CLUSTAL W(1.81) multiple sequence alignment ENSCPOP00000014824/1-1169 -------------VSGMSHEPKSPSLGMLSTATRTTATVNPLTPSPLNGALVPSGSPATS XP_004842799.1/1-1179 MLICICSPPPAAWNPGMSHEPKSPSLGMLSTATRTTATVNPLTPSPLNGALVPSGSPATS ENSP00000253458/1-1217 -------------MKGMSHEPKSPSLGMLSTATRTTATVNPLTPSPLNGALVPSGSPATS ENSMUSP00000034279/1-1223 ---MFGLKPPLYYLPGMSHEPKSPSIGMLSTATRTTATVNPLTPSPLNGALVPTGSPATS ENSRNOP00000023607/1-1213 -------------VSGMSHEPKSPSIGMLSTATRTTATVNPLTPSPLNGALVPTGSPATS **********:***************************:****** ENSCPOP00000014824/1-1169 SALSAPAAPSSSFAAALRKLARQAEEPRGSSLSSESSPVSSPATNHSSPASTPKRVPMGP XP_004842799.1/1-1179 STLSAQAAPSSSFAAALRKLAKQAEEPRGSSLSSESSPVSSPATNHSSPASTPKRVPMGP ENSP00000253458/1-1217 SALSAQAAPSSSFAAALRKLAKQAEEPRGSSLSSESSPVSSPATNHSSPASTPKRVPMGP ENSMUSP00000034279/1-1223 STLSAQAAPSSSFAAALRKLAKQAEEPRGSSLSSESSPVSSPATNHSSPASTPKRVPMGP ENSRNOP00000023607/1-1213 SALSAQAAPSSSFAAALRKLAKQAEEPRGSSLSSESSPVSSPATNHSSPASTPKRVPMGP *:*** ***************:************************************** ENSCPOP00000014824/1-1169 IIVPPGGHSVPSTPPVVTIAPTKTVNGVWRSESR-QDASSRGSGGGGRERLIMDPPLAQE XP_004842799.1/1-1179 IIVPPGGHSVPSTPPVVTIAPTKTVNGVWRSESRQQDAGSRGGSGSGRERLIVEPPLAQE ENSP00000253458/1-1217 IIVPPGGHSVPSTPPVVTIAPTKTVNGVWRSESR-QDAGSRSSSG-GRERLIVEPPLPQE ENSMUSP00000034279/1-1223 IIVPPGGHSVPSTPPVVTIAPTKTVNGVWRSESR-QDSGSRGSSS-GRERLLVEPPLAQE ENSRNOP00000023607/1-1213 IIVPPGGHSVPSTPPVVTIAPTKTVNGVWRSESR-QDSGSRGGSS-GRERLLVEPPLAQE ********************************** **:.**.... *****:::***.** ENSCPOP00000014824/1-1169 KAGAPAVPSHLLSTPYPFGLSPSSVMQDSRFPPLNLQRPVHHVVPPSTVTEDYLRSFRPY XP_004842799.1/1-1179 KAGGPAVPSHLLSTPYPFGLSPGSVMQDSRFPPLNLQRPVHHVLPPSTVTEDYLRSFRPY ENSP00000253458/1-1217 KAGGPAIPSHLLSTPYPFGLSPSSVVQDSRFPPLNLQRPVHHVVPPSTVTEDYLRSFRPY ENSMUSP00000034279/1-1223 KAAGPAIPSHLLSTPYPFGLSPGSVVQDSRFQPLNLQRPVHHVVPPSTVTEDYLRSFRPY ENSRNOP00000023607/1-1213 KAAGPAIPSHLLSTPYPFGLSPSSVVQDSRFQPLNLQRPVHHVVPPSTVTEDYLRSFRPY **..**:***************.