CLUSTAL W(1.81) multiple sequence alignment ENSMUSP00000068804/1-1197 ---------------------------------------MADSLDEFIEEQKAKLAKDKA ENSRNOP00000008480/1-1203 ---------------------------------------MADGLDEFIEEQKVKLAQDKA ENSCPOP00000013426/1-1229 QFIHLKIPGLINKINSTLIEHQVGPTKRCDKYFSPGSFKMDDNLDKFIEERKAKLAKDKA ENSP00000262210/1-1221 MLFPLQVAAVTSSVRDDPLEHCVSPRTRAR---SPEICKMADNLDEFIEEQKARLAEDKA XP_004842146.1/1-1220 ---------------------------------------MDDNLDKFIEERKAKLAKDKA * *.**:****:*.:**:*** ENSMUSP00000068804/1-1197 ELESDPPYMEMKGKASEKLSENSKILISMAKENIPPSSQQQPKGPL-GIEYGLSLPLGED ENSRNOP00000008480/1-1203 ELESDLPYMEMKGKASEKLSENSKILISMAKENIPPNS-QQPKGSL-GIDYGLSLPLGED ENSCPOP00000013426/1-1229 ELEHDPPYMEMKGKTSEKLSENSKLLISMAKENIPPNS-QQTKGSLVGIDYGLSLPLGED ENSP00000262210/1-1221 ELESDPPYMEMKGKLSAKLSENSKILISMAKENIPPNS-QQTRGSL-GIDYGLSLPLGED XP_004842146.1/1-1220 ELERDPPYMEMKGKTSEKLSENSKILISMAKENIPPNS-QQTRGSL-GIDYGLSLPLGED *** * ******** * *******:***********.* **.:*.* **:********** ENSMUSP00000068804/1-1197 YEQKKHKLKEELRQDYRRYLTQ--------KNFLSTGETDPSTLGVSLPIDERLSAKERL ENSRNOP00000008480/1-1203 YEQKKHKLKEELRQDYRRYLTQ--------KNFLSTGETDPSTLGVSLPIGDRLSAKERL ENSCPOP00000013426/1-1229 YERKKHKLKEELRQDYRRYLTQ-----------------------------------ERL ENSP00000262210/1-1221 YERKKHKLKEELRQDYRRYLTQ-----------------------------------ERL XP_004842146.1/1-1220 YEQKKHKLKEELRQDYRRYLTQGITQAKTKKNFLSMGETDSSTLGVSLPIGERLSAKERL **:******************* *** ENSMUSP00000068804/1-1197 KLERNREYNQFLRGKAESTEKVRQVEKNIE--PKSQRNKNPISQGKSDLPLQIQTAYTHS ENSRNOP00000008480/1-1203 KLERNREYNQFLRGKEESTEKVRQVERNIE--AKSQRNKNPVSQGKSDLPSQALTSYAHS ENSCPOP00000013426/1-1229 KLERNKEYNQFLRGKEESSEKFKQVEKSTEEQPKSQRNKHPVSQVKSDLPPQIQTSCTNS ENSP00000262210/1-1221 KLERNKEYNQFLRGKEESSEKFRQVEKSTE--PKSQRNKKPIGQVKPDLTSQIQTSCENS XP_004842146.1/1-1220 KLERNKEYNQFLRGKEESSEKFRQVEKSTE--SRSQRSKNPVSQVQSDLPSQIQTSCSNS *****:********* **:**.:***:. * .:***.*:*:.* :.