CLUSTAL W(1.81) multiple sequence alignment ENSMUSP00000101406/1-1420 MKAYLKSADGFFVLNKSTTIGKHADSDLVLQSADIDNHHALIEFNEAEGTFVLQDFNSRN ENSRNOP00000018953/1-850 ------------------------------------------------------------ ENSP00000365167/1-1453 MKAYLKSAEGFFVLNKSTTIGRHENSDLVLQSPDIDNHHALIEYNEAECSFVLQDFNSRN ENSCPOP00000015129/1-814 ------------------------DTNLL------------------------------- XP_004851115.1/1-1401 MKAYLKSTEGFFVLNKSTTIGKHEDSDLVLQSADIDNHHALIEYNEAEGNFILQDFNSRT ENSMUSP00000101406/1-1420 GTFVNECHIQNVAVKLIPGDILRFGSAGMTYELVIENPSPVSCPWVRGPAPWPSPQ---- ENSRNOP00000018953/1-850 ------------------------------------------------------------ ENSP00000365167/1-1453 GTFVNECHIQNVAVKLIPGDILRFGSAGLTYELVIENPPPVSFPWMRGPAPWPGPQPPRA ENSCPOP00000015129/1-814 ------------------------------------------------------------ XP_004851115.1/1-1401 GTFVNECHIQNVAVKLISGDILRFGSAGLTYELVIENPPQVSCPWVRGPAPWPRPQPSQA ENSMUSP00000101406/1-1420 ---PHLSSSPPDMPFHHGIQPATVQRSWSQGCPRPTMVPPAPHQRPMSASGKMFSFVMD- ENSRNOP00000018953/1-850 ------------------------------------------------------------ ENSP00000365167/1-1453 TQQPNQAPPPSHIPFHQGVQPAPMQRSWSQAFPRPTVVLPASHRRPVSANKEMFSFVVDD ENSCPOP00000015129/1-814 ---------------------------------------PAS----------LF------ XP_004851115.1/1-1401 TQEPNKSSSPPHFPFHQGVWPAPMQRSWSQGFPRPMVVPPASRQGPMSARGKMFSFIMD- ENSMUSP00000101406/1-1420 -PKSPVINQVWANAMDMSEQCMMDGLSGTIPPTEIFMDHDLSQQDKDEIILLLGREVNRL ENSRNOP00000018953/1-850 ------------------------------------------------------------ ENSP00000365167/1-1453 ARKPPVIKQVWTNAMKLSEKSVAEGIPGAVPPAEIYVEEDLAQQDKDEIILLLGKEVSRL ENSCPOP00000015129/1-814 ------------------------------------------------------------ XP_004851115.1/1-1401 -HRSPIIKQVWTNTVDLAEQSMPEGMPGAASASEIYVEQDLAQQEKDEIILLLGREVTRL ENSMUSP00000101406/1-1420 SDFEMESKYKDALIMNLQAEVADLSQRLSETAAVAAARQSNRCDPKLQGVDEGDDLRQKE ENSRNOP00000018953/1-850 ------------------------------------------------------------ ENSP00000365167/1-1453 SDYEIESKYKDVIIANLQNEVAELSQKVSETT--TSRQNEKEISQKCQVLDEDIDAKQKE ENSCPOP00000015129/1-814 ------------------------------------------------------------ XP_004851115.1/1-1401 SDFELESKYKDVVIANLQNEVAGLNQKLSETT--ASRPRDSGIPKKFQGPDEDSNTRQRE ENSMUSP00000101406/1-1420 IESMKSQINALQKGYSQVLSQTLAERNTEIESLKNEGENLKRDHAITSGMVTSLQKDMSA