CLUSTAL W(1.81) multiple sequence alignment ENSP00000439689/1-1220 MGDQQLYKTNHVAHGSENLFYQQPPLGVHSGLNHNYGNAVTGGGMDAPQASPISPHFPQD ENSMUSP00000077103/1-1225 MGDQQLYKTNHVGHGGENLFYQQPPLGVHSGLGHSYGNTISGAGMDAPQASPISPHFPQD ENSRNOP00000032697/1-1120 MGDQQLYKTNHVAHGGENLFYQQPPLGVHSGLNHSYGNTISGAGMDAPQASPISPHFPQD ENSCPOP00000014171/1-1183 MGDQQLYKSNHVAHGGENLFYQQPPLGVHGGLNHSYGSSAAGGGMDAPQASPISPHFPQD XP_004846629.1/1-1190 MGDQQLYKSNHVTHGGENLFYQQPPLGVHGGLNHNYGNSVAAGGMDAPQASPISPHFPQD ********:*** **.*************.**.*.**.: :..***************** ENSP00000439689/1-1220 TRDGLGLPVGSKNLGQMDTSRQGGWGSHAGPGNHVQLRGNLANSNMMWGAPAQAEPTDGY ENSMUSP00000077103/1-1225 TRDGLGLPIGSKNLGQMDTSRQGGWGSHAGPGNHVQLRSNLANSNMMWGTPTQVEPADGY ENSRNOP00000032697/1-1120 TRDGLSLPIGSKNLGQMDASRQGGWGSHAGPGSHVQLRSNLANSNMMWGAPAQVEPTDGY ENSCPOP00000014171/1-1183 TRDGLNLPIGSKNLGQIDTSRQGGWGDHTGPGNHVQLRGNLTNSNMMWGPPAQVEPADGY XP_004846629.1/1-1190 TRDGLSLPVSSKNLGQIDTSRQGGWGGHAGPGNHVQLRGNLTNSNMMWGAPAQVEPADGY *****.**:.******:*:*******.*:***.*****.**:*******.*:*.**:*** ENSP00000439689/1-1220 QYTYSQASEIRTQKLTSGVLHKLDSFTQVFANQNLRIQVNNMAQVLHTQSAVMDGAPDSA ENSMUSP00000077103/1-1225 QYTYSQASEIRTQKLTSGVLHKLDSFTQVFANQNLRIQVNNMAQVLHTQSAVMDGASDSA ENSRNOP00000032697/1-1120 QYTYSQASEIRTQKLTSGVLHKLDSFTQVFANQNLRIQVNNMAQVLHTQSAVMDGASDSA ENSCPOP00000014171/1-1183 QYTYSQASEIRTQKLTSGVLHKLDSFTQVFANQNLRIQVNNMAQVLHTQSAVMDGAPDSA XP_004846629.1/1-1190 QYTYSQASEIRTQKLTSGVLHKLDSFTQVFANQNLRIQVNNMAQVLHTQSAVMDGAPDSA ********************************************************.*** ENSP00000439689/1-1220 LRQLLSQKPMEPPAPAIPSRYQQVPQQPHPGFTGGLSKPALQVGQHPTQGHLYYDYQQPL ENSMUSP00000077103/1-1225 LRQLLSQKPVEPSASAIASRYQQVPQQPHPGFTGGLPKPALPVGQHAPQGHLYYDYQQPL ENSRNOP00000032697/1-1120 LRQLLSQKPVEPSASAIASRYQQVPQQPHPGFTGGLPKPALPVGQHAPQGHLYYDYQQPL ENSCPOP00000014171/1-1183 LRQLLSQKPMETPAAALPSRYQQVPQQPPPGFTGGLSKPALQVGQHPAQGHLYYDYQQPL XP_004846629.1/1-1190 LRQLLSQKPMEPPAAALPSRYQQVPQQPHPGFTGELSKPALQVGQHPAQGHLYYDYQQPL *********:*..*.*:.********** ***** *.**** ****..