CLUSTAL W(1.81) multiple sequence alignment ENSMUSP00000081545/1-1624 MRLWSWVLRLGLLSAALGCGLAERPRRVRRDPRAVRPPRPAAGPATCATRAARGRRASP- ENSRNOP00000046248/1-1440 ------------------------------------------------------------ ENSP00000330658/1-1627 MRLWSWVLHLGLLSAALGCGLAERPRRARRDPRAGRPPRPAAGPATCATRAARGRRASPP ENSCPOP00000013821/1-1528 ------------------------------------------------------------ XP_004849699.1/1-1587 MRLWSWVLRLGLLSAALGCG---------------------------------------- ENSMUSP00000081545/1-1624 -PPPPGGAWEAVRVPRRRQQRAARGA-EEPSPPSRALYFSGRGEQLRLRADLELPRDAFT ENSRNOP00000046248/1-1440 ------------------------------------------------------------ ENSP00000330658/1-1627 PPPPPGGAWEAVRVPRRRQQREARGATEEPSPPSRALYFSGRGEQLRLRADLELPRDAFT ENSCPOP00000013821/1-1528 ---------------------------------------XGRREQLRLRADLELPRDAFT XP_004849699.1/1-1587 -SPPPGGAWEAVRVPRRRQQREARGAVEEPSPPSRALYFSGRGEQLRLRADLELPRDAFT ENSMUSP00000081545/1-1624 LQVWLRAEGGQKSPAVITGLYDKC-SYTSRDRGWVMGIHTTSDQGNRDPRYFFSLKTDRA ENSRNOP00000046248/1-1440 -----------------------------------MGIHTISDQGNRDPRYFFSLKTDRA ENSP00000330658/1-1627 LQVWLRAEGGQRSPAVITGLYDKC-SYISRDRGWVVGIHTISDQDNKDPRYFFSLKTDRA ENSCPOP00000013821/1-1528 LQVWLRAEGGQKSPAVITGLYDKC-SYTSRDRGWVVGIHTVSDQGNRDPRYFFSLKTDRA XP_004849699.1/1-1587 LQVWLRAEGGQKSPAVITGLYDKCSSYTSRDRGWVVGIHTVSDQGDRDPRYFFSLKTDRA :**** ***.::************* ENSMUSP00000081545/1-1624 RKVTTIDAHRSYLPGQWVHLAATYDGRLMKLYMNGAQVATSAEQVGGIFSPLTQKCKVLM ENSRNOP00000046248/1-1440 RKVTTIDAHRSYLPGQWVHLAATYDGRLMKLYMNGAQVATSAEQVGGIFSPLTQKCKVLM ENSP00000330658/1-1627 RQVTTINAHRSYLPGQWVYLAATYDGQFMKLYVNGAQVATSGEQVGGIFSPLTQKCKVLM ENSCPOP00000013821/1-1528 RQVTTINAHRSYLPGQWVYLAATYDGRLMKLYVNGAQVATSGEQVGGIFSPLTQKCKVLM XP_004849699.1/1-1587 RQVTTINAHRSYLPGQWVYLAATYDGRSMKLYVNGAQVATSGEQVGGIFSPLTQKCKVLM *:****:***********:*******: ****:********.****************** ENSMUSP00000081545/1-1624 LGGSALNHNFRGHIEHFSLWKVARTQREIVSDMETRGLHTPLPQLLLQENWDNVKRTWSP ENSRNOP00000046248/1-1440 LGGSALNHNFRGHIEHFSLWKVARTQREILSDMETRGLHTPLPQLLLQENWDNVKRTWSP ENSP00000330658/1-1627 LGGSALNHNYRGYIEHFSLWKVARTQREILSDMETHGAHTALPQLLLQENWDNVKHAWSP ENSCPOP00000013821/1-1528 LGGSALNHNYRGYIEHFHLWKVARTQREILLDMETHGLHTPLPQLLLQENWDNVKRMWSP XP_004849699.1/1-1587 LGGSALNHNYRGYIEHFHLWKVARTQREILLDMQTHGLHTSLPQLLLQENWDNVKRMWSP *********:**:**** ***********: **:*:* **.