CLUSTAL W(1.81) multiple sequence alignment ENSP00000387641/1-1236 MSTAAFHISSLLEKMTSSDKDF-------------------------------------- ENSMUSP00000075377/1-1235 MSTGAFYISSLLEKMTSSDKDF-------------------------------------- ENSRNOP00000014207/1-1273 MSTGAFYISSLLEKMTSSDKDFSPKSLGGSRVLDPLPWLQILAAITDWISGDRTQDLALP ENSCPOP00000015824/1-1243 MSTAAFHVAGLLEKMTSSDKDF-------------------------------------- XP_004870503.1/1-1236 MSTAAFHVAGLLEKMTSSDKDF-------------------------------------- ***.**:::.************ ENSP00000387641/1-1236 RFMATSDLMSELQKDSIQLDEDSERKVVKMLLRLLEDKNGEVQNLAVKCLGPLVVKVKEY ENSMUSP00000075377/1-1235 RFMATSDLMSELQKDSIQLDEDSERKVVRTLLRLLEDRSGEVQNLAVKCLGPLVGKVKEY ENSRNOP00000014207/1-1273 RFMATSDLMSELQKDSIQLDEDSERKVVRTLLRLLEDRSGEVQNLAVKCLGPLVGKVKEY ENSCPOP00000015824/1-1243 RFMATSDLMAELQKDSIQLDEDSERKVVKMLLRLLDDKNGEVQNLAVRCLGPLVGKVKEC XP_004870503.1/1-1236 RFMATSDLMTELQKDSIQLDEDSEQKVVKMLLRLLEDKNGEVQNLAVRCLGPLVGKVKEC *********:**************:***: *****:*:.********:****** **** ENSP00000387641/1-1236 QVETIVDTLCTNMRSDKEQLRDIAGIGLKTVLSELPPAAT-------GSGLATNVCRKIT ENSMUSP00000075377/1-1235 QVENIVDTLCANMRSDKEQLRDIAGIGLKTVLSELPPAAT-------GSGLAINVCRKIT ENSRNOP00000014207/1-1273 QVENIVDTLCANMRSDKEQLRDIAGIGLKTVLSELPPAAT-------GSGLAISVCRKIT ENSCPOP00000015824/1-1243 QVETIVDALCANMRSDKEQLRDIAGIGLKTVLSELPPAATVHLVPGAGSGLATNVCRKVT XP_004870503.1/1-1236 QVETIVDALCANMRSDKEQLRDIASIGLKTVLSELPPAAT-------GSGLATNVCRKIT ***.***:**:*************.*************** ***** .****:* ENSP00000387641/1-1236 GQLTSAIAQQEDVAVQLEALDILSDMLSRLGVPLGAFHASLLHCLLPQLSSPRLAVRKRA ENSMUSP00000075377/1-1235 GQLTSAIAQQEDVAVQLEALDILSDMLSRLGAPLGTFHASLLHCLLPQLSSPRLAVRKRT ENSRNOP00000014207/1-1273 GQLTSAIAQQEDVAVQLEALDILSDMLSRLGAPLGTFHASLLHCLLPQLSSPRLAVRKRT ENSCPOP00000015824/1-1243 GQLTSAIAQQEDVAMQLEALDILSDMLSRLGAPLGSFHAGLLHCLLPQLSSPRLAVSKRA XP_004870503.1/1-1236 GQLTSAIAQQEDVAVQLEALDILSDMLSRLGAPLGSFHASLLHCLLPQLSSPRLAVRKRV **************:****************.***:***.