CLUSTAL W(1.81) multiple sequence alignment ENSCPOP00000014078/1-1391 ---------------------------------------------------HVQEASGNH XP_004867274.1/1-1532 MDDEDGRCLLDVICDPQALNDFLHGSEKLDSDDLLDAPGEAQSAFYEGPGLHVQEASGNH ENSP00000379946/1-1560 MDDEDGRCLLDVICDPQALNDFLHGSEKLDSDDLLDNPGEAQSAFYEGPGLHVQEASGNH ENSMUSP00000092416/1-1578 MDDEDGRCLLDVICDPQALNDFLHGSEKLDSDDLLDAPVEAQSAFYEGPGLHVQEAAANH ENSRNOP00000015059/1-1576 MDDEDGRCLLDVICDPQALNDFLHGSEKLDSDDLLDAPVEAQSAFYEGPGLHVQEAAGNH *****:.** ENSCPOP00000014078/1-1391 LNPEPSQPAPSVDLDFLEDDILGSPATAGGGGGGGGADQPCDILQQSLQEANITEQTLEA XP_004867274.1/1-1532 LNPEPSQPAPSVDLDFLEDDILGSPTTAGAGGGGGGADQPCDILQQSLQEANITEQTLEA ENSP00000379946/1-1560 LNPEPNQPAPSVDLDFLEDDILGSPATGGGGGGSGGADQPCDILQQSLQEANITEQTLEA ENSMUSP00000092416/1-1578 LNPEPSQPAPSVDLDFLEDDILGSPAAGGGGGGGGAPDQPCDILQQSLQEANITEQTLEA ENSRNOP00000015059/1-1576 LNPEPSQPAPSVDLDFLEDDILGSPAAGGGGGGGGGPDQPCDILQQSLQEANITEQTLEA *****.*******************::.*.***.*..*********************** ENSCPOP00000014078/1-1391 EAELDLGPFQLPTLQAADGGAGPTGASGAAAVATGPQALFPGGADLLGLQAQPTVLTHQA XP_004867274.1/1-1532 EAELDLGPFQLPTLQPADGGAGPTGAAGTAAVAAGPQALFPGSADLLGLQAPPTVLTHQA ENSP00000379946/1-1560 EAELDLGPFQLPTLQPADGGAGPTGAGGAAAVAAGPQALFPGSTDLLGLQGPPTVLTHQA ENSMUSP00000092416/1-1578 EAELDLGPFQLPTLQPADNGAGATGAAGATAVTAGPQALFPGSADLLGLQAPPTVLTHQA ENSRNOP00000015059/1-1576 EAELDLGPFQLPTLQPADGGAGATGAAGAAAVTAGPQALFPGSADLLGLQAPPTVLTHQA ***************.**.***.***.*::**::********.:******. ******** ENSCPOP00000014078/1-1391 LVPPQDMVNKALSVQPFLQPVGLGNVTLQPIPGLQGLPNGSPGGATAATLGLAPIQVVGQ XP_004867274.1/1-1532 LVPPQDVVNKALSVQPFLQPVGLGNVTLQPIPGLQGLPNGSPGGASAATLGLAPIQVVGQ ENSP00000379946/1-1560 LVPPQDVVNKALSVQPFLQPVGLGNVTLQPIPGLQGLPNGSPGGATAATLGLAPIQVVGQ ENSMUSP00000092416/1-1578 LVPPQDVVNKALSVQPFLQPVGLGNVTLQPISGLQGLPNGSPGNAAAATLGLTPIQVVGQ ENSRNOP00000015059/1-1576 LVPPQDVVNKALSVQPFLQPVGLGNVTLQPIQGLQGLPNGSPGGATAATLGLAPIQVVGQ ******:************************ ***********.