**:***** ***********:**************** ENSCPOP00000014824/1-1169 HTAEDLRMPSLPPLGLDPATAAAYYHPSYLAPHPFPHPAFRMEDSYCLSALRSPFYPIPA XP_004842799.1/1-1179 HTAEDLRMSSLPPLGLDPATAAAYYHPSYLAPHPFPHPAFRMDDSYCLSALRSPFYPIPT ENSP00000253458/1-1217 HTTDDLRMSSLPPLGLDPATAAAYYHPSYLAPHPFPHPAFRMDDSYCLSALRSPFYPIPT ENSMUSP00000034279/1-1223 HTAEDLRMSSLPPLGLDPATAAAYYHPSYLAPHPFPHPAFRMDDSYCLSALRSPFYPIPT ENSRNOP00000023607/1-1213 HTAEDLRMSSLPPLGLDPATAAAYYHPSYLTPHPFPHPAFRMDDSYCLSALRSPFYPIPT **::****.*********************:***********:****************: ENSCPOP00000014824/1-1169 PGSLPPLHPSAMHLHLSGVRYPPELSHSSLAALHSERMSGLGAERLKGDSGCG------- XP_004842799.1/1-1179 PGSLPPLHPSAMHLHLSGVRYPPELSHSSLAALHSERLSGLSAERLQMDEELR----RER ENSP00000253458/1-1217 PGSLPPLHPSAMHLHLSGVRYPPELSHSSLAALHSERMSGLSAERLQMDEELRRERERER ENSMUSP00000034279/1-1223 PGSLPPLHPSAMHLHLSGVRYPPELSHSSLAALHSERMSSLSAERLQMDEELR--RERER ENSRNOP00000023607/1-1213 PGSLPPLHPSAMHLHLSGVRYPPELSHSSLAALHSERISSLSAERLQMDEELR--RERER *************************************:*.*.****: *. ENSCPOP00000014824/1-1169 ---YPRILGRTRWGGGEEPGRWGPVPPPPSPSPEGCRWKEL-------------LAAKAL XP_004842799.1/1-1179 EREREREADREREKEKE---RERERERERERELEREKERELERQREQR-------AAKVL ENSP00000253458/1-1217 EREREREADREREKERERE-REKEREQEKEREREKERERELERQREQRAREKELLAAKAL ENSMUSP00000034279/1-1223 EREREREADREREKEREREQREKEREKELEREREKERERELERQREQRAREKELLAAKAL ENSRNOP00000023607/1-1213 EREREREADREREKEREREQREKEREKELEREREKERERELERQREQRAREKELLAAKAL * .* * * * . . * : :** ***.* ENSCPOP00000014824/1-1169 EPA-FLPVAELHGLRGHPAEERG----KPSEQLTPTRAEKLKDAGLQAPKPVQHPLHPVP XP_004842799.1/1-1179 EPA-FLPVVEMHGLRGHTAEERERERVKPSEQLTPTRAEKLKDVGLQAPKPVQHPLHPVP ENSP00000253458/1-1217 EPS-FLPVAELHGLRGHATEERG----KPSEQLTPTRAEKLKDAGLQAPKPVQHPLHPVP ENSMUSP00000034279/1-1223 EPTTFLPVAELHGLRGHSTEERP----KPSEQLTPTRAEKLKDVGLQAPKPVQHPLHPVP ENSRNOP00000023607/1-1213 EPT-FLPVAELHGLRGHTTEERP----KPSEQLTPTRAEKLKDTGVQAPKPVQHPLHPVP **: ****.*:******.:*** ****************.