**************: *** ENSMUSP00000081545/1-1624 MKDGNSPQVEFSNAHGFLLDTNLEPPLCGQTLCDNTEVISSYNQLPSFRQPKVVRYRVVN ENSRNOP00000046248/1-1440 MKDGHSPQVEFSNAHGFLLDTNLEPPLCGQTLCDNTEVISSYNQLPSFRQSKVVRYRVVN ENSP00000330658/1-1627 MKDGSSPKVEFSNAHGFLLDTSLEPPLCGQTLCDNTEVIASYNQLSSFRQPKVVRYRVVN ENSCPOP00000013821/1-1528 MKDGNSPQVEMSNAHGFLLDTNLEPPLCGQTLCDNTEVIANYNELPSFRQPKVVRYRVVN XP_004849699.1/1-1587 MKDGNSPRVEFSNAHGFLLDTNLEPPLCGQTLCDNTEVIASYNQLPSFRRPKVVRYRVVN **** **:**:**********.*****************:.**:*.***:.********* ENSMUSP00000081545/1-1624 IYDDHHENPTVSWQQIDFQHQQLAEAFQHYNISWELEVLNINSSSLRHRLILANCDISKI ENSRNOP00000046248/1-1440 IYDDHHENPTVSWQQIDFQHQQLAEAFQHYNISWELDVLDINSSSLRHRLILANCDISKI ENSP00000330658/1-1627 LYEDDHKNPTVTREQVDFQHHQLAEAFKQYNISWELDVLEVSNSSLRRRLILANCDISKI ENSCPOP00000013821/1-1528 LYNDDHENPTVSQQQVDFQHRQLAEAFRDYNISWELEVLEVDNSSLRHRLILANCDISKI XP_004849699.1/1-1587 LYNDDHESPTVSRQQVDFQHRQLVEAFRHYNISWELEVLEVNNSSLRHRLILANCDIGKI :*:*.*:.***: :*:****:**.***:.*******:**::..****:*********.** ENSMUSP00000081545/1-1624 GDEKCDPECNHTLTGHDGGDCRQLRYPAFMKKQQNGVCDMDCNYERFNFDGGECCDPDIT ENSRNOP00000046248/1-1440 GDEKCDPECNHTLTGHDGGDCRQLRYPAFMKKQQNGACDMDCNYERFNFDGGECCDPDIT ENSP00000330658/1-1627 GDENCDPECNHTLTGHDGGDCRHLRHPAFVKKQHNGVCDMDCNYERFNFDGGECCDPEIT ENSCPOP00000013821/1-1528 GDENCDPECNHTLTGHDGGDCRHLRYPAFMKKQQNGVCDMDCNYERFNFDGGECCDPEIT XP_004849699.1/1-1587 GDENCDPECNHTLTGHDGGDCRHLRHPAFMKKQQNGVCDMDCNYERFSFDGGECCDPEIT ***:******************:**:***:***:**.**********.*********:** ENSMUSP00000081545/1-1624 DVTKTCFDPDSPHRAYLDVNELKNILRLDGSTHLNIFFANSSEEELAGVATWPWDKEALM ENSRNOP00000046248/1-1440 DVTKTCFDPDSPHRAYLDVNELKNILKLDGSTHLNIFFANSSEEELAGVATWPWDKEALM ENSP00000330658/1-1627 NVTQTCFDPDSPHRAYLDVNELKNILKLDGSTHLNIFFAKSSEEELAGVATWPWDKEALM ENSCPOP00000013821/1-1528 DVTKTCFDPDSPHRAYLDVNELKNILRLDGSTHLNIFFANSSEEELAGVATWPWDKEALM XP_004849699.1/1-1587 DVTKTCFDPDSPHRAYLDVNELKNILRLDGSTHLNIFFANSSEEELAGVATWPWDKEALM :**:**********************:************:******************** ENSMUSP00000081545/1-1624 HLGGIVLNPSFYGIPGHTHTMIHEIGHSLGLYHIFRGISEIQSCSDPCMETEPSFETGDL ENSRNOP00000046248/1-1440 