ENSRNOP00000018953/1-850 ------------------------------------------------------------ ENSP00000365167/1-1453 IQSLKSQISALQKGYSKVLCQTLSERNSEITSLKNEGENLKRDNAITSGMVSSLQKDILA ENSCPOP00000015129/1-814 ------------------------------------------------------------ XP_004851115.1/1-1401 IQSLKSQISALQKGYSHVLCQTLSKWNSEIASLKSEGENLRRATAITAEKVTSLQKDMLA ENSMUSP00000101406/1-1420 RNEQVQQLQEEVNRLRIENREKEYQLEALSSRCSVMKEELRKEEAQKDRREAQEKELKLC ENSRNOP00000018953/1-850 ------------------------------------------------------------ ENSP00000365167/1-1453 KDEQVQQLKEEVSHLKSQNKDKDHQLEALGSRCSVLKEELKQEDAHRELREAQEKELKLC ENSCPOP00000015129/1-814 ------------------------------------------------------------ XP_004851115.1/1-1401 RNAQVRQLTEEVNRLKNQNKEKEYQLEALGSRCSALKEELKKEVAQKELREAQENELKRC ENSMUSP00000101406/1-1420 RSQMQDMEKEVRKLREELKKNYMGQNIISKTLREKNKVEEKLQEDSRRKLLQLQEMGNRE ENSRNOP00000018953/1-850 ------------------------------------------------------------ ENSP00000365167/1-1453 KTQIQDMEKEMKKLRAELRKSCTEQSVISRTLREKSKVEEKLQEDSRRKLLQLQEMGNRE ENSCPOP00000015129/1-814 ------------------------------------------------------------ XP_004851115.1/1-1401 KTQIQEMEKEMKKLREELRKSCSEQSAISRTLQEKSKVEEKLQEDSRRKLLQLQEMGNRE ENSMUSP00000101406/1-1420 NLIKINLERAVGQLENFRNQVIKATFGKTKPFRDKPITDQQLIEKIIQVTEDNLSFQQRK ENSRNOP00000018953/1-850 ------------------------------------------------------------ ENSP00000365167/1-1453 SVIKINLERAVGQLEHFRSQVIKATYGRAKPFRDKPVTDQQLIEKITQVTEDNINFQQKK ENSCPOP00000015129/1-814 ------------------------------------------------------------ XP_004851115.1/1-1401 SLIKVNLGRAVGQLEHFRSQVIKATYGQVKPSPDKPITDQQLIERITQVTEDNINFQQNK ENSMUSP00000101406/1-1420 WTLQRETHL-HPKQEETMHSVEKLRVLLDKCQACMRDSCSSIDLKKEVELLQHLPLSPLV ENSRNOP00000018953/1-850 -----------------------------------------MDLKKEVELLQHLQLSPPV ENSP00000365167/1-1453 WTLQKETQLSNSKQEETTENIEKLRTSLDSCQACMKISCCSHDLKKEVDLLQHLQVSPPV ENSCPOP00000015129/1-814 ------------------------------------------------------------ XP_004851115.1/1-1401 WSLEKETQLSNSRQEET---LERLRTALDSCQSCMKMSCCSRDLKREVDLLRGLEVSPPV ENSMUSP00000101406/1-1420 SGLQKTVVNILRVSLSWLEETEQLLGDLDIELSDSDKGFSLCL---IYLLEHYKKIMSQS ENSRNOP00000018953/1-850 LGLQKAVLNILRVSLSWLEETEQLLGDLNIELSDSDKGFSLCL---IYLLEHYKKIMIQS ENSP00000365167/1-1453 