************ ENSP00000439689/1-1220 AQVPVQGGQPLQAPQMLSQHMQQMQQHQYYP--PQQQQQAGQQRISMQEIQTQPQQ--IR ENSMUSP00000077103/1-1225 AQMSMQGGQPLQAPQVLSGHMQQLQQHQYYPQPPPQQQQAGLQRISVQEMQQQQQPQQIR ENSRNOP00000032697/1-1120 AQMSVQGGQPLQAPQVLSSHMQPLQQHQYYPQPPPQQQQAGLQRLSVQEMQQQQQQQ-IR ENSCPOP00000014171/1-1183 AQLPMQGGQPLQGPPVLSQPVPQT-QHQYYP-----QHHAGQQRLSMQEMQVQPPQQ-QQ XP_004846629.1/1-1190 GQMPMQGGQPLQGPSVLSQPVPQM-QHQYYPQQP--QQQAGQQRLSMQEMQPQPPQQLTR .*:.:*******.* :** : ****** *::** **:*:**:* * : ENSP00000439689/1-1220 PSQP---QPPPQQQQPQQLQLQQRQGSMQIPQYYQPQPMMQHLQEQQQQQMHLQPPSYHR ENSMUSP00000077103/1-1225 PSPP---------QQQQQLQLQQRQSSLQIPQYYQPQPMMQHLQEQQQPSMHLQPPSYHR ENSRNOP00000032697/1-1120 PSPPQQQQQQQQQQQQQQLQLQQRQSSLQIPQYYQPQPMMQHLQEQQQPSMHLQPPSYHR ENSCPOP00000014171/1-1183 PRAP----------QPQQ---QPRQGPMQIPQYYQPQP-MQHLQEQQQTSMHLQPPYYHR XP_004846629.1/1-1190 PPQP----------QPQQL---PRQGPMQIPQYYQPQPMMQHLQEQQQPSVHLQPPSYHR * * * ** **..:********** ********* .:***** *** ENSP00000439689/1-1220 DPHQYTPEQAHTVQLIPLGSMSQYYYQEPQQPYSHPLYQQSHLSQHQQREDSQLKTYSSD ENSMUSP00000077103/1-1225 DPHQYTPEQAHAVQLIQLGSMPQYYYQEPQQAYSHPLYPQSHLSQHQQREDGQLKTYSSD ENSRNOP00000032697/1-1120 DPHQYTPEQAHAVQLIQLGSMPQYYYQEPQQPYGHPLYQQSHLSQHLQREDSQLKTYSSD ENSCPOP00000014171/1-1183 DPHQYTPEQAHAVQLIQLGSMAPYYYQEPQQAYSHPLYQQSHLPQHQLREDSQLKTYSSD XP_004846629.1/1-1190 DPYQYTPEQAHAVQLIQLGSMAPYYYQEPQQPYSHPLYQQSHLAQHQPREDSQLKTYSSD **:********:**** ****. ********.*.**** ****.** ***.******** ENSP00000439689/1-1220 RQAQAMLSSHGDLGPPDTGMGDPASSDLTRVSSTLPHRPLLSPS-GIHLNNMGPQHQQ-L ENSMUSP00000077103/1-1225 RQTPAMLSSHGDMGTSDTGVADPASSEMTRVTSTLPHQPLLSPS-GIHLNNMGSQHQQPP ENSRNOP00000032697/1-1120 RQTPALLSSHGDMGPSDTGVADPASSEMTRVTSTLPHQPLLSPS-GIHLNSMGSQHQQ-P ENSCPOP00000014171/1-1183 RQAPALLGSQGDPTPSDTGMGDPASSDLTRVSSALPHRPILSPTSGIHLNNTGPQHPQ-P XP_004846629.1/1-1190 RQAPALLSSHGDLAPPDTGMGDSASSDLTRVGSALPHRPLLSPTSGIHLNNTDPQHPQ-P **: *:*.*:** ..***:.*.***::*** *:***:*:***: *****. ..