CLUSTAL W(1.81) multiple sequence alignment ENSCPOP00000013507/1-1256 LNAYPQYIFPYSVCVVFQILSVPYKMKGYIHHLVPQVPTITKQSKVQVAFPFDEYFQIEC ENSMUSP00000063933/1-1209 MMELPLCGRGLILSLIFLLLKLSAA-E--IPLSVQQVPTIVKQSYVQVAFPFDEYFQIEC ENSRNOP00000067122/1-1081 ------------------------------------------------------------ ENSP00000256509/1-1224 -MEPLLLGRGLIVYLMFLLLKFSKAIE--IPSSVQQVPTIIKQSKVQVAFPFDEYFQIEC XP_004854274.1/1-1225 -MAKILSGKRLILSLFFLVLKLSTAIE--IPLSVQQVPTIIKQSKVQVAFPFDEYFQIEC ENSCPOP00000013507/1-1256 EAKGNPEPVFSWTKDDKPFDLSGAPIIASNNSGTFKIPNEGHISHFQGKYRCFASNKLGV ENSMUSP00000063933/1-1209 EAKGNPEPIFSWTKDDKPFDLSDPRIIAANNSGTFKIPNEGHISHFQGKYRCFASNRLGT ENSRNOP00000067122/1-1081 ------------------------------------------------------------ ENSP00000256509/1-1224 EAKGNPEPTFSWTKDGNPFYFTDHRIIPSNNSGTFRIPNEGHISHFQGKYRCFASNKLGI XP_004854274.1/1-1225 EAKGNPEPVFSWTKDDKPFDLSDARIIASNNSGTFKIPNEGHISHFQGKYRCYASNKLGV ENSCPOP00000013507/1-1256 AMSEEIEFIVPSVPKFPKEKIEPLDVEEGDPIVLQCNPPKGLPPLHIYWMNIELEHIEQD ENSMUSP00000063933/1-1209 AVSEEIEFIVPGVPKFPKEKIEPIDVEEGDSIVLPCNPPKGLPPLHIYWMNIELEHIEQD ENSRNOP00000067122/1-1081 -----------GVPKFPKEKIEPIDVEEGDSIVLPCNPPKGHPPLHIYWMNIELEHIEQD ENSP00000256509/1-1224 AMSEEIEFIVPSVPKFPKEKIDPLEVEEGDPIVLPCNPPKGLPPLHIYWMNIELEHIEQD XP_004854274.1/1-1225 AMSEEIEFIVPSVPKFPKEKIEPLDVEEGDPIVLPCNPPKGLPPLHIYWMNIELEHIEQD .*********:*::*****.*** ****** ****************** ENSCPOP00000013507/1-1256 KRVYMSQKGDLYFANVEEKDSRNDYCCFAAFPRLRTIVQKMPMKLTVNS----------- ENSMUSP00000063933/1-1209 ERVYMSQRGDLYFANVEENDSRNDYCCFAAFPKLRTIVQKMPMKLTVNS----------- ENSRNOP00000067122/1-1081 ERVYMSQKGDLYFANVEEKDSRNDYCCFAAFPKLRTIVQKMPMKLTVNS----------- ENSP00000256509/1-1224 ERVYMSQKGDLYFANVEEKDSRNDYCCFAAFPRLRTIVQKMPMKLTVNSLKHANDSSSST XP_004854274.1/1-1225 ERVYMSQKGDLYFANVEEKDSRNDYCCFAAFPRLRTIVQKMPMKLTVNSLKHANDSSSST :******:**********:*************:**************** ENSCPOP00000013507/1-1256 -----SNSIKQRKPRLLLPPPETGSESAVVILKGETLMLECFAEGLPTPQVEWNKLGDDL ENSMUSP00000063933/1-1209 -----SNSIKQRKPKLLLPPAQMGSLSAKTVLKGDTLLLECFAEGLPTPHIQWSKPGSEL ENSRNOP00000067122/1-1081 -----SNSIKQRKPKLLLPPAQIGSASSKTVLKGDTLLLECFAEGLPTPQIEWSKLGSEL ENSP00000256509/1-1224 EIGSKANSIKQRKPKLLLPPTESGSESSITILKGEILLLECFAEGLPTPQVDWNKIGGDL XP_004854274.1/1-1225 EISSKANSIKQRKPRLLLPPPESGSESSVTILKGDTLLLECFAEGLPTPQVEWKKMGGDL :********:*****.: ** *: .:***: *:***********:::*.