CLUSTAL W(1.81) multiple sequence alignment ENSP00000396160/1-1045 MEAKVRPSRRSRAQRDRGRRREAARDARAQSPSSGDEPEPSPGKENAGLRGAPPRGAAPA ENSMUSP00000063879/1-1031 MEAKVRPSRRSRAQRDRGRRREAARDARAQSPSSGEEPEPSPGKENAGLHGAPPQRPTPL ENSRNOP00000049044/1-1033 MEAKVRPSRRSRAQRDRGRRREAARDARAQSPSSGEEPEPSPGKENAGLHGAPPQRPTPL ENSCPOP00000014781/1-737 ------------------------------------------------------------ XP_004844163.1/1-794 ------------------------------------------------------------ ENSP00000396160/1-1045 PRTARPPRRRRRESSSQEEEVIDGFAIASFSTLEALEKDMALKPHERKEKWERRLIKKPR ENSMUSP00000063879/1-1031 -RAARPPRRRRRESSSQEEEVIDGFAIASFSTLEALEKDMALKPHERKEKWDQRLVKKPR ENSRNOP00000049044/1-1033 -RAARPPRRRRRESSSQEEEVIDGFAIASFSTLEALEKDMALKPHERKEKWDQRLVKKPR ENSCPOP00000014781/1-737 -------------MEAKEEEVIDGFAIASFSTLEALEKDMALKPHERKEKWERRLIKKPR XP_004844163.1/1-794 ---------------------------------------MALKPHERKEKWERRL-KKPR ************::** **** ENSP00000396160/1-1045 ESETCPPAEPSENRRPLEAGSPGQDLEPACD-GARKVPLQPSKQMKVTVSKGGDRDSDDD ENSMUSP00000063879/1-1031 ESENCPSAELSENRQPLEVGSPGQDAEPSCDEGTRKVPLQPSKQMKVTMARGGDRNSDDD ENSRNOP00000049044/1-1033 ESENCPSAELSENRQPLEVGSPTCDTEPTCDEGTRKVPLQPSKQMKVTMARGGDRNSDDD ENSCPOP00000014781/1-737 ETENCPSSEPSVSRQPLEASSPGQDVEPTCDGGARKVPLQPSKQMKVTMSREADQNSDDD XP_004844163.1/1-794 ESENCPSSEPSVSRQPLEAGSPGQDLEPACDGGARKVPLQPSKQMKVAKSRGG-QNSDDD *:*.**.:* * .*:***..** * **:** *:*************: :: . ::**** ENSP00000396160/1-1045 SVLEA-----TSSRDPLSDSSAHAVSGRGYSCDSESGPDDKASVGSEKLFAPGTDKGPA- ENSMUSP00000063879/1-1031 SVLEASSSQRSSSREQLSDSSAQAVSGRGYSCDSESGVDDKASVGSEKLFAPAPDKGSGR ENSRNOP00000049044/1-1033 SVLEASSSQHSSSRDQLSDSSAQAVSGRGYSCDSESGMDDKASVGSEKLFAPAPDKGSGR ENSCPOP00000014781/1-737 SVLEATSSCRSRSQDQLSDSSAQAVSGKGYSCDSESGMDDKASVGSELLFAPAADTGATP XP_004844163.1/1-794 SVLEA-----TSSRDQLSDSSAQAVSGRGYSCDSESGVDDKASVGSEQLFAPAADTGCVQ ***** : *:: ******:****:********* ********* ****..*.* ENSP00000396160/1-1045 LEKSEAKAGPVPKVSGLERSRELSAESFLPTASPAPHAAPCPGPPPGSRANPLVKKEPPA ENSMUSP00000063879/1-1031 GEKSEAKAGAVPKVSGLERSSELSTEAFLPATAPAP-----SGPAPGTPASPLVKREAPV ENSRNOP00000049044/1-1033 GEKSEAKAGAVPKVSGLERSSELSTESFLPATAPTP-----SGPLPGARASPLVKREAPI ENSCPOP00000014781/1-737 GEGLEAKTGAAPKVSGLERSRELSTEPFLPAGTL-------PTAPPGACTIPLLRTEPGL XP_004844163.1/1-794 VQRSEARSGAVPKVSGLERSRELSSEPFLPA------------APPGARTSPRLKTEAVL : **::*..