SGLQKVVLDVLRHALSWLEEVEQLLRDLGILPSSPNKDQVQQFSGNSAVFTAGKAAGASG ENSCPOP00000015129/1-814 ------------------------------------QGFSSYL---LCLLEHSKKFMSQT XP_004851115.1/1-1401 SGLQKVTLHILSLLLSWLEGTEQLLRDLGLQLSGSNKGFSLYL---TCLLKHYKRIMSQT :. : :: * . ENSMUSP00000101406/1-1420 QDLQAQMNASRETQKSLRQ--------------EHLAEKEKLA-EKLEQEEKLKAKIQQL ENSRNOP00000018953/1-850 EELRAQVNASLETQQSLQE--------------ENLAEKEKLT-EKLEQEEKLKARIQQL ENSP00000365167/1-1453 REGEAERGEARARGEAQSQNQATDGREGGKALEEYITQERNRAKETLEEERKRMQELESL ENSCPOP00000015129/1-814 EELQAQINSSQEMQQTLLQ----------ETLREHMAEKERLTEERLELEEEMKARVRRL XP_004851115.1/1-1401 QELQVQINSSKEMQQAVLQ----------ETLKEHLAEKEKLNKERLEVEEKLKVRIKRL .: ..: . : :: : * ::::.. * ** *.: .:. * ENSMUSP00000101406/1-1420 T-EEKAALEESIGQEKSRSEEALEKAQARVRELENHLASQKEALENSVAQEKRKMREMLE ENSRNOP00000018953/1-850 T-EEKAALEESVAEEKNKLQGDLEMTQARVHELENDLACQKEVLESSVTQEKRKMREVLE ENSP00000365167/1-1453 LAQQKKALAKSITQEKNRVKEALEEEQTRVQELEERLARQKEVLESSIAHEKRKAKEALE ENSCPOP00000015129/1-814 M-EEKEALEDSAVQEKDRAREALEEAQRRIRELENRLAHHKEVWETSMALEKRKAKEALE XP_004851115.1/1-1401 M-EEREALEDNIAQEKGRAKEALEEAQRRVRELENRLTHQKEVWESSMAHEKRKAEEVLE ::: ** .. :**.: . ** * *::***: *: :**. *.*:: **** .* ** ENSMUSP00000101406/1-1420 AERRKAQDLENQLTQQKEISENNT-YEKLKMRDTLEKEKRKIQDLENRLTKQKEEIELKE ENSRNOP00000018953/1-850 AERRKAQDLENQLTQQKEISESNT-YEKLKMRDTLEKEKRRIQDLENRLTKQREEIELKG ENSP00000365167/1-1453 SEKRKVQDLENHLTQQKEISESNIAYEKRKAKEAMEKEKKKVQDLENRLTKQKEELELKE ENSCPOP00000015129/1-814 AEKRRVQDLENHLTQQKEICENSIAYEHHKAKEALDKERRQVQDLENRLTKQREEIELKG XP_004851115.1/1-1401 AERRRAQDLENHLTQQKEISENSITYERHKAKEALDKERRRVQDLENRLTKQREEIELKG :*:*:.*****:*******.*.. **: * :::::**::::**********:**:*** ENSMUSP00000101406/1-1420 QKENVLNNKLKDALVMVEDAQQMKTTESQRAETLALKLKETLAELETTKTKMILTDDRLK ENSRNOP00000018953/1-850 QKEDILNNKLKDALLLVEDAQQMRTAESTRAEKLSLKLKETLAELEITKAKMIMAEDRLK ENSP00000365167/1-1453 QKEDVLNNKLSDALAMVEETQKTKATESLKAESLALKLNETLAELETTKTKMIMVEERLI ENSCPOP00000015129/1-814 QKEDDLNNKLSAALAQVEETEQMKAAESRKAENLALKLNKTLVELETAKSKMVLMEERIM XP_004851115.1/1-1401 QREDDLNNKLNDAMTRVEETQHMRTAESQKAENLALKLNETLAELETAKTKMILMEEQIT *:*: *****. *: **:::: :::** :**.*:***::**.