CLUSTAL W(1.81) multiple sequence alignment ENSCPOP00000013908/1-1419 -CNVPMEITSSHCSFLRFTKNLSPDKINLSTLKGEGQLTNLELDEEVLQNVLELPTWLAI ENSMUSP00000110499/1-1429 MAGIIKKQILKHLS--RFTKNLSPDKINLSTLKGEGQLTHLELDEEVLQNVLELPTWLAI ENSRNOP00000046054/1-1425 MAGIIKKQILKHLS--RFTKNLSPDKINLSTLKGEGQLTHLELDEEVLQNVLELPTWLAI ENSP00000192788/1-1440 MAGIIKKQILKHLS--RFTKNLSPDKINLSTLKGEGQLTNLELDEEVLQNVLELPTWLAI XP_004846790.1/1-1444 MAGIIKKQILKHLS--RFTKNLSPDKINLSTLKGEGQLSNLELDEEVLQNVLELPTWLAI ..: : .* * **********************::******************** ENSCPOP00000013908/1-1419 TRVYCNRASIRIQWTKLKTHPICLCLDKVEVEMKTCEEPRPPNGQSPIALASGQRELAKT ENSMUSP00000110499/1-1429 TRVYCNRASIQIQWTKLKTHPICLCLDKVEVEMQTCEDPRPPNGQSPIALASGQSEYGFA ENSRNOP00000046054/1-1425 TRVYCNRASIRIQWTKLKTHPICLCLDKGEGEMKTCEDPRPPNGQSPIALASGQSEYGFA ENSP00000192788/1-1440 TRVYCNRASIRIQWTKLKTHPICLCLDKVEVEMKTCEDPRPPNGQSPIALASGQSEYGFA XP_004846790.1/1-1444 TRVYCNRASIRIQWTKLKTHPICLCLDKVEVEMKTCEEPRPPNGQSPIALASGQSEYGFA **********:***************** * **:***:**************** * . : ENSCPOP00000013908/1-1419 PQKLSHLNFLILYHIRSLEIILYIIECQFNIWEEQGMCVNISYQSSHKSIKGYTSHCNMN ENSMUSP00000110499/1-1429 EKVVEGM-FIVVNSI-TIKIHSKAFHASFELWQLQGYSVNPNWQQSDLRLTRITDPRRGE ENSRNOP00000046054/1-1425 EKVVEGM-FIVVNSI-TIKIHSKAFHASFELWQLQGYSVNPSWQQSDLRLTRITDPRRGE ENSP00000192788/1-1440 EKVVEGM-FIIVNSI-TIKIHSKAFHASFELWQLQGYSVNPNWQQSDLRLTRITDPCRGE XP_004846790.1/1-1444 EKVVEGM-FIIVNSI-TIKIHSKAFHASFELWQLQGYSVNPNWQQSDLRLTRITDPCRGE : :. : *::: * :::* :...*::*: ** .** .:*.*. :. *. . : ENSCPOP00000013908/1-1419 ML----ILWQLLSIFPAFSGIGIQCSYMEPFLSMIVNSGRPKLAFGLLVTHPNL---KFL ENSMUSP00000110499/1-1429 VLTFKEITWQTLRVEADAIENGDQDPVTTP-LRLITNQGRIQIALKRRTKDCNVVASKLT ENSRNOP00000046054/1-1425 VLTFKEITWQTLRVEADATENGDQDPVTTP-LRLITNQGRIQIALKRRTKDCNVVASKLT ENSP00000192788/1-1440 VLTFKEITWQTLRIEADATDNGDQDPVTTP-LRLITNQGRIQIALKRRTKDCNVISSKLM XP_004846790.1/1-1444 VLTFKEITWQTLRIEADAIDNGDQDSVTTP-LRLITNQGRIQIALKRRTKDCNVMASKLM :* * ** * : . * * . * * :*.*.