*:************** ENSCPOP00000014824/1-1169 APHHSVPSLVSSHGVFSLPPSSAAAGLLLQRNHEEEKWLARQRRLRQEKEDRQSQVSEFR XP_004842799.1/1-1179 TSQHTIPSLISNHGVFSLPAGSAAASLLLQRTNEEEKWLARQRRLRQEKEDRQSQVSEFR ENSP00000253458/1-1217 TPHHTVPSLISNHGIFSLPSSSAATALLIQRTNEEEKWLARQRRLRQEKEDRQSQVSEFR ENSMUSP00000034279/1-1223 APHHTVPSLISSHGIFSLPGSSATTALLIQRTNEEEKWLARQRRLRQEKEDRQSQVSEFR ENSRNOP00000023607/1-1213 APHHTVPSLISSHGIFSLPGSSAATALLIQRTNEEEKWLARQRRLRQEKEDRQSQVSEFR :.:*::***:*.**:**** .**::.**:**.:*************************** ENSCPOP00000014824/1-1169 QQVLEQHLDLGRPRVPDARPASVPHAVRQGPTRLEQGSREAPQHFGGPPPLISPKPQHHT XP_004842799.1/1-1179 QQVLEQHLDISRPLVPTEAEHRPES-SRAGPTRLEQGSREAPPHFGGPPPLISPKPQHHT ENSP00000253458/1-1217 QQVLEQHLDMGRPPVPAEAEHRPESTTRPGPNRHEPGGRDPPQHFGGPPPLISPKPQLHA ENSMUSP00000034279/1-1223 QQVLEQHLDLGRPLVPTEAEHRPES-TRPGTNRHEQGSREPPQHFGGPPPLISPKPQQHT ENSRNOP00000023607/1-1213 QQVLEQHLDLGRPLVPTEAEHRPES-TRPGPNRHDQGSREPPQHFGGPPPLISPKPQHHT *********:.** ** * *..* : *.*:.* ************** *: ENSCPOP00000014824/1-1169 VPTALWNPVSLMDSALETRRPESHPLHGHTATFEPSRQAAVPLVKVERIYCPEKAEE-PR XP_004842799.1/1-1179 VPTALWNPVSLMDNTLETRRAESHTLHSHPVAFEPSRQAAVPLVKVERVYCPEKTEE-PR ENSP00000253458/1-1217 APTALWNPVSLMDNTLETRRAESHSLHSHPAAFEPSRQAAVPLVKVERVFCPEKAEEGPR ENSMUSP00000034279/1-1223 VPTALWNPVSLMDNALETRRAESHSLHSHPTAFEPSRQAAVPLVKVERVYCSEKAEE-PR ENSRNOP00000023607/1-1213 VPTALWNPVSLMDNTLETRRAESHSLHSHPTAFEPSRQAAVPLVKVERVYCTEKAEE-PR .************.:*****.***.**.*..:****************::*.**:** ** ENSCPOP00000014824/1-1169 KREAAPLDKYQ-------PPAREAGGLEPAVFPHGPGPFLAELEKSTQSLLGQQRASLPQ XP_004842799.1/1-1179 NREANPLDKYQ-------PPPREAGSLEPQAFPHGPGPFLAELEKSAQTLLGQQRVSLPP ENSP00000253458/1-1217 KREPAPLDKYQ----PPPPPPREGGSLEHQPFLPGPGPFLAELEKSTQTILGQQRASLPQ ENSMUSP00000034279/1-1223 KREATPLDKYQ--PPPPPPPPREAGSLEPQTFPHGPGPFLTELEKSTQTILGQQRPSLSQ ENSRNOP00000023607/1-1213 KREATPLDKYQPPPPPPPPPPREAGGLEPQTFPHGPGPFLAELEKSTQTILGQQRPSLSQ :**. ****** **.**.*.** * ******:*****:*::***** **. ENSCPOP00000014824/1-1169 AASFGELSVPVKPGSPYRHPAPRGPDPAYIYDEVLQQRRRLVSKLDLEERRRREAQEKGY XP_004842799.1/1-1179 AASFGELSGPLKPGSPYRHPAPRGPDPAYIYDEVLQQRRRLVSKLDLEERRRREAQEKGY ENSP00000253458/1-1217 AATFGELSGPLKPGSPYRPPVPRAPDPAYIYDEFLQQRRRLVSKLDLEERRRREAQEKGY ENSMUSP00000034279/1-1223 ATSFGELSGPLKPGSPYCHPTARGPDPAYIYDEFLQQRRKLVSKLDLEERRRREAQEKGY ENSRNOP00000023607/1-1213 TTPFGELTGSLKSGSPYCHTTARGPDPAYIYDEFLQQRRRLVSKLDLEERRRREAQEKGY ::.