* *.:* ENSCPOP00000013507/1-1256 PKRSETKENHGNTLKIENISHRDKGNYRCTASNFLGTASHDFHVIVEEPPRWTKKPESAV ENSMUSP00000063933/1-1209 PEGRATIEVHEKTLKIENISYQDRGNYRCTANNLLGKASHDFHVTVEEPPRWKKKPQSAV ENSRNOP00000067122/1-1081 PKGRATIEIHEKTLKIENVSYQDRGNYRCTANNLLGKASHDFHVIVEEPPRWKKKPQSAV ENSP00000256509/1-1224 PKGRETKENYGKTLKIENVSYQDKGNYRCTASNFLGTATHDFHVIVEEPPRWTKKPQSAV XP_004854274.1/1-1225 PKGRETKENYGKTLKIENISYRDKGNYRCTANNFLGTANHDFHVIVEEPPRWRKKPESGV *: * * : :******:*::*:*******.*:**.*.***** ******* ***:*.* ENSCPOP00000013507/1-1256 YSTGSSGILLCEADGVPQPTIQWKINGFPADIVGKEYQQIFWQQTEISFTNLHPNHTAVY ENSMUSP00000063933/1-1209 YSTGSSGILLCEAEGEPQPTIKWRLNGLPIE--KHPFPGDFMFPREISFTNLLPNHTGVY ENSRNOP00000067122/1-1081 YSTGSNGILLCEAEGEPQPTIKWRVNGLPIE--NHPFPGDVMFPREISFTNLQPNHTAVY ENSP00000256509/1-1224 YSTGSNGILLCEAEGEPQPTIKWRVNGSPVD--NHPFAGDVVFPREISFTNLQPNHTAVY XP_004854274.1/1-1225 YSTGSSGILLCEAEGEPQPTIKWRVNGFPIG--NHLFAGDVVFPREVSFTNLHPNHTAVY *****.*******:* *****:*::** * : : . *:***** ****.** ENSCPOP00000013507/1-1256 QCEASNVHGTILANANIDVIDVIPLIQTKDEENYATVIGHSAFLHCEYFASPEAVVTWQR ENSMUSP00000063933/1-1209 QCEASNIHGTILANANIDVIDVIPLIKTKNEENYATVVGYSAFLHCEYFASPKATVVWEV ENSRNOP00000067122/1-1081 QCEASNIHGTILANANIDVVDVVPLIQTKNEENYETVVGYSAFLHCEYFASPKATVVWEV ENSP00000256509/1-1224 QCEASNVHGTILANANIDVVDVRPLIQTKDGENYATVVGYSAFLHCEFFASPEAVVSWQK XP_004854274.1/1-1225 QCEASNIHGTVLANANIDVVDVIPLIQTKDEENYATVIGYSAFLHCEYFASPEAIVTWQR ******:***:********:** ***:**: *** **:*:*******:****:* * *: ENSCPOP00000013507/1-1256 MDEAQPLEGGRYRIHNNGTLEITRTTEEDAGSYSCWVENAIGKTAVIANLDIRMKTDATK ENSMUSP00000063933/1-1209 ADETHPLEGDRYHTHENGTLEIYRTTEEDAGSYSCWVDNAMGKAVITANLDIR---NATK ENSRNOP00000067122/1-1081 ADETHPLEGGRYHTHENGTLEIERTTEEDAGSYSCWVDNTMGKAVITANLDIR---NATK ENSP00000256509/1-1224 VEEVKPLEGRRYHIYENGTLQINRTTEEDAGSYSCWVENAIGKTAVTANLDIR---NATK XP_004854274.1/1-1225 MDEAQALEGRRYRIHENGTLQILGTTEEDAGSYSCWVENAIGKTAVTANLDIR---NATK :*.:.