HLGGIVLNPSFYGIPGHTHTMIHEIGHSLGLYHIFRGISEIQSCSDPCMETEPSFETGDL ENSP00000330658/1-1627 HLGGIVLNPSFYGMPGHTHTMIHEIGHSLGLYHVFRGISEIQSCSDPCMETEPSFETGDL ENSCPOP00000013821/1-1528 HLGGIVLNPSFYGIPGHTHTMIHEIGHSLGLYHIFRGISEIQSCSDPCMETEPSFETGDL XP_004849699.1/1-1587 HLGGIVLNPSFYGIPGHTHTMIHEIGHSLGLYHIFRGISEIQSCSDPCMETEPSFETGDL *************:*******************:************************** ENSMUSP00000081545/1-1624 CNDTNPAPKHKFCGDPGPGNDTCGFHGFFNTPYNNFMSYADDDCTDSFTPNQVSRMHCYL ENSRNOP00000046248/1-1440 CNDTNPAPKHKFCGDPGPGNDTCGFHGFFDTPYNNFMSYADDDCTDSFTPNQVSRMHCYL ENSP00000330658/1-1627 CNDTNPAPKHKSCGDPGPGNDTCGFHSFFNTPYNNFMSYADDDCTDSFTPNQVARMHCYL ENSCPOP00000013821/1-1528 CNDTNPAPKYKFCSDPEPGNDTCGFNSFFDTPYNNFMSYADDDCTDSFTPNQVARMHCYL XP_004849699.1/1-1587 CNDTNPAPKHKFCGDPGPGNDTCGFHSFFNTPYNNFMSYADDDCTDSFTPNQVARMHCYL *********:* *.** ********:.**:***********************:****** ENSMUSP00000081545/1-1624 DLVYQSWQPSRKPAPVALAPQVVGHTMDSVMLEWFPPIDGHFFERELGSACDLCLEGRIL ENSRNOP00000046248/1-1440 DLVYQSWQPSRKPAPVALAPQIVGHTTDSVMLEWFPPIDGHFFERELGSACDLCLEGRIL ENSP00000330658/1-1627 DLVYQGWQPSRKPAPVALAPQVLGHTTDSVTLEWFPPIDGHFFERELGSACHLCLEGRIL ENSCPOP00000013821/1-1528 DLVYQSWQPSRKPGPVALAPQVVGHTTDSVMLEWFPPIDGHIFERELGSACDLCLEGRIL XP_004849699.1/1-1587 DLVYQSWQPSRKPAPVALAPQVVGHTADSVTLEWFPPIDGHFFERELGSACDLCLEGRIL *****.*******.*******::*** *** **********:*********.******** ENSMUSP00000081545/1-1624 VQYAFNASSPMPCGPSGHWSPREAEGHPDVEQPCKSSVRTWSPNSAVNPHTVPPACPEPQ ENSRNOP00000046248/1-1440 VQYAFNASSPMPCGPSGHWSPREAEGHPDVEQPCKSSVRTWSPNSAVNPHTVPPACPEPQ ENSP00000330658/1-1627 VQYASNASSPMPCSPSGHWSPREAEGHPDVEQPCKSSVRTWSPNSAVNPHTVPPACPEPQ ENSCPOP00000013821/1-1528 VQYAFKASSPMPCGPSGHWSPREAEGHPDVEQPCKSSVRTWSPNSAVNPHTVPPACPEPQ XP_004849699.1/1-1587 VQYAFKASSPMPCGPSGHWSPREAEGHPDVEQPCKSSVRTWSPNSAVNPHTVPPACPEPQ **** :*******.********************************************** ENSMUSP00000081545/1-1624 GCYLELEFRYPLVPESLTIWVTFVSSDWDSSGAVNDIKLLTISGKNISLGPQNVFCDIPL ENSRNOP00000046248/1-1440 GCYLELEFRYPLVPESLTIWVTFVSSDWDSSGAVNDIKLLTVSGKNISLGPQNVFCDIPL ENSP00000330658/1-1627 GCYLELEFLYPLVPESLTIWVTFVSTDWDSSGAVNDIKLLAVSGKNISLGPQNVFCDVPL ENSCPOP00000013821/1-1528 GCYLELEFHYPLVPESLTIWVTFVSSDWDSSGAVNDIKLLTLSGMNISLGPQNIFCDIPL XP_004849699.1/1-1587 