****: .:*.**** ...*.*********.*****:******************** ENSCPOP00000014824/1-1169 YYDLDDSYDESDEEEVRAHLRCVAEQPPLKLDTSSEKLEFLQLFGLTTQQQKEELVAQKR XP_004842799.1/1-1179 YYDLDDSYDESDEEEVRAHLRCVAEQPPLKLDTSSEKLEFLQLFGLTTQQQKEELVAQKR ENSP00000253458/1-1217 YYDLDDSYDESDEEEVRAHLRCVAEQPPLKLDTSSEKLEFLQLFGLTTQQQKEELVAQKR ENSMUSP00000034279/1-1223 YYDLDDSYDESDEEEVRAHLRCVAEQPPLKLDTSSEKLEFLQLFGLTTQQQKEELVAQKR ENSRNOP00000023607/1-1213 YYDLDDSYDESDEEEVRAHLRCVAEQPPLKLDTSSEKLEFLQLFGLTTQQQKEELVAQKR ************************************************************ ENSCPOP00000014824/1-1169 RKRRRMLKERSPSPPAVQSKRQAPSPRLALSTRYSPDDMNNSPNFEEKRRFLTIFNLTHI XP_004842799.1/1-1179 RKRRRMLKERSPSPPAVQSKRQMPSPRLALSTRYSPDEMNNSPNFEEKRKFLTIFNLTHI ENSP00000253458/1-1217 RKRRRMLRERSPSPPTIQSKRQTPSPRLALSTRYSPDEMNNSPNFEEKKKFLTIFNLTHI ENSMUSP00000034279/1-1223 RKRRRMLRERSPSPPAVQCKRQTPSPRLALSTRYSPDEMNNSPNFEEKRKFLTFFNLTHI ENSRNOP00000023607/1-1213 RKRRRMLRERSPSPPAIQCKRQTPSPRLALSTRYSPDEMNNSPNFEEKRKFLTFFNLTHI *******:*******::*.*** **************:**********::***:****** ENSCPOP00000014824/1-1169 SAEKRKDNERLVEMLRATKQRTLSAALPDAS-ANAPGDSPAVALSDAATQPASLETEKPI XP_004842799.1/1-1179 TAEKRK---------------------------------------EPATQPASVETDKPV ENSP00000253458/1-1217 SAEKRKDKERLVEMLRAMKQKALSAAVADSL-TNSPRDSPAVSLSEPATQQASLDVEKPV ENSMUSP00000034279/1-1223 SAEKRKDKERLVEMLRAMKQRALSAA--DSV-TNSSRDSPPVSLSEPATQPAPLETDQPV ENSRNOP00000023607/1-1213 SAEKRKDKERLVEMLRAMKQRALSAAVADSVATNSSRDSPTISLSEPATQPAPLETDQPA :***** :.*** *.::.::* ENSCPOP00000014824/1-1169 GIAASLSDVPKAMETGRLDPLRPRELSRAQEPAPSSGEKARLSEAPGSKKSLSMLHSIRG XP_004842799.1/1-1179 GIAASLSDVPKAVETGRLEPLRPQELSRAQEPAPTSGEKARLSEAPGGKKSLSMLHYIRG ENSP00000253458/1-1217 GVAASLSDIPKAAEPGKLEQVRPQELSRVQELAPASGEKARLSEAPGGKKSLSMLHYIRG ENSMUSP00000034279/1-1223 GVPASLSDVPKTTETGRLEQLRPQELLRVQEPAPPSGEKARLSEAPGGKKSLSMLHYLRG ENSRNOP00000023607/1-1213 GVPASLSDVPKAVETGRLEQLRPQELLRVQEPAPPSGEKARLSEAPGGKKNLSMLHYLRG *:.