*:******:******* ENSCPOP00000014078/1-1391 PVMALNPPTSQLLAKQVPVSGYLASAAGPSEPVTLASAGVSPQGAGLVIQKSLPATVATT XP_004867274.1/1-1532 PVMALNPPTSQLLAKQVPVSGYLASAAGPSEPVTLASAGVSPQGAGLVIQKSLPAAVATT ENSP00000379946/1-1560 PVMALNTPTSQLLAKQVPVSGYLASAAGPSEPVTLASAGVSPQGAGLVIQKNLSAAVATT ENSMUSP00000092416/1-1578 PVMALNPPTSQLLAKQVPVSGYLASAAGPSEPVTLASAGVSPQGAGLVIQKNLPAAVTTT ENSRNOP00000015059/1-1576 PVMALNPPTSQLLAKQVPVSGYLASAAGPSEPVTLASAGVSPQGAGLVIQKNLPAAVTTT ******.********************************************.*.*:*:** ENSCPOP00000014078/1-1391 LNGNSVFAGAGAATVAASGAPSGQPLAVAPGLGTSPLVPAPNVILHRTPTPIQPKPAGVL XP_004867274.1/1-1532 LNGNSVFAGAGAATVAASGAASGPPLAVAPGLGTSPLVPAPNVILHRTPTPIQPKPAGVL ENSP00000379946/1-1560 LNGNSVFGGAGAAS-APTGTPSGQPLAVAPGLGSSPLVPAPNVILHRTPTPIQPKPAGVL ENSMUSP00000092416/1-1578 LNGNSVFAGTGAATAAASGAPSGQPLAVAPGLGTSPLVQAPSVILHRTPTPIQPKPTGVL ENSRNOP00000015059/1-1576 LNGNSVFAGTGSATAAASGAPSGQPLAVAPGLGTSPLVQAPNVILHRTPTPIQPKPAGVL *******.*:*:*: *.:*:.** *********:**** **.**************:*** ENSCPOP00000014078/1-1391 PSKLYQLTPKPFAPAGATLTIQGEPGALPQQPKAPQNLTFMAAAGKAGQNVVLSGFPAPA XP_004867274.1/1-1532 PPKLYQLTPKPFGPAGATLTIQGEPGALPQQPKAPQNLTFMAAAGKAGQNVVLSGFPAPA ENSP00000379946/1-1560 PPKLYQLTPKPFAPAGATLTIQGEPGALPQQPKAPQNLTFM-AAGKAGQNVVLSGFPAPA ENSMUSP00000092416/1-1578 PSKLYQLTPKPFPPTGATLTIQGEPGTLPQQPKAPQNLTFM-ATGKAGQNVVLSGFPAPA ENSRNOP00000015059/1-1576 PPKLYQLTPKPFTPTGATLTIQGEPGTLPQQPKAPQNLTFM-AAGKAGQNVVLSSFPAPA *.********** *:***********:************** *:**********.***** ENSCPOP00000014078/1-1391 LQANVFKQPPVTTAGTVPPQPPGALSKPMSVHLLNQGSSIVIPAQHVLPGQNQFLLPGAP XP_004867274.1/1-1532 LQANVFKQPPVSSAGTAPPQPPGALSKPMSVHLLNQGSSIVIPAQHVLPGQNQFLLPGAP ENSP00000379946/1-1560 LQANVFKQPPATTTGAAPPQPPGALSKPMSVHLLNQGSSIVIPAQHMLPGQNQFLLPGAP ENSMUSP00000092416/1-1578 LQANVFKQPPVTTTGTAPPQPPGALSKPMSVHLLNQGSSIVIPAQHMLPGQNQFLLPGTP ENSRNOP00000015059/1-1576 LQANVFKQPPVTTTGTAPPQPPGALSKPMSVHLLNQGSSIVIPAQHMLPGQNQFLLPGTS **********.:::*:.*****************************:***********:. ENSCPOP00000014078/1-1391 AAVPLPQSLSALPASVGGQILTAAAPHPGGQLIANPILTNQNLAGPLSLGPVLAPHSGAH XP_004867274.1/1-1532 AAVPLPQPLSALPASVGGQILTATAPHPGGQLLANPILTNQNLAGPLSLGPVLAPHSGPH ENSP00000379946/1-1560 -AVQLPQQLSALPANVGGQILAAAAPHTGGQLIANPILTNQNLAGPLSLGPVLAPHSGAH ENSMUSP00000092416/1-1578 -AVQLPQSLSALPANVGGQILTAAAPHAGGQLIANPILTNQNLAGPLSLGPVLAPHSGAH ENSRNOP00000015059/1-1576 -AVQLPQSLSALPANVGGQILTAAAPHAGGQLIANPILTNQNLAGPLSLGPVLAPHSGAH ** *** ******.