CLUSTAL W(1.81) multiple sequence alignment ENSRNOP00000018225/1-1271 MSVKEGAQRKWAALKEKLGPQDSDPTEANLESAEPELCIRLLQMPSVVNYSGLRKRLESS ENSP00000376410/1-1249 MSVKEGAQRKWAALKEKLGPQDSDPTEANLESADPELCIRLLQMPSVVNYSGLRKRLEGS ENSMUSP00000098591/1-1271 MSVKEGAQRKWAALKEKLGPQDSDPTEANLESAEPELCIRLLQMPSVVNYSGLRKRLESS XP_004836920.1/1-1205 MSVKEGAQRKWVALKEKLGPQDSDPTEANLESAEPELCIRLLQMPSVVNYSGLRKRLESS ENSCPOP00000013719/1-1170 MSVKEGAQRKWAALKEKLGPQDSDPTEANLESAEPELCIRLLQMPSVVNYSGLRKRLESS ***********.*********************:************************.* ENSRNOP00000018225/1-1271 DGSWMVQFLEQSGLDLLLEALARLSGRGVARIADALLQLTCISCVRAVMNSQQGIEYILS ENSP00000376410/1-1249 DGGWMVQFLEQSGLDLLLEALARLSGRGVARISDALLQLTCVSCVRAVMNSRQGIEYILS ENSMUSP00000098591/1-1271 DGGWMVQFLEQSGLDLLLEALARLSGRGVARISDALLQLTCISCVRAVMNSQQGIEYILS XP_004836920.1/1-1205 DGSWMVQFLEQSGLDLLLEALARLSGRGVSRIADALLQLTCVSCVRAVLNSQPGIGYILS ENSCPOP00000013719/1-1170 DGGWMVQFLEQSGLDLLLEALARLSGRGVSRIADALLQLTCVSCVRAVLNSQPGIGYILS **.**************************:**:********:******:**: ** **** ENSRNOP00000018225/1-1271 NQGYVRQLSQALDTSNVMVKKQVFELLAALCIYSPEGHALTLDALDHYKMVCSQQYRFSV ENSP00000376410/1-1249 NQGYVRQLSQALDTSNVMVKKQVFELLAALCIYSPEGHVLTLDALDHYKTVCSQQYRFSI ENSMUSP00000098591/1-1271 NQGYVRQLSQALDTSNVMVKKQVFELLAALCIYSPEGHALTLDALDHYKMVCSQQYRFSV XP_004836920.1/1-1205 NQGYVRRLSLALDTSNVMVKKQVFELLAALCIYSPEGHALTLDALDHYKMVCSQQYRFSV ENSCPOP00000013719/1-1170 NQGYVRQLSLALDTSNVMVKKQVFELLAALCIYSPEGHALTLDALDHYKMVCSQQYRFSV ******:** ****************************.********** *********: ENSRNOP00000018225/1-1271 IMNELSDSDNVPYVVTLLSVINALILGPEDLRTRAQLRSEFIGKCPRLLVRLLEALPGPY ENSP00000376410/1-1249 VMNELSGSDNVPYVVTLLSVINAVILGPEDLRARTQLRNEFIGLQLLDVLARLRDLEDAD ENSMUSP00000098591/1-1271 IMSELSDSDNVPYVVTLLSVINAIILGPEDLRSRAQLRSEFIGLQLLDILTRLRDLEDAD XP_004836920.1/1-1205 IMSELSDSDNAPYVVTLLSAVNAIILGPADLRTRTQLRSEFIGLQLLDVLNRLRDLEDAD ENSCPOP00000013719/1-1170 IMNELSDSDNVPYVVTLLSVINAIILGPEDLRTRTQLRCEFIGLQLLDILTRLRDLEDAD :*.***.***.