CLUSTAL W(1.81) multiple sequence alignment ENSMUSP00000047672/1-1716 MDQEGGGDGQKAPSFQWRNYKLIVDPALDPALRRPSQKVYRYDGVHFSVSDSKYTPVEDL ENSRNOP00000025773/1-852 ------------------------------------------------------------ ENSP00000262519/1-1707 MDQEGGGDGQKAPSFQWRNYKLIVDPALDPALRRPSQKVYRYDGVHFSVNDSKYIPVEDL ENSCPOP00000014263/1-1702 MDQEGGGDGQKAPSFQWRNYKLIVDPALDPALRRPSQKVYRYDGIHFSVNDSKYIPVEDL XP_004856270.1/1-1698 MDQEGGGDGQKAPSFQWRNYKLIVDPALDPALRRPSQKVYRYDGVHFSVNDSKYIPVEDL ENSMUSP00000047672/1-1716 QDPRCHVRSKARDFSLPVPKFKLDEFYIGQIPLKEVTFARLNDNVRETFLKDMCRKYGEV ENSRNOP00000025773/1-852 ------------------------------------------------------------ ENSP00000262519/1-1707 QDPRCHVRSKNRDFSLPVPKFKLDEFYIGQIPLKEVTFARLNDNVRETFLKDMCRKYGEV ENSCPOP00000014263/1-1702 QDPRCHVRSKNRDFSLPVPKFKLDEFYIGQIPLKEVTFARLNDNVRETFLKDMCRKYGEV XP_004856270.1/1-1698 QDPRCHVRSKNRDFSLPVPKFKLDEFYIGQIPLKEVTFARLNDNVRETFLKDMCRKYGEV ENSMUSP00000047672/1-1716 EEVEILLHPRTRKHLGLARVLFTSTRGAKETVKNLHLTSVMGNIIHAQLDIKGQQRMKYY ENSRNOP00000025773/1-852 ------------------------------------------------------------ ENSP00000262519/1-1707 EEVEILLHPRTRKHLGLARVLFTSTRGAKETVKNLHLTSVMGNIIHAQLDIKGQQRMKYY ENSCPOP00000014263/1-1702 EEVEILLHPRTRKHLGLARVLFTSTRGAKETVKNLHLTSVMGNIIHAQLDIKGQQRMKYY XP_004856270.1/1-1698 EEVEILLHPRTRKHLGLARVLFTSTRGAKETVKNLHLTSVMGNIIHAQLDIKGQQRMKYY ENSMUSP00000047672/1-1716 ELIVNGSYTPQTVPTGGKALSEKFQGSGAAAETTEARRRSSSDTAAYPAGTTVGGTPGNG ENSRNOP00000025773/1-852 ------------------------------------------------------------ ENSP00000262519/1-1707 ELIVNGSYTPQTVPTGGKALSEKFQGSGAATETAESRRRSSSDTAAYPAGTTAVGTPGNG ENSCPOP00000014263/1-1702 ELIVNGSYTPQTVPTGGKALSEKFQGSGAATETTESRRRSSSDTAAYPSGTAVVGTPGNG XP_004856270.1/1-1698 ELIVNGSYTPQTVPTGGKALSEKFQGSGAATETTESRRRSCSDTAAYPSGTAVVGTPGNG ENSMUSP00000047672/1-1716 TPCSQDTNFSSSRQDTPSSFGQFTPQSSQGTPYTSRGSTPYSQDSAYSSSTTSTSFKPRR ENSRNOP00000025773/1-852 ------------------------------------------------------------ ENSP00000262519/1-1707 TPCSQDTSFSSSRQDTPSSFGQFTPQSSQGTPYTSRGSTPYSQDSAYSSSTTSTSFKPRR ENSCPOP00000014263/1-1702 TPCSQDTSFSSSRQDTPSSFGQFTPQSSQGTPYTSRGSTPYSQDSAYSSSTTSTSFKPRR XP_004856270.1/1-1698 TPCSQDASFSSSRQDTPTSFGQFTPQSSQGTPYTPRGSTPYSQDSAYSSSSTSASFKPRR ENSMUSP00000047672/1-1716 SENSYQDSFSRRHFSTSSAPATTATATSATAAATAASSSSSSSSSSSSSSSSSSSASQFR ENSRNOP00000025773/1-852 ------------------------------------------------------------ ENSP00000262519/1-1707 SENSYQDAFSRRHFSASSASTTASTAIAATTAATASSSASSSSLSSSSSSSSSSSSSQFR ENSCPOP00000014263/1-1702 SENSYQDSFSRRHFSASSVPTTVSTAISATTAATAASSSSSSS-SSSSSTSSSSSSSQFR XP_004856270.1/1-1698 SENSYQDSFSRRHFSASAAPTTASTAISATTAATAVSSSSS---SSSSSSSSSSSSSQFR ENSMUSP00000047672/1-1716 GSDSSYPAYYESWNRYQRHTSYPPRRATREDPSGASFAENTAERFPPSYTSYLAPEPNRS ENSRNOP00000025773/1-852 ------------------------------------------------------------ ENSP00000262519/1-1707 SSDANYPAYYESWNRYQRHTSYPPRRATREEPPGAPFAENTAERFPPSYTSYLPPEPSRP ENSCPOP00000014263/1-1702 GSDSNYPAYYESWNRYQRHASYPPRRATREEPSGAPFSESTAERFPPSYTSYLPPEPSRS XP_004856270.1/1-1698 GSDSNYPAYYESWNRYQRHTSYPPRRAAREEPSGAPFSESTAERFPPSYTSYLPPEPSRP ENSMUSP00000047672/1-1716 TDQDYRPPASEAPPPEPPEPGGGGGGSGGGGGGGGGGGGGAPSPEREEARTPPRPASPAR ENSRNOP00000025773/1-852 ------------------------------------------------------------ ENSP00000262519/1-1707 TDQDYRPPASEAPPPEPPEP-------------GGGGGGGGPSPEREEVRTSPRPASPAR ENSCPOP00000014263/1-1702 TDQDYRPPASEAPPPEPPEP-------------GGGGGGGGPSPEREEARTSPRAASPTR XP_004856270.1/1-1698 ADQDYRPPASEAPPPEPPEP-------------GGAGGGGGPSPEREEARTSPRPASPAR ENSMUSP00000047672/1-1716 SGSPAPETTNESVPFAQHSSLDSRIEMLLKEQRSKFSFLASDTEEEEENSSAGPGARDAG ENSRNOP00000025773/1-852 ------------------------------------------------------------ ENSP00000262519/1-1707 SGSPAPETTNESVPFAQHSSLDSRIEMLLKEQRSKFSFLASDTEEEEENSSMVLGARDTG ENSCPOP00000014263/1-1702 SGSPAPETTNESVPFAQHSSLDSRIEMLLKEQRSKFSFLASDTEEEEENCSAGSGARDTG XP_004856270.1/1-1698 SGSPVPETTNESVPFAQHSSLDSRIEMLLKEQRSKFSFLASDTEEEEENSSAGPGARDPG ENSMUSP00000047672/1-1716 AEVPSGAGHGPCTPPPAPANFEDVAPTGSGEPGAARESPKANGQNQASPCSSGEDMEISD ENSRNOP00000025773/1-852 ------------------------------------------------------------ ENSP00000262519/1-1707 SEVPSGSGHGPCTPPPAPANFEDVAPTGSGEPGATRESPKANGQNQASPCSSGDDMEISD ENSCPOP00000014263/1-1702 SEVPSGSGHGPCTPPPAPANFEDVAPTGSGEPGATRESPKTNGQNQASPCSSGEDMEISD XP_004856270.1/1-1698 SEVPSGSGHGPCTPPPAPANFEDVVPTGNGEPGATRESPKANGQNQASPCSSGEDMEISD ENSMUSP00000047672/1-1716 DDRGGSPPPAPTPPQQPPPPPPPPPPPPPPYLASLPLGYPPHQPAYLLPPRPDGPPPPEY ENSRNOP00000025773/1-852 ------------------------------------------------------------ ENSP00000262519/1-1707 DDRGGSPPPAPTPPQQ-PPPPPPPPPPPPPYLASLPLGYPPHQPAYLLPPRPDGPPPPEY ENSCPOP00000014263/1-1702 DDRGGSPPPAPTPPQQ-PPPPPPPPPPPPPYLASLPLGYPPHQPAYLLPPRPDGPPPPEY XP_004856270.1/1-1698 DDRGGSPPPAPAPPQQ---------PPPPPYLASLPLGYPPHQPAYLLPPRPDGPPPPEY ENSMUSP00000047672/1-1716 PPPPPPPPPHIYDFVNSLELMDRLGAQWGGMPMSFQMQTQMLTRLHQLRQGKGLTAASAG ENSRNOP00000025773/1-852 ------------------------------------------------------------ ENSP00000262519/1-1707 -PPPPPPPPHIYDFVNSLELMDRLGAQWGGMPMSFQMQTQMLTRLHQLRQGKGLIAASAG ENSCPOP00000014263/1-1702 -PPPPPPPPHIYDFVNSLELMDRLGAQWGGMPMSFQMQTQMLTRLHQLRQGKGLTAASAG XP_004856270.1/1-1698 -----PPPPHIYDFVNSLELMDRLGAQWGGMPMSFQMQTQMLTRLHQLRQGKGLTAASAG ENSMUSP00000047672/1-1716 PPGGAFGEAFLPFPPPQEAAYGLPYALYTQGQEGRGSYSREAYHLPLPMAAEPLPSSSVS ENSRNOP00000025773/1-852 ------------------------------------------------------------ ENSP00000262519/1-1707 PPGGAFGEAFLPFPPPQEAAYGLPYALYAQGQEGRGAYSREAYHLPMPMAAEPLPSSSVS ENSCPOP00000014263/1-1702 PPGGAFGEAFLPFPPPQEAAYGLPYALYTQGQEGRGAYTREAYHLPLPMAAEPLPSSSVS XP_004856270.1/1-1698 PPGGAFGEAFLPFPPPQEAAYGLPYALYTQGQEGRAAYSREAYHLPLPMAAEPLPSSSVS ENSMUSP00000047672/1-1716 GEEARLPHREEAEIAESKVLPSAGTVGRVLATLVQEMKSIMQRDLNRKMVENVAFGAFDQ ENSRNOP00000025773/1-852 ------------------------------------------------------------ ENSP00000262519/1-1707 GEEARLPPREEAELAEGKTLPTAGTVGRVLAMLVQEMKSIMQRDLNRKMVENVAFGAFDQ ENSCPOP00000014263/1-1702 GEEARLPPREEAELAEGKALPSAGTVGRVLATLVQEMKSIMQRDLNRKMVENVAFGAFDQ XP_004856270.1/1-1698 GEEARLPPREEAELAEGKALPSAGTVGCVLATLVQEMKSIMQRDLNRKMVENVAFGAFDQ ENSMUSP00000047672/1-1716 WWESKEEKAKPFQNAAKQQAKEEDKEKMKLKEPGMLSLVDWAKSGGITGIEAFAFGSGLR ENSRNOP00000025773/1-852 ---------------------------MKLKEPGMLSLVDWAKSGGITGIEAFAFGSGLR ENSP00000262519/1-1707 WWESKEEKAKPFQNAAKQQAKEEDKEKTKLKEPGLLSLVDWAKSGGTTGIEAFAFGSGLR ENSCPOP00000014263/1-1702 WWESKEEKAKPFQNAAKQQAKEEDKEKTKLKEPGMLSLVDWAKSGGTTGIEAFTFGSGLR XP_004856270.1/1-1698 WWESKEEKAKPFQNAAKQQAKEEEKEKTKLKEPGMLSLVDWAKSGGTTGIEAFTFGSGLR ******:*********** ******:****** ENSMUSP00000047672/1-1716 GALRLPSFKVKRKEPSEISEASEEKRPRPSTPAEEDEDDPEREKEAGEPGRPGTKPPKRD ENSRNOP00000025773/1-852 GALRLPSFKVKRKEPSEISEASEEKRPRPSTPAEEDEDDPEREKEAGEPGRPGTKPPKRD ENSP00000262519/1-1707 GALRLPSFKVKRKEPSEISEASEEKRPRPSTPAEEDEDDPEQEKEAGEPGRPGTKPPKRD ENSCPOP00000014263/1-1702 GALRLPSFKVKRKEPSEISEASEEKRPRPSTPAEEDEDDPERDKEVGEPGRPGSKPPKRD XP_004856270.1/1-1698 GALRLPSFKVKRKEPSEISEASEEKRPRPSTPAEEDEDDSERDKEVGEPGRPGTKPPKRD ***************************************.*::**.*******:****** ENSMUSP00000047672/1-1716 EERGKTQGKHRKSFTLDSEGEEASQESSSEKDEDDDDEDEEDEEQEEAVDATKKEAEASD ENSRNOP00000025773/1-852 EERGKTQGKHRKSFALDSEGEEASQESSSEKDEDDDEEDEEDEEREEAVDATKKEAEASD ENSP00000262519/1-1707 EERGKTQGKHRKSFALDSEGEEASQESSSEKDEEDDEEDEEDEDREEAVDTTKKETEVSD ENSCPOP00000014263/1-1702 EERGKTQGKHRKSFALDSEGEEASQESSSDKDEEEDEEDEEDEDREEAVDTTKKETEASD XP_004856270.1/1-1698 EDRGKTQGKHRKSFALDSEGEEASQESSSDKDEDDDEEDEEDEEQEEAVDTTKKETAVSD *:************:**************:***::*:******::*****:****: .** ENSMUSP00000047672/1-1716 GEDEDSDSSSQCSLYADSDGENGSTSDSESGSSSSSSSSSSSSSSSS-------SSESSS ENSRNOP00000025773/1-852 GEDEDGDSSSQCSLYADSDGEDGSTSDSESGSSSSSPSSSSSSSSSS-------SSESSS ENSP00000262519/1-1707 GEDEESDSSSKCSLYADSDGENDSTSDSESSSSSSSSSSSSSSSSSSSSSSSSESSSEDE ENSCPOP00000014263/1-1702 GEDEESDASSKCSLYADSDGENGSTSDSESSTSSSSSSSSSSSSSSSSS-----ESSEEE XP_004856270.1/1-1698 GEDEESDSSSKCSLYADSDGENGSTSDSESSTSSSSSSSSSSSSSES--------SSEEE ****:.*:**:**********:.*******.:****.********.* *.... ENSMUSP00000047672/1-1716 EEEEQSAVIPSAS-PPREVPEPLPAPDEKPETDGLVDSPVMPLSEKETLPTQPAGPAEEP ENSRNOP00000025773/1-852 EEEEQSAVIPSASPPPREVPEPLPAPDEKPETDRVVDSPVMPLPEKETTSTQPAGPAEEP ENSP00000262519/1-1707 EEEERPAALPSASPPPREVPVPTPAPVEVPVPERVAGSPVTPLPEQEASPARPAGPTEES ENSCPOP00000014263/1-1702 EEEEQPTTIPSASPPPREVPEPLPAPAKEPEPETAVGSPVVPLPEQEKSPARPAGPTEEP XP_004856270.1/1-1698 EEEEQAAAIPSASPPPRDVPEPLPAPVEEPEPEGAAGSPVAPLPEQEKSPSRPAGPTEEP ****:.:.:**** ***:** * *** : * .: ..*** **.*:* .::****:**. ENSMUSP00000047672/1-1716 PPSVPQPPAEPPAGPPDAAPRLDERPSSPIPLLPPPKKRRKTVSFSAAEEAPVPEPSTAA ENSRNOP00000025773/1-852 PPNIPQPPPEPPAGPPDPPPRLDERPSSPIPLLPPPKKRRKTVSFSATEEAPVPEPSTAS ENSP00000262519/1-1707 PPSAPLRPPEPPAGPPAPAPRPDERPSSPIPLLPPPKKRRKTVSFSAIEVVPAPEPPPAT ENSCPOP00000014263/1-1702 PPSVPQPPSEPQTGPSAPSPHLDERPSSPIPLLPPPKKRRKTVSFSTAEEVPAPEPPPAA XP_004856270.1/1-1698 TRSVPQLPPEPLAGPPAPPPCLDERPSSPIPLLPPPKKRRKTVSFSAMEEVRAPEPPLAA . . * *.** :**. ..* ************************: * . .***. *: ENSMUSP00000047672/1-1716 PLQAKSSGPVSRKVPRVVERTIRNLPLDHASLVKSWPEEVARGGRNRAGGRVRSTEEEEA ENSRNOP00000025773/1-852 PLQAKSPGPVSRKVPRVVERTIRNLPLDHASLVKSWPEEVARGGRNRAGGRVRSTEEEEA ENSP00000262519/1-1707 PPQAKFPGPASRKAPRGVERTIRNLPLDHASLVKSWPEEVSRGGRSRAGGRGRLTEEEEA ENSCPOP00000014263/1-1702 LPQAKSPGTVSRKVPRGAERTIRNLPLDHASLVKSWPEEVSRGGRNRAGGRGRSMEEEEV XP_004856270.1/1-1698 LPQAKPPGAVSRKGPRGAERTIRNLPLDHASLVRSWPEEVSRGGRSRAGGRGRPAEEEEV *** .*..*** ** .***************:******:****.***** * ****. ENSMUSP00000047672/1-1716 TESGTEVDLAVLADLALTP----ARRGLATLPTGDDSEATETSDEAERPSPLLSHILLEH ENSRNOP00000025773/1-852 TESGTEVDLAVLADLALTP----ARRGLAAIPTGDDSEATETSDEAERPSPLLSHILLEH ENSP00000262519/1-1707 -EPGTEVDLAVLADLALTP----ARRGLPALPAVEDSEATETSDEAERPRPLLSHILLEH ENSCPOP00000014263/1-1702 -EPGTEVDLAVLADLALTP----ARRGLAALPPGDDSEATETSDEADRLCPPLNHILLEH XP_004856270.1/1-1698 -EPGTDVDLAVLADLALAPALALAQRSLAALPPGDDSEATETSDEADRLGPPLSHIFLEH *.**:***********:* *:*.*.::*. :***********:* * *.**:*** ENSMUSP00000047672/1-1716 NYALAIKPPPTTPAPRPLEPAPALAALFSSPADEVLEAPEVVVAEAEEPK-QQLQQQHPE ENSRNOP00000025773/1-852 NYALAIKPPPTTPAPRPLEPAPALAALFSSPADEVLEAPEVVVAEAEEPKQPLQQQQHPE ENSP00000262519/1-1707 NYALAVKPTPPAPALRPPEPVPAPAALFSSPADEVLEAPEVVVAEAEEPK-P-QQLQQQR ENSCPOP00000014263/1-1702 NYALAIKPTPSTPPPRLPEPVLAPAALFSSPADEVLEAPEVVVAEAEEPK-PQQQLQVQQ XP_004856270.1/1-1698 NYALAVKPTPSTPAPRPPEPVPAPAALFSSPADEVLEAPEVVVAEAEEPK-PQQQVQVQQ *****:**.*.:*. * **. * ************************** * * . ENSMUSP00000047672/1-1716 QEGEEEEEDEEEESESSE-SSSSSSSD----------EEGAIRRRSLRSHTRRRRPPLPP ENSRNOP00000025773/1-852 QEGEDEEEDEEEESESSESSSSSSSSD----------EEGAIRRRSLRSHTRRRRPPLPP ENSP00000262519/1-1707 EEGEEEGE-EEGEEEEEESSDSSSSSD----------GEGALRRRSLRSHARRRRPPPPP ENSCPOP00000014263/1-1702 EEGEEEEE-EEEESESSESSSSSSSSD----------GDGAGRRRSLRSHARRRRPPLPP XP_004856270.1/1-1698 EEGEEEEE-EEEESESSESSSSSSSSDGARAGAGAGAGAGGGQRRSLRSHARRWRPVLPP :***:* * ** *.*..* *.****** *. :*******:** ** ** ENSMUSP00000047672/1-1716 PPPPPPSFEPRSEFEQMTILYDIWNSGLDLEDMSYLRLTYERLLQQTSGADWLNDTHWVQ ENSRNOP00000025773/1-852 PPPPPPSFEPRSEFEQMTILYDIWNSGLDLEDMSYLRLTYERLLQQTSGADWLNDTHWVH ENSP00000262519/1-1707 PPPPPRAYEPRSEFEQMTILYDIWNSGLDSEDMSYLRLTYERLLQQTSGADWLNDTHWVH ENSCPOP00000014263/1-1702 PPPPPPSFEPRSEFEQMTILYDIWNSGLDLEDMSYLRLTYERLLQQTSGADWLNDTHWVH XP_004856270.1/1-1698 PPPPP-SFEPRSEFEQMTILYDIWNSGLDLEDMSYLRLTYERLLQQTSGADWLNDTHWVH ***** ::********************* *****************************: ENSMUSP00000047672/1-1716 HTITNLSTPKRKRRPQDGPREHQTGSARSEGYYPISKKEKDKYLDVCPVSARQLEGGDTQ ENSRNOP00000025773/1-852 HTITNLSTPKRKRRPQDGPREHQTGSARSEGYYPISKKEKDKYLDVCPVSARQPEGVDTQ ENSP00000262519/1-1707 HTITNLTTPKRKRRPQDGPREHQTGSARSEGYYPISKKEKDKYLDVCPVSARQLEGVDTQ ENSCPOP00000014263/1-1702 HTITNLSTPKRKRRPQDGPREHQTGSARSEGYYPISKKEKDKYLDVCPVSARQLEGVDTQ XP_004856270.1/1-1698 HTITNLSTPKRKRRPQDGPREHQTGSARSEGYYPISKKEKDKYLDVCPVSARQLEGVDTQ ******:********************************************** ** *** ENSMUSP00000047672/1-1716 GTNRVLSERRSEQRRLLSAIGTSAIMDSDLLKLNQLKFRKKKLRFGRSRIHEWGLFAMEP ENSRNOP00000025773/1-852 GTNRVLSERRSEQRRLLSAIGTSAIMDSDLLKLNQLKFRKKKLRFGRSRIHEWGLFAMEP ENSP00000262519/1-1707 GTNRVLSERRSEQRRLLSAIGTSAIMDSDLLKLNQLKFRKKKLRFGRSRIHEWGLFAMEP ENSCPOP00000014263/1-1702 GTNRVLSERRSEQRRLLSAIGTSAIMDSDLLKLNQLKFRKKKLRFGRSRIHEWGLFAMEP XP_004856270.1/1-1698 GTNRVLSERRSEQRRLLSAIGTSAIVDSDLLKLNQLKFRKKKLRFGRSRIHEWGLFAMEP *************************:********************************** ENSMUSP00000047672/1-1716 IAADEMVIEYVGQNIRQMVADMREKRYVQEGIGSSYLFRVDHDTIIDATKCGNLARFINH ENSRNOP00000025773/1-852 IAADEMVIEYVGQNIRQMVADMREKRYVQEGIGSSYLFRVDHDTIIDATKCGNLARFINH ENSP00000262519/1-1707 IAADEMVIEYVGQNIRQMVADMREKRYVQEGIGSSYLFRVDHDTIIDATKCGNLARFINH ENSCPOP00000014263/1-1702 IAADEMVIEYVGQNIRQMVADMREKRYVQEGIGSSYLFRVDHDTIIDATKCGNLARFINH XP_004856270.1/1-1698 IAADEMVIEYVGQNIRQMVADMREKRYVQEGIGSSYLFRVDHDTIIDATKCGNLARFINH ************************************************************ ENSMUSP00000047672/1-1716 CCTPNCYAKVITIESQKKIVIYSKQPIGVDEEITYDYKFPLEDNKIPCLCGTESCRGSLN ENSRNOP00000025773/1-852 CCTPNCYAKVITIESQKKIVIYSKQPIGVDEEITYDYKFPLEDNKIPCLCGTESCRGSLN ENSP00000262519/1-1707 CCTPNCYAKVITIESQKKIVIYSKQPIGVDEEITYDYKFPLEDNKIPCLCGTESCRGSLN ENSCPOP00000014263/1-1702 CCTPNCYAKVITIESQKKIVIYSKQPIGVDEEITYDYKFPLEDNKIPCLCGTESCRGSLN XP_004856270.1/1-1698 CCTPNCYAKVITIESQKKIVIYSKQPIGVDEEITYDYKFPLEDSKIPCLCGAESCRGSLN *******************************************.*******:********