*** **: ::****:* *************:*::**:.: ****** :*** ENSCPOP00000013507/1-1256 LRVSPKNPRVSKSHMLELYCESKCDSHLQHSLKLSWSKDGEDFEINGTEDGRIVIDGANL ENSMUSP00000063933/1-1209 LRVSPKNPRIPKSHVLELYCESQCDSHLKHSLKLSWSKDGEAFEMNGTEDGRIVIDGAYL ENSRNOP00000067122/1-1081 LRVFPKNPRIPKSHVLELYCESQCDSHLKHSLKLSWSKDGEAFEMNGTEDGSMKRQCACV ENSP00000256509/1-1224 LRVSPKNPRIPKLHMLELHCESKCDSHLKHSLKLSWSKDGEAFEINGTEDGRIIIDGANL XP_004854274.1/1-1225 LRVSPKNPRVPKSHILELHCESKCDSHLKHSLKLSWSKDGEDFEINGTEDGRIVIDRANL *** *****:.* *:***:***:*****:************ **:****** : : * : ENSCPOP00000013507/1-1256 TISNVTLEDHGIYSCLAHTALDSIAEITQVTVLGKYVPDPPENLHLSERHNRSVRLSWEA ENSMUSP00000063933/1-1209 TISNITAEDQGVYSCSAQTSLDSTSEKTQVTVLG--VPDPPGNLHLSERQNRSVRLSWEA ENSRNOP00000067122/1-1081 CVCVCVRVRVCVCVCVFNSTHSKNSPNIIHTALE--VKDTNEYYQLFHKMNPRFKLSRKT ENSP00000256509/1-1224 TISNVTLEDQGIYCCSAHTALDSAADITQVTVLD--VPDPPENLHLSERQNRSVRLTWEA XP_004854274.1/1-1225 TISNVTLEDQGVFSCLAQTALDSIAEATQVTVLD--VPDPPRNLQLSERQNRSVRLSWEA :. . : * ::: .. : *.* * *. :* .: * .:*: :: ENSCPOP00000013507/1-1256 GDDHNSNITEYIVEFEGNREDPGRWEELTRVQGKATTVLLRLAPYVRYQFRVIAVNEVGK ENSMUSP00000063933/1-1209 GDDHNSKISEYIVEFEGNREEPGKWEELTRVQGEETDVVLSLAPYVRYQFRVTAVNEVGR ENSRNOP00000067122/1-1081 LYSSVSLASEYIVEFEGNREEPGKWEELTRVRGEETDVVLPLAPYVRYQFRVTAVNEVGK ENSP00000256509/1-1224 GADHNSNISEYIVEFEGNKEEPGRWEELTRVQGKKTTVILPLAPFVRYQFRVIAVNEVGR XP_004854274.1/1-1225 GADHNSNISEYIVEFEGNREEPGRWEELTRVQGKETTALLQLAPYVRYQFRVTAVNEVGK . * :*********:*:**:*******:*: * .:* ***:******* ******: ENSCPOP00000013507/1-1256 SRPSQPSVHHQTPPAAPDKNPQNIRVQASQPKEMIIKWEKLETNKTNLNMNVFRFDYRPQ ENSMUSP00000063933/1-1209 SHASLPSDHHETPPAAPDKNPQNIRVQASQPKEMIIKWEPLKSMEQNGPGLEYKVSWKPQ ENSRNOP00000067122/1-1081 SHSSQPSDHHETPPAAPDKNPHNIRVQASQPKEMIIKWEPLKSMEQNGPGLEYRVSWKPQ ENSP00000256509/1-1224 SQPSQPSDHHETPPAAPDRNPQNIRVQASQPKEMIIKWEPLKSMEQNGPGLEYRVTWKPQ XP_004854274.1/1-1225 SHPSQPSDYHETPPAAPEKNPQNIRVQASQPKEMIIKWEPLKSMEQNGPGLEYRVTWKPQ *:.