**. * *: :* ENSMUSP00000068804/1-1197 EGP-------------WLSRQ--EEGLYRQLDGEIELRSRRPLKQTKEEVGISGAEHPSL ENSRNOP00000008480/1-1203 EGP---------AHEELLNQRQREEGRYRQLDDGIELRTRRPLKQTNEEIGISGTSHQSF ENSCPOP00000013426/1-1229 EDPRRYVLTPSETYEELLNRRRLEEDRYRQLDDEIELRNKRITKKTNEEVGISNTKHQRF ENSP00000262210/1-1221 EGPRKDVLTPSEAYEELLNQRRLEEDRYRQLDDEIELRNRRIIKKANEEVGISNLKHQRF XP_004842146.1/1-1220 EGPRRDVLTPSETYEQLLNRRRLEEDRYRQLDDEIELRNKRITKKTNEKVGISNTKHQRF *.* *.:: **. *****. ****.:* *:::*::***. .* : ENSMUSP00000068804/1-1197 SGSAGVPERRARRANGERVLDRQHCRADRDPGVSEDMDERFRFESDFDRRLLRVYTNGR- ENSRNOP00000008480/1-1203 SSKTAAPERRACRFNEERVLDKQYCRADRDPDISEDMDDRFRFESDFDRKFLRVYTNDR- ENSCPOP00000013426/1-1229 ASKAGVSERRFYRFDEDPVFDRQYCKPDKDREVSEEMDERFRYESDFDRRLLRVYKNDRI ENSP00000262210/1-1221 ASKAGIPDRRFHRFNEDRVFDRRYHRPDQDPEVSEEMDERFRYESDFDRRLSRVYTNDR- XP_004842146.1/1-1220 ASKAGVPERRFCRFHEDPVFDRQYCRPDQDPEISEEMDERFRYEGDVDRRLLRVYTNDR- :..:. .:** * . : *:*::: :.*:* :**:**:***:*.*.**:: ***.*.* ENSMUSP00000068804/1-1197 PHGSRRGYV----DGDDVPEEPNTQISAAENKSVHCNGPPRSADLDITSPFAGMLFGGED ENSRNOP00000008480/1-1203 PHGSRQCA-----DEEGISEEPKTQISCAENKSVRDNGPPKCADVNVTSPFAGMLFGGED ENSCPOP00000013426/1-1229 MRRKRPGDVPSMENDGDIREQSNTRISFAGNESAQDNEPSKS-NREICSPFAGMLFGGED ENSP00000262210/1-1221 MHRNKRGNMPPMEHDGDVIEQSNIRISSAENKSAPDNETSKSANQDTCSPFAGMLFGGED XP_004842146.1/1-1220 MHGKRQGEVPPMENDGDIIEQSNTRISSAGNESAQEHKPFKSTNREICSSFAGMLFGGED : .: . .: *:.: :** * *:*. : . :. : : *.********** ENSMUSP00000068804/1-1197 RELTKRRKEKYRQELLEQIAEQQKKKRREKDLAFGITTSGVQDPEKSPDRLKQFSLTPRH ENSRNOP00000008480/1-1203 REVAKKKKEKYRQELLEQIAEQQQKKRREKDLAFGITTSGVQDPEKSPDRLKQFSLTPGH ENSCPOP00000013426/1-1229 RELTQRRKEKYRLELLEQMAEQQKNKRREKDLELRVAASGVQDPEKSPDRLKQFSVTSRQ ENSP00000262210/1-1221 RELIQRRKEKYRLELLEQMAEQQRNKRREKDLELRVAASGAQDPEKSPDRLKQFSVAPRH XP_004842146.1/1-1220 RDLTQRRKEKYRLELLEQMAEQQKNKRREKDLELRVAASGVQDPEKSPDRLKQFSVTPRH *:: :::***** *****:****::******* : :::**.**************::. : ENSMUSP00000068804/1-1197 FEEM-PPERPRVAFQTPPPPFSAPSSPSVPPVHSAPSHNEDLHSGLGSTLGELAHPRVLP ENSRNOP00000008480/1-1203 FEETIPPERPRVAFQTPPPPFSAPSVPPVPPVHSAPSHNEDLPSGLGSTLGEVVHPRIVP ENSCPOP00000013426/1-1229 FGEMTPPERPRVAFQTPLPPLSTPSVPPIPSIHSAPSQNEDLHNGLSSTLGEMLPPRIAP ENSP00000262210/1-1221 FEEMIPPERPRIAFQTPLPPLSAPSVPPIPSVHPVPSQNEDLRSGLSSALGEMVSPRIAP XP_004842146.1/1-1220 FGEMTPPERPRVAFQTPLPPLSTPSAPPIPSVHPIPSQNEDLHNGLNSTLGEMVPPRIAP * * ******:***** **:*:** *.:*.:*. **:**** .**.*:***: **: * ENSMUSP00000068804/1-1197 VPLNPPPPPLLAPPASNYRTPYDDAYYFYGARNTLDPNIVYYGSGMIGGQPAPHVSAPVT ENSRNOP00000008480/1-1203 VPLNPLPPPLLPHLVPNYRTPYDDAYYFYGARNTLDPNIVYYGSGMIGGHPVPHVSAPVT ENSCPOP00000013426/1-1229 LP----PPPVLPPLTTNYRTPYDDAYYFYGARNTLDPSLAYYGSGILGVQPAAYASAPVT ENSP00000262210/1-1221 LP----PPPLLPPLATNYRTPYDDAYYFYGSRNTFDPSLAYYGSGMMGVQPAAYVSAPVT XP_004842146.1/1-1220 LP----PPPLLPPLANNYRAPYDDAYYFYGARNTLDPSLAYYGSGMMGVQPAAYVSAPVT :* ***:*. . ***:**********:***:**.:.*****::* :*..:.***** ENSMUSP00000068804/1-1197 HQVAPPAVNTVGQNEQKVLSDGLRNSGLVFEDKPKPSTQSLQSYQEALQEQIR-EREARR ENSRNOP00000008480/1-1203 HQVAPPAVSTVGQNEQTVLSDRLRNSGLVFEDKPKPSTQSLKSYQEALQEQIR-EREARK ENSCPOP00000013426/1-1229 HQLAQPMVNTVGQNELKIASDPVVNSGLIFEDKPKPCKQSLQSYQEALQQQLKEENNEAI ENSP00000262210/1-1221 HQLAQPVVNTVGQNELKITSDQVINSGLIFEDKPKPSKQSLQSYQEALQQQIR-EREERR XP_004842146.1/1-1220 QQLAQPIVNTVGQNELKIASDPVVNSGLTFEDKPKPSKQSLQSYQEALQQQIR-EREERR :*:* * *.****** .: ** : **** *******..***:*******:*:: *.: ENSMUSP00000068804/1-1197 KKERLEKEEYEAKLEAEMRIYNPWGKGGGGAPLRDAKGNLITDLNRMHRQNIDAYHNPDA ENSRNOP00000008480/1-1203 KKERLEKEEYEAKLEAEMRIYNPWGKGGGGAPLRDAKGNLITDLNRMHRQNIDAYHNPDA ENSCPOP00000013426/1-1229 SQNREYMEEYEAKLEAEMKIYNPWGKSGGGAPLKDASGNLITDLNRMHKQNIDAYHNPDA ENSP00000262210/1-1221 KKEREEKEEYEAKLEAEMRTYNPWGKGGGGAPLRDAKGNLITDLNRMHRQNIDAYHNPDA XP_004842146.1/1-1220 KKEREEKEKYEAKLEAEMRIYNPWGKSGGGAPLRDAEGNLITDLNRMHKQNIDAYHNPDA .::* *:*********: ******.******:**.***********:*********** ENSMUSP00000068804/1-1197 RTYEDKRAVVSIDQNLATSNAENLEDSANKNSGPLQTQSSPFARGNTFGEPLSELQIKQQ ENSRNOP00000008480/1-1203 RAYEDKRAVVSIDQNLATSNAENLEDSASKNSGPLQTQGSPFARGNTFGEPLSELQIKQQ ENSCPOP00000013426/1-1229 RTYEDKRAVVSLDQNLATSNAENLEDSANNNSGHVQTQSSPFARGNIFAEPPTELQIKQQ ENSP00000262210/1-1221 RTYEDKRAVVSLDPNLATSNAENLEDAANKSSGHMQTQSSPFARGNVFGEPPTELQIKQQ XP_004842146.1/1-1220 RTYEDKRAVVSLDQNLATSNAENLEDSANKNPGHVQTQSSPFARGNIFGEPPTELQIKQQ *:*********:* ************:*.:..* :***.******* *.** :******* ENSMUSP00000068804/1-1197 ELYKNFLRFQIEEKRQREEAEREKL-RVAEEKEEKRLAEQRARIQQEYEEEQERRREKEE ENSRNOP00000008480/1-1203 ELYKNFLRFQIEEKRQREEAEREKL-RVAEEKEEKRLAEQRARIQQEYEEEQERRREKEE ENSCPOP00000013426/1-1229 ELYKNFLRFQVKDSSICRDAKRETLNRPSIQKEKKIVSPLLAAMSSDFKNRKKEEFSAEY ENSP00000262210/1-1221 ELYKNFLRFQIEEKKQREEAERERL-RIAEEKEERRLAEQRARIQQEYEEEQEKKREKEE XP_004842146.1/1-1220 EIYKNFLRFQIEEKKQREEAERERL-RIEEEKEEKRLAEQRARIQQEYEEEQEKKREKEE *:********:::. .:*:** * * :**:: :: * :..::::.::.. . * ENSMUSP00000068804/1-1197 EQRLKNEELIRLAEERRKEAERKKKEEEEKHNLQLQHYYERENIIGDETKHLRQPSPVVP ENSRNOP00000008480/1-1203 EQRLKNEELIRLAEERRKEAERKKKEEEEKHNLQLQHYYERENVIGDEAKYLRQPSPVVP ENSCPOP00000013426/1-1229 EPRFKNFEFHKIMANSLDLKQRLKNEELIRHNLQLQHHYERENKIGEETKHLRQPSPVVP ENSP00000262210/1-1221 EQRLKNEEHIRLAEERQKEAERKKKEEEEKYNLQLQHYCERDNLIGEETKHMRQPSPIVP XP_004842146.1/1-1220 EQRLKNEELIRLAEERRKEVERKKKEEEEKHNLQLQHHYERENKIGEETKHLRHPSPVVP * *:** * :: : . :* *:** ::******: **:* **:*:*::*:***:** ENSMUSP00000068804/1-1197 ALQNKIASKLQRPPSVDTIISSFIHESSMSRAQSPPVPARKNQLRAEEEKKNVIMELSEM ENSRNOP00000008480/1-1203 ALQNKTASKIQRPPSVDTIISSFIHESSMSRAQSPPVPARKNQLRAEEEKKNVIMELSEM ENSCPOP00000013426/1-1229 ALQNKITSQLQRPPSVDSIISSFIHESSMSRAQSPPVPARKNQLRAEGKINYVIMELSEM ENSP00000262210/1-1221 ALQNKIASKLQRPPSVDSIIRSFIHESSMSRAQSPPVPARKNQLRAEEEKKNVIMELSEM XP_004842146.1/1-1220 ALQNKITSKRQRPPSVDSIISSFIHESSLSRAQSPPVPARKNQLRAEEERKNVIMELSEM ***** :*: *******:** *******:****************** : : ******** ENSMUSP00000068804/1-1197 RKQLRSEERRLQGRLLHLDS-DDEIPMRKRERNPMDIFDMARHRVQAPVRRPSPKGLDAT ENSRNOP00000008480/1-1203 RKQLRSEERRLQGRLLHLESDDDDIPIRKRERNPMDIFDMARHRVQAPVRRPSPKGLDAT ENSCPOP00000013426/1-1229 RKQLRSEERRLQGRLLHMDS-DDESFIRKRERNPVDIFDMARHRVQAPVRRQSPKGLDAA ENSP00000262210/1-1221 RKQLRSEERRLQERLLHMDS-DDEIPIRKKERNPMDIFDMARHRLQAPVRRQSPKGLDAA XP_004842146.1/1-1220 RKQLRSEERRLQGRLLHMDS-DDEIFIKKRERNPVDVFDMARHRVQAPVRRQSPKGLDAA ************ ****::* **: ::*:****:*:*******:****** *******: ENSMUSP00000068804/1-1197 TFQNIHDFNELRERDSDTRVDLRLMYPDPPRDHHTLEIQQQALLREQQKRLNRIKMRRDA ENSRNOP00000008480/1-1203 TFQNIHDFNELRERDSDTRVDLRLMYPDPPRDHHTLEIQQQALLREQQKRLNRMKMRRDA ENSCPOP00000013426/1-1229 TFQNIHDFNVLKDRDSETRVDLKLMYPDPPRDHHTLEIQQQALLREQQKRLNRLKMQESA ENSP00000262210/1-1221 TFQNVHDFNELKDRDSETRVDLKFMYLDPPRDHHTLEIQQQALLREQQKRLNRIKMQEGA XP_004842146.1/1-1220 TFQNIHDFNVLKDRDSETRVDLKLMYPDLPRDHHTLEIQQQALLREQQKRLNRIKMQEGA ****:**** *::***:*****::** * ************************:**:..* ENSMUSP00000068804/1-1197 GADLDTICTDNAQGRRMPRDDTNDFLKNSLLESDSAFIGAYGETYPVIEDNAFPPPSQLP ENSRNOP00000008480/1-1203 GADLDAIPTGNEQGRRVPRDDTNDFLKNSLLESDSAFIGAYGETYPITEEDAFPPPSQLP ENSCPOP00000013426/1-1229 EADLDAILSAKVREHRTPREDTDDFLKNSLLESDSAFIGAYGETYPAIEDDALPQPSQIP ENSP00000262210/1-1221 KVDLDAIPSAKVREQRMPRDDTSDFLKNSLLESDSAFIGAYGETYPAIEDDVLPPPSQLP XP_004842146.1/1-1220 EVDLDAIPSAKVREHRMPRDDTNDFMKNSLLESDSAFIGAYGETYPAIDDDALPPPSQMP .***:* : : : :* **:**.**:******************** :::.:* ***:* ENSMUSP00000068804/1-1197 SARERRRNKLKGLDFDSSRLHTPQDGLSLKSISSVNVDQVRMRNEDRMRRLTEQQKKPTN ENSRNOP00000008480/1-1203 SARERRRNKLKGLEFESSRLHTPQDGLSLNSTSSVNVDQVRMRNEERLRRLTEHQKKPTH ENSCPOP00000013426/1-1229 SARERRRNKLKGLEFDTSCPNIPPDGLSLRSVSSINVDQLRMRNEERMRRLTELQNKPIN ENSP00000262210/1-1221 SARERRRNKWKGLDIDSSRPNVAPDGLSLKSISSVNVDELRVRNEERMRRLNEFHNKPIN XP_004842146.1/1-1220 SARERRRNKLKGLEFDISCPNIPPDCLSLKSVSSVNVDQLRMRNEERMRRLTELQNKLVN ********* ***::: * : . * ***.* **:***::*:***:*:***.* ::* : ENSMUSP00000068804/1-1197 TDDEGSLVDPDDIMRHLSDDGRNSAATEPWLRPGTSESLKRFMAEHLNEEQHKGPGKPGT ENSRNOP00000008480/1-1203 TDDEGSLVDPDDIMRHLGDDGRNSVATEPWLRPGTSETLKRFMAEQLNEGQQQVPGKPGT ENSCPOP00000013426/1-1229 TDDESSLVDPDDIMKHVGDDGSNSVATEPWLRPGTSESLKHFMAEQLNQEQQQAPGKPGT ENSP00000262210/1-1221 TDDESSLVDPDDIMKHIGDDGSNSVATEPWLRPGTSETLKRFMAEQLNQEQQQIPGKPGT XP_004842146.1/1-1220 TDDESSLVDPDDIMKHVGDDGSNSVATEPWLRPGTSETLKRFMAEQLNQEQQQAPRKPGT ****.*********:*:.*** **.************:**:****:**: *:: * **** ENSMUSP00000068804/1-1197 FTWQGLSAAHA ENSRNOP00000008480/1-1203 FPWQGLSAAHA ENSCPOP00000013426/1-1229 FTWQGLSTAHG ENSP00000262210/1-1221 FTWQGLSTAHG XP_004842146.1/1-1220 FTWQGLSTAHG *.*****:**.