******:*:***.****:*************************.* ENSCPOP00000014078/1-1391 SAAHILSAAPIQVGQPALFQMPVSLAAGSLPTQSQPAPTGPAATTTVLQGVTLPPSAVAM XP_004867274.1/1-1532 GAAHILSAAPIQVGQPALFQMPVSLAAGSLPTQSQPAPAGPAA-TTVLQGVTLPPSAVAM ENSP00000379946/1-1560 S-AHILSAAPIQVGQPALFQMPVSLAAGSLPTQSQPAPAGPAA-TTVLQGVTLPPSAVAM ENSMUSP00000092416/1-1578 SAAHILSAAPIQVGQPALFQMPVSLATGSLPTQSQPAPTGPTA-TTVLQGVTLPPSAVAM ENSRNOP00000015059/1-1576 SAAHILSAAPIQVGQPALFQMPVSLATGSLPTQSQPAPTGPTA-TTVLQGVTLPPSAVAM . ************************:***********:**:* **************** ENSCPOP00000014078/1-1391 LNTPDGLVQPATPAAATGEATPVLAVQPAPSVPPAVSTPLPLGLQQP----PPQAPL--- XP_004867274.1/1-1532 LNAPDGLVQPAAPAATTGEATPVLAVQPAPPVPPVVSTPLPLGLQQPPA-QAPQAPAPQA ENSP00000379946/1-1560 LNTPDGLVQPATPAAATGEAAPVLTVQPAPQAPPAVSTPLPLGLQQPQAQQPPQAPTPQA ENSMUSP00000092416/1-1578 LNTPDGLVQPSTPAATTGEATPVLAVQPATQVPPAVTTPLPMGLQQPQAQQPPQVPTPQA ENSRNOP00000015059/1-1576 LNTPDGLVQPSTPAATTGEATPVLAVQPATQVPPAVTTPLPMGLQQSPAQQPPQAPTPQA **:*******::***:****:***:****. .**.*:****:****. .**.* ENSCPOP00000014078/1-1391 --------------LASSPEKIILGQPPSASTTTILTQDSLQMFLPQERSQPPLSTEGPH XP_004867274.1/1-1532 TAPPQASTPQPSPGLASSPEKIVLGQ-PSAAATAILTQDSLQMFLPQERSQPPLSTEGPH ENSP00000379946/1-1560 AAPPQATTPQPSPGLASSPEKIVLGQPPSATPTAILTQDSLQMFLPQERSQQPLSAEGPH ENSMUSP00000092416/1-1578 ATQPQATPPQASPSLASSPEKIVLGQAPPAATTAILTQDSLQMFLPQERSQQPLSTEGPH ENSRNOP00000015059/1-1576 ATQPQATPPQASPGLASSPEKIVLGQAPPAATTAILTQDSLQMFLPQERSQQPLSTEGPH ********:*** *.*:.*:***************** ***:**** ENSCPOP00000014078/1-1391 LSVPASVIVSAPPPAQDPALVTPIAKVDGLRQPQCRPGLAPGTPAPAAP--TPHRGQCSM XP_004867274.1/1-1532 LSVPASVIVSAPPPAQDPALANPIAKGAGH-GPQA-NSQASPAPAPQIPAAAPLKGPGPS ENSP00000379946/1-1560 LSVPASVIVSAPPPAQDPAPATPVAKGAGL-GPQAPDSQASPAPAPQIPAAAPLKGPGPS ENSMUSP00000092416/1-1578 LSVPASVIVSAPPPAQDPALATPVTKGAGL-GAQTPDSRASPAPAPQIPAAAPLKAPGPA ENSRNOP00000015059/1-1576 LSVPASVIVSAPPPAQDPALATPVTKGAGL-GAQTPDNRASPAPAPQIPAAAPLKAPGPA ******************* ..*::* * .