CLUSTAL W(1.81) multiple sequence alignment ENSP00000254528/1-1053 ------------------------------------MWQP-------------------- ENSMUSP00000024849/1-1074 ------------------------------------MCQE-------------------- ENSRNOP00000053111/1-1069 ------------------------------------MCQE-------------------- XP_004853363.1/1-983 MKGSAEDGAEAPSQVLVLACLQYEDLGPDHAKSLGASCRPTLESWRNQRGVRIPQALPGE ENSCPOP00000014235/1-1004 ------------------------------------------------------------ ENSP00000254528/1-1053 --------------------RRPWPRVP-------------------------------- ENSMUSP00000024849/1-1074 --------------------TPPRPRAP-------------------------------- ENSRNOP00000053111/1-1069 --------------------TPPRPRAP-------------------------------- XP_004853363.1/1-983 LRFRRNRAKPARLPHVGSVTRHPHPAVPAPPRGGSGGAARRGRGRRRSRARPVPLERALR ENSCPOP00000014235/1-1004 ------------------------------------------------------------ ENSP00000254528/1-1053 -------------WR---WA---LALLALVGAGLCHAGPQPGYPARPSA--RNKNWCAYI ENSMUSP00000024849/1-1074 -------------SR---WTPALLALLALGGAGLCHASSQPGYHARPSA--RNKNWCAYI ENSRNOP00000053111/1-1069 -------------SR---WTPALLALLALGGAGLCHASSQPGYHARPSA--RNKNWCAYI XP_004853363.1/1-983 TAPGIKRARAERAWRARMRPPALLLLAALGGAGLSLGGPQPG----------RGNRCAHI ENSCPOP00000014235/1-1004 --------------------PALLLLAALGGAGLSLGGAQPGRRCSPPALCPRRNRCAHI * * ** ****. ...*** . * **:* ENSP00000254528/1-1053 VNKNVSCSVLEGSESFIQAQYNCAWNQMPCPSALVYRVNFRPRYVTRYKTVTQLEWRCCP ENSMUSP00000024849/1-1074 VNKNVSCTVQEGSESFIQAQYNCPWNQMPCPSALVYRVNFRPRFVTRYKIVTQLEWRCCP ENSRNOP00000053111/1-1069 VNKNVSCTVQEGSESFIQAQYNCPWNQMPCPSALVYRVNFRPRFVTRYKIVTQLEWRCCP XP_004853363.1/1-983 VTRDVSCAVLDGSESFVQAQPGCPWGPAPCPAARVYRVNFRPRYVTRFKTVTQLEWRCCP ENSCPOP00000014235/1-1004 VSRNVSCAVLDGSESFVQARPGCPWGQAPCAAALVYHVNFRPRYVTRFKTVTQLEWRCCP *.::***:* :*****:**: .*.*. **.:* **:******:***:* ********** ENSP00000254528/1-1053 GFRGGDCQEGPKDPVKTLRPTPARPRNSLKKATDNE-PSQFSEPRKTLSPTGTAQPSWGV ENSMUSP00000024849/1-1074 GFRGPDCQEGPKDHMKTPRPPSARPKNNLKKATDTD-PSQVSQPKKTLSPTNAVEPGQVA ENSRNOP00000053111/1-1069 GFRGADCQEGPKDAMKTPRTPPVRPRNNLKKATDTD-PSQVSQPKKTLSPTNATEPGQVA XP_004853363.1/1-983 GFHGPDCQEGPRSPAAGPRPTSARRRNSM-KAPDHE-PSQASQPRAPLAPTRAEEPRRVG ENSCPOP00000014235/1-1004 GFRGPDCQEGPRVPAQGPHPSPSRPR-SLKKATDNETPSQVSLPKTSLPPTRATAPQQPA **:* ******: :... * : .: **.* : *** * *: .*.