** ENSMUSP00000027040/1-1588 MSRLDPKIIQPFMLECHQTIAKLDNQNMKAIKGLEDRLYALDQMIASCSRLVNEQKELAQ ENSRNOP00000060201/1-1588 MSRLDPKIIQPFMLECHQTIAKLDNQNMKAIKGLEDRLYALDQMIASCSRLVNEQKELAQ ENSP00000025008/1-1594 MSRLDPRIIRPFIAECRQTIAKLDNQNMKAIKGLEDRLYALDQMIASCGRLVNEQKELAQ XP_004838144.1/1-1552 MSRLDPKIIRPFIVECHQTIAKLDNQNMKAIKGLEDRLYALDQMIASCGRLVNEQKELAQ ENSCPOP00000016880/1-1482 MSRLDPKIIRPFIVECHQTIAKLDNQNMKAIKGLEDRLYALDQMIASCGRLVNEQKELAQ ******:**:**: **:*******************************.*********** ENSMUSP00000027040/1-1588 GFLANQMRAENLKDASVLPDLCLSHANQLMIMLQNHRKLLDIKQKCTTAKQELANNLHVR ENSRNOP00000060201/1-1588 GFLANQMRAENLKDASVLPDLCLSHANQLMIMLQNHRKLLDIKQKCTTAKQELANNLHVR ENSP00000025008/1-1594 GFLANQKRAENLKDASVLPDLCLSHANQLMIMLQNHRKLLDIKQKCTTAKQELANNLHVR XP_004838144.1/1-1552 GFLANQMRAENLKDASVLPDLCLSHANQLMIMLQNHRKLLDIKQKCTTAKQELANNLHVR ENSCPOP00000016880/1-1482 GFLANQMRAENLKDASVLPDLCLSHANQLMIMLQNHRKLLDIKQKCTTAKQELANNLHVR ****** ***************************************************** ENSMUSP00000027040/1-1588 LKWCCFVMLHADQDGEKLQALLRLVIELLERVRIVEALSTVPQMYCLAVVEVVRRKMFIK ENSRNOP00000060201/1-1588 LKWCCFVMLHADQDGEKLQALLRLVIELLERVRIVEALSTVPQMYCLAVVEVVRRKMFIK ENSP00000025008/1-1594 LKWCCFVMLHADQDGEKLQALLRLVIELLERVKIVEALSTVPQMYCLAVVEVVRRKMFIK XP_004838144.1/1-1552 LKWCCFVMLHADQDGEKLQALLRLVIELLERVKIVEALSTVPQMYCLAVVEVVRRKMFIK ENSCPOP00000016880/1-1482 LKWCCFVMLHADQDGEKLQALLRLVIELLERVKIVEALSTVPQMYCLAVVEVVRRKMFIK ********************************:*************************** ENSMUSP00000027040/1-1588 HYREWAGALVKDGKQLYEAEKSKRESFGKLFRKSFLRNRLFKGLDSWPSSFCTQKPRKFD ENSRNOP00000060201/1-1588 HYREWAGALVKDGKQLYEAEKSKRESFGKLFRKSFLRNRLFKGLDSWPSSFCTQKPRKFD ENSP00000025008/1-1594 HYREWAGALVKDGKRLYEAEKSKRESFGKLFRKSFLRNRLFRGLDSWPPSFCTQKPRKFD XP_004838144.1/1-1552 HYREWAGALVKDGKRLYEAEKSKRESFGKVFRKSFLRNRLFRGLDSWPPSFCTQKPRKFD ENSCPOP00000016880/1-1482 HYREWAGALVKDGKRLYEAEKSKRESFGKVFRKSFLRNRLFRGLDSWPPSFCTQKPRKFD **************:**************:***********:******.