**************** **. ENSP00000387641/1-1236 VGALGHLAAACSTDLFVELADHLLDRLPGPRVPTSPTAIRTLIQCLGSVGRQAGHRLGAH ENSMUSP00000075377/1-1235 VVALGHLAAACSTDLFVELADHLVDRLPGPRAPASPAAIRTLIQCLGSVGRQAGHRLGAH ENSRNOP00000014207/1-1273 VVALGHLAAACSTDLFVELADHLVDRLPGPRAPASPAAIRTLIQCLGSVGRQAGHRLGAH ENSCPOP00000015824/1-1243 VIALGHLAATCNADLFTELADHLLERLPGPSTPTSPAALRTLVQCVGSVGRQAGHRLGPH XP_004870503.1/1-1236 VVALGHLAATCSADLFAELADHLLERLPGPCVPASPAALRTLVQCVGSVGRQAGHRLGLH * *******:*.:***.******::***** .*:**:*:***:**:************ * ENSP00000387641/1-1236 LDRLVPLVEDFCNLDDDELRESCLQAFEAFLRKCPKEMGPHVPNVTSLCLQYIKHDPNYN ENSMUSP00000075377/1-1235 LDRLVPMVEEFCNLDDDELRESCLQAFEAFLRKCPKEMDPHVPNVTSLCLQYMKHDPNYD ENSRNOP00000014207/1-1273 LDRLMPLVEEFCNLDDDELRESCLQAFEAFLRKCPKEMDPHVPNVTSLCLQYMKHDPNYN ENSCPOP00000015824/1-1243 LDRLVPLLEEFCGLEDDELRESCLQAYEAFLRKCPKEMGPHVPSVTRLCLQYLKHDPNYN XP_004870503.1/1-1236 LDRLVPLLEEFCGLEDDELRESCLQACEAFLRKCPKEMGPHVPRVTSLCLQYLKHDPNYN ****:*::*:**.*:*********** ***********.**** ** *****:******: ENSP00000387641/1-1236 YDSDEDEEQMETEDSEFSEQESEDEYSDDDDMSWKVRRAAAKCIAALISSRPDLLPDFHC ENSMUSP00000075377/1-1235 HDSD-DEEQMETEDSEFSEQESEDEYSDDDDMSWKVRRAAAKCMAALISSRPDLLPDFHC ENSRNOP00000014207/1-1273 HDSD-EEEQMETEDSEFSEQESEDEYSDDDDMSWKVRRAAAKCMAALISSRPDLLPDFHC ENSCPOP00000015824/1-1243 YNSDEEEEQMETEDSESSEQETEDEYSDDDDMSWKVRRAAAKCLAALLGSRPDLLPDLHH XP_004870503.1/1-1236 YNSDEDEEQMETEDSESSEQEVEDEYSDDDDMSWKVRRAAAKCLAALLGSRPDLLPDLYC ::** :********** **** *********************:***:.********:: ENSP00000387641/1-1236 TLAPVLIRRFKEREENVKADVFTAYIVLLRQTQPPKGWLEAMEEPTQTGSNLHMLRGQVP ENSMUSP00000075377/1-1235 TLAPALIRRFKEREENVKADIFGAYIMLLRHTRPPKGWLEAVEEPTQTGRNLNMLRAQVP ENSRNOP00000014207/1-1273 TLAPALIRRFKEREENVKADIFGAYIMLLRHTRPPKGWLEAVEEPTQTGRNLNMLRAQVP ENSCPOP00000015824/1-1243 SLAPALVQRFREREDNVKADVFAAYIVLLRQIRPPQGWLQAVEEPTPTGSSLQLLRGQVP XP_004870503.1/1-1236 SLAPALVRRFREREDNVKADVFAAYIVLLRQMRPPQGWLNTTEESMLADSSLRALQEQVP :***.*::**:***:*****:* ***:***: :**:***:: **. :. .*. *: *** ENSP00000387641/1-1236 LVVKALQRQLKDRSVRARQGCFSLLTELAGVLPGSLAEHMPVLVSGIIFSLADRSSSSTI ENSMUSP00000075377/1-1235 LVIKALQRQLKDRNVRTRQGCFNLFTELAGVLPGSLAEHMAVLVSGIVFSLADYSSSSTI ENSRNOP00000014207/1-1273 LVMKALQRQLKDRNVRTRQGCFNLFTELAGVLPGCLAEHMTVLVSGIVFSLADYSSSSTI ENSCPOP00000015824/1-1243 LVIKALQRQLKDRSARVRQGCFSLLAELAGVLPGSLAEHMPVLVSGIIFSLADRSSSSTI XP_004870503.1/1-1236 LVIKALQQQLKDRSARARQGCFNLLAELSGVLPGSLAKHMPVLVSGIVFSLADCSSSSTI **:****:*****..