********.:**:**** ***:*:*** **** :: *. * .. ENSRNOP00000018225/1-1271 IPLGMGGLQQRKALIERSVLRISGQWPLNKHYPVVSGLSNPTHPSIPGLQLLDILTRLRH ENSP00000376410/1-1249 LLIQLEAFEEAKAEDEEELLRVSGGVDMSSHQEVFASLFHKVSCSPVSAQLLSVLQGLLH ENSMUSP00000098591/1-1271 LLIQLEAFEEAKAEDEEELQRISDGINMNSHQEVFASLFHKVSCSPASAQLLSVLQGLMH XP_004836920.1/1-1205 LLIQLEAFEEARVEDEEELLHVCDGINMNSHQEVFTSLFHKVSCSPASAQLLSVLQGLLH ENSCPOP00000013719/1-1170 LLIQLEAFEEAKAEDEEELLHVCDGINMNNHQEVFASLFHKVSSSPASAQLLSVLQGLLH : : : .::: :. *..: ::.. :..* *.:.* : . * . ***.:* * * ENSRNOP00000018225/1-1271 PAQAVSPDGLRG-----CFQELVEGSVLTLDSDTQ-HVVAVVYPDYSQVRHHWGPLYFQQ ENSP00000376410/1-1249 ----LEPTLRSSQLLWEALESLVNRAVL-LASDAQECTLEEVVERLLSVKGRPRPSPLVK ENSMUSP00000098591/1-1271 ----LEPAGRSGQLLWEALENLVNRAVL-LASDAQACTLEEVVERLLSIKGRPRPSPLDK XP_004836920.1/1-1205 ----LEPSGSSGQLLWEALESLVNRAVL-LASDAQECTLEEVVERLLAAKGRPRPSPQDR ENSCPOP00000013719/1-1170 ----LEPSGHSGQLLWEALESLVNRAVL-LASDAQECTLEEVVERLLAGKVRPRPSLLDQ :.* . .::.**: :** * **:* .: * : : * : ENSRNOP00000018225/1-1271 VSISSLTDSTVLDGAQLQSSGTLRGS-VTGQ--AEVTPSPLMSHGDLSQVLILTIIFLTL ENSP00000376410/1-1249 AHKSVQANLDQSQRGSSPQNTTTPKPSVEGQQPAAAAACEPVDHAQSESI---------- ENSMUSP00000098591/1-1271 AHKSVQTNSVQNQGSS-SQNTTTPTTKVEGQQPVVASPCQHVGSIQSSSVDIAPQPVALE XP_004836920.1/1-1205 AHKSVQADLDRSQRDR-PPKTIAPGA-VDTPQPAVAPACQQVASTQSSNV---------- ENSCPOP00000013719/1-1170 AHKSVQADLGQNQSDTLAQNTTASGTGIDAQQPAVASVCQQVASTQSSSS---------- . * :: : . . : . .. . : : .. ENSRNOP00000018225/1-1271 HMRAQPHPVPIMIVLPYPVPGDAQVPSGQPGRTRELPLKLPFWLAEPQAGYRVNQPGPAR ENSP00000376410/1-1249 ------------LKVSQPRALEQQ----------------------------ASTPPP-- ENSMUSP00000098591/1-1271 QCITALPLPTPPLSSSTPVLPPTPPPLPGPGATSPLPPPPPPLPPPLPGSGTTSPPPP-- XP_004836920.1/1-1205 -------------TATQPVAPQQR------------------------------APRP-- ENSCPOP00000013719/1-1170 -------------TAVQPTVPPQR------------------------------APSP-- * * * ENSRNOP00000018225/1-1271 PSPPGRPGPLLGSAPWLDCPGKAVLMQVPGQASKD----QSRPSCLCLPVSRLGSPRPAE ENSP00000376410/1-1249 PPPPPLLP-----GSSAEPPPPPPPPPLPSVGAKALPTAPPPPPLPGLGAMAPPAPPLPP ENSMUSP00000098591/1-1271 PPPPPPLPPPLPGSGTISPPPPPPPPPLPGTGAVS-P--PPPPPLPSLPDSHKTQPPPPP XP_004836920.1/1-1205 PPPAPPVL---------GPTPEPSLHPMPGLGAASAP-VPPPPPLPSLGSPFFSAPPPAP ENSCPOP00000013719/1-1170 PPPAPSLP---------DPTTRSPLHHLP--------------------SSFSSVPPPAP *.