** ::*: ... *: *: ENSCPOP00000013908/1-1419 ILLPRYIWLLMIPRFSFYMGSTYSISRSDGRSQTEPEALSPEPVPLSA--PSAGQIVASR ENSMUSP00000110499/1-1429 FLLDDLLWVLTDSQLKAMMKYAESLSEAMEKSAQQRKSLAPESVQTTPPAPSAQQTWAQA ENSRNOP00000046054/1-1425 FLLDDLLWVLTDSQLKAMMKYAESLSEAMEKSAQQRKSLAPEPVQITPPAPSAQQTWAQA ENSP00000192788/1-1440 FLLDDLLWVLTDSQLKAMMKYAESLSEAMEKSAHQRKSLAPEPVQITPPAPSAQQSWAQA XP_004846790.1/1-1444 FLLDDLLWVLTDSQLKAMMKYAESLSEAMEKSAQQRKSLAPEPVQVTPPAPSAQQSWAQA :** :*:* .::. * : *:*.: :* : ::*:**.* :. *** * *. ENSCPOP00000013908/1-1419 FGRTEG----NKKSFLFYTLQYFSLIGEREISSFPTVSCVFNGLCLAFSVQKAGVSANRL ENSMUSP00000110499/1-1429 FGGSQG------SSSSSRLSQYFEKFDVKESSYHLLISRLDLHICDDSQSREPGVSANRL ENSRNOP00000046054/1-1425 FGGSQG------NSSSSRLSQYFEKFDVKESSYHLLISRLDLHICDDSQSREPGVSANRL ENSP00000192788/1-1440 FGGSQG----NSNSSSSRLSQYFEKFDVKESSYHLLISRLDLHICDDSQSREPGVSANRL XP_004846790.1/1-1444 FGGNQGSSSSSSNSNSSRLSQYFEKFDVKESSYHLLISRLDLHICDDSQSREPGVSANRL ** .:* .* ***. :. :* * . :* : :* . ::.******* ENSCPOP00000013908/1-1419 TGGAMQLTFRKMAFDYYPFHWAGDSCRHWARHCEAMETRSQWAQKLVMEFQSKMEKWQEE ENSMUSP00000110499/1-1429 TGGAMQLTFRRMAFDYYPFHRAGDSCKHWVRHCEAMETRGHWAQQLVTEFQSRVEKQCEG ENSRNOP00000046054/1-1425 TGGAMQLTFRKMAFDYYPFHRAGDSCKHWVRHCEAMETRSHWAQQLVTEFQSRMEKWCEE ENSP00000192788/1-1440 MGGAMQLTFRKMAFDYYPFHWAGDSCKHWVRHCEAMETRGQWAQKLVMEFQSKMEKWHEE XP_004846790.1/1-1444 TGGAMQLTFRKMAFDYYPFHWAGDSCKHWARHCEAMETRGQWAQKLVMEFQSKMEKWHEE *********:********* *****:**.*********.:***:** ****::** * ENSCPOP00000013908/1-1419 TGLKASWHLGVDAPFRRKAASLSSPRKNPLERMPSQGRQAAFRSPAWHRLRSSCMVVRVD ENSMUSP00000110499/1-1429 GSVKPPWLLGVDPPFRRKADSFSSPGKTPLDKSPTQGRQAAFGAPAWNRLRSSCLVVRVD ENSRNOP00000046054/1-1425 SSVKPPWHLGVDPPFRKKADSFSSPGKSPLDKSPTQGRQAAFGSPAWSRLRSSCLVVRVD ENSP00000192788/1-1440 TGLKPPWHLGVDSLFRRKADSLSSPRKNPLERSPSQGRQPAFQPPAWNRLRSSCMVVRVD XP_004846790.1/1-1444 TGLKTSWHLGVDAPFRRKAASLSSPQKNPLEKTSLQGRESTFRPPAWNRLRSSCMVVRVD .:*..* ****. **:** *:*** *.**:: . ***:.:* .