CLUSTAL W(1.81) multiple sequence alignment ENSMUSP00000026427/1-1092 MEHSPEEGASP----------EPSGQPPATDST--RDGGSGVPPAGPGAASEALAVLTSF ENSRNOP00000006119/1-1088 MERSPEEGAGP----------EPSGQSPATDSTRERDGGSGVPPAGPGAASEALAVLTSF ENSP00000267113/1-1114 MERSPGEGPSPSPMDQPSAPSDPTDQPPAAHAK--PDPGSGGQPAGPGAAGEALAVLTSF ENSCPOP00000013400/1-1102 MERSQGEGSSPSPMDQPSAPSDPPDQPPAAHAK--LDPDSGLPPAGPGARSEALAVLTSF XP_004861398.1/1-1093 MERSPGEG--PSPVDQPSAPSDPPD-PPTAHTK--LDPDSGVPPGGPGAGSEALAVLTSF **:* ** * :*.. .*::.:. * .** *.**** .********* ENSMUSP00000026427/1-1092 GRRLLVLVPVYLAGAAGLSVGFVLFGLALYLGWRRVRDGKERSLRAARQLLDDEERITAE ENSRNOP00000006119/1-1088 GRRLLVLVPVYLAGAAGLSVGFVLFGLALYLGWRRVRDGKERSLRAARQLLDDEERITAE ENSP00000267113/1-1114 GRRLLVLIPVYLAGAVGLSVGFVLFGLALYLGWRRVRDEKERSLRAARQLLDDEEQLTAK ENSCPOP00000013400/1-1102 VRRLLVLVPVYLAGAAGLSVGFVVFGLALYLGWRRVRDEKERSLRAARQLLDDEERLTAK XP_004861398.1/1-1093 VRRLLVLVPVYLAGAAGLSVGFVVFGLALYLGWRRVRDEKERSLRAARQLLDDEERLTAK ******:*******.*******:************** ****************::**: ENSMUSP00000026427/1-1092 TLYMSHRELPAWVSFPDVEKAEWLNKIVAQVWPFLGQYMEKLLAETVAPAVRGANPHLQT ENSRNOP00000006119/1-1088 TLYMSHRELPAWVSFPDVEKAEWLNKIVVQVWPFLGQYMEKLLAETVAPAVRGANPHLQT ENSP00000267113/1-1114 TLYMSHRELPAWVSFPDVEKAEWLNKIVAQVWPFLGQYMEKLLAETVAPAVRGSNPHLQT ENSCPOP00000013400/1-1102 TLYLSQRELPAWVSFPDVEKAEWLNKIVAQVWPFLGQYMEKLLAETVAPAVRGSNPHLQT XP_004861398.1/1-1093 TLYLSHRELPAWVSFPDVEKAEWLNKIVAQVWPFLGQYMEKLLAETVAPAVRGSNPHLQT ***:*:**********************.************************:****** ENSMUSP00000026427/1-1092 FTFTRVELGEKPLRIIGVKVHPSQRKDQILLDLNVSYVGDVQIDVEVKKYFCKAGVKGMQ ENSRNOP00000006119/1-1088 FTFTRVELGEKPVRIIGVKVHPSQRKDQILLDLNVSYVGDLQIDVEVKKYFCKAGVKGMQ ENSP00000267113/1-1114 FTFTRVELGEKPLRIIGVKVHPGQRKEQILLDLNISYVGDVQIDVEVKKYFCKAGVKGMQ ENSCPOP00000013400/1-1102 FTFTRVELGEKPLRIIGVKVHPNQRKDQILLDLNISYVGDVQIDVEIKKYFCKAGSQGHA XP_004861398.1/1-1093 FTFTRVELGEKPLRIIGVKVHPSQRKDQILLDLNVSYVGDVQIDVEIKKYFCKAGVKGMQ ************:*********.