CLUSTAL W(1.81) multiple sequence alignment ENSMUSP00000049054/1-1089 MEPAEEPGQISKDNFLEVPNLSDSVCEDEEVKATFKPGFSPQPSRRGSGSSEDMYLDTPT ENSRNOP00000060363/1-1096 MEPAEVPGQISKDNFLEVPNLSDSVCEDEEVKATFKPGFSPQPSRRGSESSEDLYLDTPT ENSP00000284601/1-1122 MEPSEVPSQISKDNFLEVPNLSDSLCEDEEV--TFQPGFSPQPSRRGSDSSEDIYLDTPS ENSCPOP00000014797/1-1097 MEPAEVPSPFSKENFLEIPNLSDSPCEDEEVKSNFKPGFSPQPSRRCSESSEDMYLDTPT XP_004865330.1/1-1114 MEPAEVPSQISKDNFLGVPNLSDSSCEDEDVKTAFKPGFSPQPSRRSSESPEDVYLDTPT ***:* *. :**:*** :****** ****:* *:********** * *.**:*****: ENSMUSP00000049054/1-1089 SASRRVSFADSLGFSLVSVKEFDCWELPSVSTDFDLSGDVFHTDEYVLSPLFDLPSSKEK ENSRNOP00000060363/1-1096 SASRRVSFADSLGFSLVSVKEFDCWDLPSVSTDFDLTRDVLHTDEYILSPLFDLPSSKEE ENSP00000284601/1-1122 SGTRRVSFADSFGFNLVSVKEFDCWELPSASTTFDLGTDIFHTEEYVLAPLFDLPSSKED ENSCPOP00000014797/1-1097 SGTRRVSFADNFGFNLVSIKEFDSWELPSVSTDFELRKDIFHTEEYILSPLFDLPSSKED XP_004865330.1/1-1114 SETRRVSFADSFGFNLVSIKEFDSWELPSVSTDFELRKDIFHTEEYILSPLFDLPSSK-D * :*******.:**.***:****.*:***.** *:* *::**:**:*:********* . ENSMUSP00000049054/1-1089 LMEQLQVQKAVLESAEHLPGS-SMKGIIRVLNISFEKLVYVRMSLDDWQTHYDILAEYVP ENSRNOP00000060363/1-1096 LMEQLQVQKAVLESAEHLPGSTSVKGIIRVLNISFEKLVYVRMSLDDWQTHYDILAEYVP ENSP00000284601/1-1122 LMQQLQIQKAILESTESLLGSTSIKGIIRVLNVSFEKLVYVRMSLDDWQTHYDILAEYVP ENSCPOP00000014797/1-1097 LMQQLHVRKAILESTEYPPGSTSMKGIIRVLNVSFEKLVYVRMSLDDWQTYYDILAEYVP XP_004865330.1/1-1114 LMQQLQIRKAILESTEYPPGSTCMKGIIRVLNVSFEKLVYVRMSLDDWQTYYDILAEYVP **:**:::**:***:* ** .:********:*****************:********* ENSMUSP00000049054/1-1089 NSCDGETDQFSFKISLVPPYQKEGGKVEFCIRYETSAGTFWSNNNGTNYILVCQKKRKEP ENSRNOP00000060363/1-1096 NSCDGETDQFSFKISLVPPYQMDGGKVEFCIRYETSVGTFWSNNNGTNYILVCQKKTKEP ENSP00000284601/1-1122 NSCDGETDQFSFKIVLVPPYQKDGSKVEFCIRYETSVGTFWSNNNGTNYTFICQKKEQEP ENSCPOP00000014797/1-1097 NSCDGETDQFSFKITLVPPYQKDGSKVEFCIRYETSVGTFWSNNNGTNYILLCQKKQQEP XP_004865330.1/1-1114 NSCDGETDQFSFKISLVPPYQKDGSKVEFCIRYETSMGTFWSNNNGTNYILLCQKKEQQP ************** ****** :*.