*** ******:***** ENSCPOP00000013908/1-1419 DLDIHQVSTAGQPSKKPSTLLSCSRKLHNLPAQISAIHIEFTEYYFPDSQELPVPCPNLY ENSMUSP00000110499/1-1429 DLDIHQVSTAGQPSKKPSTLLSCSRKRHHLPPQVAAIHVQFTEYYFPDNQELPVPCPNLY ENSRNOP00000046054/1-1425 DLDIHQVSTAGQPSKKPSTLLSCSRKRHRLPSQVAAIHVQFTEYYFPDNQELPVPCPNLY ENSP00000192788/1-1440 DLDIHQVSTAGQPSKKPSTLLSCSRKLHNLPTQVSAIHIEFTEYYFPDNQELPVPCPNLY XP_004846790.1/1-1444 DLDIHQVSTAGQPSKKPSTLLSCSRKLHNLPTQVSAIHIEFTEYYFPDNQKLPVPCSNLY ************************** *.**.*::***::********.*:*****.*** ENSCPOP00000013908/1-1419 IQLNDLTFTVDPVSLLWGNLFCLDLYHSLEQFKAIYKLEDSRRKDEHLDIRLDAYRLKVS ENSMUSP00000110499/1-1429 IQLNGLTFTVDPVSLLWGNLFCLDLYRSLEQFKAIYKLEASRGRDEHVDVRLDAFWLKVS ENSRNOP00000046054/1-1425 IQLNGLTLTVDPVSLLWGNLFCLDLYRSLEQFKAIYKLEDPRGKDEHLDIRLDAFWLKVS ENSP00000192788/1-1440 IQLNGLTFTMDPVSLLWGNLFCLDLYRSLEQFKAIYKLEDSSQKDEHLDIRLDAFWLKVS XP_004846790.1/1-1444 VQLNNLIFTVDPVSLLWGNLFCLDLYRSLEQFKAIYKLEDSRQKDEHLDIRLDAFRLKVN :***.* :*:****************:************ . :***:*:****: ***. ENSCPOP00000013908/1-1419 FPLEKRELAKLYRPQALVISASGMVATNTRHAPHCGCSDLQNLFRGFAATEFFHSNYGHF ENSMUSP00000110499/1-1429 FPLETRELAKLHRPQALVLSTSSMIATNTRHAPNCTRPDLQSLFRGFAATEFFRCSYGHF ENSRNOP00000046054/1-1425 FPLETRDLAKLHRPQALVLSTSGVIATNTRHAPHCSCPDLQGLFRGFAATEFFRSSYGHF ENSP00000192788/1-1440 FPLEKRERAELHRPQALVFSASGMIATNTRHAPHCSCSDLQSLFRGFAAAEFFHSNYDHF XP_004846790.1/1-1444 FPLEKKEQAKLHRPQALVFSASGMIATNTRHAPHCSCPDLQSLFRGFAAAEFFHSNYDHF ****.:: *:*:******:*:*.::********:* .***.*******:***:..*.** ENSCPOP00000013908/1-1419 PKVPGGFSLLHILFLHHAFQTDSGFSRPTTLPPQRPKTSQDLWSIHFTQISLDFEGTENL ENSMUSP00000110499/1-1429 PQVAGGFSLLHMLFLHHAFQMDS-------LPPQRLAASQDLWSLHFTQISLDFEGTENF ENSRNOP00000046054/1-1425 PKVPGGFSLLHMVFLHHAFQTDS------LPPPQRPAAAQDLWSLHFTQISLDFEGTENV ENSP00000192788/1-1440 PKVPGGFSLLHMLFLHHAFQMDSCLPQPNTLPPQRPKASWDLWSVHFTQISLDFEGTENF XP_004846790.1/1-1444 PKVLGGFSLLHMLFLHHAFQMDSGLSQPSTLPLQRPKASQDLWSIHFSQVSLDFEGTENF *:* *******::******* ** * ** :: ****:**:*:*********. ENSCPOP00000013908/1-1419 KGHSLNFVAPFPLSIWACLPLRWQQAQARKLLLASEGRLKPSASFGSPVRSEALAPDSVS