*** :*:**:: :::: ENSMUSP00000101406/1-1420 LQQQSMKALQDERESQKHGFEEEISEYKEQIKQHSQTIVSLEERLCQVTQYYQKIEGEIT ENSRNOP00000018953/1-850 LQQQSMKALQDERESQKHGFEEEITEYKEQIKQHSQTIVNLEERLSQVTQYYRKIEGEIA ENSP00000365167/1-1453 LQQKMVKALQDEQESQRHGFEEEIMEYKEQIKQHAQTIVSLEEKLQKVTQHHKKIEGEIA ENSCPOP00000015129/1-814 LHQQMIKSLQDERESQKHGFEEEILEYKEQIKQHSQTIVSLEERLQKVTQHHKKLEEEIS XP_004851115.1/1-1401 LQQQAVKSLQDEQESQKHGFEEEIMQYKEQIKQHSQTIVSLEERLQKVTQHHKKMEGKIA *:*: :*:****:***:******* :********:****.***:* :***:::*:* :*: ENSMUSP00000101406/1-1420 TLKNNDTGPKEEASQDLTAGPPLDSGDKEIACDHLIDDLLMAQKEILSQQEIIMKLRTDL ENSRNOP00000018953/1-850 TLKDSDSAQKEEVPQEFTIVPSLDSSAKEIACDHLIDDLLMAQKEILSQQEIIMKLRTDL ENSP00000365167/1-1453 TLKDNDPAPKEERPQDPLVAPMTESSAKDMAYEHLIDDLLAAQKEILSQQEVIMKLRKDL ENSCPOP00000015129/1-814 TLKDTDPAQEEEPPPKPPATPSSDSNAKEMAYESLIDDLMAAQKEILSQQEIIMRLRQDL XP_004851115.1/1-1401 TLKDSDPAQKEELPVKPPAAPPSDSSAKEMACNHLIDDLLAAQREILSQQETIMRLRQDL ***:.*.. :** . . * :*. *::* : *****: **:******* **:** ** ENSMUSP00000101406/1-1420 GEAHSRMSDLRGELSEKQKMELERQVALVRQQSGELSMLKAKVAQTTGLMEKKDRELKVL ENSRNOP00000018953/1-850 GEAHTRMSDLRGELSEKQKTELERQVALVRQQNSELSILKAKVVQTTGLVEKKDRELKVL ENSP00000365167/1-1453 TEAHSRMSDLRGELNEKQKMELEQNVVLVQQQSKELSVLKEKMAQMSSLVEKKDRELKAL ENSCPOP00000015129/1-814 NEAHGQMTDLRGELSEKQKMELERQVALVQQQNGELNALKAKMSQMNSHVEKKDKELKAL XP_004851115.1/1-1401 NEAHGRMTDLRGELSENQKMELEQQVALVQQQSSELNSLKNKMVQMSSHMEKKDRELKAL *** :*:******.*:** ***::*.**:**. **. ** *: * .. :****:***.* ENSMUSP00000101406/1-1420 REALRASQEKPRPHLST--EQKPRTLSQKCDISLQIEPAHPDSFSSFQEEQSFSDLGVKC ENSRNOP00000018953/1-850 REALRASQEKPRPYLST--EQKPRNLSQKCDISLQIEPAHPDSFSSFQEEQFFSDLGAKC ENSP00000365167/1-1453 EEALRASQEKHRLQLNTEKEQKPRKKTQTCDTSVQIEPVHTEAFSSSQEQQSFSDLGVRC ENSCPOP00000015129/1-814 KEALRSSQEKHKHHPSSEKEQKLRATTQKCDISVQIDPGHLDISSSSPEEQSFSDLGAKC XP_004851115.1/1-1401 KEALRTSQEKHKLHPSPEKEQKPRTLTQKCDISVQIDPVYLDVSSSNQEEQSFSNLGARC .****:**** : .. *** * :*.** *:**:* : : ** *:* **:**.:* ENSMUSP00000101406/1-1420 KGSRHEETIQRQRKALSELRTRVRELEKANSCNHKDHVNESFLELRTLRMEKNVQKILLD ENSRNOP00000018953/1-850 KGSRHEEVIQRQKKALSELRTRIKELEKANSSNHKDHVNESFLELKTLRMEKNVQKILLD ENSP00000365167/1-1453 KGSRHEEVIQRQKKALSELRARIKELEKARSPDHKDHQNESFLDLKNLRMENNVQKILLD ENSCPOP00000015129/1-814 KGHRHEEVIQRQRKALSELRGRVKELEKANSCNPKDHLNESLLELKTLRMEKNAPKILLD XP_004851115.1/1-1401 RGCRHEEVIQRQRKALSELRLRIKELEKTSSQNPKDHLKESLLELRTLRMEKNVPKKLLD :* ****.