CLUSTAL W(1.81) multiple sequence alignment ENSMUSP00000101040/1-1506 MESLDRRRTGSEQEEGFGVQSRRATDLGMVPNLRRSNSSLCKSRRFLCSF-SSEKQENLS ENSRNOP00000001631/1-1508 MEPLDQRRTDSDQEEGFGVQSRRATDLGMVPNLRRSNSSLCKSRRLLCSF-SSEKQENLS ENSP00000381026/1-1553 MEPSALRKAGSEQEEGFEGLPRRVTDLGMVSNLRRSNSSLFKSWRLQCPFGNNDKQESLS ENSCPOP00000014581/1-1500 MEPSAHRKASSEQEDGFGVQPSRVADLGMVPNPRQSNSRLYKNGRPQCHLSSSEKQ-HLR XP_004842537.1/1-1500 MEPSGPRKAGSEQEDGFGVQPRRVVDLGLVPNLRRSNSSLCKSRRLQCPFSSSAKQEHLS **. *::.*:**:** . *..***:*.* *:*** * *. * * : .. ** * ENSMUSP00000101040/1-1506 SWIPENIKKKECVYFVESSKLSDAGKVVCACGYTHEQHLEVAIKPHTFQGKEWDPKKHVQ ENSRNOP00000001631/1-1508 SWIPENIKKKECVYFVESSKLSDAGKVVCECGYTHEQHIEVAIKPHTFQGKEWDPKKHVH ENSP00000381026/1-1553 SWIPENIKKKECVYFVESSKLSDAGKVVCQCGYTHEQHLEEATKPHTFQGTQWDPKKHVQ ENSCPOP00000014581/1-1500 AWILENIKKKECMYFVESPKLSDAGKVVCECGYTLEQHREEAIKPHAFQDKEWDPKKHVQ XP_004842537.1/1-1500 SWIPENIKKKECVYFVESSKLSDAGKVVCECGYTREQHLEEATKPHACQGKEWDPKKHVQ :** ********:*****.********** **** *** * * ***: *..:*******: ENSMUSP00000101040/1-1506 EMPTDAFGDIVFTDLSQKVGKYVRVSQDTPSSVIYQLMTQHWGLDVPNLLISVTGGAKNF ENSRNOP00000001631/1-1508 EMPTDAFGDIVFTGLSQKVGKYVRLSQDTSSIVIYQLMTQHWGLDVPSLLISVTGGAKNF ENSP00000381026/1-1553 EMPTDAFGDIVFTGLSQKVKKYVRVSQDTPSSVIYHLMTQHWGLDVPNLLISVTGGAKNF ENSCPOP00000014581/1-1500 EMPTDAFGDIVFVGLGQKVGKYVRVSSDTPSSVIYHLMTQHWGLDVPNLLISVTGGAKNF XP_004842537.1/1-1500 EMPTDAFGDIVFAGLGQKVGKYVRVSQDTPSSVIYHLMTQHWGLDVPNLLISVTGGAKNF ************..*.*** ****:*.**.* ***:***********.************ ENSMUSP00000101040/1-1506 NMKLRLKSIFRRGLVKVAQTTGAWIITGGSHTGVMKQVGEAVRDFSLSSSCKEGEVITIG ENSRNOP00000001631/1-1508 NMKLRLKSIFRRGLVKVAQTTGAWIITGGSHTGVMKQVGEAVRDFSLSSSCKEGDVITIG ENSP00000381026/1-1553 NMKPRLKSIFRRGLVKVAQTTGAWIITGGSHTGVMKQVGEAVRDFSLSSSYKEGELITIG ENSCPOP00000014581/1-1500 NMKLRLKSIFRRGLVKVAQTTGAWIITGGSHAGVMKQVGEAVRDFSLSSSYKDGEVITIG XP_004842537.1/1-1500 NMKLRLKSIFRRGLVKVAQTTGAWVITGGSHAGVMKQVGEAVRDFSLSSGYKDGEVITIG *** ********************:******:*****************. *:*::**** ENSMUSP00000101040/1-1506 VATWGTIHNREGLIHPMGGFPAEYMLDEEGQGNLTCLDSNHSHFILVDDGTHGQYGVEIP ENSRNOP00000001631/1-1508 IATWGTIHNREALIHPMGGFPAEYMLDEEGQGNLTCLDSNHSHFILVDDGTHGQYGVEIP ENSP00000381026/1-1553 VATWGTVHRREGLIHPTGSFPAEYILDEDGQGNLTCLDSNHSHFILVDDGTHGQYGVEIP ENSCPOP00000014581/1-1500 VATWGTIHNREGLVRPMESHHAEYVLDEEGQGNLTCLDSNHSHFILVDNGTHGQYGVEIP XP_004842537.1/1-1500 VATWGSIHNREGLVHPTGSFPAEYVPDEEGQGNLTCLDCNHSHFILVDDGTHGQYGVEIP :****::*.