CLUSTAL W(1.81) multiple sequence alignment ENSMUSP00000006101/1-1167 -----------------MKWLFHTLLCMASLKPQGAFNLDVDWAWVTALQPGAPAVLSSL ENSRNOP00000065145/1-1169 -----------------MKWFFHALLCVASLKPLGAFNVDVDWSWVTALQPGAPSVLNSL ENSP00000263087/1-1179 ------------------MWLFHTLLCIASLALLAAFNVDVARPWLTP-KGGAPFVLSSL ENSCPOP00000014000/1-1164 ------------------LGELNFLICETGLAPLGAFNVDVTRPWVTR-EGGAPFVLSSL XP_004857284.1/1-1183 MGSSLPSSHTPASAPPKMMWLFPALLCMSNLAPLGAFNLDVAQPWVTR-EASMPFVLSSL : *:* :.* .***:** .*:* : . * **.** ENSMUSP00000006101/1-1167 LHQDPSNNQTCLLVARRSSNRNTAALYRCAISISPDEIACQPVEHICMPKGRYQGVTLVG ENSRNOP00000065145/1-1169 LHQDPSNNQTCLLVARRSSNRNSAVLYRCATSIIPDEIGCQPVEHILMPKGRYQGVTLVR ENSP00000263087/1-1179 LHQDPSTNQTWLLVTSPRTKRTPGPLHRC--SLVQDEILCHPVEHVPIPKGRHRGVTVVR ENSCPOP00000014000/1-1164 LHQDPSTNQTWLLVTSSRSNRASAPLHRC--SLAQDEIVCQPVEHVLVPKGKYRGVTVVR XP_004857284.1/1-1183 LHQDPSNNRTWLLVTSPRINRTSAPLHRC--SLTQDAIACQPVEHVPIPKGRYQGVTVVR ******.*:* ***: :* .. *:** *: * * *:****: :***:::***:* ENSMUSP00000006101/1-1167 NHNGVLVCIQVQARKFRSLNSELTGACSLLTPNLDLQAQAYFSDLEGFLDPGAHVDSGDY ENSRNOP00000065145/1-1169 NHNGVLVCIQVQSRKPRSLNSELTGACSLLTPNLDLQAQAYFSDLEGVLDLGASVNSGDY ENSP00000263087/1-1179 SHHGVLICIQVLVRRPHSLSSELTGTCSLLGPDLRPQAQANFFDLENLLDPDARVDTGDC ENSCPOP00000014000/1-1164 SHHGILICVQAQGRRPHSLSSELTGTCSLLAPDLRPRAYANFSDIENLLDPDTYVDVHDC XP_004857284.1/1-1183 NHHGVLICIQVQARRPHSLSLELTGACSLLTPDLRPWAQASFFDLENLLAPDAYVDAGNC .*:*:*:*:*. *: :**. ****:**** *:* * * * *:*..* .: *: : ENSMUSP00000006101/1-1167 CRSKGGSTGEEKKSARRRRT-----------VEEEDEEEDGTEIAIVLDGSGSIEPSDFQ ENSRNOP00000065145/1-1169 YGSKGGSTGEETKSARRLRRQA---------VEEEDEEEAGTEIAIVLDGSGSIEPSDFQ ENSP00000263087/1-1179 YSNKEGGGEDDVNTARQRRALEKEEEEDKEEEEDEEEEEAGTEIAIILDGSGSIDPPDFQ ENSCPOP00000014000/1-1164 NRNTEGRT-EAKNRARKSRALE-------EVEEEEEAEEAGTEIAIVLDGSGSIDPPDFQ XP_004857284.1/1-1183 NRNRRGSTGQEENGARKSRAL----------EEEEEEEEAGTEIAIVLDGSGSIDPPDFQ . * : : **: * *:*: ** ******:*******:*.