CLUSTAL W(1.81) multiple sequence alignment ENSP00000426129/1-703 ----------------------------------------------------------ME ENSMUSP00000091306/1-758 MPGCGCPVVAPLGSSSSLWDSGLAGQTTAMNWWPSNLQRWKSRSSRTQSCCQNKEDLEME ENSRNOP00000053371/1-576 --------------------MGVRVCGSLHVWFLLSFLLVFSTTCAEGHTCQNKGDLAME ENSCPOP00000015390/1-689 ----------------------------------------------------------ME XP_004834323.1/1-758 MWMSPLALAEGRAGEIVSNKSTEAGGGRDVQTPEAGHKVGGDAHARLGPSCHSKGDLAME ** ENSP00000426129/1-703 ALLEGIQNRGHGGGFLTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELK ENSMUSP00000091306/1-758 ALLEGIQNRGHSGGFLTSCEAELQELMKQIDIMVAHKKSEWEGQTHALETCLDIRDRELK ENSRNOP00000053371/1-576 ALLEGIQTRGHSGGFLTSCEAELQELMKQIDIMVAHKKSEWEGQTHALETCLDMRDRELK ENSCPOP00000015390/1-689 ALLEGIQNQGHGGGFLTSCEAELQELMKQIDIMVAHKKSEWEGQTHALETCLDIRDRELK XP_004834323.1/1-758 ALLEGIKNQGHGGGFLTSCEAELQELMKQIDIMVAHKKSEWEGQTHALETCLDIRDQELK ******:.:**.*******************************:********.:*::*** ENSP00000426129/1-703 SLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQM ENSMUSP00000091306/1-758 ALRSQLDMKHKEVGILHQQIEEHEKTKQEMAMEYKEELLKLQEELSRLKRSYEKLQKKQL ENSRNOP00000053371/1-576 ALRSQLDMKHKEVGILHQQIEEQEKTKQEMALEYKEELMKLQEELSRLKRSYEKLQKKQL ENSCPOP00000015390/1-689 TLRNQLDMKHKEVGMLHQQMEEHEKVKQQMTIEYKQELRKLQEELGRLKRSYEKLQKKQI XP_004834323.1/1-758 TLRSQLDMKHKEVGMLHQQIEEHEKVKQEMAMEYKQELKKLQEELGRLKRSYEKLQKKQI :**.***:.*****:****:**:** **:*::***:** **:*** ************: ENSP00000426129/1-703 REFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSE ENSMUSP00000091306/1-758 REFRGNTKSFREDRSEIERLTGKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSE ENSRNOP00000053371/1-576 REFRGNTKSLREDRSEIERLTGKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSE ENSCPOP00000015390/1-689 REFRGSTKNHREDRSEIQKLNGKIEEYRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSE XP_004834323.1/1-758 REFRGSTKNHKEDQSEIERLNGKVEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSE *****.**. :**:***::*..*:**:********************************* ENSP00000426129/1-703 IIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSM ENSMUSP00000091306/1-758 IIQAQLANRKQKLESVELSSQSEIQHLNSKLERAKDTICANELEIERLNIRVNDLMGTNM ENSRNOP00000053371/1-576 IIQAQLANRKQKLESVELSSQSEIQHLSSKLERAKDTICANELEIERLNIRVKDLMGTNV ENSCPOP00000015390/1-689 IIQAQLTNRKQKLESVELSSQSEIQHLSSKLERAKDTICANELEIERLNIRVNDLIGTNK XP_004834323.1/1-758 IIQAQLTNRKQKLDSVELSSQSEIQHLSSKLERAKDTICANELEIERLNMRVNDLIGTNM ******.******:*************.******:*************.:**:**:**. ENSP00000426129/1-703 TVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNT ENSMUSP00000091306/1-758 TILQDHRQKEEKLRESEKLLEALQEEQKELKASLQSQETFILEA-KMQEKLQTTLKAVGT ENSRNOP00000053371/1-576 TILQEQRQKEEKLRESEKLLEALQEEQKELKASLQAQESFILDA-KMQEKLQTKLKAVDT ENSCPOP00000015390/1-689 SILQEQQQKEEKLRESEKLLETLQEEKRELKANLQSHENFIREA-KMQKKLQ--VKDTHT XP_004834323.1/1-758 TILHEQRQKEEKLRESEKLLETLQEEKRELKANLQYHENFMHEEKKMQKKLQ--AKGNNT ::*::::**************:****::**** ** :*.:: : ::*** * * ENSP00000426129/1-703 QHAVEAIRPREESLAEKKYTSQGQGDLDSVLSQLNFTHTSEDLLQAEVTCLEGSLESVSA ENSMUSP00000091306/1-758 QQSVE--RPLEDCQKERKYSSPGQGVLDNVLSQLDFSHSSEELLQAEVTRLEGSLESVSA ENSRNOP00000053371/1-576 KHSVE--RSLEDCQVERKYSSSGQGVLDNVLSQLDISHSSEELLQAEVTRLEGSLESVST ENSCPOP00000015390/1-689 QHPEDAIRPLEDFQAERKISFQGQGDLGSVLHQLDFTHTSEELLQAEVTRLEGSLESVSA XP_004834323.1/1-758 QHLVDSIRPLEDSQAERRITFQGQGDLGSVLSQLDFTHTSEELLQAEVTRLEGSLESVSA :: : *. *: *:: : *** *..