** : * ENSP00000254528/1-1053 DPKEGPQELQEKKIQVLEEKVLRLTRTVLDLQSSLAGVSENLKHATQ----DDASRTRAP ENSMUSP00000024849/1-1074 DAKQGPPELQQSKVQVLEEKVVRLTRMVLDLQSTVVGLKENLKHTIQ----DDGRKEPDS ENSRNOP00000053111/1-1069 DPKQGPPEFQQTKVQVLEEKVVRLTRMVLDLQSSVSGLKENLKHTIQ----DDGSKEPAS XP_004853363.1/1-983 ERRPRPQELQEQQIQALEESVLRLTRTVAGLESSLAGVSENLQRAAQARAQDDAGEVRTT ENSCPOP00000014235/1-1004 EPGPGPQELQE-KIQVLEERVQRLTRTVLDLQNSLVGVAGHPKPTVH--DNDNASETLGT : * *:*: ::*.*** * **** * .*:.:: *: : : : : *:. . . ENSP00000254528/1-1053 GLSSQH--PKPDTTVSGDTETGQSPGVFNTKESGMKDIKSELAEVKDTLKNKSDKLEELD ENSMUSP00000024849/1-1074 WLGPLHPQPTPDSPLAGDAEPSQLPGIPSSKESGMKDIKSELAEVKDTLKTKSDKLEELD ENSRNOP00000053111/1-1069 WLGPLHPQPTPDGTFAGDAEPSQLPGILNSKESGMKDIKSELAEVKDTLKTKSDKLEELD XP_004853363.1/1-983 WPSS----PAPGPASVRGTEMAWLPGVLHSKEPGMKDIKSELAEVRGALKTKSDKLEELA ENSCPOP00000014235/1-1004 RLRDPHLSPTPDPAGPRDTEVAQYPGILPSKESGMRDIKSELAEVKDTLKTKSDKLEELD * *. . .:* . **: :**.**:*********:.:**.******** ENSP00000254528/1-1053 GKVKGYEGQLRQLQEAAQGPTVTMTTNELYQAYVDSKIDALREELMEGMDRKLADLKNSC ENSMUSP00000024849/1-1074 GKVKGYEGQLKQLQEAAQGPTVTMTTNELYQAYVDSKIDALREELMEGMDRKLADLKNTC ENSRNOP00000053111/1-1069 GKVKGYEGQLKQLQEAAQGPTVTMTTNELFQAYVDSKIDALREELMEGMDRKLADLKNTC XP_004853363.1/1-983 GKVQGYEGRLQQLQEAARGPTATMASAELLQAYVDGRLEALRAELLEGVDRKLGDLKATC ENSCPOP00000014235/1-1004 GKVRGYEGQLRQLQEAAQGPTATLSAPELLQAYVD------------GMDHKLGDLKDSC ***:****:*:******:***.*::: ** ***** *:*:**.*** :* ENSP00000254528/1-1053 EYKLTGLQQQCDDYGSSYLGVIELIGEKETSLRKEINNLRARLQEPSAQANCCDSEKNGD ENSMUSP00000024849/1-1074 EYKLVGLQQQCDDYGSSYLGVIELIGEKEASLKKDIADLRAQLQDPVAQPSCCNGQKSSD ENSRNOP00000053111/1-1069 EYKLVGLQQQCDDYGSSYLGVIELIGEKEASLKKDIADLRARLQDPTAQPSCCDGQKNGD XP_004853363.1/1-983 EYKQLGLQPQCEDYGSSPLGVLELLSEKEASLRQELGDLRARLQDPVARPGCCDGG-TSD ENSCPOP00000014235/1-1004 EYKLVGLQQQCDDYGSSYLGVLELLSEKEAGLRRELGDLR------------------GD *** *** **:***** ***:**:.***:.*:::: :** .* ENSP00000254528/1-1053 IGQQIKTLDQKIERVAEATRMLNGRLDNEFDRLIVPEPDVDFDAKWNELDARINVTEKNA ENSMUSP00000024849/1-1074 FGPQIKALDQKIERVAEATRMLNGRLDNEFDRLSVPEPDADFDARWTELDARINVTEKNA ENSRNOP00000053111/1-1069 FGPQIKTLDQKIERVAEATRMLNGRLDNEFDRLSFPEPDADFDARWNELDARINVTEKNA XP_004853363.1/1-983 GGPQIEALHRKIERVAEAARALNARLDNELERLAAPEAGADFGARWAELDARINAMERRA ENSCPOP00000014235/1-1004 WGPQIRVLDQKIERVAEATRMLNGRLDNEFERLAAPETDTDFDARWEELDARINVTERNA * **..*.:********:* **.*****::** **...**.*:* *******. *:.