* . *. :*** * :* :. . ENSCPOP00000014078/1-1391 ESSLTPAFLSVGKVEHLPYIPPYPVIPSPVLPC-------SQPSAEQKPDFKKPNRVPLI XP_004867274.1/1-1532 SSPSLPHQAPLGDSPHMP--SPHPARPPSRPPSRPHSRPPSQPQSLSRPP-SEPALHPCP ENSP00000379946/1-1560 SSPSLPHQAPLGDSPHLP--SPHPTRPPSRPPSR--------PQSVSRPP-SEPPLHPCP ENSMUSP00000092416/1-1578 SSPSLPHQAPLGDSPHMP--SPHPARPPSRPPSRPHSRPPSQPQSLTCPP-SEPTLHPCP ENSRNOP00000015059/1-1576 SSPSLPHQAPLGDSPHMP--SPHPARPPSRPPSRPHSRPPSQPQSLTCPP-SEPTLHPCP .*. * .:*. *:* .*:*. *.. *. *.: * .:* * ENSCPOP00000014078/1-1391 PWHSTPALPHPLARE---GVPGRAARSLPGSPGPPLALRGPPSEPALHPCPP-PQPPPTL XP_004867274.1/1-1532 PPQPPPTLPGIFVIQNQLGVPPPTSAPAPTAPGPPQPALRPPSQPPEGPLPPTPHLPAAS ENSP00000379946/1-1560 PPQAPPTLPGIFVIQNQLGVPPPASNPAPTAPGPPQPPLRPQSQPPEGPLPPAPHLPPSS ENSMUSP00000092416/1-1578 PPQGPPTLPGIFVIQNQLGAPPPASTPASTAPGPPQPPLRPPSQPPEGPLPPASHLPPAS ENSRNOP00000015059/1-1576 PPQGPPTLPGIFVIQNQLGAPPPASTPAPTAPGPPQPPLRPPSQPPEGPLPPASHLPPAS * : .*:** :. : *.* :: . . :**** . * *:*. * ** .: *.: ENSCPOP00000014078/1-1391 PSIFVIQNQDTPTRLPAPASSDFQLQYPPGQGPQ--------------------PPPRTF XP_004867274.1/1-1532 TPSGV-TSSETPTRLPAPTPSDFQLQFPPGQGPHKSPTPPPTLHLAPEPAAPPPPPPRTF ENSP00000379946/1-1560 TSSAVASSSETSSRLPAPTPSDFQLQFPPSQGPHKSPTPPPTLHLVPEPAAPPPPPPRTF ENSMUSP00000092416/1-1578 TPSAVASSSEPSARLPVPTPPDFQLQFPPSQGPHKSPTPPPALHMVPEPTAPPPPPPRTF ENSRNOP00000015059/1-1576 TPSAVASSSEPSTRLPVPTPPDF--QFPPGQGPHKSPTPPPALHLVPEPTAPPPPPPRTF .. * ..:..:***.*:..** *:**.***: ****** ENSCPOP00000014078/1-1391 QMVTTPFPALPQPKALLERFHQVQSGIILQNKTSGAP---QTSTSLVPLANPTASVLVSG XP_004867274.1/1-1532 QMVTTPFPALPQPKALLERFHQVPSGILLQNKAAGAPGTQQTPTSLGPLANPTASVLVSG ENSP00000379946/1-1560 QMVTTPFPALPQPKALLERFHQVPSGIILQNKAGGAPAAPQTSTSLGPLTSPAASVLVSG ENSMUSP00000092416/1-1578 QMVTAPFPALPQPKALLERFHQVPSGIILQNKAGGTPTTPQTSTTLGTLTGPTASVLVSG ENSRNOP00000015059/1-1576 QMVTAPFPALPQPKALLERFHQVPSGIILQNKAGGTPTTPQTSTTLGTLTSPTASVLVSG ****:****************** ***:****:.*:* **.*:* .*:.*:******* ENSCPOP00000014078/1-1391 PAPSGTPASSSHPPAPAAMATAGLPALLPAEGKAFPSNLPTLSVAKASAPGPVKSSGLQY XP_004867274.1/1-1532 PAPPGTPTGSSHPPAPAPMATTGLAPLLPAESKAFPSNLPILSVAKTAAPGPAKSSGLQY ENSP00000379946/1-1560 QAPSGTPTAPSHAPAPAPMAATGLPPLLPAENKAFASNLPTLNVAKAASSGPGKPSGLQY ENSMUSP00000092416/1-1578 QAPPGTPAASSHVPASTPMATTGLPPLLPAENKAFASNLPTLSVAKATVSGPGKPPAIQY ENSRNOP00000015059/1-1576 QAPPGTPAASSHAPASTPMATTGLPPLLPAENKAFASNLPTLSVAKATVSGPGKSPAMQY **.