CLUSTAL W(1.81) multiple sequence alignment ENSP00000355536/1-1265 MSPALQDLSQPEGLKKTLRDEINAILQKRIMVLDGGMGTMIQREKLNEEHFRGQEFKDHA ENSMUSP00000097442/1-1253 -------------MKKTLQDEIEAILRKRIMVLDGGMGTMIQRYKLSEEHFQGQEFKDHS ENSRNOP00000023973/1-1253 -------------MKKTLQDEIEAILRKRIMVLDGGMGTMIQRYKLSEENFQGQEFKDHS ENSCPOP00000013677/1-1267 TMPGFKFLFK-GDMKETLQDEIEAILQKRIMVLDGGMGTMIQQYKLSEESFQGQEFKDHT XP_004854658.1/1-1265 MSPALYDLPQSGDMKKTLQDEIEAILQKRIMVLDGGMGTMIQRYKLSEESFQGQEFKDHA :*:**:***:***:***************: **.** *:*******: ENSP00000355536/1-1265 RPLKGNNDILSITQPDVIYQIHKEYLLAGADIIETNTFSSTSIAQADYGLEHLAYRMNMC ENSMUSP00000097442/1-1253 RPLKGNNDILSITQPDIIYQIHKEYLLAGADIIETNTFSSTSIAQADYGLEHLAYRMNKC ENSRNOP00000023973/1-1253 RPLKGNNDILSITQPDVIYQIHKEYLLAGADIIETNTFSSTSIAQADYGLEHLAYRMNKC ENSCPOP00000013677/1-1267 RPLKGNNDILSITQPDIIYQIHKDYLLAGADIIETNTFSSTSIAQTDYGLEHLAYRMNKC XP_004854658.1/1-1265 RPLKGNNDILSITQPDIIYQIHQDYLLAGADIVETNTFSSTSIAQADYGLEHLAYRMNKC ****************:*****::********:************:************ * ENSP00000355536/1-1265 SAGVARKAAEEVTLQTGIKRFVAGALGPTNKTLSVSPSVERPDYRNITFDELVEAYQEQA ENSMUSP00000097442/1-1253 SADVARKAAEEITLQTGVKRFVAGALGPTNKTLSVSPSVERPDYRNITFDELVDAYQEQA ENSRNOP00000023973/1-1253 SADVARKAAEEITLQTGVKRFVAGSLGPTNKTLSVSPSVERPDYRNITFDELVEAYQEQA ENSCPOP00000013677/1-1267 SADVARKAAEEITLHTGIKRFVAGALGPTNKTLSVSPSVERPDYRNITFDELVEAYQEQA XP_004854658.1/1-1265 SADVARKAAEEITLQTGIKRFVAGALGPTNKTLSVSPSVERPDYRNITFDELVEAYQEQA **.********:**:**:******:****************************:****** ENSP00000355536/1-1265 KGLLDGGVDILLIETIFDTANAKAALFALQNLFEEKYA-PRPIFISGTIVDKSGRTLSGQ ENSMUSP00000097442/1-1253 KGLLDGRVDILLIETIFDTANAKAALFAIQNLFEENYAPPRPIFISGTIVDKSGRTLSGQ ENSRNOP00000023973/1-1253 KGLLDGGVDILLIETIFDTANAKAALFALQKLFEENYASPRPIFISGTIVDKSGRTLSGQ ENSCPOP00000013677/1-1267 KGLLDGGVDILLIETIFDTANAKAALFALKKLFEEGYT-PRPVFISGTIVDKSGRTLSGQ XP_004854658.1/1-1265 KGLLDGGVDILLIETIFDTANAKAALFALKKLFEENYT-PRPVFISGTIVDKSGRTLSGQ ****** *********************:::**** *: ***:***************** ENSP00000355536/1-1265 TGEGFVISVSHGEPLCIGLNCALGAAEMRPFIEIIGKCTTAYVLCYPNAGLPNTFGDYDE ENSMUSP00000097442/1-1253 