CLUSTAL W(1.81) multiple sequence alignment ENSP00000295641/1-1099 RFGSAPQRPVAMTTAQRDSLLWKLAGLLRESGDVVLSGCSTLSLLTPTLQQLNHVFELHL ENSMUSP00000027414/1-1072 -----------MTTAPRDSVVWKLAGLLRESGDAVLSGCSTLSLLTATLQQLNRVFELYL ENSRNOP00000027256/1-1072 -----------MTTAPRDSVVWKLAGLLRESGDAVLSGCSTLSLLTATLQQLNRVFELYL ENSCPOP00000016243/1-1092 FLRLRPQRPVAMTTAPRDSVVWKLAGLLRESGDVVLSGCSTLSLLTATLQQLNRVFELYL XP_004864548.1/1-1075 -----------MTTAPRDSLVWKLAGLLRESGDVVLSGCSTLSLLTATLQQLNRVFELYL **** ***::************.************.******:****:* ENSP00000295641/1-1099 GPWGPGQTGFVALPSHPADSPVILQLQFLFDVLQKTLSLKLVHVAGPGPTGPIKIFPFKS ENSMUSP00000027414/1-1072 GPWGPGQTGFVALPSHPADSPVILQLQFLFDVLQKTLSLKLVHIPGVGLPGPIKIFPFKS ENSRNOP00000027256/1-1072 GPWGPGQTGFVALPSHPADSPVILQLQFLFDVLQKTLSLKLVHTPGVGLPGPIKIFPFKS ENSCPOP00000016243/1-1092 GPWGPGQTGFVALPSHPADSPTILQLQFLFDVLQKTLSLKLVHIPGPGLPGPIKIFPFKS XP_004864548.1/1-1075 GPWSPNQTGFVALPSHPADSPIILQLQFLFDVLQKTLSLKLVHIPGPGLPGPIKIFPFKS ***.*.*************** ********************* .* * .********** ENSP00000295641/1-1099 LRHLELRGVPLHCLHGLRGIYSQLETLICSRSLQALEELLSACGGDFCSALPWLALLSAN ENSMUSP00000027414/1-1072 LRQLELRGVPIHSLCGLRGIYSQLESLVCNRSIQALEELLSACGGDLCSALPWLALLSAD ENSRNOP00000027256/1-1072 LRQLELRGVPIHSLCGLRGIYSQLETLVCNRSIQALEELLSACGGDLCSALPWLALLSAD ENSCPOP00000016243/1-1092 LRQLELRGIPLHCLRGLQGIYSQLETLICNRSIQALEELLSACGGDLCSALPWLALLSAD XP_004864548.1/1-1075 LRQLELRGVPLHCLRGLQGIYSQLETLICSRSLQALEELLSACGGDLCSALPWLALLSAD **:*****:*:*.* **:*******:*:*.**:*************:************: ENSP00000295641/1-1099 FSYNALTALDSSLRLLSALRFLNLSHNQVQDCQGFLMDLCELHHLDISYNRLHLVPRMGP ENSMUSP00000027414/1-1072 FSYNALRSLDSSLRLLSALRFLNLSHNHLQDCKGFLMDLCELYHLDISYNHLRLVPRVGP ENSRNOP00000027256/1-1072 FSYNALSNLDSSLRLLSALRFLNLSHNHIQDCKGFLMDLSELYHLDISYNHLRLVPRMGP ENSCPOP00000016243/1-1092 FSYNALTALDSSLGLLSVLRFLNLSHNRLQDCKGFLMDLSELCHLDVSYNHLHLVPRMGP XP_004864548.1/1-1075 FSYNALTALDSSLRLLSALRFLNLSHNRVQDCKCFLMDLSELCHLDISYNYLHLVPRMGP ****** ***** ***.*********::***: *****.** ***:*** *:****:** ENSP00000295641/1-1099 SGAALGVLILRGNELRSLHGLEQLRNLRHLDLAYNLLEGHRELSPLWLLAELRKLYLEGN ENSMUSP00000027414/1-1072 SGAALGTLILRANELRSLQGLEQLKNLRHLDVAYNLLEGHTELAPLWLLAELRKLYLEGN ENSRNOP00000027256/1-1072 SGAALGTLILRANELRSLQGLEQLKNLRHLDVAYNLLEGHTELAPLWLLAELRKLYLEGN ENSCPOP00000016243/1-1092 SGAALRTLVLRSNELRSLQGLEQLRNLYHLDVAYNLLEGHRELLPLCLLAELRQLCLEGN XP_004864548.1/1-1075 SGAALRTLILRGNELQSLQGLEQLRNLQHLDVAYNLLEGHRELWPLCLLAELRKLYLEGN ***** .