*** ENSMUSP00000006101/1-1167 KAKNFISTMMRNFYEKCFECNFALVQYGAVIQTEFDLQESRDINASLAKVQSIVQVKEVT ENSRNOP00000065145/1-1169 KAKDFISTMMRNFYEKCFECNFALVQYGGVIQTEFDLLDSRDINASLAKVQSIVQVKEVT ENSP00000263087/1-1179 RAKDFISNMMRNFYEKCFECNFALVQYGGVIQTEFDLRDSQDVMASLARVQNITQVGSVT ENSCPOP00000014000/1-1164 KAKEFISNMMKMFYEKCFECNFALVQYGAVIQTEFDLRDSQDVNASLARVQNIIQVGNVT XP_004857284.1/1-1183 RAKEFISNMMEKFYDKCFECSFALVQYGEVIQTEFDLRDSQDVSASLARVQNITQVGNVT :**:***.**. **:*****.******* ******** :*:*: ****:**.* ** .** ENSMUSP00000006101/1-1167 KTASAMQHVLDNIFIPSRGSRKKALKVMVVLTDGDIFGDPLNLTTVINSPKMQGVVRFAI ENSRNOP00000065145/1-1169 KTASAMQHVLDNIFIPSRGSRKKALKVMVVLTDGDIFRDPLNLTTVISSSKMQGVVRFAI ENSP00000263087/1-1179 KTASAMQHVLDSIFTSSHGSRRKASKVMVVLTDGGIFEDPLNLTTVINSPKMQGVERFAI ENSCPOP00000014000/1-1164 KTASAMQHVLDNIFTPSRGSREKASKVMVVLTDGDIFEDPLNLTSVISSPKMQGVERFAV XP_004857284.1/1-1183 KTASAMQHVLDHIFTPSRGSRKKASKVMVVLTDGDIFGDPLNLTTVINSAEMQDVERFAI *********** ** .*:***.** *********.** ******:**.*.:**.* ***: ENSMUSP00000006101/1-1167 GVGDAFKNNNTYRELKLIASDPKEAHTFKVTNYSALDGLLSKLQQHIVHMEGTVGDALQY ENSRNOP00000065145/1-1169 GVGNAFENNNTYRELKLIASDPKAAHTFKVTNYSALDGLLSKLQQRIIHMEGTVGDTLQY ENSP00000263087/1-1179 GVGEEFKSARTARELNLIASDPDETHAFKVTNYMALDGLLSKLRYNIISMEGTVGDALHY ENSCPOP00000014000/1-1164 GVGNAFEKVKTDRELKQIASTPSETHAFKVTNYTALNGLLSKLQQSIIHTEGTVGEALRY XP_004857284.1/1-1183 GVGNAFQKVKTEAELKLIASTPSETHAFKVTNYAALNGLLSKLQQNIIHTEGTVGEALRY ***: *:. .* **: *** *. :*:****** **:******: *: *****::*:* ENSMUSP00000006101/1-1167 QLAQTGFSAQILDKGQVLLGTVGAFNWSGGALLYSTQNGRGCFLNQT--AKEDSRTVQYS ENSRNOP00000065145/1-1169 QLAQTGFSAQILDKGQVLLGTVGAFNWSGGALLYNTQNGRGRFLNQT--AKEDFRAAQYS ENSP00000263087/1-1179 QLAQIGFSAQILDERQVLLGAVGAFDWSGGALLYDTRSRRGRFLNQTAAAAADAEAAQYS ENSCPOP00000014000/1-1164 QLAQTGFSAQILDEGQVLLGAVGAFNWSGGALLYDTRCRWGRFLNHS---AADAGAAQYS XP_004857284.1/1-1183 QLAQTGFSAQILDEGQVLLGAVGAFNWSGGALLYNMQCRQGCFLNQT---PADMGAAQYS **** ********: *****:****:********. : * ***:: * :.