ENSMUSP00000110499/1-1429 RGHTLNFVAPFPLSIWACLPLRWQQAQARRLLLASEGRLKQSASFGSPVHSEALAPESVS ENSRNOP00000046054/1-1425 KGHALNFVAPFPLSIWACLPLRWQQAQARRLLLASEGRLKPSASFGSPVHSEALAPESVS ENSP00000192788/1-1440 KGHTLNFVAPFPLSIWACLPLRWQQAQARKLLLASEGRLKPSASFGSPVQSEALAPDSMS XP_004846790.1/1-1444 RGHSLNFVAPFPLSIWACLPLRWQQAQAQRLLLASEGRLKPSASFGSPVWSEPLAPDSVS :**:************************::********** ******** **.***:*:* ENSCPOP00000013908/1-1419 HQRSKTEHDLKSLTEVTH----ILGEGNGAADSKGLPAELEDAADVHMLLHSPAHICVRL ENSMUSP00000110499/1-1429 HQRSKTERDLKSLSGSTEGPAAAVREGDAGVDHKGRVADLEDVADIHMLVHSTAHVRVRL ENSRNOP00000046054/1-1425 HQRSKTERDLKSLSGSGE-VLGAVREGDAGVDHRGQVAELEDVADIHMLVHSTAHVRVRL ENSP00000192788/1-1440 HPRSKTEHDLKSLSGLTE-VMEILKEGSSGMDNKGPLTELEDVADVHMLVHSPAHVRVRL XP_004846790.1/1-1444 HQRSKTEHDLKSLSGLTE-VMDILGEGSGAADSKGPPAELEDAADVHVLVHSPTHVRVRL * *****:*****: . : **... * :* ::***.**:*:*:**.:*: *** ENSCPOP00000013908/1-1419 DHYQYLALLRLKDVLQGLQEQLAKDTQAMTRSALQDQTACIGVLFPSAEVALLMHPAPGA ENSMUSP00000110499/1-1429 DHYQYLALLRLKEVLEGLQEQLTKDTEAMTGSPLQDQTVCIGVLFPSAEVALLMHPAPGT ENSRNOP00000046054/1-1425 DHYQYLALLRLMEVLQGLQEQLTKDTEAMTGSPLQDQTVCVGVLFPSAEVALLMPPDPGA ENSP00000192788/1-1440 DHYQYLALLRLKEVLQRLQEQLTKDTESMTGSPLQNQTACIGVLFPSAEVALLMHPAPGA XP_004846790.1/1-1444 DHYQYLALLRLKDMLQGLQEQLTKDTQAMTGSPLQDQTACIGVLFPSAEVALLMHPAPGA *********** ::*: *****:***::** *.**:**.*:************* * **: ENSCPOP00000013908/1-1419 VDADSAGSDTTSLVDSELSPSEEQEPKSDASSEQGLVSPEKVLEDSSTDNLGESQERPHS ENSMUSP00000110499/1-1429 AHADSAGSDTTSLIDSELSPSEDREPKSDASSDQGAVSPEKVLRDGSGENLAASQERLPS ENSRNOP00000046054/1-1425 AHADSAGSDTTSLIDSELSPSEDREPKSDASSDQGPVSPEKVLRDSSAENLDASQERLHG ENSP00000192788/1-1440 VDADSAGSDSTSLVDSELSPSEDRELKSDASSDQGPASPEKVLEESSIENQDVSQERPHS XP_004846790.1/1-1444 VDADSAGSDTTSLIDSELSPSEDREPKSDASSEQGPASPEKVLEDSSTENLDVSQERLHS ..*******:***:********::* ******:** .******.:.