CLUSTAL W(1.81) multiple sequence alignment ENSP00000313983/1-1437 MDFSFSFMQGIMGNTIQQPPQLIDSANIRQEDAFDNNSDIAEDGGQTPYEATLQQGFQYP ENSCPOP00000013130/1-1438 MDFSFSFMQGIMGNTIQQPPQLIDSANIRQEDAFDNNSDIVEDGGQTPYEATLQQGFQYP XP_004855408.1/1-1438 MDFSFSFMQGIMGNTIQQPPQLIDSANIRQEDAFDNSSDIVEDGGQTPYEATLQQGFQYP ENSMUSP00000117778/1-1446 MDFSFSFMQGIMGNTIQQPPQLIDSANIRQEDAFDNHSDIVEDGGPTPFEATLQQGFQYP ENSRNOP00000060879/1-1396 ------MASRIMGNTIQQPPQLIDSANIRQEDAFDNNSDIVEDGGPTPFEATLQQGFQCP : . ************************** ***.**** **:********* * ENSP00000313983/1-1437 ATTEDLPPLTNGYPSSISVYETQTKYQSYNQYPNGSANGFGAVRNFSPTDYYHSEIPNTR ENSCPOP00000013130/1-1438 PTTEDLPPLTNGYPPSIGMYETQTKYQSYNQYPNGSANGFGAVRNFSPTDYYHSEIPNTR XP_004855408.1/1-1438 PTTEDLPPLTNGYPPSISMYETQTKYQSYNQYPNGSANGFGAVRNFSPTDYYHSEIPNTR ENSMUSP00000117778/1-1446 PTTEDLPPLTNGYPPSISLYETQTKYPPYNQYPNGSANGFGAVRNFSPTDYYHSEIPNTR ENSRNOP00000060879/1-1396 PATEDLPPLTNGYPPSISLYETQTKYPPYSQYPNGSANGFGAVRNFSPTDYYHSEIPNTR .:************.**.:******* .*.****************************** ENSP00000313983/1-1437 PHEILEKPSPPQP----------PPPPSVPQTVIPKKTGSPEIKLKITKTIQNGRELFES ENSCPOP00000013130/1-1438 PHEILEKPSPPQP----------PPPPSVPQTVIPKKTGSPEIKLKITKTIQNGRELFES XP_004855408.1/1-1438 PHEILEKPSPPQP----------PPPLSVPQTVIPKKTGSPEIKLKITKTIQNGRELFES ENSMUSP00000117778/1-1446 PHEILEKPSPPQPPPLPPPPPPPPPPPSVPQTVIPKKTGSPEIKLKITKTIQNGRELFES ENSRNOP00000060879/1-1396 PHEILEKPSPPQP---PPPPLLPPPPPPVPQTVIPKKTGSPEIKLKITKTIQNGRELFES ************* *** .******************************** ENSP00000313983/1-1437 SLCGDLLNEVQASEHTKSKHESRKEKRKKSNKHDSSRSEERKSHKIPKLEPEEQNRPNER ENSCPOP00000013130/1-1438 SLCGDLLNEVQATEHTKSKHESRKEKRKKSNKHDSSRSEERKSHKIPKLEPEEQNRPNER XP_004855408.1/1-1438 SLCGDLLNEVQATEHIKSKHESRKEKRKKSNKHDSSRSEERKSHKIPKLESEEQNRPNER ENSMUSP00000117778/1-1446 SLCGDLLNEVQASEHTKSKHESRKEKRKKSNRHESSRSEERRSHKIPKLEPEGQNRPNER ENSRNOP00000060879/1-1396 SLCGDLLNEVQASEHLKSKHESRKEKRKKSSRHESSRSEERKSHKVPKLEPEGQNRPNER ************:** **************.:*:*******:***:****.* ******* ENSP00000313983/1-1437 VDTVSEKPREEPVLKEEAPVQPILSSVPTTEVSTGVKFQVGDLVWSKVGTYPWWPCMVSS ENSCPOP00000013130/1-1438 VDPTPEKPREEAVLKDTALVQPVLTSAPTTEVTTGIKFQVGDLVWSKVGTYPWWPCMVSS XP_004855408.1/1-1438 VDSTPEKPREEPVLKDAIPVQPILSSAPTTEVTTGVKFQVGDLVWSKVGTYPWWPCMVSS ENSMUSP00000117778/1-1446 VDTAPEKPREEPVLKEAIPVQPILSSVPTTETSTGVKFQVGDLVWSKVGTYPWWPCMVSS ENSRNOP00000060879/1-1396 VDPAPEKPREEPVLKEAVPVQPILSSVPTTETSTGVKFQVGDLVWSKVGTYPWWPCMVSS **...