GCYLELEFHYPLVPESLTIWVTFVSTDWDSSGAVNDIKLLTVSGMNISLGPQNVFCDIPL ******** ****************:**************::** ********:***:** ENSMUSP00000081545/1-1624 TIRLRDVGEEVYGIQIYTLDEHLEIDAAMLTSTVDSPLCLQCKPLQYKVLRDPPLLEDVA ENSRNOP00000046248/1-1440 TIRLRDVSEEVYGIQIYTLDEHLEIDAAMLTSAVDSPLCLQCKPLQYKVLRDPPLLDDVG ENSP00000330658/1-1627 TIRLWDVGEEVYGIQIYTLDEHLEIDAAMLTSTADTPLCLQCKPLKYKVVRDPPLQMDVA ENSCPOP00000013821/1-1528 TIRLRDVNEEVYGIQIYTLDEHLEIDAAMLTSLADTPLCLECKPLKYKVVRDPPLQEDVA XP_004849699.1/1-1587 TIRLRDVSEEVYGIQIYTLDEHLEIDAAMLTSIADSPLCLACKPLQYMVVRDPPLQEDMV **** **.************************ .*:**** ****:* *:***** *: ENSMUSP00000081545/1-1624 SLLHLNRRFMDTDLKLGSVYQYRIITISGNEESEPSPAAIYTHGSGYCGDGVIQKDQGEE ENSRNOP00000046248/1-1440 SLLHLNRRFMDMDLKLGNVYQYRIITISGNEESEPSPAAIYTHGSGYCGDGVIQKDQGEE ENSP00000330658/1-1627 SILHLNRKFVDMDLNLGSVYQYWVITISGTEESEPSPAVTYIHGSGYCGDGIIQKDQGEQ ENSCPOP00000013821/1-1528 SLLHRNRRFMDKDLKLGSVYQYQVITISGTEESEPSPATIYIHGSGYCGDGIIQRGQGEE XP_004849699.1/1-1587 SLLHLNRRFMDMDLKLGSVYQYRVITISGTEESEPSPAAIYIHGSGYCGDGIIQRGQGEE *:** **:*:* **:**.**** :*****.********. * *********:**:.***: ENSMUSP00000081545/1-1624 CDDMNKVNGDGCSLFCKQEVSFNCIDEPSRCYFHDGDGMCEEFEQKTSIKDCGVYTPQGF ENSRNOP00000046248/1-1440 CDDMNKVNGDGCSLFCKQEVSFNCIDEPSRCYFHDGDGMCEEFEQKTSIKDCGVYTPQGF ENSP00000330658/1-1627 CDDMNKINGDGCSLFCRQEVSFNCIDEPSRCYFHDGDGVCEEFEQKTSIKDCGVYTPQGF ENSCPOP00000013821/1-1528 CDDMNKINGDGCSLFCQQEVSFNCIDEPSRCYFHDGDGVCEEFEQQTSIKDCGVYTPQGF XP_004849699.1/1-1587 CDDMNKINGDGCSLFCQQEVSFNCIDEPSRCYFHDGDGVCEEFEQKTSIKDCGVYTPQGF ******:*********:*********************:******:************** ENSMUSP00000081545/1-1624 LDQWASNASVSHQDQQCPGWVVIGQPAASQVCRTKVIDLSEGISQHAWYPCTITYPYYHL ENSRNOP00000046248/1-1440 LDQWASNASVSHQDQQCPGWVVIGQPAASQVCRTKVIDLSEGISQHAWYPCTINYPYYQL ENSP00000330658/1-1627 LDQWASNASVSHQDQQCPGWVIIGQPAASQVCRTKVIDLSEGISQHAWYPCTISYPYSQL ENSCPOP00000013821/1-1528 LDQWASNASVSHQDQQCPGWVIIGQPAASQVCRTKVIDLSEGISQHAWYPCTISYPYSQL XP_004849699.1/1-1587 LDQWASNASVSHQDQQCPGWVIIGQPAASQVCRTKVIDLNEGISQHAWYPCTISYPYSQL *********************:*****************.*************.