CLUSTAL W(1.81) multiple sequence alignment ENSMUSP00000054837/1-1544 METSAPAPALEKKEAKSGLLEDSSFPDPGKKACPLAV----AAAVAAHGVPQQLLPAFHA ENSRNOP00000009963/1-1480 ------------------------------------------------------------ ENSP00000390436/1-1586 METSASATASEKQEAKSGILEAAGFPDPGKKASPLVVAAAAAAAVAAQGVPQHLLPPFHA ENSCPOP00000013691/1-1511 -------------------------------------------------VPQHLLPPFHA XP_004836104.1/1-1560 METSSPATALDKKEAKSGILEGSAFPGPGKKACPLAV--AAAAAVAAQGVPQHLLPPFHA ENSMUSP00000054837/1-1544 PLPIDMRHQEGRYHYDPHSVHSVHGPPTLSGSPVISDISLIRLSPHPAGPGESPFSAHHP ENSRNOP00000009963/1-1480 -----MRHQEGRYHYDPHPVHGVHGPPTLSGSPVISDISLIRLSPHPAGPGESPFSAHHP ENSP00000390436/1-1586 PLPIDMRHQEGRYHYEPHSVHGVHGPPALSGSPVISDISLIRLSPHPAGPGESPFNAPHP ENSCPOP00000013691/1-1511 PLPIDMRHQEGRYHYEPHSVHSMHGPATLSGSPVISDISLIRLSPHPAGPGESPFNAPHP XP_004836104.1/1-1560 PLPIDMRHQEGRYHYEPHSVHSVHGPPTLSGSPVISDISLIRLSPHPAGPGESPFNAPHP **********:**.**.:***.:***************************.* ** ENSMUSP00000054837/1-1544 YVNPHMEHYLRSVHSSPTLSMISAARGLSPADVAHEHLKERGLFSLAAPGTNPSDYYHQM ENSRNOP00000009963/1-1480 YMNPHMEHYLRSVHSSPTLSMISAARGLSPADVAHEHLKERGLFSLAAPGTNPSDYYHQM ENSP00000390436/1-1586 YVNPHMEHYLRSVHSSPTLSMISAARGLSPADVAQEHLKERGLFGLPAPGTTPSDYYHQM ENSCPOP00000013691/1-1511 YVNPHMEHYLRSVHGSPTLSMISAARGLSPTDVAHEHLKERGLFGLAAPGTNPSDYYHQM XP_004836104.1/1-1560 YVNPHMEHYLRSVHSSPTLSMISAARGLSPTDVTHEHLKERGLFGLAAPGTNPSDYYPQM *:************.***************:**::*********.*.****.***** ** ENSMUSP00000054837/1-1544 TLMASHPTPYGDLLMQSGGAASAPHLHDYLNPVDASRFSSPRVTPRLSRKRALSISPLSD ENSRNOP00000009963/1-1480 TLMASHPTPYGDILMQSGGAASAPHLHDYLNPVDASRFSSPRVTPRLSRKRALSISPLSD ENSP00000390436/1-1586 TLVAGHPAPYGDLLMQSGGAASAPHLHDYLNPVDVSRFSSPRVTPRLSRKRALSISPLSD ENSCPOP00000013691/1-1511 TLMAGHPTPYGDLLVQSGGAAGTPHLHDYLNQVDVSRFSSPRVTPRLSRKRALSISPLSD XP_004836104.1/1-1560 TLMAGHPAPYGDLLVQSGGPAGAPHLHDYLNPVDVSRFSSPRVTPRLSRKRALSISPLSD **:*.**:****:*:****.*.:******** **.