******.***: ***:*:*.****.:**:************************ ENSP00000313983/1-1437 DPQLEVHTKINTRGAREYHVQFFSNQPERAWVHEKRVREYKGHKQYEELLAEATKQASNH ENSCPOP00000013130/1-1438 DPQLEVHTKINTRGAREYHVQFFSNQPERAWVHEKRVREYKGHKQYEELLAEATKQASNH XP_004855408.1/1-1438 DPQLEVHTKINTRGAREYHVQFFSNQPERAWVHEKRVREYKGHKQYEELLAEATKQASNH ENSMUSP00000117778/1-1446 DPQLEVHSKINTRGAREYHVQFFSNQPERAWVHEKRVREYKGHEQYEELLAEAAKQASNH ENSRNOP00000060879/1-1396 DPQLEVHTKINTRGAREYHVQFFSNQPERAWVHEKRVREYKGHEQYEELLAEAAKQASNH *******:***********************************:*********:****** ENSP00000313983/1-1437 SEKQKIRKPRPQRERAQWDIGIAHAEKALKMTREERIEQYTFIYIDKQPEEALSQAKKSV ENSCPOP00000013130/1-1438 SEKQKIRKPRPQRERAQWDIGIAHAEKALKMTREERIEQYTFIYIDKQPEEALSQTKKNA XP_004855408.1/1-1438 SEKQKIRKPRPQRERAQWDIGIAHAEKALKMTREERIEQYTFIYIDKQPEEALSQTKKNP ENSMUSP00000117778/1-1446 SEKQKIRKPRPQRERAQWDIGIAHAEKALKMTREERVEQYTFIYIDKQPEEASSQAKKNV ENSRNOP00000060879/1-1396 SEKQKIRKPRPQRERAQWDIGIAHAEKALQMTREERVEQYTFIYIDKQPEESPSQAKKSV *****************************:******:**************: **:**. ENSP00000313983/1-1437 ASKTEVKKTRRPRSVLNTQPEQTNAGEVASSLSSTEIRRHSQRRHTSAEEEEPPPVKIAW ENSCPOP00000013130/1-1438 ASKTEVKKPRRPRSVLNAQPEQTNAGEVASSQSSSDLRRHSQRRHTSVEEEDSPPVKIAW XP_004855408.1/1-1438 ISKTEVKKPRRPRSVLHIQPEQTNSGEVASSQSSTDLRRHSQRRHTSVEEEEPPPVKIAW ENSMUSP00000117778/1-1446 TSKTEVKKPRRPRSVLNSQPEQTNAGEVASSQSSTDLRRQSQRRHTSLEEEEPPPVKIAW ENSRNOP00000060879/1-1396 TSKAEVKKPRRPRSVGNSQPEQTSAGEVASPQSSTDPRRQSQRRHTSVEEDGPPPVKIAW **:****.****** : *****.:*****. **:: **:******* **: .******* ENSP00000313983/1-1437 KTAAARKSLPASITMHKGSLDLQKCNMSPVVKIEQVFALQNATGDGKFIDQFVYSTKGIG ENSCPOP00000013130/1-1438 KTAAARKSLPASITMHKGSLDLQKCNMSPVVKIEQVFALQNATGDGKFIDQFVYSTKGIG XP_004855408.1/1-1438 KTAAARKSLPASITMHKGSLDLQKCNMSPVVKIEQVFALQNATGDGKFIDQFVYSTKGIG ENSMUSP00000117778/1-1446 KTAAARKSLPASITMHKGSLDLQKCNMSPVVKIEQVFALQNATGDGKFIDQFVYSTKGIG ENSRNOP00000060879/1-1396 RTAAARKSLPASITMHKGSLDLHKCNMSPVVKIEQVFALQNATGDGKFIDQFVYSTKGIG :*********************:************************************* ENSP00000313983/1-1437 NKTEISVRGQDRLIISTPNQRNEKPTQSVSSPEATSGSTGSVEKKQQRRSIRTRSESEKS ENSCPOP00000013130/1-1438 NKTEISVRGQDRLIISSPNQRSEKPTQNVSSPEATSGPTGSVEKKQQRRSIRTRSESEKS XP_004855408.1/1-1438 NKTEISVRGQDRLIISSPNQRNEKPTQNISSPEATSGPTGSVEKKQQRRSIRTRSESEKS ENSMUSP00000117778/1-1446 NKTEISVRGQDRLIISSPSQRSEKPAQSASSPEATSGSAGPVEKKQQRRSIRTRSESEKS ENSRNOP00000060879/1-1396 NKTEISVRGQDRLIISSPSQRNEKSTPSASPPEATSGSAGPVEKKQQRRSIRTRSESEKS ****************:*.