*:**.***:**:*****:** ***:******** ** ** ******:* **** ENSP00000295641/1-1099 PLWFHPEHRAATAQYLSPRARDAATGFLLDGKVLSLTDF-QTHTSLGLSPMGPPLPWPVG ENSMUSP00000027414/1-1072 PLWFHPAHRAATAQYLSPRARDAAHGFLLDGKVLSLKDLQQTSDSSGLGPVIQPLSWPVG ENSRNOP00000027256/1-1072 PLWFHPAHRATTAQYLSPRARDAAHGFLLDGKVLSLKDLQQTSESSRLGPMTQPLSWPVG ENSCPOP00000016243/1-1092 PLFFHPSHRVATTQYLSPRAKDAAHSFLLDGKFLSPKDF-QTSTSLGPGPLAPPQPWSLG XP_004864548.1/1-1075 PLWFHPAHRVATIQYLSPRARDAAHSFLLDGEVLSLKDF-QTSTSSGLGPLAPPQPWTLG **:*** **.:* *******:*** .*****:.** .*: ** * .*: * .*.:* ENSP00000295641/1-1099 STPETSGGPDLSDSLSSGGVVTQPLLHKVKSRVRVRRASISEPSDTDPEPRTLNPSPAGW ENSMUSP00000027414/1-1072 STTETSGGPELSDSLSSGGIVAQAPLRKVKSRVRVRRASISEPSDTDPELRTLDPSPAGW ENSRNOP00000027256/1-1072 STTETSGGPELSDSLSSGGIVAQAPLRKVKSRVRVRRASISEPSDTDPELRTLDPSPAGW ENSCPOP00000016243/1-1092 STTETSGGPELSDSLSSGGVSAQASLRRVKSKIRVRRASISEPSDTDLEPRTLDPSPAGM XP_004864548.1/1-1075 STTETSGGPELSDSLSSGGVAAQAPLCKVKSRVRVRRASISEPSDTDLEPRTLDPSPAGL **.******:*********: :*. * :***::************** * ***:***** ENSP00000295641/1-1099 FVQQHPELELMSSFRERFGRNWLQYRSHLEPSGNPLPATPTTSAPSAPPASSQGPDTAPR ENSMUSP00000027414/1-1072 FVQQHRELELLASFRERFGCDWLQYRSHLETMGSSPLSTTKTPALSTPPLDVQNLETVCS ENSRNOP00000027256/1-1072 FVQQHRELELLASFRERFGCDWLQYRSHLETMGSPPLATIKTPALGTPPLDAQSLETARS ENSCPOP00000016243/1-1092 FVQQHRELELLNSFRERFGCDWLQYRSHLEVSGSPLQTTSKTAALSTSSPSALGPETPPS XP_004864548.1/1-1075 FVQQHRELELLNSFRERFGCDWLQYRNHLEASGSPLLTTSKTPALSTSPPDALGTDT-PS ***** ****: ******* :*****.*** *.. :* .*.* .:.. . . :* ENSP00000295641/1-1099 PSPPQEEARGPQESPQKMSEEVRAEPQEEEEEKEGKEEKEEGEMVEQGEEEAGEEEEEEQ ENSMUSP00000027414/1-1072 PPAIEDDT---KESPEKVSEEGRVEPEPQEEER---EEQDK----EEGSRE-DLEEEEEQ ENSRNOP00000027256/1-1072 PPAIGEDT---KESPEKVSEEGREELEPHEEER---EEQER----EEGSRE-DLGEEEEQ ENSCPOP00000016243/1-1092 PQASEKEAGGPKESEQKVAKQSRMEPEPQPLGKLGLRGVEMFGRFLQGQVH---QGGQGS XP_004864548.1/1-1075 PLVSEKEPRGPEESEPKVAEKSMMEPEPQEEEK---EEQEK----EEGAKE-GQEEEEGQ * .:. :** *:::: * : . : . : :* . : . ENSP00000295641/1-1099 DQKEVEAELCRPLLVCPLEGPEGVRGRECFLRVTSAHLFEVELQAARTLERLELQSLEAA ENSMUSP00000027414/1-1072 