** * ENSP00000439689/1-1220 SPSAMWPQMHLPDGRAQPGSPE-SSGQPKGAFGEQFDAKNKLTCSICLKEFKNLPALNGH ENSMUSP00000077103/1-1225 SPSAMWPQMHLPDGRAQSGSPESSSGQTKGVFGEQFDAKNKLTCSICLKEFKSLPALNGH ENSRNOP00000032697/1-1120 SPSAMWPQMHLPDGRAQPGSPE-SSGQTKGVFGEQFDAKNKLTCSICLKEFKSLPALNGH ENSCPOP00000014171/1-1183 SPSAMWPQMHLPDGRAQPASPE-SSGQPKGVFGEPFDAKGKLTCPICLKEFKSLPALNGH XP_004846629.1/1-1190 SPSAIWPQMHLPDGRAQPGSPE-SSGQPKGVFGEQFDAKNKLTCPICLKEFKSLPALNGH ****:************..*** ****.**.*** ****.****.*******.******* ENSP00000439689/1-1220 MRSHGGMRASPNLKQEEGEKVLPPQPQP------PLPPP--PPPPPPPQLPPEAESLTPM ENSMUSP00000077103/1-1225 MRSHGGMRASPSLKQEEGEKAPPPQPQPQPQPQQPLPPP--PPPPPPPQLPPEAERLTPM ENSRNOP00000032697/1-1120 MRSHGGMRASPSLKQ--------------------------------------------- ENSCPOP00000014171/1-1183 MRSHGGMRASPSLKQTRRTEGHKTRGQV----SKPLFPGLVDEIDPNPNLPPEAESLTPM XP_004846629.1/1-1190 MRSHGGMRASPSLKQEEGEKAPPPQPQP--QPQQPLPP----PPPPPPQLPPEAESLTPM ***********.*** ENSP00000439689/1-1220 VMPVSVPVKLLPPKPSSQGFTNSTVAAPSARDKPASSMSDDEMPVLVRMTLSPPHSPQGA ENSMUSP00000077103/1-1225 VMPVSVPVKLIPPKPSSQGFTNSVAATPAARDKPASSMSDDEMPVLVRMTLSPPHSPQGA ENSRNOP00000032697/1-1120 ------------------------------------------------------------ ENSCPOP00000014171/1-1183 VMPVSVPVKLLPPKPSSQGFTNSVAAAPSARDKPASSVSDDEMPVL-------------- XP_004846629.1/1-1190 VMPVSVPVKLLPPKPSSQGFANSIAAAPSARDKPASSASDDEMPVL-------------- ENSP00000439689/1-1220 APRTPAEIPRKHQPSVPKAEEPLKTVQEKKKFRHRPEPLFIPPPP-SYNPNPAASYSGAT ENSMUSP00000077103/1-1225 APRAPAEIPRKHPPIAAKVEEPLKNLPEKKKFRHRPEPLFIPPPPSSYTPNP-TSYSGAT ENSRNOP00000032697/1-1120 ------EIPRKHPPITAKVEEPLKTPPEKKKFRHRPEPLFIPPPPSSYTPNP-TSYSGAT ENSCPOP00000014171/1-1183 ------TLPKGLPPVLPLRSQPRRGTRSRAPVAPSPAPLHIPGSP--AHPHPGASGSVEP XP_004846629.1/1-1190 ------DAPRRPP----RAEEPRAT--ERRKPRPRPEPLFIPPPP-ACAPGP-VVGATAT *: .:* .: * **.** .* * * . : . ENSP00000439689/1-1220 LYQSQ---LRSPRVLGDHLLLDPT--HELPPYTPPPMLSPVRQGSGLFSNVLISGH--GP ENSMUSP00000077103/1-1225 LYQSQ---LRSPRILGDHLLLDPA--HELPPYTPPPMLSPVRQGSGLFSNVLISGH--GP ENSRNOP00000032697/1-1120 LYQSQ---LRSPRILGDHLLLDPA--HELPPYTPPPMLSPVRQGSGLFSNVLISGH--GP ENSCPOP00000014171/1-1183 ALSPQETSLPSPRVLGDPLLLDPARDREPLPYTPPPMLSPARQGSGLFSSVLLGGH---- XP_004846629.1/1-1190 LFQSQ---LRSPRVLGDPLLLAPARDREPPPYTPPPMLSPARQGSGLFSSVLLGGHLGGP ..