**.*::* .. ***: **:*********.*********:*********** ENSMUSP00000101040/1-1506 LRTKLEKFISEQTKERGGVAIKIPIVCVVLEGGPGTLHTIYNAINNGTPCVIVEGSGRVA ENSRNOP00000001631/1-1508 LRTKLEKFISEQTKERGGVAIKIPIVCVVLEGGPGTLHTIYNAITNGTPCVIVEGSGRVA ENSP00000381026/1-1553 LRTRLEKFISEQTKERGGVAIKIPIVCVVLEGGPGTLHTIDNATTNGTPCVVVEGSGRVA ENSCPOP00000014581/1-1500 LRIQLEKFISEQTKERGGVAIKIPIVCVVLEGGPGTLNTIYNAVTHGTPCVIVEGSGRVA XP_004842537.1/1-1500 LRTQLEKFISEQTKERGGVAIKIPIVCVVLEGGPGTLHTIYNAITNGTPCVIVEGSGRVA ** :*********************************:** ** .:*****:******** ENSMUSP00000101040/1-1506 DVIAQVATLPVSEITISLIQQKLSIFFQEMFETFTENQIVEWTKKIQDIVRRRQLLTIFR ENSRNOP00000001631/1-1508 DVIAQVAALPVSEITISLIQQKLSVFFQEMFETFTENQIVEWTKKIQDIVRRRQLLTVFR ENSP00000381026/1-1553 DVIAQVANLPVSDITISLIQQKLSVFFQEMFETFTESRIVEWTKKIQDIVRRRQLLTVFR ENSCPOP00000014581/1-1500 DVIAQVASLPVSDITIGLIQQKLSELFQELFETFTEGSIVEWTKKIQDIVRKRQLLTIFR XP_004842537.1/1-1500 DVIAQVAGLPVSAITIGLIQQKLSELFQELFETFTEGRVVEWTKKIQDIVRKRQLLTIFR ******* **** ***.******* :***:******. :************:*****:** ENSMUSP00000101040/1-1506 EGKDGQQDVDVAILQALLK--ASRSQDHFGHENWDHQLKLAVAWNRVDIARSEIFTDEWQ ENSRNOP00000001631/1-1508 EGKDGQQDVDVAILQALLK--ASRSQDHFGHENWDHQLKLAVAWNRVDIARSEIFTDEWQ ENSP00000381026/1-1553 EGKDGQQDVDVAILQALLK--ASRSQDHFGHENWDHQLKLAVAWNRVDIARSEIFMDEWQ ENSCPOP00000014581/1-1500 EGKDGQQDVDVAILQALLKAVASRSQDHFGHENWDHQLKLAVAWNRVDIARSEIFTDEWQ XP_004842537.1/1-1500 EGKDGQQDVDVAILQALLK--ASRSQDHFGHENWDHQLKLAVAWNRVDIARSEIFTDEWQ ******************* ********************************** **** ENSMUSP00000101040/1-1506 WKPADLHPMMTAALISNKPEFVRLFLENGVRLKEFVTWDTLLCLYENLEPSCLFHSKLQK ENSRNOP00000001631/1-1508 WKPSDLHPMMTAALISNKPEFVRLFLENGVRLKEFVTWDTLLCLYENLEPSCLFHSKLQK ENSP00000381026/1-1553 WKPSDLHPTMTAALISNKPEFVKLFLENGVQLKEFVTWDTLLYLYENLDPSCLFHSKLQK ENSCPOP00000014581/1-1500 WKPSDLHPTMVAALISNKPEFMKLFLENGVQLKELVTRDMLLYLYENLEPSCLFHSKLQK XP_004842537.1/1-1500 WKPSDLHPTMTAALISNKPEFVKLFLENGVQMTELVTWDTLLYLYENLEPSCLFHSKLQK ***:**** *.