CLUSTAL W(1.81) multiple sequence alignment ENSMUSP00000036257/1-1179 -------MLSSLGCLLLCGSIALALGNAQKLPKGKKPSLKVHINTTSDSILLKFLRPNAN ENSRNOP00000049004/1-1179 -------MLSSLGCLLLCGSIALALGNAQKLPKGKKPSLKVHINTTSDSVLLKFLRPNPN ENSP00000420524/1-1777 MRGGKCNMLSSLGCLLLCGSITLALGNAQKLPKGKRPNLKVHINTTSDSILLKFLRPSPN ENSCPOP00000013299/1-1080 ---------------------------------GKKSSLKVHINTTSDSILLKFLRPNPN XP_004858042.1/1-1078 -------MLSSLGCLLLCGSITLALGNAQKLPKGKKTSLKVHINTTSDSILLKFLQPNPN **:..***********:*****:*..* ENSMUSP00000036257/1-1179 VKLEGFLLGYGSNVSPNQYFPLPTEGKFTEAVVDAEPKYLIVVRPAPPPSQKKSCSGKSR ENSRNOP00000049004/1-1179 VKLEGFLLGYGSNVSPNQYFPLPTEGKFTEAVVDAEPKYLIVVRPAPPPSQKKSCSGKSR ENSP00000420524/1-1777 VKLEGLLLGYGSNVSPNQYFPLPAEGKFTEAIVDAEPKYLIVVRPAPPPSQKKSCSGKTR ENSCPOP00000013299/1-1080 VKLEGFLLGYGSNVSPNQYFPLPTEGKYTEAVVDAESKYLIVVRPVPPPSQKKSCSVKSK XP_004858042.1/1-1078 VKLEGFLLGYGSNTSPNQYFPLPTEGKYTEAVVDAEPKYLIVVRPVPPPSQKKSCSGKAR *****:*******.*********:***:***:****.********.********** *:: ENSMUSP00000036257/1-1179 PRKPLQLVVGTLTPSSVFLS-----WGFLINPHHDWTLPSHCPSDRFYTIRYREKDKEKK ENSRNOP00000049004/1-1179 TRKPLQLVVGTLTPSSVFLS-----WGFLINPHHDWTLPSHCSSDRFYTIRYREKDKEKK ENSP00000420524/1-1777 SRKPLQLVVGTLTPSSVFLS-----WGFLINPHHDWTLPSHCPNDRFYTIRYREKDKEKK ENSCPOP00000013299/1-1080 EAKEKHLFIGTVSISSIYFCSFSLLWTVVMQAFHDLPLLERMFINRFYTIRYREKDKEKK XP_004858042.1/1-1078 PRKPLQLVVGTLTPSSVFLS-----WGFLINPHHDWTLQSHCPNDRFYTIRYREKDKEKK * :*.:**:: **:::. * .:::..** .* .: :*************** ENSMUSP00000036257/1-1179 WIFQLCPATETIVENLKPNTVYEFGVKDNIEGGIWSKIFNHKTIVGSKNKVNGKIQSTYD ENSRNOP00000049004/1-1179 WIFQLCPATETIVENLKPNTVYEFGVKDNIEGGIWSKIFNHKTIVGSKNKVNGKIQSTYD ENSP00000420524/1-1777 WIFQICPATETIVENLKPNTVYEFGVKDNVEGGIWSKIFNHKTVVGSK-KVNGKIQSTYD ENSCPOP00000013299/1-1080 WIFQLCPATETIVDNLKPNTVYEFGVKDNVEGSIWSKIFNHKTIVGSKNKVNGKIQSTYD XP_004858042.1/1-1078 WIFQLCPATETIVENLKPNTVYEFGVKDNVEGGIWSKIFNHKTIIGSKNKVNGKIQSTYD ****:********:***************:**.**********::*** *********** ENSMUSP00000036257/1-1179 QVHSVP--VPRKLIPLTIIKQVIQNVTHRASTKSPDKTPFGGTILVHLIIPGLNESTVKL ENSRNOP00000049004/1-1179 QVHSVPAYVPRKLIPITIIKQVIQNVTHRASTKSPDKIPFGGTILVHLIIPGLNDSTVKL ENSP00000420524/1-1777 QDHTVPAYVPRKLIPITIIKQVIQNVTHKDSAKSPEKAPLGGVILVHLIIPGLNETTVKL ENSCPOP00000013299/1-1080 QVHTVPAYVPRKLIPITIIKQVIQNVTHKASTKSPDKTPFGGTILVHLIIPGLNDTTVKL XP_004858042.1/1-1078 QVHTVPAYAPRKLIPITIIKQVIQNVTHRASIKSPDKIPFGGTILVHLIIPGLNETTVKL * *:** .