TGEAFVTSVSHSDPLCIGLNCSLGAAEMRPFIETIGKCTTAYVLCYPNAGLPNTFGDYDE ENSRNOP00000023973/1-1253 TGEAFVTSVSHSDPLCIGLNCALGAAEMRPFIETIGKCTTAYVLCYPNAGLPNTFGDYDE ENSCPOP00000013677/1-1267 TGEAFVISVSHGDPLCIGLNCALGATEMRPFIETIGKCTTAYVLCYPNAGLPNTFGDYDE XP_004854658.1/1-1265 TGEAFVISVSHGDPLCIGLNCALGATEMRPFIETIGKCTTAYVLCYPNAGLPNTFGDYDE ***.** ****.:********:***:******* ************************** ENSP00000355536/1-1265 TPSMMAKHLKDFAMDGLVNIVGGCCGSTPDHIREIAEAVKNCKPRVPPATAFEGHMLLSG ENSMUSP00000097442/1-1253 TPSTMATHLKDFAVDGLVNIVGGCCGSTPDHIREIAEAVKKCKPRVPPASVFEGHMLLSG ENSRNOP00000023973/1-1253 TPAMMAMHLKDFAVDGLVNVVGGCCGSTPDHIREIAEAVKNCKPRVPPDSVFEGHMLLSG ENSCPOP00000013677/1-1267 TPSMMAMHLKDFAMDGLVNIVGGCCGTTPDHIREIAEAVKNCKPRVPPANVFEGHMLLSE XP_004854658.1/1-1265 TPSMMAMHLKDFAMDGLVNIVGGCCGTTPDHIREIAEAVKNCKPRVPPASVFEGHMLLSG **: ** ******:*****:******:*************:******* ..******** ENSP00000355536/1-1265 LEP-FRIGPYTNFVNIGERCNVAGSRKFAKLIMAGNYEEALCVAKVQVEMGAQVLDVNMD ENSMUSP00000097442/1-1253 LEP-FRIGPYTNFVNIGERCNVAGSRKFAKLIMAGNYEEALSIAKAQVEMGAQVLDINMD ENSRNOP00000023973/1-1253 LEP-FRIGPYTNFVNIGERCNVAGSKKFAKLIMAGNYEEALSVAKVQVEMGAQVLDINMD ENSCPOP00000013677/1-1267 LAPAFRIGQYTNFVNIGERCNVAGSKKFAKLIMAGNYEEALSVAKVQVEMGAQVLDVNMD XP_004854658.1/1-1265 LEP-FRIGPYTNFVNIGERCNVAGSKKFAKLIMAGNYEEALSVAKVQVEMGAQVLDVNMD * * **** ****************:***************.:**.**********:*** ENSP00000355536/1-1265 DGMLDGPSAMTRFCNLIASEPDIAKVPLCIDSSNFAVIEAGLKCCQGKCIVNSISLKEGE ENSMUSP00000097442/1-1253 DGMLDGPSAMTRFCNSIASEPDIAKVPLCIDSSNFAVIEAGLKCCQGKCIVNSISLKEGE ENSRNOP00000023973/1-1253 DGMLDGPSAMTKFCNFIASEPDIAKVPLCIDSSNFAVIEAGLKCCQGKCIVNSISLKEGE ENSCPOP00000013677/1-1267 DGMLDGPSAMTKFCNFIASEPDIAKVPLCIDSSNFAVIEAGLKCCQGKCIVNSISLKEGE XP_004854658.1/1-1265 DGMLDGPSAMTRFCNLIASEPDIAKVPLCIDSSNFAVIEAGLKCCQGKCIVNSISLKEGE ***********:*** ******************************************** ENSP00000355536/1-1265 DDFLEKARKIKKYGAAMVVMAFDEEGQATETDTKIRVCTRAYHLLVKKLGFNPNDIIFDP ENSMUSP00000097442/1-1253 GDFLEKARKIKKFGAAVVVMAFDEEGQATETDVKVNVCTRAYHLLVDKVGFNPNDIIFDP ENSRNOP00000023973/1-1253 EDFLEKARKIKKFGAAVVVMAFDEEGQATETDVKVSVCTRAYHLLVEKVGFNPNDIIFDP ENSCPOP00000013677/1-1267 EDFLEKARKIKKFGAAVVVMAFDEEGQATETDVKISVCTRAYHLLVKKVGFNPNDIIFDP XP_004854658.1/1-1265 EDFLEKARKIKKFGAAVVVMAFDEEGQATETDVKISVCTRAYHLLVKKVGFNPNDIIFDP ***********:***:***************.