CLUSTAL W(1.81) multiple sequence alignment ENSP00000327442/1-1104 MGNAAGSAEQPAGPAAPPPKQPAPPKQPMPAAGELEERFNRALNCMNLPPDKVQLLSQYD ENSMUSP00000046296/1-1094 MGNAAGSAEQPAGPTASPPKQPAVPKQPMPAAGELEERFTRVLNCMNLPPDKVQLLSQYD ENSRNOP00000062888/1-1034 MGNAAGSAEQPAGPTASPPKQPAVPKQPMPAAGELEERFTRVLNCMNLPPDKVQLLSQYD ENSCPOP00000016339/1-1071 MGNAAGSAEPPLGPAAPR------ARQPMPAAGELEERFSRALNCMNLPPDKVQLLSQYD XP_004859874.1/1-1061 ----------------------------MPAAGELEERFSRALNCMNLPPDKVQLLSQYD ***********.*.****************** ENSP00000327442/1-1104 NEKKWELICDQERFQVKNPPAAYIQKLKSYVDTGGVSRKVAADWMSNLGFKRRVQESTQV ENSMUSP00000046296/1-1094 NEKKWELICDQERFQVKNPPAAYIQKLKSYLDTGGVSRKVASDWMSNLGFKRRVQESTQV ENSRNOP00000062888/1-1034 NEKKWELICDQERFQVKNPPAAYIQKLKSYLDTGGVSRKVATDWMSNLGFKRRVQESTQV ENSCPOP00000016339/1-1071 DEKKWELICDQERFQVKNPPEAYIQKLKSYLDVGGVSRKVAADWMSNLGFKRRGQESTQV XP_004859874.1/1-1061 DEKKWELICDQERFQVKNPPEAYIQKLKSYLDVGGVGRK----------FKRRSQESTQV :******************* *********:*.***.** **** ****** ENSP00000327442/1-1104 LRELETSLRTNHIGWVQEFLNEENRGLDVLLEYLAFAQCSVTYDMESTDNGASNSEKNKP ENSMUSP00000046296/1-1094 LRELETSLRTNHIGWVQEFLNEENRGLDVLLEYLAFAQCSVAYDMESTDSVASGAEKSKP ENSRNOP00000062888/1-1034 LRELETSLRTNHIGWVQEFLNEENRGLDVLLEYLAFAQCSVAYDMESTENVASGTEKNKP ENSCPOP00000016339/1-1071 LRELETSLRTNHIGWVQEFLNEENRGLDVLLEYLAFAQCSVTYDIESADSGEKNPEKGKP XP_004859874.1/1-1061 LRELETSLRTNHIGWVQEFLNKENRGLDVLLEYLAFAQCSVTYDVESTDSGEK-SEKSKP *********************:*******************:**:**::. . .**.** ENSP00000327442/1-1104 LEQSVEDLSKGPPSSVPKSRHLTIKLTPAHSRKALRNSRIVSQKDDVHVCIMCLRAIMNY ENSMUSP00000046296/1-1094 LDQSVEDLSKAPPSSVPKSR-LTIKLTPAHSRKALRNSRIVSQKDDVHVCIMCLRAIMNY ENSRNOP00000062888/1-1034 LEQSVEDLSKAPPSSVPKSR-LTIKLTPAHSRKALRNSRIVSQKDDVHVCIMCLRAIMNY ENSCPOP00000016339/1-1071 LEQSVEDLSKGPPSSLPRSRHLTVKLTPAHSRKALRSSRIVSQKDDVHVCIMCLRAIMNY XP_004859874.1/1-1061 LEQSVEDLSKGPPPSVARSRHLTVRLTPVHSRKTLRGSRLVSQKDDVHVCIMCLRAIMNY *:********.**.*:.:** **::***.****:**.