*** ENSMUSP00000006101/1-1167 YLGYSLAVLHKAHGVSYVAGAPRHKLRGAVFELRKEDREEDAFVRRIEGEQMGSYFGSVL ENSRNOP00000065145/1-1169 YLGYSVAALHKAHGVSYVAGAPRHKLRGAVFELQKEDGEE-TFMRRIEGEQMGSYFGSVL ENSP00000263087/1-1179 YLGYAVAVLHKTCSLSYIAGAPRYKHHGAVFELQKEGREA-SFLPVLEGEQMGSYFGSEL ENSCPOP00000014000/1-1164 YLGYSVAVLHNAHGVSYIAGAPRYRQRGAVFKLRPESKEA-TFVQ--EGEQLGSYFGSEL XP_004857284.1/1-1183 YLGYSVAVLHKAHGISYISGAPQYRQRGAVFELQPDSREA-TSSRVLEGEQLGSYFGSEL ****::*.**:: .:**::***::: :****:*: :. * : ****:****** * ENSMUSP00000006101/1-1167 CPVDIDMDGTTDFLLVAAPFYHIRGEEGRVYVYQVPEQDASFSLAHTLSGHPGLTNSRFG ENSRNOP00000065145/1-1169 CPVDINMDGITDFLLVAAPFYHIRGEEGRVYVYRVHEQDAPFSLVYTLSGYPGLTSSRFG ENSP00000263087/1-1179 CPVDIDMDGSTDFLLVAAPFYHVHGEEGRVYVYRLSEQDGSFSLARILSGHPGFTNARFG ENSCPOP00000014000/1-1164 CPVDVDMNGITDVLLVAAPFYHDHGEKGRVYVYSLHKQDGSFSLAHILSGCPGFPSARFG XP_004857284.1/1-1183 CPVDIDMDGTTDFLLVAAPFYHVHGEEGRVYVYRLHEQDGSFSLAHVLSGYPGFSSARFG ****::*:* **.********* :**:****** : :**..***. *** **:..:*** ENSMUSP00000006101/1-1167 FAMAAVGDINQDKFTDVAIGAPLEGFGAGDGASYGSVYIYNGHSGGLYDSPSQQIRASSV ENSRNOP00000065145/1-1169 FAMAAVGDINQDKFTDVAIGAPLEGFGAGDGASYGSVYIYNGHSGGLHASPSQQIRASSV ENSP00000263087/1-1179 FAMAAMGDLSQDKLTDVAIGAPLEGFGADDGASFGSVYIYNGHWDGLSASPSQRIRASTV ENSCPOP00000014000/1-1164 FAMAAVGDINQDKFTDVAIGAPLEGLEMNDGDSFGSVYIYNGHQDGLSSKPSQWIRASAV XP_004857284.1/1-1183 FAVAAVGDINQDKFTDVAIGAPLEGLDVDDGGSFGSVYIYNGHQDGLSARPSQWIRASSV **:**:**:.***:***********: .** *:********* .** *** ****:* ENSMUSP00000006101/1-1167 ASGLHYFGMSVSGGLDFNGDGLADITVGSRDSAVVLRSRPVVDLTVSMTFTPDALPMVFI ENSRNOP00000065145/1-1169 ALGLYYFGMSVSGGLDFSGDDLADITVGSQDVAVVLRSRPVVDLTVSMTFTPDALPMAFK ENSP00000263087/1-1179 APGLQYFGMSMAGGFDISGDGLADITVGTLGQAVVFRSRPVVRLKVSMAFTPSALPIGFN ENSCPOP00000014000/1-1164 APGLRYFGVSVAGGLDFSGDGLADITVGTMGRATVLRSRPVVHLKVSMTFTPSALPIGFT XP_004857284.1/1-1183 DSRLHYFGVSVAGGLDFSGDGLADITVATLGRATVLCSRPVVHLKVSMTFTPSALPIGFN * ***:*::**:*:.**.******.: . *.*: ***** *.***:***.