*****:**: *.*:*: :**:** *.** **.************.**.***** :** ENSCPOP00000014824/1-1169 SAPKDTPVPLSHSINGKSKPWEPFVAEEFAHQFHESVLQSTQKALQKHKGSVAMLSAEQN XP_004842799.1/1-1179 SAPKDIPVPLSHSVNGKSKSWEPFMAEEFAHQFHESVLQSTQKALQKHKGSVAVLSAEQN ENSP00000253458/1-1217 AAPKDIPVPLSHSTNGKSKPWEPFVAEEFAHQFHESVLQSTQKALQKHKGSVAVLSAEQN ENSMUSP00000034279/1-1223 AAPKDIPVPLSHSINGKSKPWEPFVAEEFAHQFHESVLQSTQKALQKHKGNSALLSAEQS ENSRNOP00000023607/1-1213 AAPKDIPVPLSHSINGKSKPWEPFMAEEFAHQFHESVLQSTQKALQKHKGSSALLSAEQN :**** ******* *****.****:*************************. *:*****. ENSCPOP00000014824/1-1169 HKVDASVHYNIPELQSSSRVPLPQHNGQQEPLAGRKGPLT-------------------- XP_004842799.1/1-1179 HKVDTSVHYNIPELQSSSRVPLPQHNGQQEPLARRKGLHTQEMDQDSEDDNEEDDSE-EE ENSP00000253458/1-1217 HKVDTSVHYNIPELQSSSRAPPPQHNGQQEPPTARKGPPTQELDRDSEEEEEEDDEDGED ENSMUSP00000034279/1-1223 HKVDTAIHYNIPELQSSSRVPLPQHNGQQEPPMGRKGPPMQEADQDSEEDSEEDSE--EE ENSRNOP00000023607/1-1213 HKVDTSVHYNIPELQSSSRVPLPQHNGQQEPPAGRKGPPMQEVDQDSEDDSE------EE ****:::************.* ********* *** ENSCPOP00000014824/1-1169 ---VPRRKWQGIEAIFEAYQEHVEEQNLERQVLQTQCRRLEAQHYSLSLTAEQLSHSMAE XP_004842799.1/1-1179 DEEAPRRKWQGIEAIFEAYQEHIEEQNLERQVLQTQCRRLEAQHYSLSLTAEQLSHSMAE ENSP00000253458/1-1217 EEEVPKRKWQGIEAVFEAYQEHIEEQNLERQVLQTQCRRLEARHYSLSLTAEQLSHSVAE ENSMUSP00000034279/1-1223 AEEAPRRQWQGIEAIFEAYQEHIEEQNLERQVLQTQCRRLEAQNYSLSLTAEQLSHSMAE ENSRNOP00000023607/1-1213 AEEAPRHQWQGIEAIFEAYQEHIEEQNLERQVLQTQCRRLEAQNYSLSLTAEQLSHSMAE .*:::******:*******:*******************::*************:** ENSCPOP00000014824/1-1169 LRSQKQKIVSERERLQAELDHLRKCLALPAMHWPRGYFKGYPR XP_004842799.1/1-1179 LRSQKQKIVSERERLQAELDHLRKCLALPAMHWPRGYFKGYPR ENSP00000253458/1-1217 LRSQKQKMVSERERLQAELDHLRKCLALPAMHWPRGYLKGYPR ENSMUSP00000034279/1-1223 LRSQKQKMVSERERLQAELDHLRKCLALPTMHWPRGYFKGYPR ENSRNOP00000023607/1-1213 LRSQKQKMVSERERLQAELDHLRKCLALPTMHWPRGYFKGYPR *******:*********************:*******:*****