**:******************** ENSP00000327442/1-1104 QSGFSLVMNHPACVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHDIILAAFDNFKEVC ENSMUSP00000046296/1-1094 QSGFSLVMNHPACVNEIALSLNNKSPRTKALVLELLAAVCLVRGGHDIILAAFDNFKEVC ENSRNOP00000062888/1-1034 Q---------------------------------------------------------VC ENSCPOP00000016339/1-1071 QSGFSLVMNHPACVNEITLSLNNKNPRTKALVLELLAAVCLVRGGHDIILAAFDNFKEVC XP_004859874.1/1-1061 QSGFSLVMNHPACVNEIALSLNNNSPRTKALVLELLAAVCLVRGGHDIILSAFDNFKEVC * ** ENSP00000327442/1-1104 GEQHRFEKLMEYFRNEDSNIDFMVACMQFINIVVHSVENMNFRVFLQYEFTHLGLDLYLE ENSMUSP00000046296/1-1094 GEQHRFEKLMEYFRHEDSNIDFMVACMQFINIVVHSVENMNFRVFLQYEFTHLGLDLYLE ENSRNOP00000062888/1-1034 GEQHRFEKLMEYFRNEDSNIDFMVACMQFINIVVHSVENMNFRVFLQYEFTHLGLDLYLE ENSCPOP00000016339/1-1071 GERHRFEKLMEYFRNEDSNIDFMVACVQFINIVVHSVENMNFRVFLQYEFTNLGLDLCLE XP_004859874.1/1-1061 GEQHRFERLMEYFHKEDSNIDFMVACMQFINIVVHSVENMNFRVFLQYEFTNLGLDLDLE **:****:*****::***********:************************:***** ** ENSP00000327442/1-1104 --RLRLTESDKLQVQIQAYLDNIFDVGALLEDTETKNAVLEHMEELQEQVALLTERLRDA ENSMUSP00000046296/1-1094 --RLRLTESDKLQVQIQAYLDNVFDVGTLLEETETKNAVLEHMEELQEQVATLTERLRDT ENSRNOP00000062888/1-1034 --RLRLTESDKLQVQIQAYLDNVFDVGTLLEETETKNAVLEHMEELQEQVATLTERLRDT ENSCPOP00000016339/1-1071 GQRLRLTESDKLRVQIQAYLDNVFDVSTLLEDTETKNAVLEHMEELQEQTTLLTERLRDA XP_004859874.1/1-1061 --RLRLTESDKLRVQIQAYLDNVFDVSALLEDTETKNALLEHMEELQEQTTQLTERLRDA **********:*********:***.:***:******:**********.: *******: ENSP00000327442/1-1104 ENESMAKIAELEKQLSQARKELETLRERFSESTAMGPSRRPPEPEKAPPAAPTRPSALEL ENSMUSP00000046296/1-1094 ENDSMAKIAELEKQLSQARKELETLRERFSESTPMGTSRRIPEPEKVPVPTVVRPSALEL ENSRNOP00000062888/1-1034 ENDSMAKIAELEKQLSQARKELETLRERFSESTPMVTSRRIPEPEKVPAPTVVRPSALEL ENSCPOP00000016339/1-1071 ENESMAKIAELEKQLSQARKELETLRERVGEANP---SSGEVWTLADAPPAPARPSALEL XP_004859874.1/1-1061 ENESMAKIAELEKQLSQARKELETRRERVGEALP---AHA--------------PSALEL **:********************* ***..*: . : ****** ENSP00000327442/1-1104 KVEELEEKGLIRI-----------------LRG------------PGDAVSIEILPVAVA ENSMUSP00000046296/1-1094 KVEELEEKGLIRI-----------------LRG------------PGDVVSIEILPGAAA ENSRNOP00000062888/1-1034 KVEELEEKGLIRI-----------------LRG------------PGDVVSIEILPGAAA ENSCPOP00000016339/1-1071 KLGELEAQGLLRV-----------------LRG------------PGDAIAIDILPVASA XP_004859874.1/1-1061 KLGELEAQGLLQVAATLGAPAGPPRPGAQALPGLGVWETLDGTDGPGGVSG-----GSGV *: *** :**::: * * **.. . : . ENSP00000327442/1-1104 TPSGGDAPTPGVPTGSPSP--DLAPAAEPAPGAAPPPPPPLPGLPSPQEAPPSAPPQAPP ENSMUSP00000046296/1-1094 TPSGDDAQAPRVSTDSPSTAESIPEAASP-PPPPPPPPPPLPNLQSQQEAPPSAPPLAPP ENSRNOP00000062888/1-1034 TPSGDDAPAPRVSTDSPSTAESVPEAASPTPPPPPPPPPPLPNLQSQQEALPSAPPLAPP