**.**.: . *.******.:*.******************* ENSP00000313983/1-1437 TEVVPKKKIKKEQVETVPQATVKTGLQKGASEISDSCKPLKKRSRASTDVEMTSSAYRDT ENSCPOP00000013130/1-1438 SEAVPKKKIKKEQVETVPQATVKTGLQKGASEISDSCKPLKKRSRASTDVEMTSSAYRDA XP_004855408.1/1-1438 AEAVPKKKIKKEQVETVPQATVKIGLQKGASEISDSCKPLKKRSRASTDVEMTGSAYRDT ENSMUSP00000117778/1-1446 AEVVPKKKIKKEQVETAPQASLKTGLQKGASEISDSCKPLKKRSRASTDVETASCTYRDT ENSRNOP00000060879/1-1396 TEVVSKKKIKKEQVETSPQASLKTGLQKGASEISDSCKPLKKRSRASTDVETASCTYRDT :*.*.*********** ***::* *************************** :..:***: ENSP00000313983/1-1437 SDSDSRGLSDLQVGFGKQVDSPSATADADVSDVQSMDSSLSRRGTGMSKKDTVCQICESS ENSCPOP00000013130/1-1438 SDSDSRGLSDLQVGFGKQVDSPSAAADADVSDVQSMDSSLSRRGIGMSRKDTVCQICESS XP_004855408.1/1-1438 SDSDSRGLSDLQVGFGKQIDSPSAAADADISDVQSMDSSLSRRGIGMSRKDTVCQICERS ENSMUSP00000117778/1-1446 SDSDSRGLSDGQVGFGKQVDSPSATADADASDAQSVDSSLSRRGVGTSKKDTVCQVCEKA ENSRNOP00000060879/1-1396 SDSDSRGPSDGQVGFGKQVDSPSAAADADASDAQSVDSSLSRRGVGLSKKDTVCQVCENT ******* ** *******:*****:**** **.**:******** * *:******:** : ENSP00000313983/1-1437 GDSLIPCEGECCKHFHLECLGLASLPDSKFICMECKTGQHPCFSCKVSGKDVKRCSVGAC ENSCPOP00000013130/1-1438 GDSLVPCEGECYRYFHLECLGWTSVPDGKFTCMECKTGQHPCFSCKVPGEDVKRCSVGAC XP_004855408.1/1-1438 GDSLVPCEGECCKHFHLECLGLTSVPDGKFMCRECKTGQHPCFSCKVPGKDVKRCSVGAC ENSMUSP00000117778/1-1446 GDCLVACEGECCRHFHVECLGLTAVPEGHFTCEECETGQHPCFSCKVSGKDVKRCSVSVC ENSRNOP00000060879/1-1396 GDSLVACEGECCRHFHPECLGLAAVPEGRFTCEECETGQHPCFSCKVSGKDVKRCSVSVC **.*:.***** ::** **** :::*:.:* * **:***********.*:*******..* ENSP00000313983/1-1437 GKFYHEACVRKFPTAIFESKGFRCPQHCCSACSMEKDIHKASKGRMMRCLRCPVAYHSGD ENSCPOP00000013130/1-1438 GKFYHEACVRKFSTAIFESKGFRCPQHCCSACSMEKDIHKASKGRMMRCLRCPVAYHSAD XP_004855408.1/1-1438 GKFYHEACVRKFSTAIFESKGFRCPQHCCSACSMEKDIYKASKGRMMRCLRCPVAYHSAD ENSMUSP00000117778/1-1446 GKFYHEACVRKFPTAIFESKGFRCPQHCCSSCSMEKDIHKASKGRMMRCLRCPVAYHVGD ENSRNOP00000060879/1-1396 GKFYHEACVRKFPTAIFESKGFRCPQHCCSSCSMEKDIHKASKGRMMKCLRCPIAYHFGD ************.*****************:*******:********:*****:*** .