***:..** **.:.**::**..*****.***.**** *.***:: .** *...:** ENSCPOP00000014078/1-1391 EGKLSGLKKPPALQPSKEACFLEHLHKHQGSVLHPDYKTAFPSFEDAVHRLLPYHVYQGT XP_004867274.1/1-1532 EGKLSGLKKTPTLQPSKEACFLEHLHKHQGSVLHPDYKTAFPSFEDALHRLLPYHVYQGA ENSP00000379946/1-1560 ESKLSGLKKPPTLQPSKEACFLEHLHKHQGSVLHPDYKTAFPSFEDALHRLLPYHVYQGA ENSMUSP00000092416/1-1578 DSKLCSLKKQPLLQPSKEACFLEHLHKHQGSVLHPDYKTAFPSFEDALHRLLPYHVYQGA ENSRNOP00000015059/1-1576 DSKLGSLKKQPLLQPSKEACFLEHLHKHQGSVLHPDYKTAFPSFEDALHRLLPYHVYQGA :.** .*** * ***********************************:***********: ENSCPOP00000014078/1-1391 LPSPSDYHKVDEEFETVSTQLLKRTHAMLNKYRLLLLEESRRVSPSAEMVMIDRMFIQEE XP_004867274.1/1-1532 LPSPSDYHKVDEEFETVSTQLLKRTHAMLNKYRLLLLEESRRVSPSAEMVMIDRMFIQEE ENSP00000379946/1-1560 LPSPSDYHKVDEEFETVSTQLLKRTQAMLNKYRLLLLEESRRVSPSAEMVMIDRMFIQEE ENSMUSP00000092416/1-1578 LPSPNDYHKVDEEFETVSTQLLKRTQAMLNKYRLLLLEESRRVSPSAEMVMIDRMFIQEE ENSRNOP00000015059/1-1576 LPSPNDYHKVDEEFETVSTQLLKRTQAMLNKYRLLLLEESRRVSPSAEMVMIDRMFIQEE ****.********************:********************************** ENSCPOP00000014078/1-1391 KTTLALDKQLAKEKPDEYVSSSRSLGLPATVAS-----------------SGVPA--PAH XP_004867274.1/1-1532 KTTLALDKQLAKEKPDEYVSSSRSLGLPVAVASSEGPRPPSHGPAPPVA-PGVPA--PAH ENSP00000379946/1-1560 KTTLALDKQLAKEKPDEYVSSSRSLGLPIAASS-EGHRLPGHGPLSSSA-PGASTQPPPH ENSMUSP00000092416/1-1578 KTTLALDKQLAKEKPDEYVSSSRSLGFPVPVSS-EGHRLPSHGQSSSSSTSGTSAQPPPH ENSRNOP00000015059/1-1576 KTTLALDKQLAKEKPDEYVSSSRSLGFPVPVSS-EGHRLPSHGPSSSSSTSGTSAQPPPH **************************:* ..:* .*..: *.* ENSCPOP00000014078/1-1391 PPTKLVIRHGGAGGSPSVTWARASSA--TLSSPSLSSSSAASSLDADEDGPMPSRNRPPI XP_004867274.1/1-1532 PPTKLVIRHGGVGGSPSVTWARTSSA--TLPSPS-LSSCAASSLDADEDGPMPSRNRPPI ENSP00000379946/1-1560 LPTKLVIRHGGAGGSPSVTWARASS---SLSSSS-SSSSAASSLDADEDGPMPSRNRPPI ENSMUSP00000092416/1-1578 LPTKLVIRHGGAGGSPSVTWARASSSLSSTSSSS-SSSSAASSLDADEDGPMPTRNRPPI ENSRNOP00000015059/1-1576 PPTKLVIRHGGAGGSPSVTWARASSSLSSTSSSS-SSSSVASSLDADEDGPMPSRSRPPI **********.**********:** : .*.* **..*************:*.