* ** :*:******::**:***************** *:: : * ::. ::** ENSCPOP00000013507/1-1256 EELYLAIFYEQSISLNYLVNSNSDSHIVYFQNAQA-NTVSKTPDPFIKISHDFTSNPDTA ENSMUSP00000063933/1-1209 GA--PEEWEEEIVTNHTLRVMTPTVYAPYDVKVQAINQLGSSPDPQPVTLYSGEDYPSTA ENSRNOP00000067122/1-1081 GA--PEEWEEETVTNHTLRVMTPTVYAPYDVQVQAINQLGSGPEPQPVTLYSGEDYPSTA ENSP00000256509/1-1224 GA--PVEWEEETVTNHTLRVMTPAVYAPYDVKVQAINQLGSGPDPQSVTLYSGEDYPDTA XP_004854274.1/1-1225 GA--PVEWEEETVTNHTLRVMTPTVYAPYDVQVQAINQLGSGPEPQSVVLYSGEDYPDTA : *: :: : * .. : * :.** * :.. *:* :. . *.** ENSCPOP00000013507/1-1256 PVVVSVDIINSTLVKVTWSTIPKDRVHGHLKGYQINWWKTKSLLDGRIHPKEVNILRFSG ENSMUSP00000063933/1-1209 PVIQRVDVMNSTLVKVTWSSIPKETVHGLLRGYQINWWKTKSLLDGRTHPKEVNILRFSG ENSRNOP00000067122/1-1081 PVIHRVDVMNSTLVKVTWSSIPKETVHGLLRGYQINWWKTKSLLDGRTHPKEVNILRFSG ENSP00000256509/1-1224 PVIHGVDVINSTLVKVTWSTVPKDRVHGRLKGYQINWWKTKSLLDGRTHPKEVNILRFSG XP_004854274.1/1-1225 PVVHSVDVINSTLVKVTWSTIPKDRVHGHLKGYQINWWKTKSLLDGRTHPKEVNILRFSG **: **::**********::**: *** *:**************** ************ ENSCPOP00000013507/1-1256 QRNYGMVPSLDAFSEFHLTVLAYNSKGAGPESEPYIFQTPEGVPEQPSFLKVIKVDKDTA ENSMUSP00000063933/1-1209 QRNSGMVPSLDPFSEFHLTVLAYNSKGAGPESEPYIFQTPEGVPEQPSFLKVIKVDKDTA ENSRNOP00000067122/1-1081 QRNSGMVPSLEPFSEFHLTVLAYNSKGAGPESEPYIFQTPEGVPEQPSFLKVIKVDKDTA ENSP00000256509/1-1224 QRNSGMVPSLDAFSEFHLTVLAYNSKGAGPESEPYIFQTPEGVPEQPTFLKVIKVDKDTA XP_004854274.1/1-1225 QRNYGMVPSLDAFSEFRLTVLAYNSKGVGPESEPYIFQTPEGVPEQPTFLKVIKVDKDTA *** ******:.****:**********.*******************:************ ENSCPOP00000013507/1-1256 TLSWNRPMKLNGNLTGYLLQYQKMHK--EMKKHLKINITTPSKSSWHLSNLNATTKYKFY ENSMUSP00000063933/1-1209 TLSWGLPKKLNGNLTGYLLQYQIINDTYELGELNEINVTTPSKSSWHLSNLNSTTKYKFY ENSRNOP00000067122/1-1081 TLSWGLPKKLNGNLTGYLLQYQIINDTYELGELNEINVTTPSKSSWHLSNLNATTKYKFY ENSP00000256509/1-1224 TLSWGLPKKLNGNLTGYLLQYQIINDTYEIGELNDINITTPSKPSWHLSNLNATTKYKFY XP_004854274.1/1-1225 TLSWEQPMKLNGNLTGYLLQYQIINDTDEIGELNEINITTPSKSSWHLSNLNATTKYKFY **** * ************** ::. *: : .**:*****.********:******* ENSCPOP00000013507/1-1256 LRACTSKGCGKPVTEESATLGEPDFLFSTDTGTKFIKYLYNKGSCSTQVLLILIFPPEGT ENSMUSP00000063933/1-1209 LRACTSRGCGKPISEEGATLGE---------GSKGIRKITEGVNVTQKIHPVEVLVPGAE ENSRNOP00000067122/1-1081 LKACTSRGCGKPISEEGATLGE---------GSKGIRKITEGVNVTQKSHPVEVLVPGAE ENSP00000256509/1-1224 LRACTSQGCGKPITEESSTLGE---------GSKGIGKIS-GVNLTQKTHPIEVFEPGAE XP_004854274.1/1-1225 LRACTSKGCGKPVTEESATSGE---------GSKGIRKISEGVNLTQKIHPVEVFEPGAE *:****:*****::**.:* ** *:* * : . : : : :: * . ENSCPOP00000013507/1-1256 VWPFLMKLLCYSVTIQSIFCFKRLYPSTYITMHLMLIVNSVFIYYNVIETRGRGEKRDCV ENSMUSP00000063933/1-1209 ---HIVHLMTKNWG------------------------DNDSIFQDVIETRG----REYA ENSRNOP00000067122/1-1081 ---HIVHLMTKNWG------------------------DNDSIFQDVIETRG----REYA ENSP00000256509/1-1224 ---HIVRLMTKNWG------------------------DNDSIFQDVIETRG----REYA XP_004854274.1/1-1225 ---HIVRLMTKNWG------------------------DNDSIFQDVIETRG----REYG .:::*: . :. *: :****** *: ENSCPOP00000013507/1-1256 RGSDDISTQGWFIGLMCAIALLTLILLTVCFVKRNKGGKYSVKEKEDLHPDPEIQSAKDE ENSMUSP00000063933/1-1209 GLYDDISTQGWFIGLMCAIALLTLILLTICFVKRNRGGKYSVKEKEDLHPDPEVQSAKDE ENSRNOP00000067122/1-1081 GLYDDISTQGWFIGLMCAIALLTLILLTVCFVKRNRGGKYSVKEKEDLHPDPEVQSAKDE ENSP00000256509/1-1224 GLYDDISTQGWFIGLMCAIALLTLLLLTVCFVKRNRGGKYSVKEKEDLHPDPEIQSVKDE XP_004854274.1/1-1225 GLYDDISTQGWFIGLMCAIALLTLILLTVCFVKRNKGGKYSVKEKEDLHPDPEVQSAKDE *********************:***:******:*****************:**.*** ENSCPOP00000013507/1-1256 TFGEYSDSDEKPLKGSLRSLNRNMQPTESADSLVQYGEGDHGLFSEDGSFIGAYAGSKEK ENSMUSP00000063933/1-1209 TFGEYSDSDEKPLKGSLRSLNRNMQPTESADSLVEYGEGDQSIFNEDGSFIGAYTGAKEK ENSRNOP00000067122/1-1081 TFGEYSDSDEKPLKGSLRSLNRNMQPTESADSLVEYGEGDQSIFNEDGSFIGAYTGAKEK ENSP00000256509/1-1224 TFGEYSDSDEKPLKGSLRSLNRDMQPTESADSLVEYGEGDHGLFSEDGSFIGAYAGSKEK XP_004854274.1/1-1225 TFGEYSDSDEKPLKGSLRSLNRVMQPTESADSLVQYGEGDHRLFNEDGSFIGAYAGSKEK ********************** ***********:*****: :*.*********:*:*** ENSCPOP00000013507/1-1256 GSVESNGSSTATFPL-- ENSMUSP00000063933/1-1209 GSVESNGSSTATFPLRA ENSRNOP00000067122/1-1081 GSVESNGSSTATFPLRA ENSP00000256509/1-1224 GSVESNGSSTATFPLRA XP_004854274.1/1-1225 GSVESNGSSTATFPLRA ***************