* :* **** . ENSCPOP00000013908/1-1419 NGGLQDLGPPALLAAGKSREAVESLQAKRLSRAQASSSPAVSKSPVGKDSPVNGQGEPIP ENSMUSP00000110499/1-1429 DGELPDPGPCAQQPVGKSHEAVESLQAKKLSRAQSARSPATLKSPADRDAALNGQGEPVP ENSRNOP00000046054/1-1425 DGELQDVGPLAQQPAGKSHEAVESLQAKKLSRAQTATSP----PTADRDAALNGQGEPIP ENSP00000192788/1-1440 NGELQDSGPLAQQLAGKGHEAVESLQAKKLSRTQASSSPAALKPPAGRETAVNGQGELIP XP_004846790.1/1-1444 NGDLQDLGPPARQVAGKGHEAIESLQPKRLSQAQGSSSPAVSKSPTSRATAVNGQSEPIP :* * * ** * .**.:**:****.*:**::* : ** ....: :.:***.* :* ENSCPOP00000013908/1-1419 LKNIEEELSSAIHMTKDATKEALH---------------AFSLGRDRMTSTMHKMLSLPP ENSMUSP00000110499/1-1429 LRSIEGDLSSAIHMTKDATKEALHATVDLTKEAVSLTRDAFSLGRDRMTSTMHKMLSLPP ENSRNOP00000046054/1-1425 LRSIEGELSSAIHMTKDATKEALHATVDLTKEAVSLTRDAFSLGRDRMTSTMHKMLSLPP ENSP00000192788/1-1440 LKNIEGELSSAIHMTKDATKEALHATMDLTKEAVSLTKDAFSLGRDRMTSTMHKMLSLPP XP_004846790.1/1-1444 LKNIEGEFSSAIHMTKDATKEALHATMDLTKEAMSLTKDAFSLGRDRMTSTMHKMLSLPP *:.** ::**************** ********************* ENSCPOP00000013908/1-1419 AKNRELVARADEGVATPMSGGAGRLRFFSMKRTVSQQSFDGVLLDNSGPEDRISVDSDGS ENSMUSP00000110499/1-1429 AK--EAMAKPDEGVVASVSGGAARLRFFSMKRTVSQQSFDGVSLDSGGPDDRISVDSDGS ENSRNOP00000046054/1-1425 AK--EAMAKSDEGVAAPASGGPARLRFFSMKRTVSQQSFDGVSLDSGGPEDRISVDSDGS ENSP00000192788/1-1440 AK--EPMAKTDEGVAAPVSGGAARLRFFSMKRTVSQQSFDGVSLDSSGPEDRISVDSDGS XP_004846790.1/1-1444 AK--EPLARTDEGVATSISGGAARLRFFSMKRTVSQQSFDGVVLDSSGPEDRISVDSDGS ** * :*:.****.:. ***..******************* **..**:********** ENSCPOP00000013908/1-1419 DSLVMLLESESVLESVPLGSLPSVLDDTGVQGSPIVDNCGQASSEADSSVSPSAEDLVLH ENSMUSP00000110499/1-1429 DSFVMLLESESGPESVPPGSVTSVLDDSGIQGSPVTDSGGQGLPETNSSASASG-DLVMH ENSRNOP00000046054/1-1425 DSFVMLLESESGPESVPPGSVTSVLDDSGIQGSPVMDSSGQGLPETNSSASASG-DLALH ENSP00000192788/1-1440 DSFVMLLESESGPESVPPGSLSNVSDNAGVQGSPLVNNYGQGSPAANSSVSPSGEDLIFH XP_004846790.1/1-1444 DSLVMLLDSESGLESVPLGSLPTVLDDARVQGTPVVDNCGHVSPEANSSASPSGEDLIRH **:****:*** **** **:..* *:: :**:*: :. *: . ::**.*.