**********::*******::.*:** * ** *****:*********** ENSMUSP00000101040/1-1506 VLAEE-QRLAYASA-TPRLHMHHVAQVLRELLGDSTQLLYPRPRYTDRPRLSMTVPHIKL ENSRNOP00000001631/1-1508 VLAEEHERLAYASE-TPRLQMHHVAQVLRELLGDSTQLLYPRPRYTDRPRLSLPMPHIKL ENSP00000381026/1-1553 VLVEDPERPACAPA-APRLQMHHVAQVLRELLGDFTQPLYPRPRHNDRLRLLLPVPHVKL ENSCPOP00000014581/1-1500 VLAEE--RQASVPNDTPCLQMHHVAQVLRELLGDSTQPLY--PRHIDQLGSSPSVPHVKL XP_004842537.1/1-1500 VLAEE--RLACAPT-APRLQMHHVAQVLRELLGDSTQPLYPRPRHGDRPRLSLPVPHIKL **.*: * * .. :* *:************** ** ** **: *: .:**:** ENSMUSP00000101040/1-1506 NVQGVSLRSLYKRSTGHVTFTIDPVRDLLIWAVIQNHRELAGIIWAQSQDCTAAALACSK ENSRNOP00000001631/1-1508 NVQGVSLRSLYKRSTGHVTFTIDPVRDLLIWAIIQNHRELAGIIWAQSQDCTAAALACSK ENSP00000381026/1-1553 NVQGVSLRSLYKRSSGHVTFTMDPIRDLLIWAIVQNRRELAGIIWAQSQDCIAAALACSK ENSCPOP00000014581/1-1500 NMQAVSLLSLCKRSSDTITFTMDPVRDLLIWAVVQNRRELAGIIWAQSQDCIAAALACSK XP_004842537.1/1-1500 NVQGVSLRSLYKRSSGHITFTMDPVRDLLIWAIVQNRRELAGIIWAQSQDCIAAALACSK *:*.*** ** ***:. :***:**:*******::**:************** ******** ENSMUSP00000101040/1-1506 ILKELSKEEEDTDSSEEMLALADEFEHRAIGVFTECYRKDEERAQKLLVRVSEAWGKTTC ENSRNOP00000001631/1-1508 ILKELSKEEEDTDSSEEMLALADEFEHRAIGVFTECYRKDEERAQKLLVRVSEAWGKTTC ENSP00000381026/1-1553 ILKELSKEEEDTDSSEEMLALAEEYEHRAIGVFTECYRKDEERAQKLLTRVSEAWGKTTC ENSCPOP00000014581/1-1500 ILKELSKEEEDMDSLEEMLALADEFELRAIGVFTECYRKDEERAQKLLTRVSEAWGKTTC XP_004842537.1/1-1500 ILKELSKEEEDTDSSEEMLALADEYELRAIGVFTECYRKDEERAQKLLTRVSEAWGKTTC *********** ** *******:*:* *********************.*********** ENSMUSP00000101040/1-1506 LQLALEAKDMKFVSHGGIQAFLTKVWWGQLCVDNGLWRIILCMLAFPLLFTGFISFREKR ENSRNOP00000001631/1-1508 LQLALEAKDMKFVSHGGIQAFLTKVWWGQLCVDNGLWRIILCMLAFPLLFTGFISFREKR ENSP00000381026/1-1553 LQLALEAKDMKFVSHGGIQAFLTKVWWGQLSVDNGLWRVTLCMLAFPLLLTGLISFREKR ENSCPOP00000014581/1-1500 LQLALEAKDMKFVSHGGVQAFLTKVWWGQLCVDNGMWQVILCMLAFPLLLTGLVSFREKR XP_004842537.1/1-1500 LQLALEAKDMKFVSHGGIQAFLTKVWWGQLCVDNGLWRVILCMLAFPLLLTGLVSFREKR *****************:************.