********* ***:*.***: . **: : * :: *. ENSP00000396160/1-1045 PHRHTPQP--PPPQPRGLLPTHVPASLGAFA----GHSQAAA-NGLH--GLSRSSSA--- ENSMUSP00000063879/1-1031 VPHHVPQPQLT-PQHRGSLPTHVPLSLGAFVGPGPGPGQVAS-SSLHLHSLSRSSSTVSG ENSRNOP00000049044/1-1033 VPHHVPQPQLT-PQHRGSLPTHVPLSLGAFVGPGPGPGQVAS-NSLHLHSLSRSSSTVSG ENSCPOP00000014781/1-737 CHA--PPLTVPLPTQTTQTQTRESAPLGAFA----GPGQTAPTTGLHLPCL-RSSIASSS XP_004844163.1/1-794 RHAAHPQPRGPLPTPTA--QTQEPAPLGTFA----GPSQAAP-SGLHLPGLSRTSSASSG * . * *: . .**:*. * .*.*. ..** * *:* : ENSP00000396160/1-1045 -PLGLGKHVSLSPHGPGPHLSTSHLALRSQAQHQLH-AAMFAAPPTLPPPPALPASSLVL ENSMUSP00000063879/1-1031 TPLGLAKHVTLSPHGPGPHLSTSHLALRSQAQHQHHAAAMFAAPPTLPPPPALPASSLVI ENSRNOP00000049044/1-1033 TPLGLAKHVTLSPHGPGPHLSTSHLALRSQAQHQHHAAAMFAAPPTLPPPPALPASSLVI ENSCPOP00000014781/1-737 TSLGLGKHGSLSLSGPSPHLSTSHLALRGQVHQ--HPATMFAT-PTLPPASALP-GSLVV XP_004844163.1/1-794 APLGLGKHGSLSQPGPGPHFSTSHLALSAQAHQ--HPAAMFAA-PTLPPGPALP-SGLVI .***.** :** **.**:******* .*.:: * *:***: ***** .*** ..**: ENSP00000396160/1-1045 PGHPA------------------------------------------------------- ENSMUSP00000063879/1-1031 PGHPADASLLISFNQPIMYCQPHSGIL--------------------------------- ENSRNOP00000049044/1-1033 PGHPTDASLLISFNQPIMYCQPHSGIL--------------------------------- ENSCPOP00000014781/1-737 PGHPA------------------------------------------------------- XP_004844163.1/1-794 PGHPADASLLLSLSQPIMYCQPHSGILIGTCHRLLSSLHPPGRPWASGPCSLALRSRECQ ****: ENSP00000396160/1-1045 ------------------------DHELLRQELNTRFLVQSAERPGASLGPGALLRAEFH ENSMUSP00000063879/1-1031 -----------------------IDHELLRQELNTRFLVQNAERPGASLGPGALLRAEF- ENSRNOP00000049044/1-1033 -----------------------IDHELLRQELNTRFLVQNAERPGASLGPGALLRAEF- ENSCPOP00000014781/1-737 -----------------------VDQELLRQELNTRFLVQST----------ALLRAEF- XP_004844163.1/1-794 VTICLAPREPMADVPLCLSLFSLIDQELLRQELNTRFLVQSAERPGAPLGPGALLRAEF- *:**************.: ******* ENSP00000396160/1-1045 QHQHTHQHTHQHTHQHQHTFAPFPAGLPPT---PPAAPPPFDKYAPKLDSPYFRHSSVSF ENSMUSP00000063879/1-1031 -HQHTHQHTHQHTHQHQHTFAPFA-GLPPTPLMPPTAPSPFDKFSPKLDSPYFRHSNTSN ENSRNOP00000049044/1-1033 -HQHTHQHTHQHTHQHQHTFAPFA-GLPPTPLMPPTAPSPFDKFSPKLDSPYFRHSNTSN ENSCPOP00000014781/1-737 --------------------APFP-GLPPAPLVPPAAPPPFDKFSAKLDSPYFRHSNVSL XP_004844163.1/1-794 -----HQHTHQHTHQHTHTFAPF----PPTQFMPPAAPPLFEKFSAKLDSPYFRHSN--L *** **: **:**. *:*::.