****:******* *::****: * : *** :**:*:*:.****:*. * *** ENSMUSP00000101406/1-1420 AKPDLTTLARVEIRPPQNSPFNSGSTLVMEKSVKTDAGEALELSEKLYTDMIKTLGSLMN ENSRNOP00000018953/1-850 AKPDLTTFSRVEIRPPLNGPFSSGSPFAMEKSMKTDAAEALELSEKLYTDMIKTLGSLMN ENSP00000365167/1-1453 AKPDLPTLSRIEILAPQNGLCNARFGSAMEKSGKMDVAEALELSEKLYLDMSKTLGSLMN ENSCPOP00000015129/1-814 TKSGFPTLSRIEIQAPQNGLPSPGPSLASEKSGKADMAEALELSEKLYMDMSRTLGSLMN XP_004851115.1/1-1401 SKPNLPILSRIEIQPPRNGLTNSGSSSTMEKSGKTDMAEALELSEKLYMDMSQTLGSLMN :*..:. ::*:** .* *. .. . *** * * .********** ** :******* ENSMUSP00000101406/1-1420 IKDMSSHTSLKHLSPKEREKVNHLRQKDLDLVFDKITQLKTRLQRKEELLKGYEQELEQL ENSRNOP00000018953/1-850 IKDMSSHMSLKHLSPKERERVNHLRQKDLDLVFDKITQLKTRLQRKEELVRGYEWELEQL ENSP00000365167/1-1453 IKNMSGHVSMKYLSRQEREKVNQLRQRDLDLVFDKITQLKNQLGRKEELLRGYEKDVEQL ENSCPOP00000015129/1-814 IKDMSGYVSMKHLSPREREKVNLLRQRDLDLVFDKITQLKSRLQRKEELLRSYERDIEQL XP_004851115.1/1-1401 IKDMSGRMSMKHLSPKEREKVNQLRQRDLDLVFEKITQLKSRLKRKEELLQGYEQDIEQL **:**. *:*:** :***:** ***:******:******.:* *****::.** ::*** ENSMUSP00000101406/1-1420 RHSKVSVQMYQTQVAKLEDDVHKEAEEKALLKEALERTEQQLSQERRFNRVFKQQKDR-G ENSRNOP00000018953/1-850 RHSKVSVQMYQTQVAKLEDDIHKEAEEKALLKEALDRTEQQLSQEKRLNRAFKQQKDR-V ENSP00000365167/1-1453 RRSKVSIEMYQSQVAKLEDDIYKEAEEKALLKEALERMEHQLCQEKRINRAIRQQKMRKL ENSCPOP00000015129/1-814 RQSKVSVQLYQSQVAKLEDDIYKEAEEKALLKEALERTQRQLQQEKRLNRATRQQRER-L XP_004851115.1/1-1401 RQSKVSVQMYQSQVAKLEDDIYKQAEEKALLKEALERMEQQLQQEKSLNRATRQQK---- *:****:::**:********::*:***********:* ::** **: :**. :**: ENSMUSP00000101406/1-1420 EDPEQRNMS----YS-PFKDNEKQRRLFVEMVKSKMQNSSVQAGAK------KATLKTGQ ENSRNOP00000018953/1-850 EDQEQRNSS----CSCPFKENEKQRRIFVEMVKRKMQDSSLQAGAK------KATLKTGQ ENSP00000365167/1-1453 RLRELRGAQVHTAAG-------KDSWDLTPDPSDPGSPAVCRVGRKCRGARTEKRKRIDT ENSCPOP00000015129/1-814 EEHEQKTAKEWTPCNCSFKERERQRRMIAETVKGKVHSANFQVGVK------KATLKIDQ XP_004851115.1/1-1401 -----KNAKEWTSCNCSFKESERQRWVIVEMVKSKRQSADFQVSQK------EERNR--- : . . :: :. . : :.. * : : ENSMUSP00000101406/1-1420 ERETKKEAYKSTQSLSFVKPGGKN- ENSRNOP00000018953/1-850 ERETKKEACKPTQSLSFIKPGGKN- ENSP00000365167/1-1453 LQLCLQ---RERQAGPAPPACSLNG ENSCPOP00000015129/1-814 DKDTSS---KSSQSLIFTKPGGRN- XP_004851115.1/1-1401 -------------------------