***:*******:*****:*****:******** :* ENSMUSP00000026427/1-1092 LHGVLRVILEPLTGDLPIVGAVSMFFIKRPTLDINWTGMTNLLDIPGLSSLSDTMIMDSI ENSRNOP00000006119/1-1088 LHGVLRVILEPLIGDLPIVGAVSMFFIKRPTLDINWTGMTNLLDIPGLSSLSDTMIMDSI ENSP00000267113/1-1114 LHGVLRVILEPLIGDLPFVGAVSMFFIRRPTLDINWTGMTNLLDIPGLSSLSDTMIMDSI ENSCPOP00000013400/1-1102 LHGILRVILEPLMGDLPIVGAVSMFFIRRPTLDINWTGMTNLLDIPGLSSLSDTMIMDSI XP_004861398.1/1-1093 LHGILRVILEPLMGDLPIVGAVSMFFIRRPTLDINWTGMTNLLDIPGLSSLSDTMIMDSI ***:******** ****:*********:******************************** ENSMUSP00000026427/1-1092 AAFLVLPNRLLVPLVPDLQDVAQLRSPLPRGIIRIHLLAARGLSSKDKYVKGLIEGKSDP ENSRNOP00000006119/1-1088 AAFLVLPNRLLVPLVPDLQDVAQLRSPLPRGIIRIHLLAARGLSSKDKYVKGLIEGKSDP ENSP00000267113/1-1114 AAFLVLPNRLLVPLVPDLQDVAQLRSPLPRGIIRIHLLAARGLSSKDKYVKGLIEGKSDP ENSCPOP00000013400/1-1102 AAFLVLPNRLLVPLVPDLHDVAQLRSPLPRGIIRIHLLAARGLSSKDKYVKGLIEGKSDP XP_004861398.1/1-1093 AAFLVLPNRLLVPLVPNLHDVAQLRSPLPRGIIRIHLLAAQGLSSKDKYVKGLIEGKSDP ****************:*:*********************:******************* ENSMUSP00000026427/1-1092 YALVRVGTQTFCSRVIDEELNPHWGETYEVIVHEVPGQEIEVEVFDKDPDKDDFLGRMKL ENSRNOP00000006119/1-1088 YALVRVGTQTFCSRVIDEELNPRWGETYEVIVHEVPGQEIEVEVFDKDPDKDDFLGRMKL ENSP00000267113/1-1114 YALVRLGTQTFCSRVIDEELNPQWGETYEVMVHEVPGQEIEVEVFDKDPDKDDFLGRMKL ENSCPOP00000013400/1-1102 YALVRVGTQTFCSRVINEELNPQWGETYEVIVHEVPGQEIEVEVFDKDPDKDDFLGRMKL XP_004861398.1/1-1093 YALVRVGTQTFCSCVINEELSPQWGETYEVMVHEVPGQEIEVEVFDKDPDKDDFLGRMKL *****:******* **:***.*:*******:***************************** ENSMUSP00000026427/1-1092 DVGKVLQAGVLDNWYPLQGGQGQVHLRLEWLSLLPDAEKLDQVLQWNRGITSRPEPPSAA ENSRNOP00000006119/1-1088 DVGKVLQAGVLDNWYPLQGGQGQVHLRLEWLSLLPDAEKLDQVLQWNRGITSRPEPPSAA ENSP00000267113/1-1114 DVGKVLQASVLDDWFPLQGGQGQVHLRLEWLSLLSDAEKLEQVLQWNWGVSSRPDPPSAA ENSCPOP00000013400/1-1102 DVGKVLQAGVLDDWYPLQSGQGQVHLRLEWLSLLPDAEKLEQVLQWNRGVSSKPEPPSAA XP_004861398.1/1-1093 DVGKVLQAGVLDDWYPLQGGKGQVHLRLEWLSLLPDAEKLEHVLQWNKGVSSQPEPPSAA ********.***:*:***.*:*************.*****::***** *::*:*:***** ENSMUSP00000026427/1-1092 ILVVYLDRAQDLP----------LKKGNKEPNPMVQLSVQDVTRESKATYSTNSPVWEEA ENSRNOP00000006119/1-1088 ILVVYLDRAQDLP----------LKKGNKEPNPMVQLSVQDVTQESKATYSTNCPVWEEA ENSP00000267113/1-1114 ILVVYLDRAQDLPMVTSELYPPQLKKGNKEPNPMVQLSIQDVTQESKAVYSTNCPVWEEA ENSCPOP00000013400/1-1102 ILVVYLDRAQDLP----------LKKGNKEPNPMVQLSVQDVTQESKAVYNTNSPVWEEA XP_004861398.1/1-1093 ILVVYLDRAQDLP----------LKKGNKEPNPMVQLSIQDVTQESKAVYGTNSPVWEEA ************* ***************:****:****.*.**.****** ENSMUSP00000026427/1-1092 FRFFLQDPRSQELDVQVKDDSRALTLGALTLPLARLLTASELTLDQWFQLSSSGPNSRLY ENSRNOP00000006119/1-1088 FRFFLQDPRSQELDVQVKDDSRALTLGALTLPLARLLTASELTLDQWFQLSSSGPNSRLY ENSP00000267113/1-1114 FRFFLQDPQSQELDVQVKDDSRALTLGALTLPLARLLTAPELILDQWFQLSSSGPNSRLY ENSCPOP00000013400/1-1102 FRFFLQDPRSQELDVQVKDDSRALTLGALTLPLARLLTASELTLDQWFQLSNSGPNSRLY XP_004861398.1/1-1093 FRFFLQDPRSQELDVQVKDDSRALTLGALTLPLARLLTASELTLDQWFQLSGSGPNSRLY ********:******************************.** ********.******** ENSMUSP00000026427/1-1092 MKLVMRILYLDYSEIRFPTVPGAQ---DWDRESLETGSSVDAPPRPYHTTPNSHFGTENV ENSRNOP00000006119/1-1088 MKLVMRILYLDSSEMRLPTEPGAQ---DWDSESPETGSSVDAPPRPYHTTPNSHFGTENV ENSP00000267113/1-1114 MKLVMRILYLDSSEICFPTVPGCPGAWDVDSENPQRGSSVDAPPRPCHTTPDSQFGTEHV ENSCPOP00000013400/1-1102 MKLVMRILYLDSSQICFPMMPGTAGPWELDSESPPAGSSVDVPPRPCHTTPDSHFGTENV XP_004861398.1/1-1093 MKLVMRILYLDSSQICFPAVPGTTTAWDPDSESPATGSSVDAPPRPCHTTPASHFGTENV *********** *:: :* ** : * *. *****.**** **** *:****:* ENSMUSP00000026427/1-1092 LRIHVLEAQDLIAKDRFLGGLVKGKSDPYVKLKVAGKSFRTHVVREDLNPRWNEVFEVIV ENSRNOP00000006119/1-1088 LRIHVLEAQDLIAKDRFLGGLVKGKSDPYVKLKVAGRSLRTHVVREDLNPRWNEVFEVIV ENSP00000267113/1-1114 LRIHVLEAQDLIAKDRFLGGLVKGKSDPYVKLKLAGRSFRSHVVREDLNPRWNEVFEVIV ENSCPOP00000013400/1-1102 LRIHVLEAQDLIAKDRFLGGLVKGKSDPYVKLKLAGRSFRSRVVREDLNPRWNEVFEVIV XP_004861398.1/1-1093 LRIHILEAQDLIAKDRFLGGLVKGKSDPYVKLKLAGRSFRSRVVREDLNPRWNEVFEVIV ****:****************************:**:*:*::****************** ENSMUSP00000026427/1-1092 TSIPGQELEIEVFDKDLDKDDFLGRYKVSLTTVLNSGFLDEWLTLEDVPSGRLHLRLERL ENSRNOP00000006119/1-1088 TSIPGQELDIEVFDKDLDKDDFLGRYKVGLTTVLNSGFLDEWLTLEDVPSGRLHLRLERL ENSP00000267113/1-1114 TSVPGQELEVEVFDKDLDKDDFLGRCKVRLTTVLNSGFLDEWLTLEDVPSGRLHLRLERL ENSCPOP00000013400/1-1102 TSIPGQELEAEVFDKDLDKDDFLGRCKMSLTTVLNSGFLDEWLTLEDVPSGRLHLRLERL XP_004861398.1/1-1093 TSVPGQELEVEVFDKDLDKDDFLGRCKVSLTTVLNSGFLDEWLTLEDVLSGRLHLRLERL **:*****: *************** *: ******************* *********** ENSMUSP00000026427/1-1092 TPRPTAAELEEVLQVNSLIQTQKSSELAAALLSVFLERAEDLPLRKGTKPPSPYATITVG ENSRNOP00000006119/1-1088 SPRPTAAELEEVLQVNSLIQTQKSSELAAALLSVYLERSEDLPLRKGTKPPSPYAILTVG ENSP00000267113/1-1114 TPRPTAAELEEVLQVNSLIQTQKSAELAAALLSIYMERAEDLPLRKGTKHLSPYATLTVG ENSCPOP00000013400/1-1102 TPRLTTADLEEVLQVNSLIQTQKSAELAAALLSVYLERAEDLPLRKGTKPPSPYATLTVG XP_004861398.1/1-1093 SPRPTAADLEEVLQVNSLIQTQKSAELASALLSVYLERAEDLPLRKGTKPPSPYATLTVG :** *:*:****************:***:****:::**:********** **** :*** ENSMUSP00000026427/1-1092 ETSHKTKTVSQSSAPVWEESASFLIRKPHAESLELQVRGEGTGTLGSVSLPLSELLQEDQ ENSRNOP00000006119/1-1088 ETSHKTKTVSQTSAPIWEESASFLIRKPHAESLELQVRGEGTGTLGSISLPLSELLQEEQ ENSP00000267113/1-1114 DSSHKTKTISQTSAPVWDESASFLIRKPHTESLELQVRGEGTGVLGSLSLPLSELLVADQ ENSCPOP00000013400/1-1102 DTTHKTKTVSQSSAPVWDESTSFLIRKPHTESLELQVRGEGTGTLGSLSLPCSELLEAEG XP_004861398.1/1-1093 ETSHKTKTVSHSSAPVWDESASFLIRKPHTESLELQVRGEGTGTLGSLSLPFSELLEADR :::*****:*::***:*:**:********:*************.***:*** **** : ENSMUSP00000026427/1-1092 LCLDHWFALS-GQGQVLMRAQLGILVSQHSGVEAHSHSYSHSHSSSSLNDEPEALGGPTH ENSRNOP00000006119/1-1088 LCLDRWFALS-GQGQVLMRVQLGILVSQHSGVEAHSH------SSSSLNEEPEVLGDPTH ENSP00000267113/1-1114 LCLDRWFTLSSGQGQVLLRAQLGILVSQHSGVEAHSHSY--SHSSSSLSEEPELSGGPPH ENSCPOP00000013400/1-1102 LCLDRWFTLTNGQGQVLLRAQLGILVSQHSGVEAHSH----SHSFSSLAEEPELWGRLPH XP_004861398.1/1-1093 LCLDRWFVLTNGQGQVLLKAQLGILVSQHSGVEAHSH----SHSSSSLTEEAE------S ****:**.*: ******::.***************** * *** :*.* ENSMUSP00000026427/1-1092 PASPVLEVRHRLTHGDSPSEAPVGPLGQVKLTVWYHSDEQKLISIIHSCRALRQNGRDLP ENSRNOP00000006119/1-1088 TASPVLEVRHRLTHGDSPSEALIGPLGQVKLTVWYHSDEQKLISIIHSCRALRQNGRDLP ENSP00000267113/1-1114 ITSSAPELRQRLTHVDSPLEAPAGPLGQVKLTLWYYSEERKLVSIVHGCRSLRQNGRDPP ENSCPOP00000013400/1-1102 ATTSAPELRQRLVHGDGPPEATVGPLGQVKLTVWYYGEERKLVSIVHSCRALRQNGRDPP XP_004861398.1/1-1093 STSSAPELRQRLVHGDSPLQAPVGPLGQVKLTVWYYSEERKLVSIVHGCRALRQNGRDPP ::.. *:*:**.* *.* :* *********:**:.:*:**:**:*.**:******* * ENSMUSP00000026427/1-1092 DPYVSVLLLPDKNRSTKRKTPQKKRTLNPEFNERFEWDLPLDGTLRRKLDVSVKSNSSFM ENSRNOP00000006119/1-1088 DPYVSVLLLPDKNRGTKRKTSQKKRTLNPEFNERFEWDLPLDGTLRRKLDVSVKSNSSFM ENSP00000267113/1-1114 DPYVSLLLLPDKNRGTKRRTSQKKRTLSPEFNERFEWELPLDEAQRRKLDVSVKSNSSFM ENSCPOP00000013400/1-1102 DPYVSLLLLPDKNRGTKRKTSQKKRTLNPEFNERFEWEMPMDEVFRRKLDVSVKSSSSFM XP_004861398.1/1-1093 DPYVSLLLLPDKNRGTKRKTSLKKRTLNPEFSERFEWELPMDEVLRRKLDVSVKSSSSFM *****:********.***:*. *****.***.*****::*:* . **********.**** ENSMUSP00000026427/1-1092 SRERELLGKVQLDLAEIDLSQGAAQWYDLMDDRDKGGS ENSRNOP00000006119/1-1088 SRERELLGKVQLDLAEIDLSQGAAQWYDLIDDRDKGGS ENSP00000267113/1-1114 SRERELLGKVQLDLAETDLSQGVARWYDLMDNKDKGSS ENSCPOP00000013400/1-1102 SRERELLGKVQLDLTEIDLSQGAAQWYDLLDDKDKGSS XP_004861398.1/1-1093 SRERELLGKVQLDLAEIDLSQGAAQWYDLMDDKDKGSS **************:* *****.*:****:*::***.*