*. ** * ENSCPOP00000013908/1-1419 PVSVLVLKVKDVALGIEVRGEDLTVALQAEELALQQPGTMGLWKFLHGQCPGPTLQESSS ENSMUSP00000110499/1-1429 SVSILVLKVNEVSLGIEVRGEDLAVALQAEELALQQLGTVGLWQFLHGQCPGAGFQEPSN ENSRNOP00000046054/1-1425 SVSVLVLKVSEVSLGLEVRGEDLAVALQAQQLALQQLGTVGLWQFLHGQCPGPSFEGPSD ENSP00000192788/1-1440 PVSVLVLKVNEVSFGIEVRGEDLTVALQAEELTLQQLGTVGLWQFLHGQCPGTCFQESST XP_004846790.1/1-1444 SVSVLVLKVNEVTFGIEVRGEDLTVALQAEELALQQLGTVGLWKFLHGQCPGTSLQERSK .**:*****.:*::*:*******:*****::*:*** **:***:********. :: * ENSCPOP00000013908/1-1419 VQTDHVRPAVGLRFEVGPGAAVHSPLAIQNGFLHFVLHGCDVELLTSMLNGLGPFLEDEE ENSMUSP00000110499/1-1429 LKTNPIRPAVGLRFEVGPGAAVHSPLATQNGFLQFLLRGCDLELFTSVLNGLGPFLEDEE ENSRNOP00000046054/1-1425 LKTDSTRPAVGLRFEVGPGAAVHSPLAAQNGFLRFSLRGCDLELFTSVLNGLGPFLEDEC ENSP00000192788/1-1440 LKTGHIRPAVGLRFEVGPGAAVHSPLASQNGFLHLLLHGCDLELLTSVLSGLGPFLEDEE XP_004846790.1/1-1444 VQTDHIRPAVGLRFEVGPGAAVRSPLATQNGFLHFVLHGCDLELLTSVLNGLGPFLEDEE ::*. ****************:**** *****:: *:***:**:**:*.********* ENSCPOP00000013908/1-1419 VPVVVPMQIELLNSSVTLKDDIPPIYPTSPGPVPITLAMEHVVLKRSDDGVFHISAVAQD ENSMUSP00000110499/1-1429 VPVVVPMQIELLDCRVTLKDDIPPVYPTSPGPVPITLAMERLVLKRGDDGVFHLGAPAHD ENSRNOP00000046054/1-1425 VPVVVPMQMELLDCSVTLKDDIPPIYPTSPGPVPITLTMERLMLKRGDDGVFHLGAPAQD ENSP00000192788/1-1440 IPVVVPMQIELLNSSITLKDDIPPIYPTSPGPIPITLAMEHVVLKRSDDGVFHIGAAAQD XP_004846790.1/1-1444 IPVVVPMQIELLNSSVTLKDDIPPIYPTSPGPVPITLAMEHIVLKRSDDGVFHISAAAQD :*******:***:. :********:*******:****:**:::***.******:.* *:* ENSCPOP00000013908/1-1419 RPHATVPGNEKRQPPEEQVVLAPTGEVFGQQVKALPALQKELTETKQALARAKQEKEKLL ENSMUSP00000110499/1-1429 RPLTDVP--EKLRLPKEQVLLVPLGQGLGCQEKESPTLQQELMDTKQALAIANQDKEKLL ENSRNOP00000046054/1-1425 RPLAEGP--EKQQLPKEQVPLVPTGQGLGHQEKGSPTLQQELADTKQALAIANQDREKLL ENSP00000192788/1-1440 KPSAEVLKSEKRQPPKEQVFLVPTGEVFEQQVKELPILQKELIETKQALANANQDKEKLL XP_004846790.1/1-1444 RPSAEVPKSEKRQPPQGQLFLAPTGEVSGQQVKELPALQKELIETKQALANANQEKEKLL :* : ** : *: *: *.* *: * * * **:** :****** *:*::**** ENSCPOP00000013908/1-1419 QEIRKYNPLFEL ENSMUSP00000110499/1-1429 QEVRKYNPLFEL ENSRNOP00000046054/1-1425 QEIRKYNPLFEL ENSP00000192788/1-1440 QEIRKYNPFFEL XP_004846790.1/1-1444 QEIRKYNPLFEL **:*****:***