ENSCPOP00000016339/1-1071 APG--------------------RDAATPGAPVGLPCPGMRDLEIEGAE-PQKRPGKALG XP_004859874.1/1-1061 APAAAQVQEVDARRPAESSPGAARTPPLPLPPPGPPPPPEAPPLPGGPE-PPPAPPLPPP :*. .. * . * * * * . ENSP00000327442/1-1104 LPGSPEPPPAPPLPGDLPPPPPPPPPPPGTDGPVPPPPPPPPPPPGGPPDALGRRDSELG ENSMUSP00000046296/1-1094 LPGCAEPPPAPPLPGDL--PPPPPPPPLGTDGPVPPPPPPP---PGGPPDILGGQGPDIG ENSRNOP00000062888/1-1034 LPGCAAPPPAPPLPGDL--PPPPPPPPLGTDGPVPPPPPPP---PGGPPDILGGQDPEIG ENSCPOP00000016339/1-1071 ASGGLGPR--RALSREV--PGPVSEPRGGSGAKVREMTSWP---PQGSPDAPGGPGTETG XP_004859874.1/1-1061 VTEGLVPP--PP-------PPPPPPPPPPVTEGLVPPPPPP---PGSLPDAPGGPGAETG . * . * * . * : .. * * . ** * ..: * ENSP00000327442/1-1104 PGVKAKKPIQTKFRMPLLNWVALKPSQITGTVFTELNDEKVLQELDMSDFEEQFKTKSQG ENSMUSP00000046296/1-1094 PGVKAKKPIQTKFRMPLLNWVALKPSQITGTVFTELNDEKVLQELDMNDFEEHFKTKSQG ENSRNOP00000062888/1-1034 PGVKAKKPIQTKFRMPLLNWVALKPSQITGTVFTELNDEKVLQELDMNDFEEQFKTKSQG ENSCPOP00000016339/1-1071 PGLKTKKPIQTKFRMPLLNWVALKPSQITGTVFNELNDEKVLQELDMSDFEEQFKTKSQG XP_004859874.1/1-1061 LGVKARKPVQTKFRMPLLNWVALNPSQISGTVFTELDDEKVLQELDMSDFEEQFKTKSQG *:*::**:**************:****:****.**:**********.****:******* ENSP00000327442/1-1104 PSLDLSALKSKAAQKAPSKATLIEANRAKNLAITLRKGNLGAERICQAIEAYDLQALGLD ENSMUSP00000046296/1-1094 PCLDISALKGKASQKAPTKTILIEANRAKNLAITLRKGNLGADRICQAIETYDLQTLSLD ENSRNOP00000062888/1-1034 PSLDISALKGKTAHKAPTKATLIEANRAKNLAITLRKGNLGADRICEAIETYDLQTLSLD ENSCPOP00000016339/1-1071 PSLDLSALKGRTAQKGPSQATLIEANRAKNLAITLRKGNMSADRICQAIETYDLQALGLD XP_004859874.1/1-1061 PSLDLSALKGRATQKGPSQATLIEANRAKNLAITLRKGNLGADRICQAIETYDLQALGLD *.**:****.::::*.*::: ******************:.*:***:***:****:*.** ENSP00000327442/1-1104 FLELLMRFLPTEYERSLITRFEREQRPMEELSEEDRFMLCFSRIPRLPERMTTLTFLGNF ENSMUSP00000046296/1-1094 FLELLTRFLPTDYERSLIARFEKEQRPMEELSEEDRFMLRFSRIQRLPERMNTLTFLGNF ENSRNOP00000062888/1-1034 FLELLTRFLPTDYERSLIARFEKEQRPMEELSEEDRFMLRFSRIQRLPERMNTLTFLGNF ENSCPOP00000016339/1-1071 FLELLTRFLPTEYERSLIARFEQERQPLEQLSEEDQFMLRFSRIPRLPERMATLTFLGSF XP_004859874.1/1-1061 FLELLTRFLPTEYERSLIARFERERRPLEELSEEDCFMLRFSRIPRLPERMATLSFLGSF ***** *****:******:***:*::*:*:***** *** **** ****** **:***.