*********** ENSMUSP00000027040/1-1588 CELPDISLKDLQFLQSFCPSEVQPFLRVPLLCDFEPLHQHVLALHNLVKAAQSLDEMSQT ENSRNOP00000060201/1-1588 CELPDISLKDLQFLQSFCPSEVQPFLRVPLLCDFEPLHQHVLALHNLVKAAQSLDEMSQT ENSP00000025008/1-1594 CELPDISLKDLQFLQSFCPSEVQPFLRVPLLCDFEPLHQHVLALHNLVKAAQSLDEMSQT XP_004838144.1/1-1552 CELPDISLKDLQFLQSFCPSEVQPFLRVPLLCDFEPLHQHVLALHNLVKAAQSLDEMSQT ENSCPOP00000016880/1-1482 CELPDISLKDLQFLQSFCPSEVQPFLRVPLLCDFEPLHQHVLALHNLVKAAQSLDEMSQT ************************************************************ ENSMUSP00000027040/1-1588 ITDLLNEQKVSTSQASPQSAASPRIESTTGITTTTSPKTPPPLTVQDTLCPAVCPLEELS ENSRNOP00000060201/1-1588 ITDLLNEQKVSTSQASPQSAASPRIESTTGITTTTSPKAPPPLTVQDTLYPAACPLEELS ENSP00000025008/1-1594 ITDLLSEQKASVSQTSPQSASSPRMESTAGITTTTSPRTPPPLTVQDPLCPAVCPLEELS XP_004838144.1/1-1552 ITDLLNEQKASMSQASPQLASSPRTENAAGIITTTSPRTPPPLIVQGPLCPAVCPLEELS ENSCPOP00000016880/1-1482 ITDLLNEQKVSMSQASPQWASSPRTESTAGITTTTSPRTPPPLTVEGTLCPAVCPLEELS *****.***.* **:*** *:*** *.::** *****::**** *:..* **.******* ENSMUSP00000027040/1-1588 PDSIDAHTFDFETISHPNTEQPVHQASIDLDSLAESPESDFMSAVNEFVIEENLSSPNPI ENSRNOP00000060201/1-1588 PDSIDAHTFDFETVSHPNTEQTVHQASIDLDSLAESPESDFMSAVNEFVIEENLSSPNPI ENSP00000025008/1-1594 PDSIDAHTFDFETIPHPNIEQTIHQVSLDLDSLAESPESDFMSAVNEFVIEENLSSPNPI XP_004838144.1/1-1552 PDSIDAHTFDFETIPHP------------------------------------------- ENSCPOP00000016880/1-1482 PDSIDAHTFDFETIPHPNIEQTIHQVSLDLDSLAESPESDFMSAVNEFVIEENLSSPNPI *************:.** ENSMUSP00000027040/1-1588 SDPQSPEMMVESLYSSVINAIDSRRMQDTSTRGNEGFGDRAALHVQLEKCRAAAQDSHSS ENSRNOP00000060201/1-1588 SDPQSPEMMVESLYSSVINAIDSRRMQDTSTRGNEGFGDRAALHVQLEKCRVAAQDSHIS ENSP00000025008/1-1594 SDPQSPEMMVESLYSSVINAIDSRRMQDTNVCGKEDFGDHTSLNVQLERCRVVAQDSHFS XP_004838144.1/1-1552 ------------------------RMQDTNTCGKEDFGDHASLSVQLEKCRVVAQDSHFS ENSCPOP00000016880/1-1482 SDPQSPEMMVESLYSSVINAIDSRRLQDTNTGGKEDFGDNASLNVQLEKYRVFAQNSHCS *:***.. *:*.***.::* ****: *. **:** * ENSMUSP00000027040/1-1588 IQTIKDDLCHFRTFVQKEQCDLANYLKCTAVEIRNIIEKVKCSLEITLKEKHQQELQSLK ENSRNOP00000060201/1-1588 IQTIKDDLCHFRTFVQKEQCDLSNYLKCTAVEIRNIIDKVKCSLEITLKEKHQQELQSLK ENSP00000025008/1-1594 IQTIKEDLCHFRTFVQKEQCDFSNSLKCTAVEIRNIIEKVKCSLEITLKEKHQKELLSLK XP_004838144.1/1-1552 IQTIKEDLCHFKTFIQKEQCDFSNSLKCTAIEIRSIMEKVKCSLEITLKEKHQKELQSLK ENSCPOP00000016880/1-1482 IQTIKEDLCHFKTFVQKEQCDFSNSLKCTAVEIRNIIEKVKCSLEITLKEKHQKELHSLK *****:*****:**:******::* *****:***.