************************* ENSMUSP00000054837/1-1544 ASLDLQRMIRTSPNSLVAYINNSRSSSAASGSYGHLSAGALSPAFTFPHPINPVAYQQIL ENSRNOP00000009963/1-1480 ASLDLQRMIRTSPNSLVAYINNSRSSSAASGSYGHLSAGALSPAFTFPHPINPVAYQQIL ENSP00000390436/1-1586 ASLDLQRMIRTSPNSLVAYINNSRSSSAASGSYGHLSAGALSPAFTFPHPINPVAYQQIL ENSCPOP00000013691/1-1511 ASLDLQRMIRTSPNSLVAYINNSRSSSAASGSYGHLSAGALSPAFTFPHPINPVAYQQIL XP_004836104.1/1-1560 ASLDLQRMIRTSPNSLVAYINNSRSSSAASGSYGHLSAGALSPAFTFPHPINPVAYQQIL ************************************************************ ENSMUSP00000054837/1-1544 SQQRGLGSAFGHTPPLIQPSPTFLAQQPMTLTSISTMPTQLSSS-SSNCLNDANQNKQNS ENSRNOP00000009963/1-1480 SQQRGLGSAFGHTPPLIQPSPTFLAQQPMTLTSI-TVPTQLGSN-SSNCISDANQNKQNS ENSP00000390436/1-1586 SQQRGLGSAFGHTPPLIQPSPTFLAQQPMALTSINATPTQLSS--SSNCLSDTNQNKQSS ENSCPOP00000013691/1-1511 SQQRGLGSAFGHTPPLIQPSPTFLAQQPMALTSISSAPTQLSSS-SSNCLSDTNQNKQSS XP_004836104.1/1-1560 SQQRGLGSAFGHTPPLIQPSPTFLAQQPMALASISAAPTQLSSSGSSNCLTNANQNKQSS *****************************:*:** : ****.* ****:.::*****.* ENSMUSP00000054837/1-1544 ESAVSSTVNPITIHKRSKVKTEAEGLRPASPLGLT-----------------QEQLADLK ENSRNOP00000009963/1-1480 ESAVSSTVNPITIHKRSKVKTEAEGLRPASPLGLT-----------------QEQLADLK ENSP00000390436/1-1586 ESAVSSTVNPVAIHKRSKVKTEPEGLRPASPLALTQGQVSGHGSCGCALPLSQEQLADLK ENSCPOP00000013691/1-1511 ESAVTSTVNPITIHKRSKVKTEAEGLRPASPLRLT-----------------QEQLADLK XP_004836104.1/1-1560 ESAVSSTVNPITIHKRSKVKTEAEGLRPASPLGLT-----------------QEQLADLK ****:*****::**********.********* ** ******** ENSMUSP00000054837/1-1544 EDLDRDDCKQEAEVVIYETNCHWADCTKEYDTQEQLVHHINNEHIHGEKKEFVCRWQACT ENSRNOP00000009963/1-1480 EDLDRDDCKQEAEVVIYETNCHWADCTKEYDTQEQLVHHINNEHIHGEKKEFVCRWQACT ENSP00000390436/1-1586 EDLDRDDCKQEAEVVIYETNCHWEDCTKEYDTQEQLVHHINNEHIHGEKKEFVCRWQACT ENSCPOP00000013691/1-1511 EDLERDDCKQEAEVVIYETNCHWEDCTKEYDTQEQLVHHINNEHIHGEKKEFVCRWQACT XP_004836104.1/1-1560 EDLDKDDCKQEAEVVIYETNCHWEDCTKEYDTQEQLVHHINNEHIHGEKKEFVCRWQACT ***::****************** ************************************ ENSMUSP00000054837/1-1544 REQKPFKAQYMLVVHMRRHTGEKPHKCTFEGCSKAYSRLENLKTHLRSHTGEKPYVCEHE ENSRNOP00000009963/1-1480 REQKPFKAQYMLVVHMRRHTGEKPHKCTFEGCSKAYSRLENLKTHLRSHTGEKPYVCEHE ENSP00000390436/1-1586 REQKPFKAQYMLVVHMRRHTGEKPHKCTFEGCSKAYSRLENLKTHLRSHTGEKPYVCEHE ENSCPOP00000013691/1-1511 REQKPFKAQYMLVVHMRRHTGEKPHKCTFEGCSKAYSRLENLKTHLRSHTGEKPYVCEHE XP_004836104.1/1-1560 REQKPFKAQYMLVVHMRRHTGEKPHKCTFEGCSKAYSRLENLKTHLRSHTGEKPYVCEHE ************************************************************ ENSMUSP00000054837/1-1544 GCNKAFSNASDRAKHQNRTHSNEKPYICKIPGCTKRYTDPSSLRKHVKTVHGPDAHVTKK ENSRNOP00000009963/1-1480 GCNKAFSNASDRAKHQNRTHSNEKPYICKIPGCTKRYTDPSSLRKHVKTVHGPDAHVTKK ENSP00000390436/1-1586 GCNKAFSNASDRAKHQNRTHSNEKPYICKIPGCTKRYTDPSSLRKHVKTVHGPDAHVTKK ENSCPOP00000013691/1-1511 GCNKAFSNASDRAKHQNRTHSNEKPYICKIPGCTKRYTDPSSLRKHVKTVHGPDAHVTKK XP_004836104.1/1-1560 GCNKAFSNASDRAKHQNRTHSNEKPYICKIPGCTKRYTDPSSLRKHVKTVHGPDAHVTKK ************************************************************ ENSMUSP00000054837/1-1544 QRNDVHVRAPLLKENGDNEASAEPGGRGPEESVEASSTSHTVEDCLHIKAIKTESSGLCQ ENSRNOP00000009963/1-1480 QRNDVHLRAPLLKENGDNEAGAEPGGRGPEESVEASSTSHTAEDCLHIKAIKTESSGLCQ ENSP00000390436/1-1586 QRNDVHLRTPLLKENGDSEAGTEPGG---PESTEASSTSQAVEDCLHVRAIKTESSGLCQ ENSCPOP00000013691/1-1511 QRNDVHLRAPLLKENGDNEASIEPSGQGSEDSTEASSTSQAVEDCLHVRAIKTEGSGLCH XP_004836104.1/1-1560 QRNDVHLRAPLLKENGDSEASIEPLGQGSEDSAEASSTNQAVEDCLHIKAIKTEGSGLCQ ******:*:********.**. ** * :*.*****.::.*****::*****.****: ENSMUSP00000054837/1-1544 SSPGAQSSCSSEPSPLGSAPNNDSGMEMPGTGPGSLGDLTALADTCPGADTSALAAPSTG ENSRNOP00000009963/1-1480 SSPGAQSSCSSEPSPLGSVPNNDSGVEMPGTGPGSLGDLTALDDTSPGADTSALAVPSTG ENSP00000390436/1-1586 SSPGAQSSCSSEPSPLGSAPNNDSGVEMPGTGPGSLGDLTALDDTPPGADTSALAAPSAG ENSCPOP00000013691/1-1511 SSPGAQSSCSSEPSPLGNAPNNDSGVEMPGAGPGSLGDLTALDDTAPGADAPALAAPSAG XP_004836104.1/1-1560 SSPGAQSSCSSEPSPLGSAPNNDSGVEMPGTGPGSLGDLTALDDTTPGADAPALAAPSAG *****************..******:****:*********** ** ****:.***.**:* ENSMUSP00000054837/1-1544 GLQLRKHMSTVHRFEQLKREKLKSLKDSCSWAGPAPHTRNTKLPPLPVNGSVLENFNNTG ENSRNOP00000009963/1-1480 GLQLRKHMTTMHRFEQLKREKLKSLKDSCSWAGPAPHTRNTKLPPLPVNGSVLENFNNTG ENSP00000390436/1-1586 GLQLRKHMTTMHRFEQLKKEKLKSLKDSCSWAGPTPHTRNTKLPPLPGSGSILENFSGSG ENSCPOP00000013691/1-1511 GLHLRKHVNSMHRFEQLKREKLKSLKDSCSWAGPAPHTRNTKLPPLPSSGSILENFSGPG XP_004836104.1/1-1560 GLQLRKHVSSMHRFEQLKREKLKSLKDSCSWAGPAPHTRNTKLPPLPASGSILENFSGPG **:****:.::*******:***************:************ .**:****...