******:************: * ***:* *:**.***********::**** ENSMUSP00000036257/1-1179 PTSIMLEISDALKAQLAKNETLALPAESKTPEVEKLAGQPVTVTPESVSRSTKPTLSSAL ENSRNOP00000049004/1-1179 PSSIMLEISDALKAQLAKNETLALPAESKTPEVEKVAGQPVTVTPETVSRSTKPTLASAL ENSP00000420524/1-1777 PASLMFEISDALKTQLAKNETLALPAESKTPEVEKISARPTTVTPETVPRSTKPTTSSAL ENSCPOP00000013299/1-1080 PSSIMLEISDALKAQLAKNETLALPAESKTPEVEKTTSQRITVTPETVPRTTKPTVSSTL XP_004858042.1/1-1078 PSSIMVEISDALKAQLANNETLALPAESRTPKVEKTTAQHITVTPETVPRATKPTVSSTL *:*:*.*******:***:**********:**:*** :.: *****:*.*:**** :*:* ENSMUSP00000036257/1-1179 DTAETALVLSEKTSETARSVLIPEFELPLSTLAPKRFPEFPEAKTAFPLEKPRGSWASSE ENSRNOP00000049004/1-1179 DTAETALVLSEKTPETAQSVLIPESELLLSSLAPKGSPEFPEAKTAFPSEKPGGSLASSE ENSP00000420524/1-1777 DVSETTLVLSKRTPETLQTILIPQFELPLSTLAPKSLPEFPEAKTPFPFEKPRGTLASSE ENSCPOP00000013299/1-1080 DISETTLVISQRTPESLQTILLPKFELPQSTLAPKRLPEFPEAKTAFPFEKPGVSYVTSE XP_004858042.1/1-1078 DISETTRVLSQRTPETLQTILLPKFELPLSTLAPKRLPEFPEAKTSFPFEKPEVTLVTKE * :**: *:*::*.*: :::*:*: ** *:**** ********.** *** : .:.* ENSMUSP00000036257/1-1179 EPWVVPGAKTSEDSRVVQPQTATYDVISSSTTSDETEI-EIHTATRDPILDSVPPKTSRT ENSRNOP00000049004/1-1179 EPWVVPGAKTSEDSRVVQPRTATYDVVSSSATSDETEV-EPHTATSDPILDSVPPKTSRT ENSP00000420524/1-1777 KPWIVPTAKISEDSKVLQPQTATYDVFSSPTTSDEPEISDSYTATSDRILDSIPPKTSRT ENSCPOP00000013299/1-1080 KSWMAPTSKTSGDSKVVKPQTAAYDVFSSPSTSAEPDVSDPHTATSDPILDSIPPKTSRT XP_004858042.1/1-1078 KSWMAPTAKTSEDSKVVKPQTATYEVFSSPSTSDEPDISEPHTATSDPILDSIPPKTSRI :.*:.* :* * **:*::*:**:*:*.**.:** *.:: : :*** * ****:****** ENSMUSP00000036257/1-1179 AEQPRATLAPIEALFESRNVEIFTSPEVRPTTAAPQQTTSIPSTPKRQSTPKPPRVKPAP ENSRNOP00000049004/1-1179 AEQPRATLAPSEASFDPRTVEIFTSPEVRPTTAAPQQTTSIPSTPKRQSTPKPPRVKPAP ENSP00000420524/1-1777 LEQPRATLAPSETPFVPQKLEIFTSPEMQPTTPAPQQTTSIPSTPKRRPRPKPPRTKPER ENSCPOP00000013299/1-1080 LEQPRATLAPSEAPFIPQKVETFTSPAMKSTTHAPQQTPSTPSSPKRRPRPKTPRTK--- XP_004858042.1/1-1078 LEQPRATLAPSETSFIPQKVETFTSPAMKPTTSAPQKTTSIPSPPKRRPRPKTPRTK--- ********* *: * .:.:* **** ::.** ***:*.* **.***:. **.**.