*** :* ENSMUSP00000081545/1-1624 PQTTFWLQTYFSQPMVAAAVIIHLVTDGTYYGDQKQETISVQLLDTKDQSHDLGLHVLSC ENSRNOP00000046248/1-1440 PQTTFWLQTYFSQPMVAAAVIIHLVTDGTYYGDQKQETIS--------------LHVLSC ENSP00000330658/1-1627 AQTTFWLRAYFSQPMVAAAVIVHLVTDGTYYGDQKQETISVQLLDTKDQSHDLGLHVLSC ENSCPOP00000013821/1-1528 AQTTFWLQAFFSQPVVATAVIVHLVTDGTYYGDQKQETISVQLLDTKEQSHDLGLHVLSC XP_004849699.1/1-1587 AQTTFWLQAYFSQPMVAAAVLVHLVTDGTYYGDQKQETISVQLLDTKDRSHDLGLHVLSC .******:::****:**:**::****************** ****** ENSMUSP00000081545/1-1624 RNNPLIIPVVHDLSQPFYHSQAVHVSFSSPLVAISGVALRSFDNFDPVTLSSCQRGETYS ENSRNOP00000046248/1-1440 RNNPLIIPVVHDLSQPFYHSQAVHVSFSSPLVAISGVALRSFDNFDPVTLSSCQRGETYS ENSP00000330658/1-1627 RNNPLIIPVVHDLSQPFYHSQAVRVSFSSPLVAISGVALRSFDNFDPVTLSSCQRGETYS ENSCPOP00000013821/1-1528 RNNPLIIPVVHDLSQPFYHSQAVRVSFSSPLVAISGVALRSFDNFDPVTLSSCQRGETYS XP_004849699.1/1-1587 RNNPLIIPVVHDLSQPFYHSQAVRVSFSSPLVAISGVALRSFDNFDPVTLSSCQRGETYS ***********************:************************************ ENSMUSP00000081545/1-1624 PAEQSCVHFACQAADCPELAVGNASLNCSSNHHYHGAQCTVSCQTGYVLQIQRDDELIKS ENSRNOP00000046248/1-1440 PAEQSCVHFACEATDCPELTVENASLNCSSSHRYHGAQCTVSCQTGYVLQIQRDDELIKS ENSP00000330658/1-1627 PAEQSCVHFACEKTDCPELAVENASLNCSSSDRYHGAQCTVSCRTGYVLQIRRDDELIKS ENSCPOP00000013821/1-1528 PAEQSCVHFACEASDCPALAVENAFLNCSSSDSYHGAQCTVSCQKGYVLQIQRDDELIKS XP_004849699.1/1-1587 PAEQSCVHFACEASDCPELAVENASLNCSSSDRYHGAQCTVSCQMGYVLQIQRDDELIKS ***********: :*** *:* ** *****.. **********: ******:******** ENSMUSP00000081545/1-1624 QVGPSITVTCTEGKWNKQVACEPVDCGIPDHHHVYAASFSCPEGTTFGRRCSFQCRHPAQ ENSRNOP00000046248/1-1440 QVGPSVTVTCTEGKWNKQVACEPVDCGIPDHHHVYAASFSCPE----------------- ENSP00000330658/1-1627 QTGPSVTVTCTEGKWNKQVACEPVDCSIPDHHQVYAASFSCPEGTTFGSQCSFQCRHPAQ ENSCPOP00000013821/1-1528 KTGPSVTVTCTEGKWNKQVACEPVDCGVPDHHHVYAASFSCLEGTTFGSKCSFQCRHPAQ XP_004849699.1/1-1587 QTGPSVTVTCTEGKWNKQVACEPVDCGVPDHHHVYAASFSCLEGTTFGSKCSFQCRHPAQ :.***:********************.:****:******** * ENSMUSP00000081545/1-1624 LKGNNSFLTCMEDGLWSFPEALCELMCLAPPPVPNADLQTARCRENKHKVGSFCKYKCKP ENSRNOP00000046248/1-1440 --GNNSFLTCMEDGLWSFPEALCELMCLAPPPVPNADLQTARCRENKHKVGSLCKYKCKP ENSP00000330658/1-1627 LKGNNSLLTCMEDGLWSFPEALCELMCLAPPPVPNADLQTARCRENKHKVGSFCKYKCKP ENSCPOP00000013821/1-1528 LKGNNSFLTCMEDGLWSFPEALCELMCLAPAPVPNADLQTARCRENKHKVGSFCKYKCKP XP_004849699.1/1-1587 LKGNNSLLICMEDGLWSFPESLCELMCLAPPPVPNADLQTARCRENKHKVGSFCKYKCKP ****:* ***********:*********.