* ENSMUSP00000054837/1-1544 GGGPAGLLPSQRLPEL--TEVTMLSQLQERRDSSTSTMSSAYTVSRRSSGISPYFSSRRS ENSRNOP00000009963/1-1480 GCGPAGLLPNQRLPEL--TEVTMLSQLQERRDSSTSTMSSAYTVSRRSSGISPYFSSRRS ENSP00000390436/1-1586 GGGPAGLLPNPRLSELSASEVTMLSQLQERRDSSTSTVSSAYTVSRRSSGISPYFSSRRS ENSCPOP00000013691/1-1511 GSGPAGLLPNPRLSELSASEVTMLSQLQERRDSSTSTVSSAYTVSRRSSGISPYFSSRRS XP_004836104.1/1-1560 GGGPAGLLPNPRLSELSASEVTMLSQLQERRDSSTSTVSSAYTVSRRSSGISPYFSSRRS * *******. **.** :******************:********************** ENSMUSP00000054837/1-1544 SEASPLGGLRPHNASSADSYDPISTDASRRSSEASQCSGGGPGLLNLTPAQQYNLRAKYA ENSRNOP00000009963/1-1480 SEASPLGGIRPHNASSADSYDPISTDASRRSSEASQCSGGGPGLLNLTPAQQYSLRAKYA ENSP00000390436/1-1586 SEASPLGAGRPHNASSADSYDPISTDASRRSSEASQCS-GGSGLLNLTPAQQYSLRAKYA ENSCPOP00000013691/1-1511 SEASPLGAGRPHNASSADSYDPISTDASRRSSEASQCSGGGSGLLNLTPAQQYSLRAKYA XP_004836104.1/1-1560 SEASPLGASRPHNASSADSYDPISTDASRRSSDASQCSGGGSGLLNLTPAQQYSLRAKYA *******. ***********************:***** **.***********.****** ENSMUSP00000054837/1-1544 AATGGPPPTPLPGLDRVSLRTRLALLDAPERALPGACPHPLGPRRGSDGPTYSHGHGHGY ENSRNOP00000009963/1-1480 AATGGPPPTPLPGLDRVSLRTRLALLDAPERALPGACPQPLGPRRGSDGPTY--NHGHGY ENSP00000390436/1-1586 AATGGPPPTPLPGLERMSLRTRLALLDAPERTLPAGCPRPLGPRRGSDGPTY--GHG--H ENSCPOP00000013691/1-1511 AATGGPPPTPLPGLERMSLRTRLALLDAPERALPGNCPHPLGPRRGSDGPIY--GHS--P XP_004836104.1/1-1560 AATGGPPPTPLPGLERMSLRTRLSLLDAPERALPGSCPHPLGPRRGSDGPAY--SHAHGP **************:*:******:*******:**. **:*********** * .*. ENSMUSP00000054837/1-1544 AGAAPAFPHEGPNSSTRRASDPVRRPDPLILPRVQRFHSTHNMNPGSLPPCADRRGLHVQ ENSRNOP00000009963/1-1480 VGAAPALPHEGPNGSTRRASDPVRRPDPLVLPRVQRFHSIHNMNPGPLPPCTDRRGLHLQ ENSP00000390436/1-1586 AGAAPAFPHEAPGGGARRASDPVRRPDALSLPRVQRFHSTHNVNPGPLPPCADRRGLRLQ ENSCPOP00000013691/1-1511 LGAAPAFPHEAPGGGARRASDPVRRPEGLTLPRVQRFHSAHNMNPAPLLPCTERRGLRLQ XP_004836104.1/1-1560 LGAAPAFPHEAP-GGARRASDPVRRPDALTLPRVQRFHSAHNMNPGQLLPCTERRGLRLQ *****:***.* ..:**********: * ********* **:**. * **::****::* ENSMUSP00000054837/1-1544 SHPSVDSNLTRNAYSPRPPSINENVVMEAVAAGVDGPGLECDLGLVEDELVLPDDVVQYI ENSRNOP00000009963/1-1480 SHPSVDGSLTRHAYSPRPPSINENVVMEAVAAGVEGAGLESDLGLVEDDLVLPDDVVQYI ENSP00000390436/1-1586 SHPSTDGGLARGAYSPRPPSISENVAMEAVAAGVDGAGPEADLGLPEDDLVLPDDVVQYI ENSCPOP00000013691/1-1511 NHTSLEGSLVRNAYSPRPPSISENVVMEAMATGVDGTGPEPDLGLPEDDLVLPDDVVQYI XP_004836104.1/1-1560 SHLSTEGSLARSAYSPRPPSISENAVMEAMASGVTCTGPEPDLGLPEDELVLPDDVVQYI .