****:*:: *********:**::****** ENSMUSP00000101040/1-1506 LQALCRP-ARVRAFFNAPVVIFHMNILSYFAFLCLFAYVLMVDFQPSPSWCEYLIYLWLF ENSRNOP00000001631/1-1508 LQALCRL-ARVRAFFNAPVVIFYLNILSYFAFLCLFAYVLMVDFQPSPSWCEYLIYLWLF ENSP00000381026/1-1553 LQDVGTPAARARAFFTAPVVVFHLNILSYFAFLCLFAYVLMVDFQPVPSWCECAIYLWLF ENSCPOP00000014581/1-1500 LQTLGHP-ARVWAFFSAPVIVFHVNILSYFAFLCLFAYVLMVDFQPTPSWSEYLIYLWLF XP_004842537.1/1-1500 LQALGGP-ARARAFFSAPVVVFHLNILSYFAFLCLFAYVLMVDFQPTPSWSECLIYLWLF ** : **. ***.***::*::********************** ***.* ****** ENSMUSP00000101040/1-1506 SLVCEETRQLFYDPDGCGLMKMASLYFSDFWNKLDVGAILLFIVGLTCRLIPATLYPGRI ENSRNOP00000001631/1-1508 SLVCEETRQLFYDPDGCGLMKMASLYFSDFWNKLDVGAILLFIAGLTCRLIPATLYPGRI ENSP00000381026/1-1553 SLVCEEMRQLFYDPDECGLMKKAALYFSDFWNKLDVGAILLFVAGLTCRLIPATLYPGRV ENSCPOP00000014581/1-1500 SLVCEEMRQLFCVPDECRLMKMVSLYFSDFWNKVDVGAILLFIAGLTCRLIPATLYPGRV XP_004842537.1/1-1500 SLVCEEMRQLFYDPDECGLMKMASLYFSDFWNKLDVGAILLFIAGLTCRLIPATLYPGRV ****** **** ** * *** .:*********:********:.***************: ENSMUSP00000101040/1-1506 ILSLDFIMFCLRLMHIFTISKTLGPKIIIVKRMMKDVFFFLFLLAVWVVSFGVAKQAILI ENSRNOP00000001631/1-1508 ILSLDFIMFCLRLMHIFTISKTLGPKIIIVKRMMKDVFFFLFLLAVWVVSFGVAKQAILI ENSP00000381026/1-1553 ILSLDFILFCLRLMHIFTISKTLGPKIIIVKRMMKDVFFFLFLLAVWVVSFGVAKQAILI ENSCPOP00000014581/1-1500 ILSLDFIIFCLRLMHIFTISKTLGPKIIIVKRMMKDVFFFLFLLALWVVSFGVAKQAILI XP_004842537.1/1-1500 ILSLDFIMFCLRLMHIFTVSKTLGPKIIIVKRMMKDVFFFLFLLAVWVVSFGVAKQAILI *******:**********:**************************:************** ENSMUSP00000101040/1-1506 HNESRVDWIFRGVVYHSYLTIFGQIPTYIDGVNFSMDQCSPNGTDPYKPKCPESDWTGQA ENSRNOP00000001631/1-1508 HNESRVDWIFRGVIYHSYLTIFGQIPTYIDGVNFSMDQCSPNGTDPYKPKCPESDWTGQA ENSP00000381026/1-1553 HNERRVDWLFRGAVYHSYLTIFGQIPGYIDGVNFNPEHCSPNGTDPYKPKCPESDATQQR ENSCPOP00000014581/1-1500 HNEHRVDWIFRGVVYNSYLTIFGQIPPYIDGVDFNLERCSPNGTDPYKPKCPEIDAARQA XP_004842537.1/1-1500 HNESRVDWIFRGVVYHSYLTIFGQIPAYIDGVNFDLEHCSPNGTDPYKPKCPESDTTQQR *** ****:***.:*:********** *****:*. ::*************** * : * ENSMUSP00000101040/1-1506 PAFPEWLTVTLLCLYLLFANILLLNLLIAMFNYTFQEVQEHTDQIWKFQRHDLIEEYHGR ENSRNOP00000001631/1-1508 PAFPEWLTVTLLCLYLLFANILLLNLLIAMFNYTFQEVQEHTDQIWKFQRHDLIEEYHGR ENSP00000381026/1-1553 PAFPEWLTVLLLCLYLLFTNILLLNLLIAMFNYTFQQVQEHTDQIWKFQRHDLIEEYHGR ENSCPOP00000014581/1-1500 PAFPEWLTVTMLCLYLLLTNILLLNLLIAMFNYTFQQVQEHTDQIWKFQRHDLIEEYHSR XP_004842537.1/1-1500 PAFPEWLTVILLCLYLLFTNILLLNLLIAMFNYTFQQVQEHTDQIWKFQRHDLIEEYHGR ********* :******::*****************:*********************.