*********** ************ ::**** ::* ENSMUSP00000049054/1-1089 EP-VKPLEEAPSRQIKGCLKVKSRSKEEPLLAP-EENKFETLKFTESYIPTIICSHEDKD ENSRNOP00000060363/1-1096 EPVVKPLEEGPSRQIKGCLKVKSSSKEEPLLTP-EENKLGTLKFTESYIPTIICSHEDRD ENSP00000284601/1-1122 EP-VKPWKEVPNRQIKGCLKVK-SSKEESSVTS-EENNFENPKNTDTYIPTIICSHEDKE ENSCPOP00000014797/1-1097 EP-EKPQEEVSGRLLKGKIKIKNSSKEKPTITPSEENNFEESKFKDTDIPTIVCSHEDKK XP_004865330.1/1-1114 VP-EKPQEEVSSTQKKGCLKVK-SSKEESSITS-EENNFRESKFTDTDIPTIICFHEDEE * ** :* .. ** :*:* ***:. ::. ***:: * .:: ****:* ***.. ENSMUSP00000049054/1-1089 DLGANHPNVDDINKKHDEHNGKELDLM---INQRLI-----TSQDEKNTFATDTVNFTNK ENSRNOP00000060363/1-1096 DLGANYQHVKDIDKKHDEHNEKELDLM---INQRLI-----TSHDEKNTFSTDAVNSTNK ENSP00000284601/1-1122 DLEASNRNVKDVNREHDEHNEKELELM---INQHLIRTRSTASRDERNTFSTDPVNFPNK ENSCPOP00000014797/1-1097 DVEAGNQNVKDINKQTTEYNERPLLFLSHKINQHLIRTRSTASRDEKETLSSDPVNFPNK XP_004865330.1/1-1114 DLESSNQNVKDVNSEQDEHNEKELDLM---INQHLIRTRSAASRDEKDTFSSDPVNFPNK *: :. :*.*:: : *:* : * :: ***:** :*:**::*:::*.** .** ENSMUSP00000049054/1-1089 AEGSEKKQAYHEINTDLFMGPLSPSLSAESSLKRDFYHSRSSSPGNEYGHPHSEEIISDM ENSRNOP00000060363/1-1096 AEGSEKKQARHEIHTDLCRGPLSPSLSAESSLKRDFYHSRNYSPGNEHGHPPSEEIISDV ENSP00000284601/1-1122 AEGLEKKQIHGEICTDLFQRSLSPSSSAESSVKGDFYCNEKYSSGDDCTHQPSEETTSNM ENSCPOP00000014797/1-1097 AERLEKK-THGELCTDLLESPLSPSSLEESSLKGGSYDDEKYSSRNEHSHQ--------- XP_004865330.1/1-1114 AEGLEKKKIHGKLRTDLFERPLSPNSSVENSLKGDFYHNDKYSSRNECSHQLSEEIISEM ** *** :: *** .***. *.*:* . * . . *. :: * ENSMUSP00000049054/1-1089 GEKGPSLGDTSSDELMQLELCSKEDLDDNANPANGSGRV---CSSFDQRMACGL-KNNEA ENSRNOP00000060363/1-1096 GAIGSPLGDTSSDELMQLKVCSKEDVDDNANPAHGSGRL---CSSSDQLRAGGL-ENNEA ENSP00000284601/1-1122 GEIKPSLGDTSSDELVQLHTGSKEVLDDNANPAHGNGTVQIPCPSSDQLMAGNLNKKHEG ENSCPOP00000014797/1-1097 ------LSDTSSDESVQVHIDSKEVLDDNANPAHMSVRVKISCSSPDQQIEGDLNESHEG XP_004865330.1/1-1114 REIKPSLKDTSSDELVQLHIDSKEVLDDNGNLGHRSCRVKVSWFSPAQQMASDLNKKHEG * ****** :*:. *** :***.* .: . : * * .* :.:*. ENSMUSP00000049054/1-1089 GIKKTGIQDYKYSHGD-----STKLEES--NASSRDD-YAKVDNKKEKQTCLGVNENPSK ENSRNOP00000060363/1-1096 GIKKTGIKDYKYSHGDSYLEASTSLRES--NASYKDE-YDKVDDKREKKTCLGVNENPGK ENSP00000284601/1-1122 GAKNIEVKDLGCLRRDFHSDTSACLKESTEEGSSKEDYYGNGKDDEEQRIYLGVNEKQRK ENSCPOP00000014797/1-1097 GDKKSEIKDWECLRKDFHASSCAYAEQPSKNGSLKED-YSKIKDEKEQRGHLSVNKKQSK XP_004865330.1/1-1114 GGKKSKIKDWEGLSKDFHSGSCACTERSTDNRSLKED-YGKVKDEKEQSVHLGVNKKQSK * *: ::* * .: ... : * ::: * : .:..*: *.