CLUSTAL W(1.81) multiple sequence alignment ENSP00000406571/1-872 --------------MAPASASGEDLRKLPTMAEVNGEQ-----DFIDLTRETRPRTKDRS ENSMUSP00000113676/1-1354 MEDFIVISDDSGSESSAGTRSGRARRLRRALSRTPGALPRRTVDFIDLTRENRARTKDRN ENSRNOP00000060156/1-1223 -------------------------------------------DFIDLTRETRTRAKDRN ENSCPOP00000016001/1-680 -----------------------------------------------LTRETRPRAK-IA XP_004836405.1/1-861 MEDFIVISDDSGSESSGGTRSGRVRRLRRALSRTPSALPRRTVDFIDLTTETRPRAKDRN ** *.*.*:* ENSP00000406571/1-872 GLYVIDLTRAEGENRPIATLDLTLEPVTPSQKEPTSLQTCASLSGKAVMEGHVDRSSQPT ENSMUSP00000113676/1-1354 GLCVIDLTRNEEENRPIATLDLTLEPVASSQKEPTSLQTCTSLSGKEVMEAHEDRGSQPA ENSRNOP00000060156/1-1223 GLCVIDLTRSEEENRPIATLDLTLEPVASSQKEPPSLQTCTNLSGKEMIEAQGDRGTQPA ENSCPOP00000016001/1-680 WLCVIDLTRSEEENRPIDTLDLTLESVVPSQKEPASLQTCASLSSKEVTEARGNRSSWPV XP_004836405.1/1-861 GLCVIDLTGSEDENRPIDTLDLTLESVIPSQKEPGSLQTCAILSSKEVME-RGNRSSRPV * ***** * ***** *******.* .***** *****: **.* : * : :*.: *. ENSP00000406571/1-872 ARRIINSDPVDLDLVEENTFVGPPPATSISGGSVYPTEPNCSSATFTGNLSFLASLQLSS ENSMUSP00000113676/1-1354 AQRIINNDPVDLDLLEENLFEGSRPPTSISQDSVYPPEPNCSSITYKGDLSFLTSLQLSS ENSRNOP00000060156/1-1223 AQRVINNDPVDLDLLEENMFEGSRPPTSISQDSVYPPEPNCSSITYKGDLSFLTSLQLSS ENSCPOP00000016001/1-680 TQRIINSVPVDLELLEETSFENLQPLASISQDSVYPEEPNCSSATFLNDLSFLPSTQLSS XP_004836405.1/1-861 PQRIINSNPVDLDLLEETTFEGPQPPTSISQDSVYPEEPNCSSATFKGDLSFLPSTQLSS .:*:**. ****:*:**. * . * :*** .**** ****** *: .:****.* **** ENSP00000406571/1-872 DVSSLSPTSNNSRSSSSSSNQKAPLPCPQQDVSRPPQALPCPLRPLPCPPRASPCPPRAS ENSMUSP00000113676/1-1354 DVSSFSST----------SNQRASLPCPQQDVPCQSQGLLCPLQALSCPQTASPCPPRAS ENSRNOP00000060156/1-1223 DVSPFSSTSNN---SSSSSNQRTSLPCPQQDVPCQSQGLLCSLQALSYPLRGSPCPPRAS ENSCPOP00000016001/1-680 DVSFFLPTSNN-----SNSNQRAPLSCPRQGEPCPPQTLPCSLRGFPSPRRASPCPPRAA XP_004836405.1/1-861 DISSLSPSSNN----GSSSNPRAPLP--------------CSLRALPSPLRASPCPPRAS *:* : .: ** ::.*. *.*: :. * .*******: ENSP00000406571/1-872 SCPPRALSC----------PSQTMQCQLPALTHPPQEVPCPRQNIP-------------- ENSMUSP00000113676/1-1354 SCPPQALSCPPQA---LSCPSQTLQCQLQALPQPPQEVPCSTQNVPCPQQNMPSTPQGLS ENSRNOP00000060156/1-1223 SCPPQALSCPPQALSSLSCPSQTVQCQLQALPQPPQEVPCSTQNVPCPQQNIPSTPQDLP ENSCPOP00000016001/1-680 SCPPRALSC----------PSQTTQCQLPALPRPSQEVPCPPQDVP-------------- XP_004836405.1/1-861 SCPPRALSC----------PSQTTQCQLQALPHPPQEMSCPSQDVPC-TQNMPVLSQDSS ****:**** **** **** **.:*.**:.*. *::* ENSP00000406571/1-872 -------GPPQDSLGLPQDVPGLPQSILHPQDVAYLQDMPRS------------------ ENSMUSP00000113676/1-1354 WHPRHTLYPYQDTLGLPQDVPGRPQNMSYPQDVTQLQDMPWSLHDMPLSLQDVLQSLQDV ENSRNOP00000060156/1-1223 WHPRHPLYPSQDTLGLPQDVPGRPQNVSYPQDMTQLQDMPWSLQDMPLSLQDVLQSLQDV ENSCPOP00000016001/1-680 -------SPPQGSLGLPQDIPGPPQNLLYPQDVAYQQNIK--------PLQDMSQSLENI XP_004836405.1/1-861 WHPHCPLSPPQGPLDLPQDVPGPPQNLSYPQDVAYQQNLR-SLRNLSQSLGDVPQPLENM * *..*.****:** **.: :***:: *:: ENSP00000406571/1-872 ------------------------------------------------------------ ENSMUSP00000113676/1-1354 PPLLGDVPPSPEVMQLPGYVTQTSRDVIQSPAGVTQSLGSMMQSPGSVTQSLRSVMQSSG ENSRNOP00000060156/1-1223 PPLLGDVPQSPEVMQLPGYMTQSSRNVIQSSAGVIRSSGGVMQPSG-------------- ENSCPOP00000016001/1-680 PQL--------------------------------------------------------- XP_004836405.1/1-861 PQL--------------------------------------------------------- ENSP00000406571/1-872 ------------------------------------------------------------ ENSMUSP00000113676/1-1354 SVTQSLRSVMQSSGSVTQSLRSVMQSSGSVMQSPGGVTQSLRSVTQSPGGVMQSPGGVMQ ENSRNOP00000060156/1-1223 -------CMMQPSGGVTQSLRSAIQSSGGVMQSS-GVTQSLRSVMQSSGGVMQSSG---- ENSCPOP00000016001/1-680 ------------------------------------------------------------ XP_004836405.1/1-861 ------------------------------------------------------------ ENSP00000406571/1-872 ------------------------------------------------------------ ENSMUSP00000113676/1-1354 SPRDVMQSPRDVMQSPRDVMQSPRGVTQSLGSMMQSPGGVMQSLRSVMQSSGGVTQSLRS ENSRNOP00000060156/1-1223 -----------VTQSSGGVTWSLRSVMQSSGCMMQSPGGVMLSAGDMMQSSGGATRSLRS ENSCPOP00000016001/1-680 ------------------------------------------------------------ XP_004836405.1/1-861 ------------------------------------------------------------ ENSP00000406571/1-872 ------------------------------------------------------------ ENSMUSP00000113676/1-1354 VMQSPGGVMQSPGGVTQSPRGMIKSPGMMLSPGDVIQSLNSVPQSSRDRMQSAGHVPSAS ENSRNOP00000060156/1-1223 MMQSSGCMMQSPGGVTQ-------------SSGSVMQSL-------RNVIQSSGGVTQSS ENSCPOP00000016001/1-680 ------------------------------------------------------------ XP_004836405.1/1-861 ------------------------------------------------------------ ENSP00000406571/1-872 ------------------------------------------------------------ ENSMUSP00000113676/1-1354 GDAIQSPGGMSPTSRDRMQSPGGVSLATEDSIQLP-GGVPLSSDVIQSQGGVPLSSKDRM ENSRNOP00000060156/1-1223 GGVIQSSSGVPQSLRDRMQSPGSVSQSSGDVIQSPRGASPASGDVIKSQGGMPRSLRDRM ENSCPOP00000016001/1-680 ------------------------------------------------------------ XP_004836405.1/1-861 ------------------------------------------------------------ ENSP00000406571/1-872 --PGDVPQSPSDV----------------------------------------------- ENSMUSP00000113676/1-1354 QSPGGVPPSSGDMIQSQGGVPQSLGDAIQSAGGVPQSSGDAIQSPGGVSLATGDSIQLPG ENSRNOP00000060156/1-1223 QSPGGVPQSSEDV--------------IQSAGGVSPASGDAIQSPGGVSPASGDAMQSSG ENSCPOP00000016001/1-680 --PGNIIQSPDNT----------------------------------------------- XP_004836405.1/1-861 --PGNITQSPGNM----------------------------------------------- **.: *. : ENSP00000406571/1-872 -----------------SPSPDAPQSPGGMPHLPGDVLH--------------------- ENSMUSP00000113676/1-1354 GVPLSSGDVIQSQGGVPRSSRDRMQSPGGVPPSSGGVIQSPGGVSPASGDAIQSPGSVLP ENSRNOP00000060156/1-1223 GVTPSLGDVPQSSGGVSPASGDAMQSPGGVTPSLGDAMQSPGGVSPASGDAMQSPGGVSP ENSCPOP00000016001/1-680 -----------------------SQSPRGALLLP-DVLH--------------------- XP_004836405.1/1-861 -----------------------SQSPRGVLLLP-DVLH--------------------- *** * ..:: ENSP00000406571/1-872 -----------------------------------SPGDMPHSSGDVTHSPRDIPHLPG- ENSMUSP00000113676/1-1354 ASGDAIQSAGGVLLASGDAIQSPRSVPQSPSGTLRSPGNMSESLGDTPNLSGDVSNSPQA ENSRNOP00000060156/1-1223 SLGD---------------------VPQ-------SPGNMLESLGNTPNLSGDVSHVPQE ENSCPOP00000016001/1-680 -----------------------------------SPENMVRSSRDMPCSQGDLPPLPQ- XP_004836405.1/1-861 -----------------------------------SPENMVHSSRDMSCSRGDLPRLPQ- ** :* .* : . *:. * ENSP00000406571/1-872 ------DRPDFTQNDVQNRDMPMDISALSSPSCSPSP---QSETPLEKVPWLSVMETPAR ENSMUSP00000113676/1-1354 LLDLARDRPKSSPNDVQNRDTPMDISASSSSSCSANPQSRQSEFKLDKVPWLTITDSSAR ENSRNOP00000060156/1-1223 LLDLAKGRPKLSLNAVQNRHSPMTISAPSSPSCSANPLSQQSEFSSEKRPWLTVSNSSAR ENSCPOP00000016001/1-680 ------DRPNSPENDVQNCDSPMDISTPSSTSCSPDSPSPQSETSLEKVPWLSVTETSAR XP_004836405.1/1-861 ------DRPHSPQNDVQNCDSPMDISTPSSTSCSPGPPSPQSETSLEKVPWLSVTETSAR .**. . * *** . ** **: **.***... *** :* ***:: ::.** ENSP00000406571/1-872 KEISLSEPAKPGSAHVQSRTPQGGLYNRPCLHRLKYFLRPPVHHLFFQTLIPDKDTRENK ENSMUSP00000113676/1-1354 REKSLPQLANPGSAQIQGQIPQVGVYNRPCLHRLKYFLRPPVHHLFFQTLIPDKDTRESK ENSRNOP00000060156/1-1223 EERSLPQSATPGSAQIQGQIAQAGVYNRPCLHRLKYFLRPPVHHLFFQTLIPDKDTRESK ENSCPOP00000016001/1-680 KEMSLSEPACAKSVRVQAQTLQGGLYNRPCLHRMKYFLRPPVHHLFFQTLIPDKDARESK XP_004836405.1/1-861 KEMSLSEPACARSVQVQTQTLQGGLCNRPCLHRMKYFLRPPVHHLFFQTLIPDKDARESK .* **.: * . *.::* : * *: *******:*********************:**.* ENSP00000406571/1-872 GQKLEPIPHRRLRMVTNTIEENFPLGTVQFLMDFVSPQHYPPREIVAHIIQKILLSGSET ENSMUSP00000113676/1-1354 GQKLEPIPHRRLRMVTNTIEENFPLGTVQFLMDFVSPQHYPPREIVAHIVQKILLSGSET ENSRNOP00000060156/1-1223 GQKLEPIPHRRLRMVTNTIEENFPLGTVQFLMDFVSPQHYPPREIVAHIIQKILLSGSET ENSCPOP00000016001/1-680 AQKLEPIPHRRLRMVTNTIEENFPLGTVQFLMDFVSPQHYPPREIVAHIIQKILLSDSET XP_004836405.1/1-861 TQKLEPIPHRRLRMVTNTIEENFPLGTVQFLMDFVSPQHYPPREIVAHIIQKILLSDSET ************************************************:******.*** ENSP00000406571/1-872 VDVLKEAYMLLMKIQQLHPANAKTVEWDWKLLTYVMEEEGQTLPGRVLFLRYVVQTLEDD ENSMUSP00000113676/1-1354 VDVLKEAYMLLMKIQQLHPANAKTVEWDWKLLTYVMEEEGQTLPGRVLFLRYVVQTLEDD ENSRNOP00000060156/1-1223 VDVLKEAYMLLMKIQQLHPANAKTVEWDWKLLTYVMEEEGQTLPGRVLFLRYVVQTLEDD ENSCPOP00000016001/1-680 VDVLKDAYMLLMKIQQLHPANAKTVEWDWKLLTYVMEEEGQILPGRILFLRYVVQTLEDD XP_004836405.1/1-861 VDVLKDAYMLLMKIQQLHPANAKTVEWDWKLLTYVMEEEGQTLPGRVLFLRYVVQTLEDD *****:*********************************** ****:************* ENSP00000406571/1-872 FQQTLRRQRQHLQQSIANMVLSCDKQPHNVRDVIKWLVKAVTEDGLTQPPNGNQTSSGTG ENSMUSP00000113676/1-1354 FQQILRRQRQHLQQSIANTVLSCDKQPHNVRDVIKWLVKAVTENELTPPQDETQTSPRTG ENSRNOP00000060156/1-1223 FQQILRRQRQHLQQSIANTVLSCDKQPHNVRDVIKWLVKAVTENALTPPQDETQTSPGPG ENSCPOP00000016001/1-680 FQHTLRRQRHHLQQSIANTVLSCDKQPHNVRDVIKWLVKAVTEDGLTQYPSGSQTSSGRG XP_004836405.1/1-861 FQHTLRRQRHHLQQSIANTVLSCDKQPHNVRDVIKWLVKAVTEDRLTPYPSGNQTSSRRG **: *****:******** ************************: ** . .***. * ENSP00000406571/1-872 ILKASSSHPSSQPNLTKNTNQLIVCQLQRMLSIAVEVDRTPTCSSNKIAEMMFGFVLDIP ENSMUSP00000113676/1-1354 VLKTSSDHLSPRPNQNKNTNQLIVCQLQRMLSIAVEVDRTPTCSSNKIAEMMFGFVLDIP ENSRNOP00000060156/1-1223 VLKTSSDHLSPQPNLARNTNQLIVCQLQRMLSIAVEVDRTPTCSSNKIAEMMFGFVLDIP ENSCPOP00000016001/1-680 VLKTSSGQPPPQPNLTKNTNQLIVCQLQRMLSIAVEVDRTPTCSSNKIAEMMFGFVLDIP XP_004836405.1/1-861 ISKASSGHPAPQPNLTKNTNQL-------------------------------------- : *:**.: ..:** :***** ENSP00000406571/1-872 ERSQREMFFTTMESHLLRCKVLEIIFLHSCETPTRLPLSLAQALYFLNNSTSLLKCQSDK ENSMUSP00000113676/1-1354 ERSQREMFFTTMESHLLRCKVLEIIFLHSCETPTRLPLSLAQTLYFLNNSTSLLKCQSDK ENSRNOP00000060156/1-1223 ERSQREMFFTTMESHLLRCKVLEIIFLHSCETPTRLPLSLAQALYFLNNSTSLLKCQSDK ENSCPOP00000016001/1-680 LRSQR------------------------------------------------------- XP_004836405.1/1-861 -----EMFFTTMESHLLRCKVLEIIFLHSCETPTRLPLCLAQALYFLNNSTSLLKCQSDK ENSP00000406571/1-872 SQWQTWDELVEHLQFLLSSYQHVLREHLRSSVIDRKDLIIKRIKPKPQQGDDITVVDVEK ENSMUSP00000113676/1-1354 TQWQTWDELVEHLQFLLSSYQHVLREHLRSSVIDRKDLIIKRIKPKPQQGDDITVLDVEK ENSRNOP00000060156/1-1223 SQWQTWDELVEHLQFLLSSYQHVLREHLRSSVIDRKDLIIKRIKPKPQQGDDITVVDVEK ENSCPOP00000016001/1-680 ------------------------------------------------------------ XP_004836405.1/1-861 TQWQTWDELVEHLQFLLSSYQHVLREHLRSSVIDRKDLIIKKIKPKPQQGDDITVMDVEK ENSP00000406571/1-872 QIEAFRSRLIQMLGEPLVPQLQDKVHLLKLLLFYAADLNPDAEPFQKGWSGS ENSMUSP00000113676/1-1354 QIEAFRSRLVHILGEPLVPQLQDKVHLLKLLLFYAADLNPDTEPASEH---- ENSRNOP00000060156/1-1223 QIEAFRSRLVHILGEPLVPQLQDKVHLLKLLLFYAADLNPDTEPASER---- ENSCPOP00000016001/1-680 ---------------------------------------------------- XP_004836405.1/1-861 HIEAFRNRLIQMLGEPLVPQLQNKVHLLKLLLFYAADLNPDAEPSSKH----