* * ***:*** *** *: :* **********.********.**:.** ENSP00000439689/1-1220 GAHPQLPLTPLTPTPRVLLCRSNSIDGSNVTVTPGPGEQTVDVEPRINIGLRFQAEIPEL ENSMUSP00000077103/1-1225 GVHPQLPLTPLTPTPRVLLCRSSSIDGSNVTVTPGPGEQTVDVEPRINIGLRFQAEIPEL ENSRNOP00000032697/1-1120 GVHPQLPLTPLTPTPRVLLCRSSSIDGSNVTVTPGPGEQTVDVEPRINIGLRFQAEIPEL ENSCPOP00000014171/1-1183 ---------LLTPTPRVLLCRLNSIDGNNVTVTPGPGEQTVDVEPRINIGLRFQAEIPEL XP_004846629.1/1-1190 GAPPALPRTPLTPTPRVLLCRLNSIDGNNVTVTPGPGEQTVDVEPRINIGLKFQAEIPEL *********** .****.***********************:******** ENSP00000439689/1-1220 QDISALAQDTHKATLVWKPWPELENHDLQQRVENLLNLCCSSALPGGGTNSEFALHSLFE ENSMUSP00000077103/1-1225 QDVSALAQDTHRATLVWKPWPELENQALQQQVENLLNLCCSSALPGGGTNSEFALHSLFE ENSRNOP00000032697/1-1120 QDVSAMAQDTHKATLVWKPWPELENQALQQQVENLLNLCCSSALPGGGTNSEFALHSLFE ENSCPOP00000014171/1-1183 QDASALAQDTHKATLVWKPLPELENQDLQQQVENLLNLCCSSALPGGGTNFEFALHSLFE XP_004846629.1/1-1190 QDVSALAQDTHKATLVWKPLPELENQDLQQQVENLLNLCCSSALPGGGTNSEFALHSLFE ** **:*****:******* *****: ***:******************* ********* ENSP00000439689/1-1220 AKGDVMVALEMLLLRKPVRLKCHPLANYHYAGSDKWTSLERKLFNKALATYSKDFIFVQK ENSMUSP00000077103/1-1225 AKGDVMATLEMLLLRKPVRLKCHPLANYHYAGSDKWTSLERKLFNKALATYSKDFIFVQK ENSRNOP00000032697/1-1120 AKGDVMATLETLLLRKPVRLKCHPLANYHYAGSDKWTSLERKLFNKALATYSKDFIFVQK ENSCPOP00000014171/1-1183 ARGDVMATLEMLLLEKPVRLKCHPLANYHYAGSDKWTSLERKLFNKALATYNKDFIFVQK XP_004846629.1/1-1190 ARGDVMATLEMLLLEKPVRLKCHPLANYHYAGSDKWTSLERKLFNKALATYNKDFIFVQK *:****.:** ***.************************************.******** ENSP00000439689/1-1220 MVKSKTVAQCVEYYYTWKKIMRLGRKHRTRLAEIIDDCVTSEEEEELEEEEEEDPEEDRK ENSMUSP00000077103/1-1225 MVKSKTVAQCVEYYYTWKKIMRLGRKHRTRLAEIIDDCMTSEEEEEA-EEEEEDPEEDRK ENSRNOP00000032697/1-1120 MVKSKTVAQCVEYYYTWKKIMRLGRKHRTRLAEIIDDCMTSEEEEDA-EEEEEDPEEDRK ENSCPOP00000014171/1-1183 MVKSKTVAQCVEYYYTWKKIMRLGRKHRTRLAEIIEDCMTSEEEEEF-EEEEEDPEEDRK XP_004846629.1/1-1190 MVKSKTVAQCVEYYYTWKKIMRLGRKHRTRLVEIIEDCMTSEEEEEL-EEEEEDPEEDRK *******************************.***:**:******: ************ ENSP00000439689/1-1220 STKEEESEVPKSPEPPPVPVLAPTEGPPLQALG-QPSGSFICEMPNCGAVFSSRQALNGH ENSMUSP00000077103/1-1225 SIKEEESEVAKSPEPPPAPALAPTEGPPMQAVGQQPSGNFICEMPNCGAVFSSRQALNGH ENSRNOP00000032697/1-1120 SIKDEESEVPKTPEPPPAPALAPTEGAPMQAGG-QPSGSFICEMPNCGAVFSSRQALNGH ENSCPOP00000014171/1-1183 STKEEESEVQKSPEPPPVPLAAPTEGLSLQAPG-QPSGAFVCEMPNCGAVFSSRQALNGH XP_004846629.1/1-1190 STKEEESEVQKSPEPPPVPALAPTEGLSVQAPG-QPLGAFICEMPNCGAVFSSRQALNGH * *:***** *:*****.* ***** .:** * ** * *:******************* ENSP00000439689/1-1220 ARIHGGTNQVTKARGAIPSGKQKPGGTQSGYCSVKSSPSHSTTSGETDPTTIFPCKECGK ENSMUSP00000077103/1-1225 ARIHGGTNQVAKTRGAIPSGKQKPGGTQSGYCSVKSSPSHSTTSGETDPTTIFPCKECGK ENSRNOP00000032697/1-1120 ARIHGGTNQVAKTRGAVPSGKQKPGGTQSGYCSVKSSPSHSTTSGETDPTTIFPCKECGK ENSCPOP00000014171/1-1183 ARIHGGTNQVAKTRGNVPSGKQKPSGAQSGYCSVKSSPSHSTTSGETDPTTIFPCKECGK XP_004846629.1/1-1190 ARIHGGTNQVTKTRGAVPCTKQKPGGAQSGYCSVKSSPSHSTTSGETDPTTIFPCKECGK **********:*:** :*. ****.*:********************************* ENSP00000439689/1-1220 VFFKIKSRNAHMKTHRQQEEQQRQKAQKAAFAAEMAATIERTTGPVGAPGLLPLDQLSLI ENSMUSP00000077103/1-1225 VFFKIKSRNAHMKTHRQQEEQQRQKAQKAAFAAEMAATIERTTGPVGAPELLPLDQLSLM ENSRNOP00000032697/1-1120 VFFKIKSRNAHMKTHRQQEEQQRQKAQKAAFAAEMAATIERTTGPVGAPELLPLDQLSLM ENSCPOP00000014171/1-1183 VFFKIKSRNAHMKTHRQQEEQQRQKAQKAAFAVEMAATIERTTEPAGPQRLLPLGQLGLI XP_004846629.1/1-1190 VFFKIKSRNAHMKTHRQQEEQQRQKAQKAAFAVEMAATIERTTEPVGAPRLLPLGQLSLI ********************************.********** *.*. ****.**.*: ENSP00000439689/1-1220 KPIKDVDILDDDVVQQLGGVMEEAEVVDTDLLLDDQDSVLLQGDAEL ENSMUSP00000077103/1-1225 KPVKDVDILDDDVVQQL-GVMDEAEVVGTDLLLDDQDSVLLQGDTEL ENSRNOP00000032697/1-1120 KP-KDVDILDDDMVQQL-GVMDEAEVVGTDLLLDNQDSVLLQGDTEL ENSCPOP00000014171/1-1183 KPIKDVDILDDDVVQQLGGVMEEAEVVDTNLLLDDQDSVLLHGDTEL XP_004846629.1/1-1190 KPIKDMDILDDDVVQQLGGVIEEAEVVDTDLLLDDQDSVLLHGDTEL ** **:******:**** **::*****.*:****:******:**:**