***: * ENSMUSP00000006101/1-1167 GKMDVKLCFEVDSSGVASEPGLREMFLNFTVDVDVTKQRQRLQCEDSSGCQSCLRKWNGG ENSRNOP00000065145/1-1169 DKMDVELCFKVDSSAVPSEPGLRGMSLNFTVDVDVTKQKQRLQCADRSCCQSCLMKWSGG ENSP00000263087/1-1179 GVVNVRLCFEISSVTTASESGLREALLNFTLDVDVGKQRRRLQCSDVRSCLGCLREWSSG ENSCPOP00000014000/1-1164 GSVNGHLCFEVSPTTAAAESGLREKSLNFTVDVDVAKSRKRLQCVDVGECLNHHQQWSIG XP_004857284.1/1-1183 DSVYGHLCFEMSSTTVAAESGLRETALNFTVSVDVAKQRKRLQCADTRECLNHRLEWNSE . : .***::.. ..:*.*** ****:.*** *.::**** * * . :*. ENSMUSP00000006101/1-1167 SFLCEHFWLISTE-ELCEEDCFSNITIKVTYEFQTSGGRRDYPNPTLDHYKEPSAIFQLP ENSRNOP00000065145/1-1169 SSLCEHFGLISTEEELCEDDCFSNITIKVSYEFQTSEERRNHPNPILDHYKEPSAIFQLP ENSP00000263087/1-1179 SQLCEDLLLMPTEGELCEEDCFSNASVKVSYQLQTPEGQTDHPQPILDRYTEPFAIFQLP ENSCPOP00000014000/1-1164 PRLCKSLQLVSTEGELCEEDCFSNITVKVIYQLQDPEGWRRDSCPILAN-KEPFAVFQLP XP_004857284.1/1-1183 PRLCKHLQLVSTEGELCEEDCFSNIIVKINYELQAPEGRERHIYPILDIYMEPSVIFQLP . **: : *:.** ****:***** :*: *::* . * * ** .:**** ENSMUSP00000006101/1-1167 YEKDCKNKVFCIAEIQLTTNISQQELVVGVTKEVTMNISLTNSGEDSYMTNMALNYPRNL ENSRNOP00000065145/1-1169 YEKDCKNKVFCIAEIQLTTAISQQDLVVGITKEVTMNISLTNSGEDSYMTNMALNYPRNL ENSP00000263087/1-1179 YEKACKNKLFCVAELQLATTVSQQELVVGLTKELTLNINLTNSGEDSYMTSMALNYPRNL ENSCPOP00000014000/1-1164 YQKACKNNLFCNAELQLATSMSQQELVVGLTKELTMNISLTNSGEDSYLTSMALNYPRNL XP_004857284.1/1-1183 YEKACKNQLFCIAELQLATAMSQQELVVGLSKELTMNISLTNSGEDSYMTSMALNYPRNL *:* ***::** **:**:* :***:****::**:*:**.*********:*.********* ENSMUSP00000006101/1-1167 QFKKIQKPVSPDVQCDDPKPVASVLVMNCKIGHPILKRSSVNVSVTWQLEESVFPNRTAD ENSRNOP00000065145/1-1169 QFKKIQKPLSPDIQCDDPKPVASVLVMNCKIGHPILKRSSVNVSVTWQLEESIFPNRTAD ENSP00000263087/1-1179 QLKRMQKPPSPNIQCDDPQPVASVLIMNCRIGHPVLKRSSAHVSVVWQLEENAFPNRTAD ENSCPOP00000014000/1-1164 HFKMLQKPPSPNVQCTNPKPAASVLVMTCKIGYPILRRSSVNMSIVWQLEESPFPNRTAH XP_004857284.1/1-1183 QFKRIQKPPAPNIQCADPKPVASILVMNCKIGYPILKRSSVNMSVVWQLEENIFPNRTAD ::* :*** :*::** :*:*.**:*:*.*:**:*:*:***.::*:.