*********************:******* ENSMUSP00000081545/1-1624 GYHVPGSSRKSKKRAFKTQCTQDGSWQEGTCVPVTCDPPPPKFHGLYQCTNGFQFNSECR ENSRNOP00000046248/1-1440 GYHVPGSSRKSKKRAFKTQCTQDGSWQEGTCVPVTCDPPPPKFHGLYQCTNGFQFNSECR ENSP00000330658/1-1627 GYHVPGSSRKSKKRAFKTQCTQDGSWQEGACVPVTCDPPPPKFHGLYQCTNGFQFNSECR ENSCPOP00000013821/1-1528 GYHVPGSSRKSKKRAFKTQCTQDGSWQEVACVPVTCDPPPPKFHGLYQCTNGFQFNSECR XP_004849699.1/1-1587 GYHVPGSSRKSKKRAFKTQCTQDGSWQEAACVPVTCDPPPPKFHGLYQCTNGFQFNSECR **************************** :****************************** ENSMUSP00000081545/1-1624 IKCEDSDASQGRGSNIIHCRKDGTWSGSFHVCREMQGQCSAPNQLNSNLKLQCPDGYAIG ENSRNOP00000046248/1-1440 IKCEDSDASQGRGSNTIHCRKDGTWSGSFHVCREMQGQCSAPNQLNSHLKLQCPDGYAIG ENSP00000330658/1-1627 IKCEDSDASQGLGSNVIHCRKDGTWNGSFHVCQEMQGQCSVPNELNSNLKLQCPDGYAIG ENSCPOP00000013821/1-1528 IKCEDSDTSQGHGSNIILCRKDGTWSGSFHVCQEMQGQCSVPNQLNSNLKLQCPDGYAIG XP_004849699.1/1-1587 IKCEDSDTSQGLGSNIIHCRKDGTWSGSFHVCQEMQGQCSAPNQLDSNLKLQCPDGYSIG *******:*** *** * *******.******:*******.**:*:*:*********:** ENSMUSP00000081545/1-1624 SECAISCLDHNSESIILPVNLTVRDIPHWMNPTRVQRIVCTAGLQWYPHPALIHCVKGCE ENSRNOP00000046248/1-1440 SECATSCLDHNSESIILPVNLTVRDIPHWMNPTRVQRIVCTAGLQWYPHPARIHCVKGCE ENSP00000330658/1-1627 SECATSCLDHNSESIILPMNVTVRDIPHWLNPTRVERVVCTAGLKWYPHPALIHCVKGCE ENSCPOP00000013821/1-1528 AECATSCLDHNSESIILPTNMTVRDIPHWLNPTRVQRVVCTAGLKWYPLPALIHCVKGCE XP_004849699.1/1-1587 SECATSCLDHNSESILLPTNVTVRDIPYWLNPTRVQRVVCTAGLKWYPHPALIHCVKGCE :*** **********:** *:******:*:*****:*:******:*** ** ******** ENSMUSP00000081545/1-1624 PFMGDNYCDAINNRAFCNYDGGDCCTSTVKTKKVTPFPMSCDLQNDCACRDPEAQEHNRK ENSRNOP00000046248/1-1440 PFMGDNYCDAINNRAFCNYDGGDCCTSTVKTKKVTPFPMSCDLQDDCACRDPEAQEHSRK ENSP00000330658/1-1627 PFMGDNYCDAINNRAFCNYDGGDCCTSTVKTKKVTPFPMSCDLQGDCACRDPQAQEHSRK ENSCPOP00000013821/1-1528 PFMGDNYCDAINNRAFCNYDGGDCCTSTVKTKKVTPFPMSCDLQGDCACRDPEAQEHSQK XP_004849699.1/1-1587 PFMGDNYCDAINNRAFCNYDGGDCCTSTVKTKKVTPFPMSCDLQGDCACRDPEAQEHSRK ********************************************.*******:****.:* ENSMUSP00000081545/1-1624 DLRGYSHG ENSRNOP00000046248/1-1440 DLRGYSHG ENSP00000330658/1-1627 DLRGYSHG ENSCPOP00000013821/1-1528 DLRGYSHG XP_004849699.1/1-1587 DLRGYSHG ********