EQKAVEAELCRPMLVCPLQGLGGVQGKECFLRVTSAHLFEVELQAARTLERLELQSLVAA ENSRNOP00000027256/1-1072 EQKAVEAELCRPMLVCPLQGTEGVQGRECFLRVTSAHLFEVGLQAAQTLERLELQSLVSA ENSCPOP00000016243/1-1092 SLGVSTAELCRPMLVCPLQRPEGVRGMECFLQVTSAHVVEVELQAGRTLGRLELQSLVTA XP_004864548.1/1-1075 ERKEVEAELCRPMLVCPLQQPEGVRGTECFLRVTSAHVVEVELQAARTLGRLELQSLMTA . ******:*****: **:* ****:*****:.** ***.:** ******* :* ENSP00000295641/1-1099 EIEPEAQAQRSPRPTGSDLLPGAPILSLRFSYICPDRQLRRYLVLEPDAHAAVQELLAVL ENSMUSP00000027414/1-1072 ELESETETQGEPVSEGSGPFPGAPVLVLRFSYICPDRQLRRYAVLEPEAREAVQELLAVL ENSRNOP00000027256/1-1072 ELQSETESQREPGSEGSGPPSGAPVLVLRFSYICPDRQLRCYAVLEPEAHEAIQELLAVL ENSCPOP00000016243/1-1092 ELEPESPTQREPVAEGSDGLPGAPVLVLRFAYICPDRQLRRYVVLEPDAHTAAQELLTVL XP_004864548.1/1-1075 ELEPESPTPGEPLSAGSDSLPRAPVLVLRFAYICPDRQLRRYVVLEPDAHVAAQELLDVL *::.*: : .* . **. . **:* ***:********* * ****:*: * **** ** ENSP00000295641/1-1099 TPVTNVAREQLGEARDLLLGRFQCLRCGHEFKPEEPRMGLDSEEGWRPLFQKTESPAVCP ENSMUSP00000027414/1-1072 TPFTSVKEQQPGANKDPQGARFQCLRCSCEFKPEESRLGLESDEGWKPLFQNTESPVVCP ENSRNOP00000027256/1-1072 TPFTSVKDQQPGEAKDPQGPRFQCLRCSCEFKPQEPRLGLESDDGWKPLFQNTESPVVCP ENSCPOP00000016243/1-1092 SPFTTEARQQLGKASRALGGSFQCLRCGCEFRPGEPRMGLGSEEGWRPLFQETESPAVCP XP_004864548.1/1-1075 NPFTTVAQQQHGKARSPLGGRFQCLRCGCEFRPEEPGLGMDSEKGWRPLFQKTESPAVCP .*.*. :* * ******. **:* *. :*: *:.**:****:****.*** ENSP00000295641/1-1099 NCGSDHVVLLAVSRGTPNRERKQGEQSLAPSPSASPVCHPPGHGDHLDRAKNSPPQAPST ENSMUSP00000027414/1-1072 NCGSDHVVLLAVSGEVPNREQNQEEQSADSA------CDLADHGGCPSRPDGIPPQTSIS ENSRNOP00000027256/1-1072 NCGSDHVVLLAVSGEVPNRERNQEEQSSDSA------CDLADHSGCPSVPDGIPPQASIS ENSCPOP00000016243/1-1092 SCASDHVVLLAVSGETPHREQTQAEQSRAPSQSSSPVCDSPGHRDHLGRTDSIL----VP XP_004864548.1/1-1075 SCGSDHVVLLALSGETPYREQNQAEQSPAPSQAPSPGCDSPGHSDHPSRADNIL----VS .*.********:* .* **:.* *** .: *. ..* . . ... . ENSP00000295641/1-1099 RDHGSWSLSPPPERCGLRSVDHRLRLFLDVEVFSDAQEEFQCCLKVPVALAGHTGEFMCL ENSMUSP00000027414/1-1072 HDRSSWSLSPSPGCSGFRSVDHRLRLFLDVEVFSDSEEEFQCCIKVPVVLAGHTEEFPCL ENSRNOP00000027256/1-1072 HGCSSWNLSPTLGHTGFRSVDHRLRLFLDVEVFSDSEEEFQCCTKVPVVLAGHTRESLCL ENSCPOP00000016243/1-1092 HGHSGWSLSPPGECCGFRSVDHRLRLFLDVEVFSDAQEEFQCCIKVPVVLSGHVGEFLCL XP_004864548.1/1-1075 HGRSNWSLSPSGERCGFRSVDHRLRLFLDVEVFGDAQEEFQCCIKVPVVLSGHQEEFLCL :. ..