*. . . :* * . ENSRNOP00000018225/1-1271 EVMEYSSSL-PPPPPLPTAGQVPPPPPL----------------PGFSVPSVVGGVEEII ENSP00000376410/1-1249 PLPGSCEFLPPPPPPLPGLGCPPPPPPLLPGMGWGPPPPPPPLLPCTCSPPVAGGMEEVI ENSMUSP00000098591/1-1271 PLPGMCPV--PPPPPLPRAGQIPPPPPL----------------PGFSVPSMMGGVEEII XP_004836920.1/1-1205 PLPGCGSALPPPPPPLPGTGCPPPPPPLPPGVGWG---------PGISGLPMAAGMEEVI ENSCPOP00000013719/1-1170 PLPGFGSALL----------------------------------PGTSGLPMAAGVEEII : * . .: .*:**:* ENSRNOP00000018225/1-1271 VAQVDHSLGSAWVPSHRRVNPPTLRMKKLNWQKLPSNVARGMSTVHATSEDIVSSGTEPW ENSP00000376410/1-1249 VAQVDHGLGSAWVPSHRRVNPPTLRMKKLNWQKLPSNVAREHNSMWASLSSPDAEAVEPD ENSMUSP00000098591/1-1271 VAQVDHSLGSAWVPSHRRVNPPTLRMKKLNWQKLPSNVARERNSMWATLGSPCTAAVEPD XP_004836920.1/1-1205 VAQVDHGLGSTWVPSHRRVNPPTLRMKKLNWQKLPSNVAQEQNSMWATLSGPGTQQVELD ENSCPOP00000013719/1-1170 VAQVDHGLGSTWVPSHRRVNPPTLRMKKLNWQKLPSNVARERNSMWATMSSPGTEQVEPD ******.***:****************************: .:: *: . : .* ENSRNOP00000018225/1-1271 EDSPASQF--PNPYLRAPSSSSSGAYQPPPSLSIDGDREEGNSCSLTPVFTLSSSNEEVT ENSP00000376410/1-1249 FSSIERLFSFPAAKPKEPTMVAPRARKEPKEITFLDAKKSLNLNIFLKQF--KCSNEEVA ENSMUSP00000098591/1-1271 FSSIEQLFSFPTAKPKEPS--AAPARKEPKEVTFLDSKKSLNLNIFLKQF--KCSNEEVT XP_004836920.1/1-1205 FSSIERLFSFPTAKPKECT--TAPTRKEPKEVTFLDPKKSLNLNIFLKQF--KRSNEEVT ENSCPOP00000013719/1-1170 FSSIERLFSFPTAKPKEPT--AAPTRKEPKEVTFLDAKKSLNLNIFLKQF--KCSNEEIT .* * * . : : :. : : * .::: . ::. * : * . ****:: ENSRNOP00000018225/1-1271 GMIQAGDTSKFDVEVLKQLLKLLPEKHEIENLRAFTEDRAKLASADQFYILLLDIPCYQL ENSP00000376410/1-1249 AMIRAGDTTKFDVEVLKQLLKLLPEKHEIENLRAFTEERAKLASADHFYLLLLAIPCYQL ENSMUSP00000098591/1-1271 SMIQAGDTSKFDVEVLKQLLKLLPEKHEIENLRAFTEERAKLSNADQFYVLLLDIPCYPL XP_004836920.1/1-1205 AMIRAGDTAMFDVEVLKQLLKLLPEKHEIENLRTFTEDRAKLASADQFYVLLLDVPCYQL ENSCPOP00000013719/1-1170 AMIRAGDTAKFDVEILKQLLKLLPEKHEIENLRTFTEERTKLANADQFYVLLLDIPCYQL .**:****: ****:******************:***:*:**:.