*.*****.*::**:*****.**:**.******:***** ****** ENSP00000387641/1-1236 RMDALAFLQGLLGTEPAEAFHPHLPILLPPVMACVADSFYKIAAEALVVLQELVRALWPL ENSMUSP00000075377/1-1235 RMDALAFLQGLLGTEPAEAFHPHLPTLLPPVMACVADPFYKVAAEALLVLQELVRTLWPL ENSRNOP00000014207/1-1273 RMDALAFLQGLLGTEPAEAFHPHLPTLLPPVMACVADPFYKVAAEALLVLQELVRTLWPL ENSCPOP00000015824/1-1243 RMDALTFLQGLLGTEPAEAFHPHLPNLLPPVMACVADPFYKIAAEALLVLQELVRTLWPL XP_004870503.1/1-1236 RMDTLAFLQGLLSTEPPEAFQPHLPVLLPPVMACVADPFYKIAAEALLVLQELVRALWPL ***:*:******.***.***:**** ***********.***:*****:*******:**** ENSP00000387641/1-1236 HRPRMLDPEPYVGEMSAVTLARLRATDLDQEVKERAISCMGHLVGHLGDRLGDDLEPTLL ENSMUSP00000075377/1-1235 DRPRLLDPEPYVGEMSTATLARLRATDLDQEVKERAISCVGHLVGHLGDRLGDDLEPTLM ENSRNOP00000014207/1-1273 DRPRLLDPEPYVGEMSTATLARLRATDLDQEVKERAISCVGHLVGHLGDRLGDDLEPTLL ENSCPOP00000015824/1-1243 GKPRVLDPAPYMAEMTEATLVRLRATDLDQEVKERAISCMGHLIGHLGDQLGDTLQPTLL XP_004870503.1/1-1236 GKPRVLDPAPYVVKMSEATLARLHATDLDQEVKERAISFVGYLVGHLGDQLGDILQPTLL :**:*** **: :*: .**.**:************** :*:*:*****:*** *:***: ENSP00000387641/1-1236 LLLDRLRNEITRLPAIKALTLVAVSPLQLDLQPILAEALHILASFLRKNQRALRLATLAA ENSMUSP00000075377/1-1235 LLLDRLRNEITRLPAVKALTLVAMSPLRLDLQPILAEALPILASFLRKNQRALRLATLAA ENSRNOP00000014207/1-1273 LLLDRLRNEITRLPAVKALTLVAVSPLRLDLQPILAEALPILASFLRKNQRALRLATLAA ENSCPOP00000015824/1-1243 LLLDRLRNEITRLPAVKALTLVAASPLQLDLRPILAEVLPILASFLRKNQRALRLATLAA XP_004870503.1/1-1236 LLLDHLRNEITRLPAVKALTLVAMSPLQLDLQPILAEVLPILASFLRKNQRALRLATLAV ****:**********:******* ***:***:*****.* *******************. ENSP00000387641/1-1236 LDALAQSQGLSLPPSAVQAVLAELPALVNESDMHVAQLAVDFLATVTQAQPASLVEVSGP ENSMUSP00000075377/1-1235 LDALAQSQGLGLPPPAVRTVLTELPALVSENDMHVAQLAVDFLTTVTQTQPSSLVEVSGP ENSRNOP00000014207/1-1273 LDALAQSQGLGLPPPAVRSVLAELPALVSENDMHVAQLAVDFLTTVTQTQPASLVEVSGP ENSCPOP00000015824/1-1243 LDALAQGQGRGLPPSAVRTVLAEVPALVSESDMHVAQLAVDFLATVTPAQPACLAEVSDT XP_004870503.1/1-1236 LDALAQSQGHSLPPPAVRTVLAELPALVSESDMHVAQLAVDFLATMTPVQPACMAEVSGP ******.** .***.