* ENSP00000313983/1-1437 ACIAAGSMLVSSYILICSNHSKRSSNS-SAVNVGFCFVCARGLIVQDHSDPMFSSYAYKS ENSCPOP00000013130/1-1438 ACIAAGSMFVSSYILICSDHSKRSNNSAAAVNVGFCFVCARGLIVQDHSDPMFSSYAYKS XP_004855408.1/1-1438 ACIAAGSLFVSSYILICSNHSKRSSNSSSAVNVGFCFVCARGLIVQDHSDPMFSSYAYKS ENSMUSP00000117778/1-1446 ACVAAGSVSVSSHILICSNHSKRSSQS-AAINVGFCFVCARGLIVQDHSDPMFSSYAYKS ENSRNOP00000060879/1-1396 ACVAAGSVSVSSHILICSNHSKRSSHS-AAINVGFCFVCARG------------------ **:****: ***:*****:*****.:* :*:*********** ENSP00000313983/1-1437 HYLLNESNRAELMKLPMIPSSSASKKKCEKGGRLLCCESCPASFHPECLSIEMPEGCWNC ENSCPOP00000013130/1-1438 HYLLNESNRAELMKLPMIPSSSASKKKCEKGGRLLCCESCPASFHPECLNIDTPEGCWNC XP_004855408.1/1-1438 HYLLNESNRAELMKLPMIPSSSASKKKCEKGGRLLCCESCPASFHPECLNIDTPEGRWNC ENSMUSP00000117778/1-1446 HYLLSESNRAELMKLPMIPSSSASKKRCEKGGRLLCCESCPASFHPECLSIDMPEGCWNC ENSRNOP00000060879/1-1396 -------------------------------GRLLCCESCPASFHPECLSIDMPEGCWNC ******************.*: *** *** ENSP00000313983/1-1437 NDCKAGKKLHYKQIVWVKLGNYR--------WWPAEICNPRSVPLNIQGLKHDLGDFPVF ENSCPOP00000013130/1-1438 NDCKAGKKLHYKQIVWVKLGNYR--------WWPAEICNPRSVPLNIQSLKHDLGDFPVF XP_004855408.1/1-1438 NDCKAGKKLHYKQIVWVKLGNYR--------WWPAEICNPRSVPLNIQGLKHDLGDFPVF ENSMUSP00000117778/1-1446 NDCKAGKKLHYKQIVWVKLGNYR--------WWPAEICSPRSVPLNIQGLKHDLGDFPVF ENSRNOP00000060879/1-1396 NDCKAGKKLHYKQIVWVKLGNYRQVSQADRKWWPAETCSPRSVPLNIQGLKHGVGDFPVL *********************** ***** *.*********.***.:*****: ENSP00000313983/1-1437 FFGSHDYYWVHQGRVFPYVEGDKSFAEGQTSINKTFKKALEEAAKRFQELKAQRESKEAL ENSCPOP00000013130/1-1438 FFGSHDYYWVHQGRVFPYVEGDKSFAEGQTSINKTFKKALEEAAKRFQELKAQRESKEAL XP_004855408.1/1-1438 FFGSHDYYWVHQGRVFPYVEGDKSFAEGQTSINKTFKKALEEAAKRFQELKAQRESKEAL ENSMUSP00000117778/1-1446 FFGSHDYYWVHQGRVFPYVEGDKHFAEGQTSINKTFKKALEEAAKRFQELKAQRESKEAL ENSRNOP00000060879/1-1396 FFGSHDYYWVHQGRVFPYVEGDTNFAEGQTSINKTFKKALEEAAKRFQELKAQRESKEAL **********************. ************************************ ENSP00000313983/1-1437 EIEKNSRKPPPYKHIKANKVIGKVQIQVADLSEIPRCNCKPADENPCGLESECLNRMLQY ENSCPOP00000013130/1-1438 EVEKNSRKPPPYKHIKANKVIGKVQIHVADLSEIPRCNCKPADENPCGLESECLNRMLQY XP_004855408.1/1-1438 EVEKNSRKPPPYKHIKANKVIGKVQIHVADLSEIPRCNCKPADENPCGLESECLNRMLQY ENSMUSP00000117778/1-1446 EMERTSRKPPPYKHIKANKVIGKVQVQVADLSEIPRCNCKPGDENPCGLESQCLNRMSQY ENSRNOP00000060879/1-1396 EIEKTSRKPPPYKHIKANKVIGKVQIQVADLSEIPRCNCKPGDENPCGLESECLNRMSQY *:*:.********************::**************.*********:***** ** ENSP00000313983/1-1437 ECHPQVCPAGDRCQNQCFTKRLYPDAEIIKTERRGWGLRTKRSIKKGEFVNEYVGELIDE ENSCPOP00000013130/1-1438 ECHPQVCPAGDRCQNQCFTKRLYPDAEIIKTERRGWGLRTKRSIKKGEFVNEYVGELIDE XP_004855408.1/1-1438 ECHPQVCPAGDRCQNQCFTKRLYPDAEIIKTERRGWGLRTKRSIKKGEFVNEYVGELIDE ENSMUSP00000117778/1-1446 ECHPQVCPAGDRCQNQCFTKRLYPDAEVIKTERRGWGLRTKRSIKKGEFVNEYVGELIDE ENSRNOP00000060879/1-1396 ECHPQVCPAGDRCQNQCFTKRLYPDAEIIKTERRGWGLRTKRSIKKGEFVNEYVGELIDE ***************************:******************************** ENSP00000313983/1-1437 EECRLRIKRAHENSVTNFYMLTVTKDRIIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDV ENSCPOP00000013130/1-1438 EECRLRIKRAHENSVTNFYMLTVTKDRIIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDV XP_004855408.1/1-1438 EECRLRIKRAHENSVTNFYMLTVTKDRIIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDV ENSMUSP00000117778/1-1446 EECRLRIKRAHENSVTNFYMLTVTKDRIIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDV ENSRNOP00000060879/1-1396 EECRLRIKRAHENSVTNFYMLTVTKDRIIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDV ************************************************************ ENSP00000313983/1-1437 RVGLFALCDIPAGMELTFNYNLDCLGNGRTECHCGADNCSGFLGVRPKSACASTNEEKAK ENSCPOP00000013130/1-1438 RVGLFALCDIPAGMELTFNYNLDCLGNGRTECHCGADNCSGFLGVRPKAACAATAEEKAK XP_004855408.1/1-1438 RVGLFALCDIPAGMELTFNYNLDCLGNGRTECHCGADNCSGFLGVRPKSACASTAEEKAK ENSMUSP00000117778/1-1446 RVGLFALCDIPAGMELTFNYNLDCLGNGRTVCHCGADNCSGFLGVRPKSACTSAVDEKTK ENSRNOP00000060879/1-1396 RVGLFALCDIPAGMELTFNYNLDCLGNGRTVCHCGADNCSGFLGVRPKSACTSAADEKTK ****************************** *****************:**::: :**:* ENSP00000313983/1-1437 NAKLKQKRRKIKTEPKQMHEDYCFQCGDGGELVMCDKKDCPKAYHLLCLNLTQPPYGKWE ENSCPOP00000013130/1-1438 NAKLKQKRRKVKTEPKQMHEDYCFQCGDGGELVMCDKKDCPKAYHLLCLNLTQPPYGKWE XP_004855408.1/1-1438 NAKLKQKRRKIKTEPKQMHEDYCFQCGDGGELVMCDKKDCPKAYHLLCLNLTQPPYGKWE ENSMUSP00000117778/1-1446 NAKLK-KRRKVKAEAKPIHEDYCFQCGDGGELVMCDKKDCPKAYHLLCLNLTQPPHGKWE ENSRNOP00000060879/1-1396 NAKLK-KRRRGKAEAKQIHEDYCFQCGDGGELVMCDKKDCPKAYHLLCLNLTQPPYGKWE ***** ***: *:*.* :*************************************:**** ENSP00000313983/1-1437 CPWHQCDECSSAAVSFCEFCPHSFCKDHEKGALVPSALEGRLCCSEHDPMAPVSPEYWSK ENSCPOP00000013130/1-1438 CPWHQCNMCSSAAVSFCEFCPHSFCKDHGKGALVASALEGRLCCSEHDPVCPVSPEYWSK XP_004855408.1/1-1438 CPWHQCDACSSAAVSFCEFCPRSFCKDHGKGALVASALEGRLCCSEHDPLSPVSPEYWSK ENSMUSP00000117778/1-1446 CPWHRCDECGSVAVSFCEFCPHSFCKAHGKGALVPSALEGRLCCSSHDPASPVSPEYWSK ENSRNOP00000060879/1-1396 CPWHQCDECGSAAISFCEFCPHSFCKAHEKGALVPSALEGRLCCSNHDPASPVSPEYWSK ****:*: *.*.*:*******:**** * *****.**********.*** .********* ENSP00000313983/1-1437 IKCKWESQDHGEEVKE ENSCPOP00000013130/1-1438 IKCKWESQDRGEEAQE XP_004855408.1/1-1438 VRCKWESQDRKEEAKE ENSMUSP00000117778/1-1446 IRCKWESQDSGEEVKE ENSRNOP00000060879/1-1396 MRCKWESQDGGEEVKE ::******* **.:*