* * :..*.* *********.**..***:*:** .* * **** **:*********** ENSMUSP00000054837/1-1544 KAHTGGTLDDGIRQGYPTEGTGFPENSKLPSPGLQGHRRLAAADSNMGPSAPGLGGCQLS ENSRNOP00000009963/1-1480 KAHTGGALDDSTRQVYPTEGTGFPENSKLPSPGLQGHRRLAAADSNMSPSAPGLGGCQLS ENSP00000390436/1-1586 KAHASGALDEGTGQVYPTESTGFSDNPRLPSPGLHGQRRMVAADSNVGPSAPMLGGCQLG ENSCPOP00000013691/1-1511 KAHTGGALDENTRQLYPTESTGFPENPKLPSPGLHSHRRVAAADSNVGPSAPGMGGCQLG XP_004836104.1/1-1560 KAHTGGALDESTRQVYPTESTGFPENSKLPSPGLHGHRRVVTADSNVGPPAPGMGGCQLG ***:.*:**:. * ****.***.:*.:******:.:**:.:****:.*.** :*****. ENSMUSP00000054837/1-1544 YSPSSNLNKSNMPVQWNEVSSGTVDALPTQVKPPPFPHSNLAVVQQKPAFGQYPGYNPQS ENSRNOP00000009963/1-1480 YSPSSSLNKSNMPVQWNEVSSGTVDALPTQVKPPSFPQSNL--VQQKPAFAHYPGYSPQA ENSP00000390436/1-1586 FGAPSSLNKNNMPVQWNEVSSGTVDALASQVKPPPFPQGNLAVVQQKPAFGQYPGYSPQG ENSCPOP00000013691/1-1511 YGAPSSLNKNNMPVQWNEVSSGTVDALPSQVKPPSFSQGNLAVVQQKPVFGQYPGYSAQG XP_004836104.1/1-1560 YGAPSSLNKNNMPVQWNEVSSGTVDALPSQVKPPPFPQGNLAMVQQKPAFVQYPGYSPQN :...*.***.*****************.:*****.*.:.** *****.* :****..* ENSMUSP00000054837/1-1544 VQSSSGGLDSTQPHLQLR-GAPSA--SRGSYTQQPRQPAAGSQCLGMSAAMSPQASYSQA ENSRNOP00000009963/1-1480 LQSGSGGLDSTQPHLQLR-GAPSA--SRGSYTQQPRLPATGSQCLGVTAAMSPQANYSQT ENSP00000390436/1-1586 LQASPGGLDSTQPHLQPRSGAPSQGIPRVNYMQQLRQPVAGSQCPGMTTTMSPHACYGQV ENSCPOP00000013691/1-1511 LQPSPGVLDSTQS----RNVALSA--TRGNYMQQLRHPATGTQCDSMTATGSSHTNYGPA XP_004836104.1/1-1560 LQPSSGALDGTQP----RNGAPSA--PRGNYMQQLRQAATGGQCVSMTAAGSPQGNYGPA :*...* **.**. * * * .* .* ** * ..:* ** .:::: *.: *. . ENSMUSP00000054837/1-1544 HPQLSPNIVSGSLNQFSPSCSNMAAKPSHLGLPQQMEVVPNATIMNGHQREHGVPNSSLA ENSRNOP00000009963/1-1480 HHQLSPNVVSGSLNQFAPSCSNMAAKPSHLGLPQQMEVVPNATIISGHQRELGIASSSLA ENSP00000390436/1-1586 HPQLSPSTISGALNQFPQSCSNMPAKPGHLGHPQQTEVAPDPTTMGNRHRELGVPDSALA ENSCPOP00000013691/1-1511 HSQLSPSSVSGALNPFPTPCSSITAKPGPLGLPQQMEIASDPALMGSHRRELGVP----- XP_004836104.1/1-1560 HPQLSPSSLNGALNQFPTSCSGLAAKPGVLGLPQQMEIASDPTLVGSHHRELGMP----- * ****. :.*:** *. .**.:.