*.***. *:****************.*::****** ****.*:** * ** ENSP00000295641/1-1099 VVVSDRRLYLLKVTGEMREPPASWLQLTLAVPLQDLSGIELGLAGQSLRLEWAAGAGRCV ENSMUSP00000027414/1-1072 VVVSNHMLYLLKVLGAICGPPASWLQPTLAIALQDLSGMELGLAGQSLRLEWAAGTGSCV ENSRNOP00000027256/1-1072 VVVSDRMLYLLKVTGPICGPPASWLEPTLAIPLQDLSGMELGLAGQSLRLEWAAGTGHCV ENSCPOP00000016243/1-1092 VVMSDHRLYLLKVTGDIRGPPASWLQPTLAVPLQDLSGVQQGLAGQSLRLEWAAGVGSCV XP_004864548.1/1-1075 VVVSDHRLYLLKVTGDICGPPASWLQPTLAVPLQDLSGMELGLAGQSLRLEWVAGVGSCV **:*:: ****** * : ******: ***:.******:: ***********.**.* ** ENSP00000295641/1-1099 LLPRDARHCRAFLEELLDVLQSLPPAWRNCVSATEEEVTPQHRLWPLLEKDSSLEARQFF ENSMUSP00000027414/1-1072 LLPRDARQCRAFLEELTGVLQSLPRTQRNCISATEEEVTPQHRLWPLLGKDPSAEVPQFF ENSRNOP00000027256/1-1072 LLPRDARQCRAFLEELTGVLQSLPRTQRNCISATEETVTPQHRLWPLLGKDTSAETPQFF ENSCPOP00000016243/1-1092 LLPRDARRCRLFLEELIGVLQSLPPTRKNCVSVTEEEVTPQHRLWPLLGQDASPETPQFF XP_004864548.1/1-1075 LLPRDARRCQLFLEELIGVLQSLPPTRRNCVSATEEEVTPQHRLWPLLGQDTSLEPPQFF *******:*: ***** .****** : :**:*.*** *********** :*.* * *** ENSP00000295641/1-1099 YLRAFLVEGPSTCLVSLLLTPSTLFLLDEDAAGSPAEPSPPAASGEASEKVPPSGPGPAV ENSMUSP00000027414/1-1072 YLRAFLAEGSSTCPVSLLLTLSTLYLLDEDPGGSHAESPLPVVSDETSEQPASLGPGPSL ENSRNOP00000027256/1-1072 YLRAFLAEGSSTCPVSLLLTLSTLYLLDEDPVRSHAESPLPVGSGEASEQPAPQGPGPSL ENSCPOP00000016243/1-1092 YLQAFLVEGPSACPVSLLLTLATLYLLDEDLVGSQPEPSLPAASGEVSEKAPSLGLGPSV XP_004864548.1/1-1075 YLRVFLVDGPSTCPVSLLLTLATLYLLDEDPSGSQAELPLPAASGEASEKAPSLRLGSSV **:.**.:*.*:* ****** :**:***** * .* . *. *.*.**: .. *.:: ENSP00000295641/1-1099 RVREQQPLSSLSSVLLYRSAPEDLRLLFYDEVSRLESFWALRVVCQEQLTALLAWIREPW ENSMUSP00000027414/1-1072 QVREQQPLSCLSSVQLYRTSPLDLRLIFYDEVSRLESFWALHVVCGEQLTALLAWIREPW ENSRNOP00000027256/1-1072 QVREQQPLSSLSSVQLYRTSPLDLRLIFYDEVSRLESFWALRVVCGEQLTDLLAWIREPW ENSCPOP00000016243/1-1092 RIREQQPLSSLSSVLLYRTAPEDLQLAFYDEVSRLKSFWALRVVCQEQLTALLAWIREPW XP_004864548.1/1-1075 QVREQQPLSSLSSVLLYRTAPEDLRLVFYDEVSRLESFWALRVVCQEQLTALLAWIREPW ::*******.**** ***::* **:* ********:*****:*** **** ********* ENSP00000295641/1-1099 EELFSIGLRTVIQEALALDR ENSMUSP00000027414/1-1072 EELFSIGLRTVTQEALDLDR ENSRNOP00000027256/1-1072 EELFSIGLRTVTQEALDLDR ENSCPOP00000016243/1-1092 EELFSIGLRTVTQEALDLDR XP_004864548.1/1-1075 EELFSIGLRTVTQETLDLDR *********** **:* ***