**:**:*** :*** * ENSRNOP00000018225/1-1271 RVECMMLCEGTAIVLDMVRPKAQLVLTACESLLTSQRLPVFCQLILKIGNFLNYGSHTGD ENSP00000376410/1-1249 RIECMLLCEGAAAVLDMVRPKAQLVLAACESLLTSRQLPIFCQLILRIGNFLNYGSHTGD ENSMUSP00000098591/1-1271 RVECMMLCEGTAIVLDMVRPKAQLVLTACESLLTSQRLPVFCQLILKIGNFLNYGSHTGD XP_004836920.1/1-1205 RIECMLLCEGTAVMLDMVRPKAQLVLNACERLLTSHRLPIFCQLILKIGNFLNYGSHTGN ENSCPOP00000013719/1-1170 RIECMQLCEGTAIVLDMVRPKAQLVLNACESLLNSHRLPVFCQLILKIGNFLNYGSHTGD *:*** ****:* :************ *** **.*::**:******:************: ENSRNOP00000018225/1-1271 ADGFKISTLLKLTETKSQQSRVTLLHHVLEEVEKSHPDLLQLSRDLESPSQAAGIHLEII ENSP00000376410/1-1249 ADGFKISTLLKLTETKSQQNRVTLLHHVLEEAEKSHPDLLQLPRDLEQPSQAAGINLEII ENSMUSP00000098591/1-1271 ADGFKISTLLKLTETKSQQSRVTLLHHVLEEVEKSHPDLLQLSRDLEPPSQAAGINVEII XP_004836920.1/1-1205 ADGFKISTLLKLTETKSQQSRVTLLHHVLEEVEKSHPDLLQLAGDLEQPSQAAGINVEII ENSCPOP00000013719/1-1170 ADGFKISTLLKLTETKSQQNRVTLLHHVLEEVEKSHPDLLQLPKDLDQPSQAAGINVEII *******************.***********.**********. **: *******::*** ENSRNOP00000018225/1-1271 HSEASANLKKLLEAERKVSSSIPEVQKQYAERLQASIEASRALDKVFDAIEQKKLELADY ENSP00000376410/1-1249 RSEASSNLKKLLETERKVSASVAEVQEQYTERLQASISAFRALDELFEAIEQKQRELADY ENSMUSP00000098591/1-1271 HSEASANLKKLLEAERKVSASIPEVQKQYAERLQASIEASQELDKVFDAIEQKKLELADY XP_004836920.1/1-1205 RTEASANLKKLLDTERKVSASVPEVQEQYKQRLQASITTCQELNSVFEAIEQKKLELADY ENSCPOP00000013719/1-1170 RTEAGTNLKKLLDAEQKVSASIPEVQEQYKHRLQTSITASRELDAVFSAIEQRKLELADY ::**.:******::*:***:*:.***:** .***:** : : *: :*.****:: ***** ENSRNOP00000018225/1-1271 LCEDPQKLSLEDTFSTMKTFRDLFTRALKENKDRKEQMAKAEKRKQQLAEEEARRPRDED ENSP00000376410/1-1249 LCEDAQQLSLEDTFSTMKAFRDLFLRALKENKDRKEQAAKAERRKQQLAEEEARRPRGED ENSMUSP00000098591/1-1271 LCEDPQQLSLEDTFSTMKTFRDLFTRALKENKDRKEQMAKAERRKQQLAEEEARRPRDED XP_004836920.1/1-1205 LCEDPQKLSLEDTFSTMRTFRDLFTCALKENKDRKEQVEKAVRRKQQLAEEEARRPQGGD ENSCPOP00000013719/1-1170 LCEDPQQLSLEDTFSTLRSFRDLFTCSLKENKDRKEQMAKAERRKRQLAEEEARRPLGKD ****.*:*********:::***** :********** ** :**:********** . * ENSRNOP00000018225/1-1271 GKPVRKGPGKQEEVCVIDALLADIRKGFQLRKTARGRGDTEASGRVAPADPPKITEPATA ENSP00000376410/1-1249 GKPVRKGPGKQEEVCVIDALLADIRKGFQLRKTARGRGDTDGGSKAASMDPPRATEPVAT ENSMUSP00000098591/1-1271 GKPIRKGPGKQEEVCVIDALLADIRKGFQLRKTARGRGDTEASGRVAPADPPKATEPATA XP_004836920.1/1-1205 RKPGRKAPGRQEEVCVIDALLADIRKGFQLRKTARGRGDAEGLSKVAAVDPVRPREPAAA ENSCPOP00000013719/1-1170 GKPGRKAPGRQEEVCVIDALLADIRKGFQLRKTARGRGEAEGSSKVASKDPLRVPEPAAA ** **.