**:: * ENSMUSP00000049054/1-1089 NFQSVFQTQEGHMGYPKISTEGDKANNQDLTSLLSKDITANTWAVTVDPCPSTNAKRSWR ENSRNOP00000060363/1-1096 NFQSIFQNQERQMGCAKISGEGANANNQDLTTLLSKDTTTNTWAVTVDPSPSTNTNVNWR ENSP00000284601/1-1122 NFQTILHDQERKMGNPKISVAGIGASNRDLATLLSEHTAIPTRAITADVSHSPRTNLSWE ENSCPOP00000014797/1-1097 NFHSSLYDQERKLGHSEISVEGTETRKTGSTALSSKDASVPGQAITVGMFPSSWTNLNWE XP_004865330.1/1-1114 NFQLSLHDQERKSGHSEISLEGTEARKKDLPALSCKDATIPAQAIAV-MFPSTRTNLNWE **: : ** : * .:** * : : . .:* .:. : *::. *. :: .*. ENSMUSP00000049054/1-1089 EV-----------GSGSNLEPGTSDLSSPRNFSPLTDDHLFQADRENSDSSNPENQNMNT ENSRNOP00000060363/1-1096 EA-----------GNGTDLERRTTDLGSPRNFSLLTDGYLFQADREKSDSSNSEDRNMNP ENSP00000284601/1-1122 EAVL-TPEHHHLTSEGSALGGITGQVCSSRTGNVLRNDYLFQVE-EKSGGINSEDQDNSP ENSCPOP00000014797/1-1097 ETTLMAPESGHSTGKGTVSEGVTREVSSSKNRNILRDDYLFQTEGEKSDWINPEDWSKKS XP_004865330.1/1-1114 ETTLTTSESDHPAGEGMTSEGITSKVCLSRKRNVLRDDYVFQAEEEKSDWINPEDRGRNT *. ..* * .: .:. . * :.::**.: *:*. *.*: . .. ENSMUSP00000049054/1-1089 RHRKKWNVLETQSETSETESDIAKHTKEQAEYKDMWEKTDNSRNLKATPTEHLFTCRETE ENSRNOP00000060363/1-1096 QHKKNWNVLESQPETRETETNITKHTKEQAEYKDTWGKRDNSRNLKATSTEQLFTCQETE ENSP00000284601/1-1122 QHKQSWNVLESQGKSRENKTNITEHIKGQTDCEDVWGKRDNTRSLKAT-TEELFTCQETV ENSCPOP00000014797/1-1097 QHRQNWNILQSQGEIKGNTTNKTEQIREQAACKDMWEKGETT-SLNVTPTRELFTCQETE XP_004865330.1/1-1114 QHTENWNILERQEKVKGNKTNISEQIKEQADCKDMWGERDNT-SLNVTPTEELFTCQKTE :* :.**:*: * : . :: ::: : *: :* * : :.: .*:.* *..****::* ENSMUSP00000049054/1-1089 CYGLSSLADHGITEKAQAVTAYIIKTTLESTPESASARGKAIIAKLPQETAGNDRPIEVK ENSRNOP00000060363/1-1096 CCELSSLADHGITEKAQAVAAYIIKTTLESTPESASARGKAIIAKLPQETARHDRPIEVK ENSP00000284601/1-1122 CCELSSLADHGITEKAEAGTAYIIKTTSESTPESMSAREKAIIAKLPQETARSDRPIEVK ENSCPOP00000014797/1-1097 CDELYSPADHGVTEKAQAGAAYIIKTTSESTPESMSAREKAIIAKLPQETARSDRLIEVK XP_004865330.1/1-1114 CDELYSLADHGVTEKAQAGTAYIIKTTSESTPESMSAREKAIIAKLPQETARSDRPIEVK * * * ****:****:* :******* ****** *** ************ ** **** ENSMUSP00000049054/1-1089 ETAFDPHEGRKDDSHYSLCHGDTAGVIHDNDFERESHLDICNLRVDEMKKEKTTSTCFPQ ENSRNOP00000060363/1-1096 ETAFDPHEGRKDDSHYSLCHGDTAGVIHDNDFERESHLDICNVRVDEMEKEKTTSTCSPR ENSP00000284601/1-1122 ETAFDPHEGRNDDSHYTLCQRDTVGVIYDNDFEKESRLGICNVRVDEMEKEETMSMYNPR ENSCPOP00000014797/1-1097 ETAFDPHEGRNDDSHYTFCQRDAAVVIYDNEFERESHSNICNVRTDKTEKEESMHMYTPG XP_004865330.1/1-1114 ETAFDPHEGKNDDAHYTLCQRDTAGVIYDNEFEKESHADICIVRADETEKEETMHMYNPG *********::**:**::*: *:. **:**:**:**: .** :*.