***. ** *** *:..:.: :..::** *:. ENSMUSP00000054837/1-1544 AVSQPHPVLSYPQ----------QDSYQQGSNLLSSHQPGFMESQQ------NAGFGLMQ ENSRNOP00000009963/1-1480 AVSQPHPVLGYPQ----------QDGYQQVSGLPSSHQPSFMESQQ------NTGFGLMQ ENSP00000390436/1-1586 GVPPPHPVQSYPQQSHHLAASMSQEGYHQVPSLLPARQPGFMEPQTGPMGVATAGFGLVQ ENSCPOP00000013691/1-1511 ---ALHAAQSYPGQSHHLATPLSQEGYHQAPSLLPSHQPGFMEPQQGSMGPTTSSFGLLQ XP_004836104.1/1-1560 ---PPHPAQGYPQQSHHLAGPLNQEGYRQAPSLLPAHQPGFMEPQQGSLGPGESSFGLVQ *.. .** *:.*:* ..* .::**.***.* :.***:* ENSMUSP00000054837/1-1544 PRPPLEPNTASRHRGVRSGQQQL--YARTTGQAMVT-SANQETAEAMPKGPAGTMVSLAP ENSRNOP00000009963/1-1480 PRPPLEPNTASRHRGVRSGQQQQQLYARTAGQAVVT-SANQETAEAMPKGTAGTVVSLTP ENSP00000390436/1-1586 PRPPLEPSPTGRHRGVRAVQQQLA-YARATGHAMAAMPSSQETAEAVPKGAMGNMGSVPP ENSCPOP00000013691/1-1511 PRPPLEPSPAGRHRGVRAGQQQLA-YARATGQTMATMSAGQETAEAVPKGTVDTIRSLPP XP_004836104.1/1-1560 PRPPLEPSPAGRHRGVRAGQQQLA-YARATGQTMAAMSVSQETAEVVTKGAVGTIRSMPP *******..:.******: *** ***::*:::.: . .*****.:.**. ..: *:.* ENSMUSP00000054837/1-1544 Q-PSQDTGRAQDQNTLYYYGQIHMYEQN------GGCPAVQPQPPQPQACSDSIQPEPLP ENSRNOP00000009963/1-1480 Q-PSQDTGRSQDQNTLYYYGQIHMYEQN------GGCPAMQPQPPQPQGCSDNIQPEPLP ENSP00000390436/1-1586 QPPPQDAGGAPDHSMLYYYGQIHMYEQDGGLENLGSCQVMRSQPPQPQACQDSIQPQPLP ENSCPOP00000013691/1-1511 QLASQDVGGTQDHSMVYYYGQIHMYEQNGSLEGHGGSPNTRLQPPQPQACPDSVQPQSLP XP_004836104.1/1-1560 QLVLQDAGGTQDHSMLYYYGQIHMYEQNGSLEGHGGCPAVRPQPPQPQACPDSIQPPPLP * **.* : *:. :***********: *.. : ******.* *.:** .** ENSMUSP00000054837/1-1544 SPGVNQVSSTVDSQLLEPPQIDFDAIMDDGDHSSLFSGALSPTLLHNLSQNSSRLTTPRN ENSRNOP00000009963/1-1480 SPGVNQVSSTVDSQLLEPPQIDFDAIMDDGDHSSLFSGALSPSLLHNLSQNSSRLTTPRN ENSP00000390436/1-1586 SPGVNQVSSTVDSQLLEAPQIDFDAIMDDGDHSSLFSGALSPSLLHSLSQNSSRLTTPRN ENSCPOP00000013691/1-1511 SPGVNQVSSTVDSQLLEAPQIDFDAIMDDGDHSSLFSGVLSPSLLHNLSQSSSRLTTPRN XP_004836104.1/1-1560 SPGANQVSSTVDSQLLEAPQIDFDAIMDDGDHSSLFSGALSPSLLHNLSQSSSRLTTPRN ***.*************.********************.***:***.***.********* ENSMUSP00000054837/1-1544 SLTLPSIPAGISNMAVGDMSSMLTSLAEESKFLNMMT ENSRNOP00000009963/1-1480 SLTLPSIPVGISNMAVGDMSSMLTSLAEENKFLNMMT ENSP00000390436/1-1586 SLTLPSIPAGISNMAVGDMSSMLTSLAEESKFLNMMT ENSCPOP00000013691/1-1511 SLTLPSIPAGISNMAVGDMSSMLTSLAEENKFLNMMT XP_004836104.1/1-1560 SLTLPSIPTGISNMAVGDMSSMLTSLAEENKFLNMMT ********.********************.*******