**::**:*:****.*.************:*:* .**:.:.***.. ENSP00000387641/1-1236 VLSELLRLLRSPLLPAGVLAAAEGFLQALVGTRPPCVDYAKLISLLTAPVYEQAVDGGPG ENSMUSP00000075377/1-1235 VLGELLQLLHSPLLPAGVLAATEGFLQALVGTRPPCVEYSELISLLTAPVYNQVGDGGPG ENSRNOP00000014207/1-1273 VLEELLQLLHSPLLPAGVLAATEGFLQALVGTRPPCVEYSELISLLTAPVYNQVGDGGPG ENSCPOP00000015824/1-1243 VLAELLRLLRSPLLPTSVLAAAEGFLQALVGTHPPCVAYNKLLSLLTAPVYEQTGDSGPA XP_004870503.1/1-1236 VLVQLLRLLRSPLLPASVLVAAEGFLQTLVGSRPPCMAYTELLSLLTAPVYNQPRDGGPG ** :**:**:*****:.**.*:*****:***::***: * :*:********:* *.**. ENSP00000387641/1-1236 LHKQVFHSLARCVAALSAACPQEAASTASRLVCDARSPHSSTGVKVLAFLSLAEVGQVAG ENSMUSP00000075377/1-1235 LHKQVFHSLARCVAALSAACPQEAAGTASRLVCDAKSPHSSTGVKVLAFLSLAEVGQVAG ENSRNOP00000014207/1-1273 LHKQVFHSLARCVAALSAACPQEAAGTASRLVCDARSPHSSTGVKVLAFLSLAEVGQVAG ENSCPOP00000015824/1-1243 LHKQVFHSLARCVAALSAACPQEAAGTANRLVMDAKSPHSSTGVKVLAFLSLAEIGQVAG XP_004870503.1/1-1236 LHKQVFHSLARCVAALSAACPQEAASTANLLVGDARSPNSSTGVKVLAFLSLAEVGQVAG *************************.**. ** **:**:***************:***** ENSP00000387641/1-1236 PGHQRELKAVLLEALGSPSEDVRAAASYALGRVGAGSLPDFLPFLLEQIEAEPRRQYLLL ENSMUSP00000075377/1-1235 PGPQRELKTVLLEALGSPSEDVRAAAAYALGRVGAGNLPDFLPFLLAQIEAQPRRQYLLL ENSRNOP00000014207/1-1273 PGPQRELKTVLLEALGSPSEDVRAAAAYALGRVGAGNLPDFLPFLLAQIEAQPRRQYLLL ENSCPOP00000015824/1-1243 PGPQRELKAVLLEALGSPSEDVRAAASYALGRVGAGNLPNFLPFLLAQIEAEPKRQYLLL XP_004870503.1/1-1236 PGPQRELKAVLLEALGSPSEDVRAAASYALGRVGAGNLPDFLPFLLAQIEAEPRRQYLLL ** *****:*****************:*********.**:****** ****:*:****** ENSP00000387641/1-1236 HSLREALGAAQPDSLKPYAEDIWALLFQRCEGAEEGTRGVVAECIGKLVLVNPSFLLPRL ENSMUSP00000075377/1-1235 HALREALGAAQPDNLKPYVEDVWALLFQRCESPEEGTRCVVAECIGKLVFVNPPYLLPRF ENSRNOP00000014207/1-1273 HALREALGAAQPDNLKPYVEDVWALLFQRCESPEEGTRCVVAECIGKLVFVNPPFLLPRF ENSCPOP00000015824/1-1243 QALREALGAAPPDGLKPYAEDIWALLFQRCEGAEEGTRGVVAECIGKLVLVNPPFLLPRL XP_004870503.1/1-1236 QALREALGAAPPDGLKPYAEDIWALLFQHCEGTEEGTRGVVAECIGKLVLVNPPFLLPRL ::******** **.****.**:******:**..