*::***************:** *** ENSMUSP00000027040/1-1588 IEYECKLDALVKDSEENVNKILKLKENLVSLEEALQNKDNEFTSIKHEKDAIVCVQQEKD ENSRNOP00000060201/1-1588 IEYECKLNTLEKDSEENVNKILKLKEDLVSLEEALQNKDSEFAIIKHEKDAIVCMQHEKD ENSP00000025008/1-1594 NEYEGKLDGLIKETEENENKIKKLKGELVCLEEVLQNKDNEFALVKHEKEAVICLQNEKD XP_004838144.1/1-1552 TEYEGKINVLIKESEENENKIKKLKGDLAYLEEVLQNKDNEFALVKHEKEAVICLQNEKD ENSCPOP00000016880/1-1482 SEYEGKISALVKESEENENKIKKLKGDLVYLEEVLQNKDNEFALVKHEKEAVIC--QMKG *** *:. * *::*** *** *** :*. ***.*****.**: :****:*::* : *. ENSMUSP00000027040/1-1588 QKLLEMEKIMHTQHCEIKELKQSREMALEDLKKLH---DEKIESLRAEFQCLEQNHLKEL ENSRNOP00000060201/1-1588 QKLLEMENIMHTQNSEIKELKQSREMVLEDLKKLH---DEKIESLRAEFQCLEQNHLKEL ENSP00000025008/1-1594 QKLLEMENIMHSQNCEIKELKQSREIVLEDLKKLHVENDEKLQLLRAELQSLEQSHLKEL XP_004838144.1/1-1552 QKLLEMENIMRTQNCEINELKQSREVVLEDLKKLHVENDEKIEVLRAELQCLEQSHLKEL ENSCPOP00000016880/1-1482 SKVLEMENIVR------------------------------------------------- .*:****:*:: ENSMUSP00000027040/1-1588 EDTLHIRHTQEFEKVMTDHNMSLEKLKKENQQRIDQMLESHASTIQEKEQQLQELKLKVS ENSRNOP00000060201/1-1588 EDTLHIRHTEEFEKVITDHKVSLEKLKKENQQKIDQMLESHASAIQEKEQQLQELKVKVS ENSP00000025008/1-1594 EDTLQVRHIQEFEKVMTDHRVSLEELKKENQQIINQIQESHAEIIQEKEKQLQELKLKVS XP_004838144.1/1-1552 EDTLHVRHTQEFEKVMTDHTISLEKLKQENQQRIDQLQESQAIAIHEKEQQLQELKLKIS ENSCPOP00000016880/1-1482 ---------------------------------------------------------KIS *:* ENSMUSP00000027040/1-1588 DLSDMRCKLEVELALKEAETDEIKILLEESRTQQKEMLKSLLEQETENLRTEISKLNQKI ENSRNOP00000060201/1-1588 DLSDMRCKLEVELALKEAETDEIKILLEESRTQQKETLKSLLEQETENLRTEINKLNQKI ENSP00000025008/1-1594 DLSDTRCKLEVELALKEAETDEIKILLEESRAQQKETLKSLLEQETENLRTEISKLNQKI XP_004838144.1/1-1552 DLSDMRCKLEVEIALKEAETDEIKMLLEESRMQQKETLKSLLEKETENLRTEISQLNQKI ENSCPOP00000016880/1-1482 DLSDTRCKLEVELA-KEAETDEIKMLLEESRMQQKETLKSLLEKETENLRIEIS-LNQKI **** *******:* *********:****** **** ******:****** **. ***** ENSMUSP00000027040/1-1588 HDNNESYQVGLSELRALMTIEKDQCISELISRHEEESNILKAELDNVTSLHRQAYEIEKK ENSRNOP00000060201/1-1588 HDNSESYQVGLSELRSLMTIEKDQCISELISRHEEESNILKAELDSVTALHHQAFEIEKK ENSP00000025008/1-1594 QDNNENYQVGLAELRTLMTIEKDQCISELISRHEEESNILKAELNKVTSLHNQAFEIEKN XP_004838144.1/1-1552 HDNNENYQVGLAELRTLMTIEKDQCISELISRHEEESGILKAELDRVASLHHQAFEIEKN ENSCPOP00000016880/1-1482 QDNNENYQVGLAELRTLMTVEKDLCISELISRHEEESNILKTELDKVTSLHHQAFEIEKN :**.*.*****:***:***:*** *************.***:**: *::**.**:****: ENSMUSP00000027040/1-1588 LKEQIVELQTRLNSELSALEKQKDEKITQQEEKYEALIQNLEKDKERLVKNHEQDKEHLI ENSRNOP00000060201/1-1588 LKEQIVELQTKLNSELSALEKQKDEKITQQEEKYKALIQNLEKDKQRLAMNHEQDKEQLI ENSP00000025008/1-1594 LKEQIIELQSKLDSELSALERQKDEKITQQEEKYEAIIQNLEKDRQKLVSSQEQDREQLI XP_004838144.1/1-1552 LKEQIVELQNKLDSELCVLEKQKDEKITQQEEKYEAIIQNFEKDTEKLVMSHEQEREQLI ENSCPOP00000016880/1-1482 LKEQVVELQNKLDSELHALAKQKDEKITQQEEKYEAIIQNLEEDKEKLIMSYEQEREQLI ****::***.:*:*** .* :*************:*:***:*:* ::* . **::*:** ENSMUSP00000027040/1-1588 QELNFEKNKAVQTALDEFKVERELVEKELLEKVKHLENQIAKTPAFESAREDSSSLVAEL ENSRNOP00000060201/1-1588 QKLNFEKDEAIQTALDEFKLERELVEKELLEKVKHLENQIAKSPAFESAREDSSSLVAEL ENSP00000025008/1-1594 QKLNCEKDEAIQTALKEFKLEREVVEKELLEKVKHLENQIAKSPAIDSTRGDSSSLVAEL XP_004838144.1/1-1552 QNLNCEKDEAIQTALKEFKLEREVVEKELLEKIKHLENQIAKSPVIESTREDSSSLVAEL ENSCPOP00000016880/1-1482 QKLSCEKEEAVQTALKEFKLEREVVEKELLEKIKHLENQIAQSAVIESTREDSSSLVAEL *:*. **::*:****.***:***:********:********::..::*:* ********* ENSMUSP00000027040/1-1588 QEKLQEEKAKFLEQLEEQEKRKNEEMQNVRTSLIAEQQTNFNTVLTREKMRKENIINDLS ENSRNOP00000060201/1-1588 QEKLQEEKAKFLEQLEEQEKRKNEEMQNVRTSLIAEQQTNFNTVLTREKMRKENIINDLS ENSP00000025008/1-1594 QEKLQEEKAKFLEQLEEQEKRKNEEMQNVRTSLIAEQQTNFNTVLTREKMRKENIINDLS XP_004838144.1/1-1552 QEKLQEEKAKFLEQLEEQEKRKNEEMQNVRTSLIAEQQTNFNTVLTREKMRKENIINDLN ENSCPOP00000016880/1-1482 QEKLQEEKAKFLEQLEEQEKRKNEEMQNVRTSLIAEQQTNFNTVLTREKMKKENIINDLS **************************************************:********. ENSMUSP00000027040/1-1588 