*: **********.*:*********** ENSP00000355536/1-1265 NILTIGTGMEEHNLYAINFIHATKVIKETLPGARISGGLSNLSFSFRGMEAIREAMHGVF ENSMUSP00000097442/1-1253 NILTIGTGMEEHNLYAINFIHATRVIKETLPGVRISGGLSNLSFSFRGMEAIREAMHGVF ENSRNOP00000023973/1-1253 NILTIGTGMEEHNLYAINFIHATRVIKETLPGVRISGGLSNLSFAFRGMDAIREAMHGVF ENSCPOP00000013677/1-1267 NILTIGTGMEEHNWYAINFIHATKVIKETLPGVRINGGLSNLSFSFRGMEAIREAMHGVF XP_004854658.1/1-1265 NILTIGTGMEEHNWYAVNFIHATKVIKETLPGVRISGGLSNLSFSFRGMEAIREAMHGVF ************* **:******:********.**.********:****:********** ENSP00000355536/1-1265 LYHAIKSGMDMGIVNAGNLPVYDDIHKELLQLCEDLIWNKDPEATEKLLRYAQTQGTGGK ENSMUSP00000097442/1-1253 LYHAIKFGMDMGIVNAGNLPVYDAIHKDLLQLCEDLIWNKDSEATEKLLRYAQTHGTGGK ENSRNOP00000023973/1-1253 LYHAIKFGMDMGIVNAGSLPVYDDIHKDLLQLCEDLIWNRDAEATEKLLRYAQTHGKGGK ENSCPOP00000013677/1-1267 LYHAIKFGMDMGIVNAGNLPVYDDIHKDLLQLCEDLIWNKDPEATEKLLRYAQTQGKGGK XP_004854658.1/1-1265 LYHAIKFGMDMGIVNAGNLPVYDDIQKELLKLCEDLIWNKDPEATEKLLRYAQTHGKGGK ****** **********.***** *:*:**:********:*.************:*.*** ENSP00000355536/1-1265 KVIQTDEWRNGPVEERLEYALVKGIEKHIIEDTEEARLNQKKYPRPLNIIEGPLMNGMKI ENSMUSP00000097442/1-1253 KVIQTDEWRNGSIEERLEYALVKGIEKHIVEDTEEARLNGEKYPRPLNIIEGPLMNGMKV ENSRNOP00000023973/1-1253 KVIQTDEWRNGSIEERLEYALVKGIEKHIVEDTEEARLNREKYPRPLNIIEGPLMNGMKV ENSCPOP00000013677/1-1267 KVIQTDEWRNGPIEERLEYALVKGIEKYIIEDTEEARLNQEKYPRPLNIIEGPLMNGMKV XP_004854658.1/1-1265 KVIQTDEWRNGPIEERLEYALVKGIEKYIIEDTEEARLNQEKYPRPLNIIEGPLMNGMKV ***********.:**************:*:********* :******************: ENSP00000355536/1-1265 VGDLFGAGKMFLPQVIKSARVMKKAVGHLIPFMEKEREETRVLNGTVEEEDPYQGTIVLA ENSMUSP00000097442/1-1253 VGDLFGAGKMFLPQVIKSARVMKKAVGHLIPFMEKEREEARLINGSVEEEDPYQGTIVLA ENSRNOP00000023973/1-1253 VGDLFGAGKMFLPQVIKSARVMKKAVGHLIPFMEKEREEARVLNGSVEEEDPYQGTIVLA ENSCPOP00000013677/1-1267 VGDLFGAGKMFLPQVIKSARVMKKAVGHLIPFMEKEREEKRVINGTVEEEDPYQGTIVLA XP_004854658.1/1-1265 VGDLFGGGKMFLPQVIKSARVMKKAVGHLIPFMEKEREANRLITGTVEEEDPYQGTIVLA ******.