*: :**:: * ENSMUSP00000049054/1-1089 KTYDKEKHGIGSVTSIDEPSQVITGNQKATSKLDLHLGVLPTDRAIFQANADLELLQELS ENSRNOP00000060363/1-1096 KTYDKEKHGIGSVTSIDEPSQVITGNQKATSKLDLHLGVLPTDRAILSANADLELLQELS ENSP00000284601/1-1122 KTHDREKCGTGNITSVEESSWVITEYQKATSKLDLQLGMLPTDKTVFSENRDLRQVQELS ENSCPOP00000014797/1-1097 ETHDREKQGAGNITSVEGSSQVITSSQKGSSNLDLHLEVLSTNKRIFSENSNLGHVQTLS XP_004865330.1/1-1114 KMQDREKHGVGNIISVEESSQVITNNQKATSNLDLHLEVLSTDKRIFAENSDLGQVQNLS : *:** * *.: *:: .* *** **.:*:***:* :*.*:: :: * :* :* ** ENSMUSP00000049054/1-1089 RRTDFNA-VPSAFNSDTASASRDSSQVYRHCSKKSVPSYGE----EKAVTNTTLQSIPTK ENSRNOP00000060363/1-1096 RRTDFNA-VHSAFNSDPGSASQDSSQVYRRCSKKPVPSYGE----QKAVINTTLQSVPTK ENSP00000284601/1-1122 KKTDSDAIVHSAFNSDTNRAPQNSSPFSKHHTEISVSTNEQAIAVENAVTTMASQPISTK ENSCPOP00000014797/1-1097 KKTDLETVVHSAFNSGTNRASQNGSSISNHHLKTSVASYEQ--AVENTIVTTNLQSTSTE XP_004865330.1/1-1114 KKTDLEVAVLSASNSDTNRASQTDCHISSHHPKTSVPSYEQ--AGENTITTTHLQSISTE ::** :. * ** **.. *.: .. . : : .*.: : :::: . *. .*: ENSMUSP00000049054/1-1089 SEYNWHPESEVLG-----HAMSKPEDVFKSSEIMKSGSGGERGGGPILQQKEGSLENSQG ENSRNOP00000060363/1-1096 SEYNCHPESEIFG-----HATSKPEVVFKSSEIIKSGSGGEQGVGPILQQKEGSLEKSQD ENSP00000284601/1-1122 SENICNSTREIQGIEKHPYPESKPEEVSRSSGIVTSGSRKERCIGQIFQTEEYSVEKSLG ENSCPOP00000014797/1-1097 SEDNYNP----RD-----HLGSKLKESFTGSG-NSSG-----CMGHVFQTEESSVEKSVE XP_004865330.1/1-1114 SGDNCNP-GEIQG-----HLGSKPKKASTNSE-SSSGCRKERCMGQIFQPGECSVEKSVG * :. . : ** : .* .** * ::* * *:*:* ENSMUSP00000049054/1-1089 PMFFTNEPLENLDEASSENEGLMHSGQSQCYLGDKGLVSSASATVSTQELEAQGRESLLS ENSRNOP00000060363/1-1096 PMISINEPLENLDEVRSENEGLMRSGQLQCYLGDKGSVSSASATVPTQELQAQGSESLLS ENSP00000284601/1-1122 PMILINKPLENMEEARHENEGLVSSGQSLYTSGEKESDSSASTSLPVEESQAQGNESLFS ENSCPOP00000014797/1-1097 PMILTSEPLENTKGARNEKQELFSSGLSQYSSGDRRSESSTSVGFPVQESEIQSSESLFS XP_004865330.1/1-1114 PMILINEPLENMEEARHDNEGLLSSGQSQYSSGDNTSENYASASFPDHESEAQSHESLLL **: .:**** . . ::: *. ** *:. . :*. .. .* : *. ***: ENSMUSP00000049054/1-1089 ISTNSKIPYFLLFLIFLATVYYYDLMIGLAFYLFSLYWLYWEGGRQRESVKKK ENSRNOP00000060363/1-1096 ISINSKIPYFLLFLIFLATVYYYDLMIGLAFYLFSLYWLYWEGGRQRESVKKK ENSP00000284601/1-1122 KYTNSKIPYFLLFLIFLITVYHYDLMIGLTFYVLSLSWLSWEEGRQKESVKKK ENSCPOP00000014797/1-1097 KYANSRIPYFLLFLIFLVTVYQYDLMIGLAFYLFSLYWLYWEEGRQKESVKKK XP_004865330.1/1-1114 KYANSKIPYFLLFLVFLVTIYQYDLMIGLAFYLFSLYWLYREGGRQKESAKKK **:********:** *:* *******:**::** ** * ***:**.***