* ENSP00000327442/1-1104 PDTAQLLMPQLNAIIAASMSIKSSDKLRQILEIVLAFGNYMNSSKRGAAYGFRLQSLDAL ENSMUSP00000046296/1-1094 PDTAQLLMPQLNAIIAASMSIKSSDKLRQILEIVLAFGNYMNSSKRGAAYGFRLQSLDAL ENSRNOP00000062888/1-1034 PDTAQLLMPQLNAIIAASISIKSSDKLRQILEIVLAFGNYMNSSKRGAAYGFRLQSLDAL ENSCPOP00000016339/1-1071 PDTAQLLMPQLNAIIAASMSIKSSDKLRQILEIVLAFGNYMNSSKRGAAYGFRLQSLDVL XP_004859874.1/1-1061 LDTAQLLMPQLNAVIAASMSIKSSDKLRQILEIVLAFGNYMNSSKRGAAYGFRLQSLDTL ************:****:***************************************.* ENSP00000327442/1-1104 LEMKSTDRKQTLLHYLVKVIAEKYPQLTGFHSDLHFLDKAGSVSLDSVLADVRSLQRGLE ENSMUSP00000046296/1-1094 LEMKSTDRKQTLLHYLVKVIAEKYPQLTGFHSDLHFLDKAGSVSLDSVLGDVRSLQRGLE ENSRNOP00000062888/1-1034 LEMKSTDRKQTLLHYLVKVIAEKYPQLTGFHSDLHFLDKAGSVSLDSVLGDVRSLQRGLE ENSCPOP00000016339/1-1071 LEMKSTDRKQTLLHYLVKVIAEKYPQLSGFHSDLHFLDKAGSVSLDSVLADVRSLQRGLE XP_004859874.1/1-1061 LEMKSTDRKQTLLHYLVKVIGEKYPQLSCFHSDLHFLDKAGTVSLDSVLADVRSLQRGLE ********************.******: ************:*******.********** ENSP00000327442/1-1104 LTQREFVRQDDCMVLKEFLRANSPTMDKLLADSKTAQEAFESVVEYFGENPKTTSPGLFF ENSMUSP00000046296/1-1094 LTQREFVRQDDCLVLKEFLRANSPTMDKLLADSKTAQEAYESVVEYFGENPKTTSPSMFF ENSRNOP00000062888/1-1034 LTQREFVRQDDCLVLKEFLRANSPTMDKLLADSKTAQEAYESVVEYFGENPKTTSPSMFF ENSCPOP00000016339/1-1071 LVQREFVRQDDCVVLKEFLRTNSPTMDKLLADSKTAQEAYDSVVEYFGENPKTMSPSVFF XP_004859874.1/1-1061 VAQREFVRQDDCTVLKEFLRANSPTMDKLLADSRTAQEAYDSVVEYFGENPKTTPPAVFF :.********** *******:************:*****::************ .*.:** ENSP00000327442/1-1104 SLFSRFIKAYKKAEQEVEQWKKEAAAQEAGADTPGKGEPPAPKSPPKARRPQMDLISELK ENSMUSP00000046296/1-1094 SLFSRFTKAYKKAEQEVEQWKKEAAA-----DTSGREEPPTPKSPPKARRQQMDLISELK ENSRNOP00000062888/1-1034 SLFSRFTKAYKKAEQEVEQWKKEAAA-----DTSGREEPPAPKSPPKARRQQMDLISELK ENSCPOP00000016339/1-1071 SLFSRFVKAYKGAEQEVEQWKKAAAAQEAGMDPSGQGEPSVPKSSPRARRQQMDLISELK XP_004859874.1/1-1061 CLFSRFTKAYKKAEQEVEQWKKAAAAQEAGLDTPGRGEAPVPKSPPRARRQQMDLISELK .***** **** ********** *** *..*: *...***.*:*** ********* ENSP00000327442/1-1104 RRQQKEPLIYESDRDGAIEDIITDLRNQPYIRADTGRRSARRRPPGPPLQVTSDLSL ENSMUSP00000046296/1-1094 RKQQKEPLIYESDRDGAIEDIITDLRNQPYIRADTGRRSARRRPPGPPLPVTTDLAL ENSRNOP00000062888/1-1034 RKQLKEPLIYESDRDGAIEDIITVLKTVPFT-ARTGKRTSR---LLCEASLGEEMTL ENSCPOP00000016339/1-1071 RKQQKEPLIYESDRDGAIEDIITDLRNQPYIRADMGRRSARRRPLGPSLQVTTDMAL XP_004859874.1/1-1061 RKQQKEPLVYESDRDGAIEDIITDLRNQPYIRADTGRRSARRRPPVPPLQVTADLAL *:* ****:************** *:. *: * *:*::* : :::*