** **:::*:**:******* *********: ENSP00000426129/1-703 TCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHLTQ ENSMUSP00000091306/1-758 TCKQLSQELMEKYEELKRMEGHNNEYRTEIKKLKEQILQADQTYSSALEGMKMEISQLTR ENSRNOP00000053371/1-576 TCKQLSQELMEKYEELKRMEGHNNEYRTEIKKLKEQILQADQTYSSALEGMKTEISQLTR ENSCPOP00000015390/1-689 TCKQLSQELMEKYEELKKMEGHNNEYRAEIKKLKEQILQADQTYSSALEGMKMEIAQLTR XP_004834323.1/1-758 TCKQLSQELMEKYEELKKMEGHNNEYRAEIKTLKEQILQAEQTYSSALEGMKMEISHLTR *****************:**.*****::***.*******.:*:********* **::**: ENSP00000426129/1-703 ELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMVMK ENSMUSP00000091306/1-758 ELHQRDITIASAKCSSSDMEKQLKAEMQKAEEKAVEHKEILSQLESLKLENHRLSETVMK ENSRNOP00000053371/1-576 ELHQRDITIASAKCSSSDMERQLKAEMQKAEEKAVEHKEILSQLESLRLENRRLSETVMK ENSCPOP00000015390/1-689 ELHQRDITIASAKCSSSDMEKQLKAEMKKAEEKAVEHKEILNQLESLKLENRRLSETVVK XP_004834323.1/1-758 ELHQRDSTIASAKCSSSDMEKQLKAEMQKAEEKAVEHKEILNQLESLKLENHRLSEMVMK ****** ****:* ******::*:***:***:*********.*****:***::*** *:* ENSP00000426129/1-703 LELGLHEAKEISLADLQENYIEALNKLVSENQQLQKDLMNTKSQLEISTQMCKKQNDRIF ENSMUSP00000091306/1-758 LELGLHEAKEISLADLQENYIEALNKLVSENQQLQKDLMSTKSELEHATNMCKKKDGEIF ENSRNOP00000053371/1-576 LELGLHE----------------------------------------------------- ENSCPOP00000015390/1-689 LEFGLHEAKEISLAELQENYIGTLNKLLSENQQLQKDLMDTKAQLEIATQTC-----SVF XP_004834323.1/1-758 LEFGLHKAKEISLADLQENYIETLNKLVSENQQLQKDVMHTKSQLEIATQMCKQKD-NVF **:***: ENSP00000426129/1-703 KPTHSRTTEFKNTEFKPTHGQHRHDGIKTEHYKTDLHSPRGQASDSINPMSRVLSPLSPQ ENSMUSP00000091306/1-758 NPAHSRAAGFKNAELKPIHGQHRHDGIKTEQYKTGHHSPRGQTLDSIDPVARGPSPLSSH ENSRNOP00000053371/1-576 ------------------------------------------------------------ ENSCPOP00000015390/1-689 KPTLSRTTELKNTEFKPTHGQHRHDGIKTEHYT------RGRAPDSTRPMSRVCSPLSSH XP_004834323.1/1-758 KLTLSRTTQFKNTEFKPTHGQHRHDGIKTEHCKTGLHSPRGQAPDSTGPVSRACSPLSPH ENSP00000426129/1-703 ISPCSSTRSLTSYSLCKTHSLPSALDTNEANFSDTMSESMNDQEEFISSCSLPVSPLGSI ENSMUSP00000091306/1-758 ISPGSSTVSLPSNFLFEAHSLPSVLDINDVNFSDSLSDCMNDQEEFVSSGSLPTSPLGSI ENSRNOP00000053371/1-576 -------------------------------------------------CSMPVSPLGLI ENSCPOP00000015390/1-689 LSSCSSTISLPSNFLGQTHSLPSLLDIHDANFSDTMSDGMNDQEEFISLYCSPIPPLGSI XP_004834323.1/1-758 LSSCSSTISLPSYFLGQTHSLPSLLDTNDANFSDTMSDGTNDQEEFISLYSTPASPLGSI . * .*** * ENSP00000426129/1-703 ATRFLEEEELRSHHILERLDAHIEELKRESEKTVRQFTALK ENSMUSP00000091306/1-758 ATRFLEEEELRSHHILERLDAHIEELKRESEKTVRQFTALV ENSRNOP00000053371/1-576 ATRFLEEEELRSHHILERLDAHIEELKRESEKTVRQFTALV ENSCPOP00000015390/1-689 ATRFLEEEELRSHHILERLDAHIEELKRESEKTVRQFTAPM XP_004834323.1/1-758 ATRFLEEEELRSHHILERLDAHIEELKRESEKTVRQFTALM ***************************************