DKLKSTMQQQERDKDLIESLSEDRARLLEEKKQLEEEVSKLRTSSFLSSAPVAAAPELYG ENSRNOP00000060201/1-1588 DKLKSTMQQQERDKDLIESLSEDRARLLEEKKKLEEEVSKLRTSSVLPSAPVLAAPELYG ENSP00000025008/1-1594 DKLKSTMQQQERDKDLIESLSEDRARLLEEKKKLEEEVSKLRSSSFVPSPYVATAPELYG XP_004838144.1/1-1552 DKLKSTMQQQERDKDLIESLSEDRARLLEEKKKLEEEVSKLRSSTFVSSPYVTAAPELYG ENSCPOP00000016880/1-1482 DKLKSTMKQQERDKDLIESLSEDRARLLEEKKKLEEEVSKLRGSTLVPSPYAAAAPELYG *******:************************:********* *:.:.*. . :****** ENSMUSP00000027040/1-1588 ACAPELPGEPERSVMETADEGRLDSAMETSMMSVQEN--MLSEEKQRIMLLERTLQLKEE ENSRNOP00000060201/1-1588 ACAPELPGEPERSAMETTDEGRVDSAMETSMMSVQEN--MLSEEKQRIMLLERTLQLKEE ENSP00000025008/1-1594 ACAPELPGESDRSAVETADEGRVDSAMETSMMSVQENIHMLSEEKQRIMLLERTLQLKEE XP_004838144.1/1-1552 ACAPGSPSEADRPALETADEGKVDSAMETSMMSVQENVHMLSEEKQRIMLLERTLQLKEE ENSCPOP00000016880/1-1482 ACAPEFPGEADSAASEAADEGRMDSAMETSMVSVQENVHMLSEEKQRIMLLERTLQLKEE **** *.*.: .. *::***::********:***** ********************* ENSMUSP00000027040/1-1588 ENKRLNQRLMSQSLSSVSSRHSEKIAIRDFQVGDLVLIILDERHDNYVLFTVSPTLYFLH ENSRNOP00000060201/1-1588 ENKRLNQRLMSQSLSSVSSRHSEKIAIRDFQVGDLVLIILDERHDNYVLFTVSPTLYFLH ENSP00000025008/1-1594 ENKRLNQRLMSQSMSSVSSRHSEKIAIRDFQVGDLVLIILDERHDNYVLFTVSPTLYFLH XP_004838144.1/1-1552 ENKRLNQRLMSQSMSSVSSRHSEKIAIRDFQVGDLVLIILDERHDNYVLFTVSPTLYFLH ENSCPOP00000016880/1-1482 ENKRLNQRLMSQSMSSVSARHSEKIAIRDFQVGDLVLIILDERHDNYVLFTVSPTLYFLH *************:****:***************************************** ENSMUSP00000027040/1-1588 SESLPALDLKPGEGASGASRRPWVLGKVMEKEYCQAKKAQNRFKVPLGTKFYRVKAVSWN ENSRNOP00000060201/1-1588 SESLPALDLKPGEGASGVSRRPWVLGKVMEKEYCQAKKAQNRFKVPLGTKFYRVKAVSWN ENSP00000025008/1-1594 SESLPALDLKPGEGASGASRRPWVLGKVMEKEYCQAKKAQNRFKVPLGTKFYRVKAVSWN XP_004838144.1/1-1552 SESLPALDLKP---ASGASRRPWVLGKVMEKEYCQAKKAQNRFKVPLGTKFYRVKAVSWN ENSCPOP00000016880/1-1482 SESLPALDLKPGEGASGASRRPWVL-KSNGKEYCQAKKAQNRFKVPLGTKFYRVKAVSWN *********** ***.******* * ****************************** ENSMUSP00000027040/1-1588 KKV ENSRNOP00000060201/1-1588 KKV ENSP00000025008/1-1594 KKV XP_004838144.1/1-1552 KKV ENSCPOP00000016880/1-1482 KKV ***