******************************* *::.*:************** ENSP00000355536/1-1265 TVKGDVHDIGKNIVGVVLGCNNFRVIDLGVMTPCDKILKAALDHKA--DIIGLSGLITPS ENSMUSP00000097442/1-1253 TVKGDVHDIGKNIVGVVLACNNFRVIDLGVMTPCDKILQAALDHKA--DIIGLSGLITPS ENSRNOP00000023973/1-1253 TVKGDVHDIGKNIVGVVLGCNNFRVIDLGVMTPCDKILQAALDHKA--DIIGLSGLITPS ENSCPOP00000013677/1-1267 TVKGDVHDIGKNIVGVVLGCNNFRVIDLGVMTPCDKILKAALDHKAVIDIIGLSGLITPS XP_004854658.1/1-1265 TVKGDVHDIGKNIVGVVLGCNNFRVIDLGVMTPCDKILKAALDHKA--DIIGLSGLITPS ******************.*******************:******* ************ ENSP00000355536/1-1265 LDEMIFVAKEMERLAIRIPLLIGGATTSKTHTAVKIAPRYSAPVIHVLDASKSVVVCSQL ENSMUSP00000097442/1-1253 LDEMIFVAKEMERLAIKIPLLIGGATTSRTHTAVKIAPRYSAPVIHVLDASKSVVVCSQL ENSRNOP00000023973/1-1253 LDEMIFVAKEMERLAIKIPLLIGGATTSRTHTAVKIAPRYSAPVIHVLDASKSVVVCSQL ENSCPOP00000013677/1-1267 LDEMIFVAKEMERLAIKIPLLIGGATTSKTHTAVKIAPRYSAPVIHVLDASKSVVVCSQL XP_004854658.1/1-1265 LDEMIFVAKEMERLAIKIPLLIGGATTSRTHTAVKIAPRYSAPVIHVLDASKSVVVCSQL ****************:***********:******************************* ENSP00000355536/1-1265 LDENLKDEYFEEIMEEYEDIRQDHYESLKERRYLPLSQARKSGFQMDWLSEPHPVKPTFI ENSMUSP00000097442/1-1253 LDENLRDDYFEEILEEYEDIRQDHYESLKERKYVPLSQARKHGFHIDWLSEPHPVKPTFI ENSRNOP00000023973/1-1253 LDENLKDDYFEEILEEYEDIRQDHYESLKERKYLPLSQARKHSFHIDWLSEPHPVKPTFI ENSCPOP00000013677/1-1267 LDENLKEEYFEEIMEEYEDIRQEHYESLKERKYVPLSQARKNGFHIDWLSEPPPVKPTFI XP_004854658.1/1-1265 LDENLKDEYFEEIMEEYEDIRQDHYESLKERKYVSLSQARKNGFHIDWLSEPPPVKPTFI *****:::*****:********:********:*:.****** .*::****** ******* ENSP00000355536/1-1265 GTQVFEDYDLQKLVDYIDWKPFFDVWQLRGKYPNRGFPKIFNDKTVGGEARKVYDDAHNM ENSMUSP00000097442/1-1253 GTQVFEDYNLQKLVDYIDWKPFFDVWQLRGKYPNRGFPKIFNDKAVGEEARKVYNDAQNM ENSRNOP00000023973/1-1253 GTQVFEDYNLQKLVDYIDWKPFFDVWQLRGKYPNRGFPKIFNDKAVGEEARKVYEDAQNM ENSCPOP00000013677/1-1267 GTQVFEDYDLQKLVPYIDWKPFFDVWQLRGKYPNRGFPKIFNDKTVGEEARKVYNDAQNM XP_004854658.1/1-1265 GTRVFEDYDLQKLVHYIDWKPFFDVWQLRGKYPNRGFPKIFNDKTVGEEARKLYDDAQNM **:*****:***** *****************************:** ****:*:**:** ENSP00000355536/1-1265 