* ENSP00000254528/1-1053 EEHCFYIEETLRGAINGEVGDLKQLVDQKIQSLEDRLGSVLLQMTNNTGAELSPPGAAAL ENSMUSP00000024849/1-1074 EEHCFYIEETLRGTINGEVDDLRKLLNEKIHSLEDRLG-IVLQAANSSDVELTPMG-PAL ENSRNOP00000053111/1-1069 EEHCFYIEETLRGAINGEVDDLRKLLNEKIHSLEDRLG-IILQVTNGSDLELTPVG-PAL XP_004853363.1/1-983 REQ--------------------------------------------------------- ENSCPOP00000014235/1-1004 EEHCFYVEETLRGAIDGEVGGLRQLLDQKIHSLEDRLDSVLLQAANVSE------G-SAL .*: ENSP00000254528/1-1053 PGVSGSGDERVMMELNHLKDKVQVVEDICLLNIQGKPHGMEGALPNREDRAVRDSLHLLK ENSMUSP00000024849/1-1074 PEQPGAENEQVLMELSRLKDKVQVVEDFCL---QSLPHGIDGALPSVED-LTHVSLSLLE ENSRNOP00000053111/1-1069 SGQPGAENEQLLRELSRLKDKVQVVEDICL---QSLPHGIDGALPSGED-LTHVGLSLLE XP_004853363.1/1-983 -----------------------------------RPGG--------------------- ENSCPOP00000014235/1-1004 PEGPGWDGAHVLAELQRLQEQVQGVQDVCL------PPG-DGDRDRGGD-----GRSLWT * * ENSP00000254528/1-1053 SLNDTMHRKFQETEQTIQKLQQDFSFLYSQLNHTENDVTHLQKEMSNCRAGENAGMGRFT ENSMUSP00000024849/1-1074 SLNDTMHRQFQETSHSIQKLQEDVNALHSQLNHSECTGTYLQNGVSDSRTGDSMEASGFT ENSRNOP00000053111/1-1069 SLNDTMHRQFQETSHSIQKLQEDFSALYSQLNHSEYTGTRLPNGVSD-----SMEASGFT XP_004853363.1/1-983 ------------------------------------------------------------ ENSCPOP00000014235/1-1004 AVNDTVHRRFQEAERGIRQLQEDLGALQSRLSHTEDSVSRLQKAVDDCISGVGTAASQGA ENSP00000254528/1-1053 KVGEQERTVDTLPSPQHPVAHCCSQLEERWQRLQSQVISELDACKECTQGVQREVSMVEG ENSMUSP00000024849/1-1074 KTGEQERTVGTVPSPGTPAAPCCGQLEERWQKLQNQMLAELDTCKESAHGVQSGVSAIEG ENSRNOP00000053111/1-1069 KTGEQERTVGTVPSPGGPVAPCCGQLEERWQRLQNQVLAELDTCKESAHGVQSGVSAVEG XP_004853363.1/1-983 ---------SALPVPPLPGAPCCAQLEGRWQTLQARMQAE-------------------- ENSCPOP00000014235/1-1004 E-GEQTAPAGTLLAPQESGAPCCAQLEDRWQGLLAQVQAELATCSQQARGA--------- .:: * . * **.*** *** * :: :* ENSP00000254528/1-1053 RVSHMEKTCSKLDSISGNLQRIKEGLNKHVSSLWNCVRQMNGTLRSHSRDISGLKNSVQQ ENSMUSP00000024849/1-1074 RVFQLEQTCRRLDTISGSLQRIKEGLGKHVGSLWNCIRQMNGTLKSHSRDISGLKNSVQQ ENSRNOP00000053111/1-1069 RVSQLEKTCSRLDAISGSLQRIKEGLGKHVGSLWNCVRQMNGTLRSHSRDISGLKNSVQQ XP_004853363.1/1-983 -----------LDAVAGGLRGVGEGLGQQVSALWGCVQGLNGTLRAQAGDLAGLQSSVRQ ENSCPOP00000014235/1-1004 ------RTCGRLDAVASSLQRIKEGLGKHVAGLWACVRQLNGTLGAHARDISGLQSSVRQ **:::..*: : ***.::*..** *:: :**** ::: *::**:.**:* ENSP00000254528/1-1053 FYSHVFQISTDLQDLVKFQPSA-----------------KAP---SPPPPA---EAPKEP ENSMUSP00000024849/1-1074 FYSHVFQISTDLQDLVKFQPSATEEPSEAT----EGPSGKTP-LESTRPSE---EAPTEP ENSRNOP00000053111/1-1069 FYSHVFQISTDLQDLVKFQPSATEEPLEAT----QGPSGKTP-LESTRPLE---EAPTEP XP_004853363.1/1-983 FYSHVFQVPSDPRGLVTLPPPPPAEPGTGTRGPSQGPSAAPPTRKSPKVPAGPGEALTAS ENSCPOP00000014235/1-1004 FYSHVFQISPDLQDLVTFPPPAG-----------EKPSAVSPSLETLQVPA---EATDAV *******:..* :.**.: *.. .* : ** ENSP00000254528/1-1053 LQPEPAPPRPSGPATAEDPGRRPVLPQR-----PPEERPPQP-----------PGSTGVI ENSMUSP00000024849/1-1074 PRLTPLPEDPAGPPQT---GQQPVLPQR------PLQPPPLPAWPGRTGLPFLPGSSGVI ENSRNOP00000053111/1-1069 PRLTPLPEHPAGPPQI---GQRPVLPQR------PLQPPPLPAWPGRMGLPVLPGSSGVI XP_004853363.1/1-983 PQPDRGPASPE--------DQGPALPPQ-----LP-QPPPAA-RPGWTGPPRLPGSAGLT ENSCPOP00000014235/1-1004 PQPEPSLAPPEDTARQWPTDQRPGLPKRPLAPWPPEQPLPAPFGPGWTGPPLLPGATGVV : * .: * ** : * : * . **::*: ENSP00000254528/1-1053 AETGQAGPPAGAGVSGRGLPRGVDGQTGSGTVPGAEGFAGAPGYPKSPPVASPGAPVPSL ENSMUSP00000024849/1-1074 METGEAGPPGRMGVSGRGLPRGVDGQMGQGPIHSSEGYAGAPGYPKSPPVTTPGVPLPTL ENSRNOP00000053111/1-1069 METGEAGPPGRMGMSGRGLPQGVDGQMGQGPIPSSEGYAGAPGYPKSPPVATQGVSLPAL XP_004853363.1/1-983 TETGEAGPPGGRGVSGRGLPRGEHGQTGPRPVPSAEGHAGAPGYPQAPPAASPGLLVPAL ENSCPOP00000014235/1-1004 METGEAGPPGRKAVWGKGLLRGVDGQSGRRPEPSAEGYAGAPGYPQTPPVAAPGLLVPGL ***:****. .: *:** :* .** * . .:**.*******::**.:: * :* * ENSP00000254528/1-1053 VSFSAGLTQKPFPSDGGVVLFNKVLVNDGDVYNPSTGVFTAPYDGRYLITATLTPERDAY ENSMUSP00000024849/1-1074 VSFSAGLTQKPFPSDGGVVLFNKVLVNDGDVYNPNTGIFTAPYDGRYLITATLTPERDTY ENSRNOP00000053111/1-1069 VSFSAGLTQKPFPSDGGVVLFNKVLVNDGDVYNPSTGIFTAPYDGRYLITATLTPERDAY XP_004853363.1/1-983 VSFSAGLTQNPFPSDGGVILFNKVLVNDGNVYNPNTGVFTAPYDGRYLLSATLTPERDAY ENSCPOP00000014235/1-1004 VSFSAGLTQKPFHSDGGVVLFNKVLVNDGDVYDPSTGVFTAPYDGRYLITATLTPERDAY *********:** *****:**********:**:*.**:**********::********:* ENSP00000254528/1-1053 VEAVLSVSNASVAQLHTAGYRREFLEYHRPPGALHTCGGPGAFHLIVHLKAGDAVNVVVT ENSMUSP00000024849/1-1074 VEAVLSVSNASVAQLHTAGYRREFLEYHRPPGAVHTCGGPGAFHLIVHLKAGDGVNVVVT ENSRNOP00000053111/1-1069 VEAVLSVSNASVAQLHTAGYRREFLEYHRPPGAVHTCGGPGAFHLIVHLKAGDGVNVVVT XP_004853363.1/1-983 VEAVLSVANASVAQLHTAGYQRELLEYHRPPGALHPCGGPGAFHLVVHLRAGDGVSVVLT ENSCPOP00000014235/1-1004 VEAVLSVANASVAQLHTAGYRRELLEVHRPRGA-HTCGGPGAFQLVVHLKAGDGVNVVVT *******:************:**:** *** ** *.*******:*:***:***.*.**:* ENSP00000254528/1-1053 GGKLAHTDFDEMYSTFSGVFLYPFLSHL ENSMUSP00000024849/1-1074 GGRLAHTDFDEMYSTFSGVFLYPFLSHL ENSRNOP00000053111/1-1069 GGRLAHTDFDEMYSTFSGVFLYPFLSHL XP_004853363.1/1-983 GGRLAHADFGEVYSTFSGVFLYPALGAL ENSCPOP00000014235/1-1004 GGRLAHTDSDEMYSTFSGVFLYPFLGRL **:***:* .*:*********** *. *