*****. ******. ENSMUSP00000006101/1-1167 ITVTISNSNE-KSLARETRSLQFRHAFIAVLSRPSVMYMNTSQSPSDHKEFFFNVHGENL ENSRNOP00000065145/1-1169 ITVTISNSNE-KSLARETHSLQFRHAFIAVLSRPSVMYMNTSQSSSDHKEFFFNVHGENH ENSP00000263087/1-1179 ITVTVTNSNERRSLANETHTLQFRHGFVAVLSKPSIMYVNTGQGLSHHKEFLFHVHGENL ENSCPOP00000014000/1-1164 ITVTISNSDE-RSLATETHSLQFRHAFTAVLSKPSVMYMNTSQRLSDYKEFLFSIHGENR XP_004857284.1/1-1183 ITVTTGNSNG-RSLARKTHTLQFRHVFIAVLSKPSVMYMNTSRGLSDHKEFLFNIYGENL **** **: :*** :*::***** * ****:**:**:**.: *.:***:* ::*** ENSMUSP00000006101/1-1167 FGAVFQLQICVPIKLQDFQIVRVKNLTKTQDHTECTQSQEPACGSDPVQHVKEWHSVVCA ENSRNOP00000065145/1-1169 FGAVFQLQICVPITLRDLQIIRVKHLTKTQAHTECTQSQEPTCGSDPVQNVEEWHSVICA ENSP00000263087/1-1179 FGAEYQLQICVPTKLRGLQVVAVKKLTRTQASTVCTWSQERACAYSSVQHVEEWHSVSCV ENSCPOP00000014000/1-1164 FKAQFQLQICVPTKLQGLQVVRVKNLTKIQDSTECIQSQESACGSTPVQHVEEWHSVSCN XP_004857284.1/1-1183 FGARFQLQICVPIRLQGLEILRVKNLTKIQDYTVCTQSEERACGSDPVQHVEKWHSVSCA * * :******* *:.:::: **:**: * * * *:* :*. .**:*::**** * ENSMUSP00000006101/1-1167 ITSNKENVTVAAEISVGHTKQLLRDVSELPILGEISFNKSLYEGLNAENHRTKITVIFLK ENSRNOP00000065145/1-1169 ITSNKENVTVAAEISMGHTKQLLRDISELQILGEISFNKSLYEGLNAENHRTKITVIFLK ENSP00000263087/1-1179 IASDKENVTVAAEISWDHSEELLKDVTELQILGEISFNKSLYEGLNAENHRTKITVVFLK ENSCPOP00000014000/1-1164 ITSDEENVTVAAEISLGHSNQLQRDITDLQVLGEISFNKTLYEGLKAENHRTKITVIFLK XP_004857284.1/1-1183 ITSDKENVTVAAEISLDHSKQLLRDVTELQVLGEISFNKALYEGLNAENHRTKITVIFLK *:*::********** .*:::* :*:::* :********:*****:**********:*** ENSMUSP00000006101/1-1167 EEETRSLPLIIGSSIGGLLVLVVIIAILFKCGFFKRKYQQLNLESTRRAQLKADSLLQD- ENSRNOP00000065145/1-1169 EEKPHSLPLIIGSSIGGLLVLVVIIAILFKCGFFKRKYKQLNLESVRKAQLKSDSLLED- ENSP00000263087/1-1179 DEKYHSLPIIIKGSVGGLLVLIVILVILFKCGFFKRKYQQLNLESIRKAQLKSENLLEEE ENSCPOP00000014000/1-1164 DEVYHSLPVIIGSSVGGLLVLIVIIIILFKCGFFKRKYQQLNLESVRRAQLRAEDLLTEG XP_004857284.1/1-1183 DEVYHSLPLIVGSSVGGLLVLVVIVIILFKCGFFKRKYQQLNLESMRRAQLKADDLLTEE :* :***:*: .*:******:**: ************:****** *:***:::.** : ENSMUSP00000006101/1-1167 - ENSRNOP00000065145/1-1169 - ENSP00000263087/1-1179 N ENSCPOP00000014000/1-1164 N XP_004857284.1/1-1183 N