LNTLISQKKLRARGVVGFWPAQSIQDDIHLYAEAAVPQAAEPIATFYGLRQQAEKDSAST ENSMUSP00000097442/1-1253 LNILISQKKLQARGVVGFWPAQSVQDDIHLYAEGVVPQAAEPIATFYGLRQQAEKDSSST ENSRNOP00000023973/1-1253 LNILISRKKLRARGVVGFWPAQSVQDDIHLYAEGAVPQAAEPIATFYGLRQQAEKDSSST ENSCPOP00000013677/1-1267 LNILISQKKLQAKGVVGFWPAQSVQDDIHLYAEDVVPQAAEPIATFFGLRQQAEKDSTST XP_004854658.1/1-1265 LNILVSQKKLQARGVVGFWPAQSVQDDIRLYAEDVVPQATEPIATFYGLRQQAEKDSAST ** *:*:***:*:**********:****:**** .****:******:**********:** ENSP00000355536/1-1265 EPYYCLSDFIAPLHSGIRDYLGLFAVACFGVEELSKAYEDDGDDYSSIMVKALGDRLAEA ENSMUSP00000097442/1-1253 DPYHCLSDFIAPLHSGVCDYLGLFAVACFGVEELSKTYEDDGDDYSSIMVKALGDRLAEA ENSRNOP00000023973/1-1253 DPYHCLSDFVAPLHSGVRDYLGLFAVACFGVEELSKAYEDDGDDYSSIMVKALGDRLAEA ENSCPOP00000013677/1-1267 DPYHCLSDFIAPLHSGVCDYLGLFAVACFGVEKLSKAYEDDGDDYSSIMVKALGDRLAEA XP_004854658.1/1-1265 DPYHCLSDFIAPLHSGVRDYLGLFAVACFGVEKLSKAYEDDGDDYSSIMVKALGDRLAEA :**:*****:******: **************:***:*********************** ENSP00000355536/1-1265 FAEELHERVRRELWAYCGSEQLDVADLRRLRYKGIRPAPGYPSQPDHTEKLTMWRLADIE ENSMUSP00000097442/1-1253 FAEELHERVRRELWAYSRSEQLGVPDLRRLRYEGIRPAPGYPSQPDHTEKLTMWRLASIE ENSRNOP00000023973/1-1253 FAEELHERVRRELWAYCGSEQLGVTDLRKLRYEGIRPAPGYPSQPDHTEKLTMWRLANIE ENSCPOP00000013677/1-1267 FAEELHERVRKELWAYSASEQLDVADLRRLRYEGIRPAPGYPSQPDHTEKLTMWRLASIE XP_004854658.1/1-1265 FAEELHERVRRELWAYCDSEQLGIADLRRLRYEGIRPAPGYPSQPDHTEKLTMWRLASIE **********:*****. ****.:.***:***:************************.** ENSP00000355536/1-1265 QSTGIRLTESLAMAPASAVSGLYFSNLKSKYFAVGKISKDQVEDYALRKNISVAEVEKWL ENSMUSP00000097442/1-1253 QATGIRLTESLAMAPASAVSGLYFSNVKAKYFAVGKISKDQTEDYALRKNMPVAEVEKWL ENSRNOP00000023973/1-1253 QATGIRLTESLAMAPASAVSGLYFSNVKSKYFAVGKISKDQIEDYALRKNMSVAEVEKWL ENSCPOP00000013677/1-1267 QCTGIRLTESLAMTPASAVSGLYFSNLNSKYFAVGKISKDQIEDYALRKNMSVAEVEKWL XP_004854658.1/1-1265 QCTGIRLTESLAMAPASAVSGLYFSNLNSRYFAVGKISKDQIEDYALRKNMSVAEVEKWL *.***********:************::::*********** ********:.******** ENSP00000355536/1-1265 GPILGYDTD ENSMUSP00000097442/1-1253 GPILGYDTD ENSRNOP00000023973/1-1253 GPILGYDTD ENSCPOP00000013677/1-1267 GPILGYDTN XP_004854658.1/1-1265 GPILGYDTN ********: