CLUSTAL W(1.81) multiple sequence alignment ENSMUSP00000043555/1-1418 ------------------------------------------------------MAEGLE ENSRNOP00000004058/1-1013 MLLLPVRPPSFGEGRQEGAGKRVGVGERAPPVRRGFLAARGGGGVAAAVAAAAKMAEGLE ENSP00000263073/1-1419 ------------------------------------------------------MAEGLE ENSCPOP00000013406/1-1419 ------------------------------------------------------MAEGLE XP_004857224.1/1-1420 ------------------------------------------------------MAEGLE ****** ENSMUSP00000043555/1-1418 RVRISASELRGILATLAPQAGSRENMKELKEPRQRKDNRRPDLEIYKPGLSRLRNRPKTK ENSRNOP00000004058/1-1013 RVRISASELRGILATLAPQAGSRENMKELKEPRQRKDNRRPDLEIYKPGLSRLRNRPKTK ENSP00000263073/1-1419 RVRISASELRGILATLAPQAGSRENMKELKEARPRKDNRRPDLEIYKPGLSRLRNKPKIK ENSCPOP00000013406/1-1419 RVRISASELRGILATLAPQAGSRENMKELKEPRQRKDNRRPDLEIYKPGLSRLRNRPKVK XP_004857224.1/1-1420 RVRISASELRGILATLAPQAGSRENMKELKEPRQRKDNRRPDLEIYKPGLSRLRNRPKIK *******************************.* *********************:** * ENSMUSP00000043555/1-1418 EASGNEEFKDEIVNDRDSSAVGNDTQLIQ-VCKELDSQQQNGPIDAENSQAQETFPKTVG ENSRNOP00000004058/1-1013 EASGNEEFKDEIVNDRDASAVGNDTQLIK-VCKELDSQQQNGPIDAENSQAQETFSKTVG ENSP00000263073/1-1419 EPPGSEEFKDEIVNDRDCSAVENGTQPVKDVCKELNNQEQNGPIDPENNRGQESFPRTAG ENSCPOP00000013406/1-1419 ESSGSEEFKDELINVRDSSAVGNGTQLIKDACKKLDSQQQNGPVDPENNQRQETFHRTGG XP_004857224.1/1-1420 EPSGGEEFKDELVNDRDSSAVGNGTQLIKDACKELDNQQQNGPVDLENNQGQETFHRTAG *..*.******::* **.*** *.** :: .**:*:.*:****:* **.: **:* :* * ENSMUSP00000043555/1-1418 LEDRSLKIIKRSKKPDLQIYQPGRRLQTITKESAGRADEEEILNQVEQLRIEEDECKGEA ENSRNOP00000004058/1-1013 LEDRSLKIIKRIKKPDLQIYQPGRRLQTVTKESAGRADEEEILNQVEQLTMEGDECRGEA ENSP00000263073/1-1419 QEDRSLKIIKRTKKPDLQIYQPGRRLQTVSKESASRVEEEEVLNQVEQLRVEEDECRGNV ENSCPOP00000013406/1-1419 QEDRSLKVSKRTKKPDLQIYQPGRRLQAVNKESASQIDEEEILNQVEQLRVVEDECRGKV XP_004857224.1/1-1420 QEDQSLRIIKRTKKPDLQIYQPGRRMQTVNKESASRVDEEEILNQVEHLRVAEDECRGKL **:**:: ** *************:*::.****.: :***:*****:* : ***:*: ENSMUSP00000043555/1-1418 IKEEVNNKPDKTEIEKHQSNDRVRTAKGEKGKKIEKGEGSKKVADDSVPGKPGSVKRYSR ENSRNOP00000004058/1-1013 IKEEVINKPDKTEIEKSQSNDRVRTAKGEKGKKIDKGEGSKKVTDDSVQGKPGSVKRYSR ENSP00000263073/1-1419 AKEEVANKPDRAEIEKSPGGGRVGAAKGEKGKRMGKGEGVRETHDDPARGRPGSAKRYSR ENSCPOP00000013406/1-1419 VKEEVVNKPDKIETEKSQNSDRIKTSKGEKGKRIEKGEGTKKVNDDMAQGKLGSAKRYSR XP_004857224.1/1-1420 VKEEVVNKPDKTQTEKSQNSDRIRTSKGEKGKRVKRGEGTKKVNDDMTQGKLGSAKRYSR **** ****: : ** ...*: ::******:: :*** ::. ** . *: **.***** ENSMUSP00000043555/1-1418 SDKRRNRYRTCSTSSAGSNNSAEGAGLTDNGCRRRRQDRAKERPRLKKQVSLSSTDSLDE ENSRNOP00000004058/1-1013 SDKRRNRYRTCSTSSAGSNNSAEGAGLTDNGCRRRRQDRTKERPRLKKQVSMSSTDSLDE ENSP00000263073/1-1419 SDKRRNRYRTRSTSSAGSNNSAEGAGLTDNGCRRRRQDRTKERPRLKKQVSVSSTDSLDE ENSCPOP00000013406/1-1419 SDKRRNRYRTCSTSSAGSNNSAEGAGLTDNGCRRRRQERTKERPRLKKQVSLSSTDSLDD XP_004857224.1/1-1420 SDKRRNRYRTCSTSSAGSNNSAEGAGLTDNGCRRRRQDRTKERPRLKKQVSLSSTDSLDD ********** **************************:*:***********:*******: ENSMUSP00000043555/1-1418 DRVDEPDVLGSRRSSERKKHLERNWSGCGEGEQKSNGKENRSALRVTFD--AETMSKDSP ENSRNOP00000004058/1-1013 DRVTEPDGLGSRRSSERKKHLDRNWSGRGEGEQKSNGKENRGALRVTFD--AEAMSKDSP ENSP00000263073/1-1419 DRIDEPDGLGPRRSSERKRHLERNWSGRGEGEQKNSAKEYRGTLRVTFD--AEAMNKESP ENSCPOP00000013406/1-1419 DRMDEPDELESKRSLEKRKHSEKNWSGHGEGEQKSNGKENRSTLHVTFD--AETRNKDSS XP_004857224.1/1-1420 DKIDEPDELGPRRSSERRKHSERNWSAHGEGEQKSNGKENRGTLRVTFEENAETMNKDSP *:: *** * .:** *:::* ::***. ******...** *.:*:***: **: .*:*. ENSMUSP00000043555/1-1418 VVRSVKDNVDRMKSDKGPSSGGKGSEKQELRHPRQELRDRGRGILILPAHTALSVSSSGS ENSRNOP00000004058/1-1013 VVRSVKENVDRMNSDKGSSSGGKGSEKQEFRNPKQELRDRGRGILILPAHTALSVSSSGS ENSP00000263073/1-1419 MVRSARDDMDRGKPDKGLSSGGKGSEKQESKNPKQELRGRGRGILILPAHTTLSVNSAGS ENSCPOP00000013406/1-1419 MVRSAREDVDRIKPDKSLSSEGRGSEKQESKNPKQELRGPGRGILILPACTTLSVNSAGS XP_004857224.1/1-1420 KMRSARKDVDRIKPDKSLSNEGRGSEKQESKNLKQELRGQGRGILILPAHTALSVNSAGS :**.:.::** :.**. *. *:****** :: :****. ********* *:***.*:** ENSMUSP00000043555/1-1418 PESTPLGPRLLFGSGSKGSRSWGRGGTTRRLWDPNNPDQKPALKSQTPQLHFLDTDDEIS ENSRNOP00000004058/1-1013 PESTPLGPRLLFGSGSKGSRSWGRGGTTRRLWDPNNPDQKPALKSQTPQLHFLDTDDEIS ENSP00000263073/1-1419 PESAPLGPRLLFGSGSKGSRSWGRGGTTRRLWDPNNPDQKPALKTQTPQLHFLDTDDEVS ENSCPOP00000013406/1-1419 PESTPLGPRLLFGSGSKGSRSWGRGGTTRRLWDPNNPDQKPALKSQTPQLHFLDTDDEVS XP_004857224.1/1-1420 PESTPLGPRLLFGSGSKGSRSWGRGGTTRRLWDPNNPDQKPALKSQTPQLHFLDTDDEVS ***:****************************************:*************:* ENSMUSP00000043555/1-1418 PTSWGDSRQAQASYYKFQNSDNPYYYPRTPGPASQYPYAGYSPLQYPVGPTNGMYPGAYY ENSRNOP00000004058/1-1013 PTSWGDSRQAQASFYKFQNSDNPYYYPRTPGPASQYPYTGYSPLQYPVGPTNGMYPGPYY ENSP00000263073/1-1419 PTSWGDSRQAQASYYKFQNSDNPYYYPRTPGPASQYPYTGYNPLQYPVGPTNGVYPGPYY ENSCPOP00000013406/1-1419 PTSWSDSRQAQASYYKFQNSDNPYYYPRTPGPASQYPYTGYNPLQYSVGPTNGMFPGPYY XP_004857224.1/1-1420 PTSWGDSRQAQTSYYKFQNSDNP-YYPRTPGPASQYPYTGYSPLQYPAGPTNGVYPAPYY ****.******:*:********* **************:**.****..*****::*..** ENSMUSP00000043555/1-1418 PGYPAPSGQYVCSPLPASTMSPEEIEQHVRNMQQQELHRLLRVADNQELQLSNLLSRDRI ENSRNOP00000004058/1-1013 PGYPAPSGQYVCSPLPASTMSPEEIEQHVRNMQQQELHRLLRVADNQELQLSNLLSRDRI ENSP00000263073/1-1419 PGYPTPSGQYVCSPLPTSTMSPEEVEQHMRNLQQQELHRLLRVADNQELQLSNLLSRDRI ENSCPOP00000013406/1-1419 PGYPTPPGQYVCSPLSASTMSPEEIEQHVRNMQQQELHRLLRVADNQELQLSNLLSRDRI XP_004857224.1/1-1420 PGYPTPPGQYVCSLLPASAMSPEEVEQHVRNMQQQELHRLLRVADNQELQLSNLLSRDHI ****:*.****** *.:*:*****:***:**:**************************:* ENSMUSP00000043555/1-1418 STEGMEKMAQLRTELLQLYERCILLDIEFSDSQNVDQILWKNAFYQVIEKFRQLLKDPNS ENSRNOP00000004058/1-1013 STEGMEKMAQLRTELLQLYERCILLDIEFSDSQNVDQILWKNAFYQVIEKFRQLLKDPNI ENSP00000263073/1-1419 SPEGLEKMAQLRAELLQLYERCILLDIEFSDNQNVDQILWKNAFYQVIEKFRQLVKDPNV ENSCPOP00000013406/1-1419 STEGMEKMTQLRAELLQLYERCILLDIEFSDNQNVDQILWKNAFYQVIEKFRQLLKDPNV XP_004857224.1/1-1420 STEGMEKMAQLRAELLQLYERCILLDIEFSDNQNVDQILWKNAFYQVIEKFRQLLKDPNV *.**:***:***:******************.**********************:**** ENSMUSP00000043555/1-1418 ENPEQIRNRLLELLDEGSDFFDSLLQKLQVTYKFKLEDYMDGLAIRSKPLRKTVKYALIS ENSRNOP00000004058/1-1013 ENPEQIRNRLLELLDEGSDFFDSLLQKLQVTYKFKLEDYMDGLAIRSKPLRKTVKYALIS ENSP00000263073/1-1419 ENPEQIRNRLLELLDEGSDFFDSLLQKLQVTYKFKLEDYMDGLAIRSKPLRKTVKYALIS ENSCPOP00000013406/1-1419 DNPEQIRNRLLELLDEGSDFFDSLLQKLQVTYKFKLEDYMDGLAIRSKPLRKTVKYALIS XP_004857224.1/1-1420 DNPEQIRNRLLELLDEGSNFFDSLLQKLQVTYKFKLEDYMDGLAIRSKPLRKTVKYALIS :*****************:***************************************** ENSMUSP00000043555/1-1418 AQRSMICQGDISRYREQANDTANYGKARSWYLKAQHIAPKNGRPYNQLALLAVYTRRKLD ENSRNOP00000004058/1-1013 AQRSMICQGDISRYREQANDTANYGKARSWYLKAQHIAPKNGRPYNQLALLAVYTRRKLD ENSP00000263073/1-1419 AQRCMICQGDIARYREQASDTANYGKARSWYLKAQHIAPKNGRPYNQLALLAVYTRRKLD ENSCPOP00000013406/1-1419 AQRCMICQGDIARYREQANDTANYGKARSWYLKASTLPPRNGRPYNQLALLAVYTRRKLD XP_004857224.1/1-1420 AQRCMICQGDIARYREQANDTANYGKARSWYLKAQHIAPKNGRPYNQLALLAVYTRRKLD ***.*******:******.***************. :.*:******************** ENSMUSP00000043555/1-1418 AVYYYMRSLAASNPILTAKESLMSLFEETKRKAEQMEKKQHEEFDMSPDKWRKGKKSTFR ENSRNOP00000004058/1-1013 AVYYYMRSLAASNPILTAKESLMSLFEETKRKAEQMEKKQHEEFDLSPDQWRKGKKSTFR ENSP00000263073/1-1419 AVYYYMRSLAASNPILTAKESLMSLFEETKRKAEQMEKKQHEEFDLSPDQWRKGKKSTFR ENSCPOP00000013406/1-1419 AVYYYMRSLAASNPILTAKESLMSLFEETKRKAEQMEKKQHEEFELNPDQWRKGKKSTFR XP_004857224.1/1-1420 AVYYYLRSLAASNPILTAKESLMSLFEETKRKAEQMEKKQQEEFELNPDQWRKGKKSTFR *****:**********************************:***::.**:********** ENSMUSP00000043555/1-1418 HVGDDTTRLEIWIHPSHSRSAQGTESGKDSEQENGLGSLSPSDLNKRFILSFLHAHGKLF ENSRNOP00000004058/1-1013 HVGDDTTRLEIWIHPSHSRSSQGTESGKDSEQENGLGSLSPSDLNKRFILSFLHAHGKLF ENSP00000263073/1-1419 HVGDDTTRLEIWIHPSHPRSSQGTESGKDSEQENGLGSLSPSDLNKRFILSFLHAHGKLF ENSCPOP00000013406/1-1419 HVGDDTTRLEIWIRPSHPRFSLGTESGKNSEQENGLGTLSPSDLNKRFILSFLHAHGKLF XP_004857224.1/1-1420 HVGDDTTRLEIWIHPSHPRSSQGTESGKDSEQENGLGSLSASDLNKRFILSFLHAHGKLF *************:***.* : ******:********:**.******************* ENSMUSP00000043555/1-1418 TRIGMETFPAVAEKVLKEFQVLLQHSPSPIGSTRMLQLMTINMFAVHNSQLKDCFSEECR ENSRNOP00000004058/1-1013 TRIGMETFPAVAEKVLKEFQVLLQHSPSPIGSTRMLQLMTINMFAVHNSQLKGCHS---- ENSP00000263073/1-1419 TRIGMETFPAVAEKVLKEFQVLLQHSPSPIGSTRMLQLMTINMFAVHNSQLKDCFSEECR ENSCPOP00000013406/1-1419 TRIGMETFPAVAEKVLKEFQVLLQHSPSPIGSTRMLQLMTINMFAVHNSQLKDCFSEECR XP_004857224.1/1-1420 TRIGMETFPSVAEKVLKEFQVLLQHSPSPIGSTRMLQLMTINMFAIHNSQLKDCFSEECR *********:***********************************:******.*.* ENSMUSP00000043555/1-1418 SVIQEQAASLGLAMFSLLVQRCTCLLKDSAKAQLSSPEDQEDQDDIKVSSFVPDLKELLP ENSRNOP00000004058/1-1013 ------------------------------------------------------------ ENSP00000263073/1-1419 SVIQEQAAALGLAMFSLLVRRCTCLLKESAKAQLSSPEDQDDQDDIKVSSFVPDLKELLP ENSCPOP00000013406/1-1419 SVIQEQAAALGLAMFSLLVQRCTCLLQESAKAQQSSPKDQDDQDDIKVSSFISDLKELLP XP_004857224.1/1-1420 SVIQEQAAALGLAMFSLLVRRCTCLLKESAKAQQSSPEDQDDQDDIRVSSFIPDLKELLP ENSMUSP00000043555/1-1418 SVKVWSDWMLGYPDTWNPPPTSLDLPLQVAVDVWSTLADFCNILTAVNQSEVPLYKDPDD ENSRNOP00000004058/1-1013 ------------------------------------------------------------ ENSP00000263073/1-1419 SVKVWSDWMLGYPDTWNPPPTSLDLPSHVAVDVWSTLADFCNILTAVNQSEVPLYKDPDD ENSCPOP00000013406/1-1419 SVKVWSDWMLGYPDTWNPPPTSLDLPSQVAVDVWSTLADFCNILTAVNQSEVPLYKDPDD XP_004857224.1/1-1420 SVKVWSDWMLGYPNTWNPPPTSLDLPSQVAVDVWSTLADFCNILTAVNQSEVPLYKDPDD ENSMUSP00000043555/1-1418 DLTLLILEEDRLLSGFVPLLAAPQDPCYVEKTSDKVIAADCKRVTVLKYFLEALCGQEEP ENSRNOP00000004058/1-1013 ------------------------------------------------------------ ENSP00000263073/1-1419 DLTLLILEEDRLLSGFVPLLAAPQDPCYVEKTSDKVIAADCKRVTVLKYFLEALCGQEEP ENSCPOP00000013406/1-1419 DLTLLILEEDRLLSGFVPLLAAPQDPCYVEKTSDKVIAADCKRVTVLKYFLEALCGQEEP XP_004857224.1/1-1420 DLTLLILEEDRLLSGFVPLLAAPQDPCYVEKTSDKVIAADCKRVTVLKYFLEALCGQEEP ENSMUSP00000043555/1-1418 LLAFKGGKYVSVAPVPDTMGKEMGSQEGKQLEDEEEDVVIEDFEEDSEAEGSGGEDDIRE ENSRNOP00000004058/1-1013 ------------------------------------------------------------ ENSP00000263073/1-1419 LLAFKGGKYVSVAPVPDTMGKEMGSQEGTRLEDEEEDVVIEDFEEDSEAEGSGGEDDIRE ENSCPOP00000013406/1-1419 LLAFKGGKYVSVAPVPDTMGKEMGSQEGKQLEDEEEDVVIEDFEEDSEAEGSGGEDDIRE XP_004857224.1/1-1420 LLAFKGGKYVSVAPVPDTMGKEMGSQEGKQLEDEEEDVVIEDFEEDSEGEGSGGEDDIRE ENSMUSP00000043555/1-1418 LRAKKLALARKIAEQQRRQEKIQAVLEDQSQMRQMELEIRPLFLVPDTNGFIDHLASLAR ENSRNOP00000004058/1-1013 ------------------------------------------------------------ ENSP00000263073/1-1419 LRAKKLALARKIAEQQRRQEKIQAVLEDHSQMRQMELEIRPLFLVPDTNGFIDHLASLAR ENSCPOP00000013406/1-1419 LRAKKLALARKIAEQQRRQEKIQAVLEDQSQMRQMELEIRPLFLVPDTNGFIDHLTSLAQ XP_004857224.1/1-1420 LRAKKLALARKIAEQQRRQEKIQAVLEDQSQMRQMELEIRPLFLVPDTNGFIDHLASLAR ENSMUSP00000043555/1-1418 LLESRKYILVVPLIVINELDGLAKGQETDHRAGGYARVVQEKARKSIEFLERRFESRDSC ENSRNOP00000004058/1-1013 ------------------------------------------------------------ ENSP00000263073/1-1419 LLESRKYILVVPLIVINELDGLAKGQETDHRAGGYARVVQEKARKSIEFLEQRFESRDSC ENSCPOP00000013406/1-1419 LLESRKYILVVPLIVINELDGLAKGQETDHRAGGYARVVQEKARKSIEFLERRFESRDSC XP_004857224.1/1-1420 LLESRKYILVVPLIVINELDGLAKGQETDHRAGGYARVVQEKARKSIEFLERRFESRDSC ENSMUSP00000043555/1-1418 LRALTSRGNELESIAFRSEDITGQLGNNDDLILSCCLHYCKDKAKDYMPTSKEEPIRLLR ENSRNOP00000004058/1-1013 ------------------------------------------------------------ ENSP00000263073/1-1419 LRALTSRGNELESIAFRSEDITGQLGNNDDLILSCCLHYCKDKAKDFMPASKEEPIRLLR ENSCPOP00000013406/1-1419 LRALTSRGNELESIAFRSEDITGQLGNNDDLILSCCLHYCKDKAKDFMPTSKEEPIRLLR XP_004857224.1/1-1420 LRALTSRGNELESIAFRSEDITGQLGNNDDLILSCCLHYCKDKAKDFMPTSKEEPIRLLR ENSMUSP00000043555/1-1418 EVVLLTDDRNLRVKALTRNVPVRDIPAFLTWAQVG ENSRNOP00000004058/1-1013 ----------------------------------- ENSP00000263073/1-1419 EVVLLTDDRNLRVKALTRNVPVRDIPAFLTWAQVG ENSCPOP00000013406/1-1419 EVVLLTDDRNLRVKALTRNVPVRDIPAFLAWAQVG XP_004857224.1/1-1420 EVVLLTDDRNLRVKALTRNVPVRDIPAFLTWAQVG