**** ENSCPOP00000014078/1-1391 KTYEARSRIGLKLKIKQEAGFSKVVHNTALDPVHQ-----ASLRRARSTARLSAHPLP-- XP_004867274.1/1-1532 KTYEARSRIGLKLKIKQEAGLSKVVHNTALDPVHQPPPTASQVNGTAERASPAPER---- ENSP00000379946/1-1560 KTYEARSRIGLKLKIKQEAGLSKVVHNTALDPVHQPPPPPATLKVAEPPPRPPPPPPP-- ENSMUSP00000092416/1-1578 KTYEARSRIGLKLKIKQEAGLSKVVHNTALDPVHQPLPAPTPAKGAEPPPHPAPPPLPPA ENSRNOP00000015059/1-1576 KTYEARSRIGLKLKIKQEAGLSKVVHNTALDPVHQPLPAPTPAKGAEPPPHPAPPPLPPA ********************:************** : . : . .. ENSCPOP00000014078/1-1391 --------------------PSAKGAHCPRLPLRKTYRENVGV----------------- XP_004867274.1/1-1532 -ERKPSGPGPGPGPG---PGPG-PGTHGPRLPLRKTYRENVGG----------------- ENSP00000379946/1-1560 -TGQMNGTVDHPPPAAPERKPLGTAPHCPRLPLRKTYRENVGGPGAPEGTPAGRARG-GS ENSMUSP00000092416/1-1578 TQAQMNGTLDHPPPAV--RKPTVPAS-CPRLPLRKTYRENMGNPGAAEGAQ-GRPRGAGS ENSRNOP00000015059/1-1576 TQAQMNGTLDHPPPIV--RKPTVPAS-CPRLPLRKTYRENMGDPSATEGAQ-GRPRGAGS * .. ************:* ENSCPOP00000014078/1-1391 ------RADEATSGLIRELAAVEDELYQRLRKAAPTEPTAPG---APAA-DPGWDAVTAP XP_004867274.1/1-1532 ------RAEEATSGLIRELAAVEDELYQRLRKAAAPEPAAPS---APDP-DPGWDAAPAP ENSP00000379946/1-1560 PAPLPAKVDEATSGLIRELAAVEDELYQRMLKGPPPEPAASA---AQGTGDPDWEAPGLP ENSMUSP00000092416/1-1578 PTPLPTKVDEATSGLIRELAAVEDELYQRVLKGGPPPPETPASATSQGPTEPSWEAPVLP ENSRNOP00000015059/1-1576 PTPLPTKVDEATSGLIRELAAVEDELYQRVLKGGPPPPETPASATSQGPTESGWEAPMLP :.:********************: *. .. * :.. : . :..*:* * ENSCPOP00000014078/1-1391 PTKRRKSESPDMDQASFSSDSPQDDALTEHLQSAIDSILNLQQP---------------- XP_004867274.1/1-1532 PAKRRKSESPDMDQASFSSDSPQDDALTEHLQSAIDSILNLQQPPGR----PGPHPA--- ENSP00000379946/1-1560 PAKRRKSESPDVDQASFSSDSPQDDTLTEHLQSAIDSILNLQQAPGRTPAPSYPHAA-SA ENSMUSP00000092416/1-1578 PAKRRKSESPDVDQASFSSDSPQDDTLTEHLQSAIDSILNLQQAPGRTPAGPYPHTGPTP ENSRNOP00000015059/1-1576 PTKRRKSESPDVDQASFSSDSPQDDTLTEHLQSAIDSILNLQQAPGRTPAGPYPHTGPTP *:*********:*************:*****************. ENSCPOP00000014078/1-1391 --PTSPQPRHRPEAFPPSSHNGGLGPGRTLNR XP_004867274.1/1-1532 --PQSPPPLHRPEAFPPSSHNGGLGPGRTLNR ENSP00000379946/1-1560 GTPASPPPLHRPEAYPPSSHNGGLG-ARTLTR ENSMUSP00000092416/1-1578 GTPTSPAPLHRPDAFPPSSHNGGLG-ARTLNR ENSRNOP00000015059/1-1576 GTPTSPAPLHRPDAFPPSSHNGGLG-ARTLNR * ** * ***:*:********** .***.*