***** **********:***.:****: ENSP00000387641/1-1236 RKQLAAGRPHTRSTVITAVKFLISDQPHPIDPLLKSFIGEFMESLQDPDLNVRRATLAFF ENSMUSP00000075377/1-1235 RKQLAAGQPYTRSTVITAVKFLISDQPHSIDPLLKSFIAEFMESLQDPDLNVRRATLTFF ENSRNOP00000014207/1-1273 RKQLAAGQPYTRSTVITAVKFLISDQPHSIDPLLKSFIAEFMESLQDPDLNVRRATLTFF ENSCPOP00000015824/1-1243 QKQLTTGQPHTRSTVITAVKFLISDQPHAIDSLLKTFIGEFMESLRDPDLGVRRATLAFF XP_004870503.1/1-1236 QKQLSAGQPHTRSTVITAVKFLITDQPHPIDPLLKTFIGNFMESLRDPDLSVRRATLAFF :***::*:*:*************:****.**.***:**.:*****:****.******:** ENSP00000387641/1-1236 NSAVHNKPSLVRDLLDDILPLLYQETKIRRDLIREVEMGPFKHTVDDGLDVRKAAFECMY ENSMUSP00000075377/1-1235 NSAVHNKPSLVRDLLDDILPLLYQETKIRRDLIREVEMGPFKHTVDDGLDVRKAAFECMY ENSRNOP00000014207/1-1273 NSAVHNKPSLVRDLLDDILPLLYQETKIRRDLIREVEMGPFKHTVDDGLDVRKAAFECMY ENSCPOP00000015824/1-1243 NSAVHNKPSLVRDLLDGILPLLYQETKVRRDLIREVEMGPFKHTVDDGLDVRKAAFECMY XP_004870503.1/1-1236 NSAVHNKPSLVRDLLDTILPLLYQETKVRRDLIREVEMGPFKHTVDDGLDMRKAAFECMY **************** **********:**********************:********* ENSP00000387641/1-1236 SLLESCLGQLDICEFLNHVEDGLKDHYDIRMLTFIMVARLATLCPAPVLQRVDRLIEPLR ENSMUSP00000075377/1-1235 SLLESCLGQLDMCEFLNHVEDGLKDHYDIRMLTFIMLARLATLCPAPVLQRVDRLIEPLR ENSRNOP00000014207/1-1273 SLLESCLGQLDICEFLNHVEDGLKDHYDIRMLTFIMLARLAALCPAPVLQRVDRLIEPLR ENSCPOP00000015824/1-1243 SLLESCLGQLDVSEFLSHVEDGLKDHYDIRMLTFILLARLATLCPAPVLQRVDRLIEPLR XP_004870503.1/1-1236 SLLESCLGQLDVSQFLSHVEDGLKDHYDVRMLTFIMLARLATLCPAPVLQRVDRLIEPLR ***********:.:**.***********:******::****:****************** ENSP00000387641/1-1236 ATCTAKVKAGSVKQEFEKQDELKRSAMRAVAALLTIPEVGKSPIMADFSSQIRSNPELAA ENSMUSP00000075377/1-1235 ATCTAKVKAGSVKQELEKQEELKRSAMRAVAALLTNPEVRKSPTVADFSAQIRSNPELTT ENSRNOP00000014207/1-1273 ATCTAKVKAGSVKQELEKQDELKRSAMRAVAALMTNPEVRKSPSVADFSTQIRSNPELAT ENSCPOP00000015824/1-1243 ATCAAKVKAGSVKQEFEKQDELKRSAMRAVAALLTIPEAGRSPIMADFAAQICSNPELSA XP_004870503.1/1-1236 ATCTAKVKAGSVKQEFEKQDELKRSAMRVVAALLTIPEAGRSPIMADFEAQIRSNPELSA ***:***********:***:********.****:* **. :** :*** :** *****:: ENSP00000387641/1-1236 LFESIQKDSASAPSTDSMELS ENSMUSP00000075377/1-1235 LFESIQKDTASGPSTDSMELS ENSRNOP00000014207/1-1273 LFESIQKDTASGPSMDSMELS ENSCPOP00000015824/1-1243 LYESIQKDPASAPSTEAMELS XP_004870503.1/1-1236 LFESIQKDPASMLGTEPMELS *:******.** . :.****