**:****************************:::. .:.*. ** : **.:: ENSRNOP00000018225/1-1271 SNPTQGTNQPASEPSS----DTTAAGEPQGWDLVDAVTPSPQPT---KEDGGPPSLERRS ENSP00000376410/1-1249 SNPAGDPVGSTRCPASEPGLDATTASESRGWDLVDAVTPGPQPTLEQLEEGGPRPLERRS ENSMUSP00000098591/1-1271 SNPTQGTNHPASEP-----LDTTAADEPQGWDLVDAVTPSPQPS---KEEDGPPALERRS XP_004836920.1/1-1205 SDTAQGPAGGTGCPAPDLDLRVTVTSEPQGWDLGDAVSRSPVPP---GEESGLPRLERRS ENSCPOP00000013719/1-1170 SDPVQGPTGGTSDPAPELDLHAAVASEPPGCDFVDTVIPSPASH---GKESGPPPLERRS *:.. .. : * .:.:.*. * *: *:* .* . ::.* ***** ENSRNOP00000018225/1-1271 SWYVDASDFLAPEDILNTQPSEGAWPVTLGDDQALKPLEFSSNKPPGVERS-HQDATDPE ENSP00000376410/1-1249 SWYVDASDVLTTEDPQCPQPLEGAWPVTLGDAQALKPLKFSSNQPPAAGSS-RQDAKDPT ENSMUSP00000098591/1-1271 SWYVDAIDFLDPEDTPDAQPSEGVWPVTLGDGQALNPLEFSSNKPPGVKSS-HQDATDPE XP_004836920.1/1-1205 SWYVDARDFLDAEDALNVCPSKEACPVALGDSQALKPLQFSIEKPLGSQSSGPQDHENPK ENSCPOP00000013719/1-1170 SWYVDASDFLDTKDALNTCPSTEAWPVVLGDSHALKLLEFSSKEPPGSQSSGPQDTEDPE ****** *.* .:* * . **.*** :**: *:** ::* . * ** :* ENSRNOP00000018225/1-1271 ALWGVHRAEADSTSVRPEDATERGQGTHLPR--PGE--DEDEEDTALESALDTSLDRSFS ENSP00000376410/1-1249 SLLGVLQAEADSTSEGLED-AVHSRGARPPAAGPGGDEDEDEEDTAPESALDTSLDKSFS ENSMUSP00000098591/1-1271 ALWGVHRTEADSTSEGPEDEAQRGQSTHLPRTGPGE--DEDGEDTAPESALDTSLDRSFS XP_004836920.1/1-1205 ASQGVHQAKADSTSLAPED------------IGPSG--DEDREDTAPESALDTSLDKS-S ENSCPOP00000013719/1-1170 NSQGVHLAKADSTSQGPED------------IGPGG--DEDREDTALESALDTSLDKSFS ** ::***** ** *. *** **** *********:* * ENSRNOP00000018225/1-1271 EDAVTDSSGSGTLPRVQ--GRISKGTGKRRKKRPSRRQE-EFAPDSDDNKAKRLCVIQ ENSP00000376410/1-1249 EDAVTDSSGSGTLPRAR--GRASKGTGKRRKKRPSRSQE-EVPPDSDDNKTKKLCVIQ ENSMUSP00000098591/1-1271 EDAVTDSSGSGTLPRVQ--GRVSKGTSKRRKKRPSRNQE-EFVPDSDDIKAKRLCVIQ XP_004836920.1/1-1205 EHAVTDSSGSGTLPRAQAWGRASKGSSRRRKKHPSRSQE-GLRPKP---RAK------ ENSCPOP00000013719/1-1170 EDAVTDSSGSGTLPR----GLASKGSSKRRKRRPARSQEAEVAPDSDDNKTKRLCVVQ *.************* * ***:.:***::*:* ** . *.. ::*