**********. ENSP00000396160/1-1045 FPSFPPAIPGLPTLLPHPGPFGSLQGAFQPKVSDPYRAVVKVSTCWEGPWQGRTLVPPGR ENSMUSP00000063879/1-1031 SIEITGRSSAVHTFLQKA-----------PGVSDPYRTAVR------------------- ENSRNOP00000049044/1-1033 SIEITGRSSAVHTFLQKA-----------PGVSDPYRTAVR------------------- ENSCPOP00000014781/1-737 FPAIPSAVPGLPTLLAHASPLGSLQGAFQPKTTNPIQVQGRASTVHALLQKAPGVGVSAA XP_004844163.1/1-794 FPPLPSAVPGLPALLTHASPFGSLQGAFQPKTANPIQVPGRASAVHNLLQKAPGVTDPYR :. ..: ::* :. * .::* :. : ENSP00000396160/1-1045 P--RGARDSRSLQKTWVGVAPAPLSASILS-QKPGRWCAVHVQIAWQIYRHQQKIKEMQL ENSMUSP00000063879/1-1031 --------------------------------KPGKWCAVHVQIAWQIYHQQQKMK-MQL ENSRNOP00000049044/1-1033 --------------------------------KPGKWCAVHVQIAWQIYHQQQKMK-MQL ENSCPOP00000014781/1-737 HTFRGAASVWMLSYPAPGVQSRPSSPSALSPQKPGKWCAVHVQIAWQILHHQRKVKQLQL XP_004844163.1/1-794 TAAR----------------------------KPGKWCAVHVQIAWQILHHQQKVK-LQL ***:************ ::*:*:* :** ENSP00000396160/1-1045 DPHKLEVGAKLDLFGRPPAPGVFAGFHYPQDLARPLFPSTGAAHPASNPFGPSAHPGSFL ENSMUSP00000063879/1-1031 DPHKLEVGTKLDLFSRPPAPGMFSGFHYPQDLARPLFSSTGATHPTANPFGPSAHHGSFL ENSRNOP00000049044/1-1033 DPHKLEVGTKLDLFSRPPAQGMFSGFHYPQDLARPLFSSTGATHPTANPFGPSAHHGSFL ENSCPOP00000014781/1-737 DPHKLEVGVKLDLSSRLPAPGVVSGAHYPQDLARPLFPGTGTAHPAAHPLGPSAHHASFL XP_004844163.1/1-794 DPHKLDVGTKLDLFSRPPAPRVFSGFHYPQGLARPLFCSTGTAHPATHPFGPSAHHGSFL *****:**.**** .* ** :.:* ****.****** .**::**:::*:***** .*** ENSP00000396160/1-1045 PTGPLTDPFSRPSTFGGLGSLSSHAFGGLGSHALAPGGSIFAPKEGSSVHGLPSPHEAWN ENSMUSP00000063879/1-1031 PTGHLTDPFSRSSTFGGLGSLSNHAFGGLGSHALTPGSSIFAPKEGTALLGLPSPHDAWN ENSRNOP00000049044/1-1033 PTGHLTDPFSRSSTFGGLGSLSNHAFGGLGSHALTPGSSIFAPKEGTALLGLPSPHDAWN ENSCPOP00000014781/1-737 PAAHLTDPFSRSGTFGGLGSLGSHAFGGLGSHTLAPGGSIFTPKEGSPLHGLPSPHEAWS XP_004844163.1/1-794 PAAHLTDPFSRSGTFGALGSLASHAFGGLGSHALAPGDSIFAPKEGATLHGLPSPHEAWG *:. *******..***.****..*********:*:**.***:****:.: ******:**. ENSP00000396160/1-1045 RLHRAPPSFPAPPPWPKSVDAERVSALTNHDREPDNGKEEQERDLLEKTRLLSRASPATP ENSMUSP00000063879/1-1031 RLHRVPPSFPTPPPWPKPVDTERLSALTNHDREPDKGQEEHERDLLEKTRLLSHGSPVAP ENSRNOP00000049044/1-1033 RLHRVPPSFPTPPPWPKPMDTERLSALTNHDREPDKGQEEHERNLLEKTRLLSHGSPIAP ENSCPOP00000014781/1-737 RLHRAPSSFPTPPPWPTPTD--KLSSHAREPQELEPGHEEFERDLLEKTRL-----PRPP XP_004844163.1/1-794 RLHRA------PPPWPSPAD--ALSSHPREPREPELGLEERERDLLEKTSL-----PRPP ****. *****.. * :*: ... :* : * ** **:***** * * .* ENSP00000396160/1-1045 AGHPVSGLLLRAQSELGRSGAPAEREAEPRVKESRSP--AKEEAAKMPARASPPHSKAAP ENSMUSP00000063879/1-1031 VGHPISSLLQRGSGELSRPGVLTEREAETRVKESHSP--SKEDGAKLAARPPSPYCKAAL ENSRNOP00000049044/1-1033 VGHPISSLLQRDSGELSRPGVLTEREAETRVKENHSP--SKEDGAKLAARPPSPYCKAAL ENSCPOP00000014781/1-737 VTH---ALLLHA--------------PESRVKDPCSPVQVQEDGAMLAARPPSPCSRAAL XP_004844163.1/1-794 VTH---ALLLRA--------------PEPRVKDPRSP--VQEDGAMLAARPPSPCSQAAL . * .** : .*.***: ** :*:.* :.**...* .:** ENSP00000396160/1-1045 GD-----------------------VKVKEERGEDEASEPPAGGLHPAPLQLGLGRERLG ENSMUSP00000063879/1-1031 GDCLRLAGLLGRESGKQTPDRPQGDVKVKEERREDETPDLTGVSVHSTATHMG-----LG ENSRNOP00000049044/1-1033 GDCLRLAGLLGRESGKQTPDRPQGDVKVKEERREDETPDLTGVSVHSTATHLG-----LG ENSCPOP00000014781/1-737 GD---------------------------------------------------------- XP_004844163.1/1-794 GDSLHLSGLLGCELA------PGAAVKVKEERAEDGRA---------------------- ** ENSP00000396160/1-1045 APGFAWEP----FRGLELPRRAFPAAAPAPGSAALLEPPERPYRDREPHGYSPERL---- ENSMUSP00000063879/1-1031 TAGFVWDPPRDTYRGLELPRRSFPAPPPAAGPSP-FELSERAYRDREPHDYSPERLQEVR ENSRNOP00000049044/1-1033 TSGFVWDPPRDTYRGLDLPRRSFPAPPPAAGPAP-FELSERAYRDRESHDYSPERLREVR ENSCPOP00000014781/1-737 ------------------------------------------------------------ XP_004844163.1/1-794 ------------------------------------------------------------ ENSP00000396160/1-1045 RGELERARAPHLPPAAPALDGALLPSLGALHFPRLSPAALHNGLLARTPPAAAALGAPPP ENSMUSP00000063879/1-1031 REELERARVPDSDAAAL---------LPAVHYPRLAPGALHGALLARTPPAAAVLGAPPP ENSRNOP00000049044/1-1033 REELERARAPDSDAAL----------LPAMHYPRLAPGALHGALLARTPPAAAALGAPPP ENSCPOP00000014781/1-737 ------------------------------------------------------------ XP_004844163.1/1-794 ------------------------------------------------------------ ENSP00000396160/1-1045 LVTAAGPPTPPGPPRSRTTPLGGLGPGEARDYSPSRNPPEVEAR ENSMUSP00000063879/1-1031 LVTAGGVPTPPAHPRTT------LGPGEAREYSPACNPPEVEAR ENSRNOP00000049044/1-1033 LVTAGGVPTPPARPRTTPL---ALGPGEARDYSPACNPPEVEAR ENSCPOP00000014781/1-737 -------------------------------------------- XP_004844163.1/1-794 ----------------------------------------AGAR