* ENSMUSP00000101040/1-1506 PPAPPPLILLSHLQLLIKRIVLKIPAKRHKQLKNKLEKNEETALLSWELYLKENYLQNQQ ENSRNOP00000001631/1-1508 PPAPPPLILLSHLQLLIKRIVLKIPAKRHKQLKNKLEKNEEAALLSWELYLKENYLQNQQ ENSP00000381026/1-1553 PAAPPPFILLSHLQLFIKRVVLKTPAKRHKQLKNKLEKNEEAALLSWEIYLKENYLQNRQ ENSCPOP00000014581/1-1500 PPAPPPLILLSHLYLLVKKVVLKVPNKRHMQLKTKLKKEEEAALLSWEIYLKENYLHNQQ XP_004842537.1/1-1500 PPAPPPLILLSHLQLLVKRLVLKVPAKRHTQLKNKLEKNEEAALLSWEIYLKENYLHNQQ *.****:****** *::*::*** * *** ***.**:*:**:******:*******:*:* ENSMUSP00000101040/1-1506 YQQKQRPEQKIQDISEK------------------------------------------- ENSRNOP00000001631/1-1508 YQHKQRPEQKIQDISEK------------------------------------------- ENSP00000381026/1-1553 FQQKQRPEQKIEDISNKAGLELWGSRTSSVCKSRQFLHLTVVESRGSEKAPVTTLACLQG ENSCPOP00000014581/1-1500 YQHQQQPEQRIQDISEK------------------------------------------- XP_004842537.1/1-1500 HQHHQRPEQRIQDISEK------------------------------------------- .*::*:***:*:***:* ENSMUSP00000101040/1-1506 -------VDTMVDLLDMDQVKRSGSTEQRLASLEEQVTQVTRALHWIVTTLKDSGFGSGA ENSRNOP00000001631/1-1508 -------VDTMVDLLDMDRVKRSGSTEQRLASLEEQVTQMGRSLHWIVTTLKDSGFGSGA ENSP00000381026/1-1553 CLGKHGRVDAMVDLLDLDPLKRSGSMEQRLASLEEQVAQTAQALHWIVRTLRASGFSSEA ENSCPOP00000014581/1-1500 -------VDSMVDLLDMDRLKRSGPTEQRLASLEEQVAQVTKSLHWIVKTLKDSGFGSAV XP_004842537.1/1-1500 -------VDSMVDLLDMDRLKRSGPTEQRLASLEEQVAQMAGSLHWIVRTLKDSGFGSAA **:******:* :****. ***********:* :***** **: ***.* . ENSMUSP00000101040/1-1506 GALTLAPQRAFDEPDAELSIRRKVEEPGDGYHVSARHLLYPNARIMRFPVPNEKVPWAAE ENSRNOP00000001631/1-1508 GALTLAAQRAFDEPDAELSIRKKGEEGGDGYHVSARHLLYPDARIMRFPVPNEKVPWEAE ENSP00000381026/1-1553 DVPTLASQKAAEEPDAEPGGRKKTEEPGDSYHVNARHLLYPNCPVTRFPVPNEKVPWETE ENSCPOP00000014581/1-1500 GAPGLAPTKTPDEPDAELVGRRKEEEPGDGYHVNARHLLYPSSPITRFPVPNEKVPWKTE XP_004842537.1/1-1500 GVPALAPPKAPDEPDADLAGRRKEEEPGDGFHVNARHLLYPVSPVTRFPVPNEKVPWETE .. **. :: :****: *:* ** **.:**.