* ENSMUSP00000036257/1-1179 E----------------------------------------------------------- ENSRNOP00000049004/1-1179 E----------------------------------------------------------- ENSP00000420524/1-1777 TTSAGTITPKISKSPEPTWTTPAPGKTQFISLKPKIPLSPEVTHTKPAPEPQTLLPSQST ENSCPOP00000013299/1-1080 ------------------------------------------------------------ XP_004858042.1/1-1078 ------------------------------------------------------------ ENSMUSP00000036257/1-1179 --PETRPSAQTTK-APRKTKKPGH--HRLRRPKTTRSPEVPKSKPALEPATVTPEILVPK ENSRNOP00000049004/1-1179 --PETRPSAQSTKAPPHKTKKPGR-----RRPKTTRSPEVPKSKPALEPATVPPEILVPT ENSP00000420524/1-1777 IGPETPGTKPSTTLAPRKTKRPGRRPRPRPRPKTTPSPEVPKSKPALEPATIQPEPLVPT ENSCPOP00000013299/1-1080 ------------------------------------------------------------ XP_004858042.1/1-1078 ------------------------------------------------------------ ENSMUSP00000036257/1-1179 IVPKPPQKPKATRRPEVPQVK--------------------------------------- ENSRNOP00000049004/1-1179 IVPKPPQRPKATRRPEAPQIQ--------------------------------------- ENSP00000420524/1-1777 TASKPSERPKTTHRPDAPQIQPGSKPPKQLLPKPQTTAEPDMPPTKSVSEPVPFETEAPS ENSCPOP00000013299/1-1080 ------------------------------------------------------------ XP_004858042.1/1-1078 ------------------------------------------------------------ ENSMUSP00000036257/1-1179 ------------------------------------------------------------ ENSRNOP00000049004/1-1179 ------------------------------------------------------------ ENSP00000420524/1-1777 MTIVPTTDIEPVTVRTEATVTTLAPKTSQRTRTRRPRPKHKTTPRPETLQTKLDFGPITP ENSCPOP00000013299/1-1080 ------------------------------------------------------------ XP_004858042.1/1-1078 ------------------------------------------------------------ ENSMUSP00000036257/1-1179 ------------------------------------------------------------ ENSRNOP00000049004/1-1179 ------------------------------------------------------------ ENSP00000420524/1-1777 GTSSAPTTTTKRTRRPHPKPKTTPHPEVPQTKLVPATILEPVLRTEASGTTAAPKVPQRT ENSCPOP00000013299/1-1080 ------------------------------------------------------------ XP_004858042.1/1-1078 ------------------------------------------------------------ ENSMUSP00000036257/1-1179 ------------------------------------------------------------ ENSRNOP00000049004/1-1179 ------------------------------------------------------------ ENSP00000420524/1-1777 HRPHPKPKTTLSPEELQTELVPATIFEPVSPIKEAPGTTFVPVTDLEPVTFRTEIPATTL ENSCPOP00000013299/1-1080 ------------------------------------------------------------ XP_004858042.1/1-1078 ------------------------------------------------------------ ENSMUSP00000036257/1-1179 ------------------------------------------------------------ ENSRNOP00000049004/1-1179 ------------------------------------------------------------ ENSP00000420524/1-1777 ATKTSKRTRPPRPRPKTTPSPQAPETKPVPATVLEPVTLRPEASTTLASKTSQRTRRPRL ENSCPOP00000013299/1-1080 ------------------------------------------------------------ XP_004858042.1/1-1078 ------------------------------------------------------------ ENSMUSP00000036257/1-1179 ------------------------------------------------------------ ENSRNOP00000049004/1-1179 ------------------------------------------------------------ ENSP00000420524/1-1777 RTKTTPRPEAPESKPVPTAELKPVTLRTETWVTTQAPKTSQRTRRPRPKTKTTPSPEVPQ ENSCPOP00000013299/1-1080 ------------------------------------------------------------ XP_004858042.1/1-1078 ------------------------------------------------------------ ENSMUSP00000036257/1-1179 ------------------------------------------------------------ ENSRNOP00000049004/1-1179 ------------------------------------------------------------ ENSP00000420524/1-1777 TKLVPSTDLEPGTLRTEAPKTMVVTTVLEPDTFRTKFPETTLAPKTQRTRRPRPRPKTTS ENSCPOP00000013299/1-1080 ------------------------------------------------------------ XP_004858042.1/1-1078 ------------------------------------------------------------ ENSMUSP00000036257/1-1179 ------------------------------------------------------------ ENSRNOP00000049004/1-1179 ------------------------------------------------------------ ENSP00000420524/1-1777 SPEVPQNKSVSVTGFEPVVHSTDAPGTTFALTELQTLILKPVTSPSLEMTESQPVSDVLE ENSCPOP00000013299/1-1080 ------------------------------------------------------------ XP_004858042.1/1-1078 ------------------------------------------------------------ ENSMUSP00000036257/1-1179 ------------------------------------------------------------ ENSRNOP00000049004/1-1179 ------------------------------------------------------------ ENSP00000420524/1-1777 SVTLSTESPKETIAPAKTDYVYPTAKAPLWPEEPKTEVVESITYVSEPPETTLETSPLPS ENSCPOP00000013299/1-1080 ------------------------------------------------------------ XP_004858042.1/1-1078 ------------------------------------------------------------ ENSMUSP00000036257/1-1179 --------------PAPRQTTSMPPKLKT-PHSRMPAKEPVPKEPLHTTSKPKMPPSPEV ENSRNOP00000049004/1-1179 --------------PAPRQTTSPPPKLKP-PHSRRPAKEQVPKGSLHTTSKPKMPPSPEV ENSP00000420524/1-1777 QSITLPSPDEPQTEPAPKQTPRAPPKPKTSPRPRIPQTQPVPKVPQRVTAKPKTSPSPEV ENSCPOP00000013299/1-1080 --------------PALRQTPRTPPKTKTSQHPRIPQTQPVPKGTLHATSKPKVSPSPEV XP_004858042.1/1-1078 --------------PALRQTPRTPPKTKTSQHPRITQTQPVPKGSPHATSKPKMSPRPEV ** :**. *** *. :.* . .: *** . :.*:*** .* *** ENSMUSP00000036257/1-1179 ADTTSVPKDERLSLKPDPEVTHSETAPLETRGIPLIPVISPRPSQEELQTAMEETDQSTQ ENSRNOP00000049004/1-1179 VDITSVPKDEQLSHKPDPEVSQSETVPLETRDIPLIPVISPRPSEEELQTTMEQTDQSTQ ENSP00000420524/1-1777 SYTTPAPKDVLLPHKPYPEVSQSEPAPLETRGIPFIPMISPSPSQEELQTTLEETDQSTQ ENSCPOP00000013299/1-1080 SYTTYGPEDVPFPHLPDPDISQSEPAPLETRGIPFIPIISPRLSQEELLPTPEETDQTTQ XP_004858042.1/1-1078 SYTTS--------------------APLETRGIPFIPIISPSLSQEELQPTLEETDQSTQ * .*****.**:**:*** *:*** .: *:***:** ENSMUSP00000036257/1-1179 ELFTTKIPRTTELAKTTQAPHRLHTAPVRPRIPGRPHGRPALNKTTTRPDKTKPRGTSHK ENSRNOP00000049004/1-1179 ELFTTKIPRTTELAKTTQAPHRLHTTPVRPRIPERPHGRPALNKTTTRPDRTKSRGMSHK ENSP00000420524/1-1777 EPFTTKIPRTTELAKTTQAPHRFYTT-VRPRTSDKPHIRPVLNRTTTRPTRPKPSGMPSG ENSCPOP00000013299/1-1080 KLFTTKSPRTTELAKTTHAPHRLYTTPVRPRMPDKLYVRPVLNRTTTKPIRPKPSGIPSR XP_004858042.1/1-1078 ELFTTKIPRTTESAKTTPAPHRLYTTPWRFRIPDKPHIRPVLNRTTTKPVRPKPSGIPSR : **** ***** **** ****::*: * * . : : **.**:***:* :.*. * . ENSMUSP00000036257/1-1179 NGVGTGTKQAPKPPSPGRNASVDS-HATRKPGSVSGTRRPPIPHRHSSTRPVSPERRPLP ENSRNOP00000049004/1-1179 NGVGPGTKQTPKPSSTGRNTSVDS-HATRKPGKAEDVNPPGTRHRHTSPRPVPPQRKPLP ENSP00000420524/1-1777 NGVGTGVKQAPRPSGADRNVSVDSTHPTKKPG----TRRPPLP-----PRPTHPRRKPLP ENSCPOP00000013299/1-1080 NGVETGAKQGPKPSGIGRNVSVDSVQSTKRPATIPGTRRPPLP-----PRPVHPRRKPLP XP_004858042.1/1-1078 NGVGTGAKQPPKPSGSGRNVSVDSTQYTRKPGTIPRTHHPPLP-----SRPVPPRRKPLP *** .*.** *:*.. .**.**** : *::*. .. * .**. *.*:*** ENSMUSP00000036257/1-1179 PNNVTGKPGRAGIVSSSRVTSPPLKATLHPIGTATARPGAEQKEPTAPASEEEFGTTTDF ENSRNOP00000049004/1-1179 PNNVTGKPGSAGIISSSRATSPPLKATLKPTGTATERPGAEKKQPTAPASEEEFGNTTDF ENSP00000420524/1-1777 PNNVTGKPGSAGIISSGPITTPPLRSTPRPTGTPLERIETDIKQPTVPASGEELENITDF ENSCPOP00000013299/1-1080 PNNVTGKPGSSGIISSHRVTSPPQRATLKPMLTTSEIPGADKKQPTAPASGEELGNTTDF XP_004858042.1/1-1078 PNNVTGKPGSSRIISS-RVTSPPMRATLKPTETTSEIKEADKRQPTPPASGEELGNTTDF ********* : *:** *:** ::* :* *. :: ::** *** **: . *** ENSMUSP00000036257/1-1179 SSSPTKETDPLGKPRFIGPHVRYIPKPENKPCSITDSVRRFPTEEATEGNATSPPQNPPT ENSRNOP00000049004/1-1179 SSSPTKETDPLGKPRFIGPHVRYIPKPDNKPCSITDSVRRFPTEEATEGNATSPPQNPPT ENSP00000420524/1-1777 SSSPTRETDPLGKPRFKGPHVRYIQKPDNSPCSITDSVKRFPKEEATEGNATSPPQNPPT ENSCPOP00000013299/1-1080 SSSPTRETDHLGKPRFKGPHVRYIPKPDNKPCSITDSIKRFPTEEAMEGNATSPPQNPPT XP_004858042.1/1-1078 SSSPTRETDHLGKPRFKGPHVRYIPKPDNRPCSITDSIKRFPTEEVMEGNATSPPQNPPT *****:*** ****** ******* **:* *******::***.**. ************* ENSMUSP00000036257/1-1179 NLTVVTVEGCPSFVILDWEKPLNDTVTEYEVISRENGSFSGKNKSIQITNQTFSTVENLK ENSRNOP00000049004/1-1179 NLTVVTVEGCPSFVILDWEKPLNDTVTEYEVISRENGSFSGKNKSIQITNQTFSTVENLK ENSP00000420524/1-1777 NLTVVTVEGCPSFVILDWEKPLNDTVTEYEVISRENGSFSGKNKSIQMTNQTFSTVENLK ENSCPOP00000013299/1-1080 NLTVVTVEGCPSFVILDWEKPLNDTVTEYEVISRENGTFSGKNKSIQLTNQTFSTVENLK XP_004858042.1/1-1078 NLTVVTVEGCPSFVILDWEKPLNDSVTEYEVISRENGSFSGKNKSIQITNQTFSTVENLK ************************:************:*********:************ ENSMUSP00000036257/1-1179 PDTSYEFQVKPKNPLGEGPASNTVAFSTESADPRVSEPIS--AGRDAIWTERPFNSDSYS ENSRNOP00000049004/1-1179 PDTSYEFQVKPKNPLGEGPASNTVAFSTESADPRVSEPIS--AGRDAIWTERPFNSDSYS ENSP00000420524/1-1777 PNTSYEFQVKPKNPLGEGPVSNTVAFSTESADPRVSEPVS--AGRDAIWTERPFNSDSYS ENSCPOP00000013299/1-1080 PDTSYEFQVKPKNPLGEGPVSNTVAFSTESADPRVSEPISDAAGRDAIWTERPFNSDSYS XP_004858042.1/1-1078 PDTSYEFQVKPKNPLGEGPASNTVAFSTESADPRVSEPVS--GGRDAIWTERPFNSDSYS *:*****************.******************:* .***************** ENSMUSP00000036257/1-1179 ECKGKQYVKRTWYKKFVGVQLCNSLRYKIYLSDSLTGKFYNIGDQRGHGEDHCQFVDSFL ENSRNOP00000049004/1-1179 ECKGKQYVKRTWYKKFVGVQLCNSLRYKIYLSDSLTGKFYNIGDQRGHGEDHCQFVDSFL ENSP00000420524/1-1777 ECKGKQYVKRTWYKKFVGVQLCNSLRYKIYLSDSLTGKFYNIGDQRGHGEDHCQFVDSFL ENSCPOP00000013299/1-1080 ECKGKQYVKRTWYKKFVGVQLCNSLRYKIYLSDSLTGKFYNIGDQRGHGEDHCQFVDSFL XP_004858042.1/1-1078 ECKGKQYVKRTWYKKFVGVQLCNSLRYKIYLSDSLSGKFYNIGDQRGHGEDHCQFVDSFL ***********************************:************************ ENSMUSP00000036257/1-1179 DGRTGQQLTSEQLPTKEGYFRAVRQEPVQFGEIGGHTQINYVQWYECGTTIPGKW ENSRNOP00000049004/1-1179 DGRTGQQLTSDQLPTKEGYFRAVRQEPVQFGEIGGHTQINYVQWYECGTTIPGKW ENSP00000420524/1-1777 DGRTGQQLTSDQLPIKEGYFRAVRQEPVQFGEIGGHTQINYVQWYECGTTIPGKW ENSCPOP00000013299/1-1080 DGRTGQHLSSDQLPTKEGYFRAVRQEPVQFGEIGGHTQINYVQWYECGTTIPGKW XP_004858042.1/1-1078 DGRTGHHLSSDQLPTKEGYFRAVRQEPVQFGEIGGHTQINYVQWYECGTTIPGKW *****::*:*:*** ****************************************