******* . : *********** :* ENSMUSP00000101040/1-1506 FLIYDPPFYTAE-KDVALTDPVGDTAEPLSKISYNVVDGPTDRRSFHGVYVVEYGFPLNP ENSRNOP00000001631/1-1508 FLIYDPPFYTAEKKDATLTDPVGDTAEPLSKINYNVVDGLMDRCSFHGTYVVQYGFPLNP ENSP00000381026/1-1553 FLIYDPPFYTAERKDAAAMDPMGDTLEPLSTIQYNVVDGLRDRRSFHGPYTVQAGLPLNP ENSCPOP00000014581/1-1500 FLIYKPPFYTVERKDAALVDPVGEAPELLAKIRYNALDGSTDRRSFHGAYMVQDGLPLNP XP_004842537.1/1-1500 FLIYKPPFYTAERKDTALMDPVGDVPDLLAKIRYNTLDGPTDRRSFHGAYVVQDGLPLNP ****.*****.* **.: **:*:. : *:.* **.:** ** **** * *: *:**** ENSMUSP00000101040/1-1506 MGRTGLRGRGSLSWFGPNHTLQPVVTRWKRNQGGAICRKSVRKMLEVLVMKLPRSEHWAL ENSRNOP00000001631/1-1508 MGRTGLRGRGSLSWFGPNHTLQPVVTRWKRNQGGGICRKSVRKMLEVLVVKLPQSEHWAL ENSP00000381026/1-1553 MGRTGLRGRGSLSCFGPNHTLYPMVTRWRRNEDGAICRKSIKKMLEVLVVKLPLSEHWAL ENSCPOP00000014581/1-1500 MGRTGLRGRGSLKCFGPNHMLHPVVTRWRRNQDGAICRKSIKKMLEVLVVKQPLSELWAL XP_004842537.1/1-1500 MGRTGLLGRGSLSCFGPNHMLHPVVTRWRRNQDGVICRKSIKKMLEVLVVKQPLSGLWAL ****** *****. ***** * *:****:**:.* *****::*******:* * * *** ENSMUSP00000101040/1-1506 PGGSREPGEMLPRKLKRVLRQEFWVAFETLLMQGTEVYKGYVDDPRNTDNAWIETVAVSI ENSRNOP00000001631/1-1508 PGGSREPGKMLPRKLKQVLQQEYWVTFETLLRQGTEVYKGYVDDPRNTDNAWIETVAVSI ENSP00000381026/1-1553 PGGSREPGEMLPRKLKRILRQEHWPSFENLLKCGMEVYKGYMDDPRNTDNAWIETVAVSV ENSCPOP00000014581/1-1500 PGGSRELGERLPRKLKEILLQGAWPMVEGLLQKGVEVYKGYVDDPRNTDNAWIETVAISI XP_004842537.1/1-1500 PGGSREPGETLPRKLKQILLREAWPEVEGLLQRGSEVYKGYVDDPRNTDNAWVETVAISI ****** *: ******.:* : * .* ** * ******:**********:****:*: ENSMUSP00000101040/1-1506 HFQDQNDMELKRLEENLHTHDPKELTRDLKLSTEWQVVDRRIPLYANHKTILQKVASLFG ENSRNOP00000001631/1-1508 HFQDQNDVELKRLEENLQTHDPKESARGLEMSTEWQVVDRRIPLYVNHKKILQKVASLFG ENSP00000381026/1-1553 HFQDQNDVELNRLNSNLHACDSGASIR-------WQVVDRRIPLYANHKTLLQKAAAEFG ENSCPOP00000014581/1-1500 HFSDQNDVELTRLNSHLLASDPGVSVR-------WQVVDKRIPMYENHKTILQKTAILFG XP_004842537.1/1-1500 HFPDQNDMELKRLNSHLHACDPGVSIR-------WQVVDKRIPLYVNHKTILQKTAVLFG ** ****:**.**:.:* : *. * *****:***:* ***.:***.* ** ENSMUSP00000101040/1-1506 AHF ENSRNOP00000001631/1-1508 AHF ENSP00000381026/1-1553 AHY ENSCPOP00000014581/1-1500 AHY XP_004842537.1/1-1500 AHY **: