CLUSTAL W(1.81) multiple sequence alignment ENSP00000399797/1-1003 ------------------------------------------------------------ ENSMUSP00000126897/1-1077 MSGALPFALQLFYVPRLWRVGVGVALAEAPRSSGLFRGPQAISTFGSWLAARGGSSGFIS ENSRNOP00000018061/1-1004 ------------------------------------------------------------ ENSCPOP00000013099/1-1031 --------------------------------------------------AAAATFSFIS XP_004853800.1/1-1034 ----------------------------------------MRRGGGDRTERPQGRLSFIS ENSP00000399797/1-1003 -------------MPSKFSCRQLREAGQCFESFLVVRGLDMETDRERLRTIYNRDFKISF ENSMUSP00000126897/1-1077 ADPPAWAAAAAAAMPSKFSCRKLRETGQRFESFLAERGLDLETDRERLRTIYNHDFKPSY ENSRNOP00000018061/1-1004 -------------MPSKFSCRKLRETGQGFESFLAERGLDLETDRERLRAIYNRDFKPSY ENSCPOP00000013099/1-1031 TEFSPWATAAAA-MPNKFSRRQLRETGQHFQSFLLARGLDTETDRERLRTIYNRDFKTSS XP_004853800.1/1-1034 TDPPAWAAAAAA-MPSKFSRRQLRETGQDFQSFLLDRGLDKETDRELLRTIYNRDFKASS **.*** *:***:** *:*** **** ***** **:***:*** * ENSP00000399797/1-1003 GTPAPGFSSMLYGMKIANLAYVTKTRVRFFRLDRWADVRFPEKRRMKLGSDISKHHKSLL ENSMUSP00000126897/1-1077 GTPAPGFSSMLYGMKIANLAFVTKTRVRFFKLDRWADVQLPEKRRIKPGSNISKQHRSLL ENSRNOP00000018061/1-1004 GTPAPGFSSMLYGMKIANLAFVTKTRVRFFKLDRWADVQLPEKRRIKPGSSISKQHRSLL ENSCPOP00000013099/1-1031 GTPTPGFSSMLYGMKIANLAYVSKTQVRFFSLDRWADVQLPEKRKMKLGSDISKHHKSLL XP_004853800.1/1-1034 RTPTPGFSSVLYGMKIANLAFVSKTQVRFFSLDRWADVEFPEKRKVKLGSDISKHHKSLL **:*****:**********:*:**:**** *******.:****::* **.***:*:*** ENSP00000399797/1-1003 AKIFYD--RAEYLHGKHGVDVEVQGPHEARDGQLLIRLDLNRKEVLTLRLRNGGTQSVTL ENSMUSP00000126897/1-1077 ARIFHD--RAEYLHGKHGVDVEVQGPHEARDGQLLIHLDLNRKEVLTLRLRNGGSKPVTL ENSRNOP00000018061/1-1004 ARIFHD--RAEYLHGKHGVDVEVQGPHEARDGQLLIRLDLNRKEVLTLRLRNGGTKPVTL ENSCPOP00000013099/1-1031 ATIFYDRLRAQYLHGKHGVDVEVQGPHETQDGQLLIHLDLNHKEVLTLRLRNGGTKPVTL XP_004853800.1/1-1034 ATIFYD--RAQYLHGKHGVDVEVQGPHETRDGQLLIHLDLNHKEELTLRLRNGGTKPVTL * **:* **:*****************::******:****:** *********::.*** ENSP00000399797/1-1003 THLFPLCRTPQFAFYNEDQELPCPLGPGECYELHVHCKTSFVGYFPATVLWELLGPGESG ENSMUSP00000126897/1-1077 THLFPLCWTPQFVFYHGEQDLPCPLGPGESYELHIYCKTSIVGYFPATVLWELLGPGESG ENSRNOP00000018061/1-1004 THLFPLCWTPQFVFYHGEQDLPCPLGPGESYELHVYCKTSIVGYFPATVLWELLGPGESG ENSCPOP00000013099/1-1031 THLFPLCWTPQFTFYN-DQELPCPLDPGECYELQVHCKTNLVGYFPATVLWELLGPAESD XP_004853800.1/1-1034 THLFPLCWTPQFAFYD-DQELPCPLGPGECYELQIHCKTNFVGYFPATVLWELLGPGESD ******* ****.**. :*:*****.***.***:::***.:***************.**. ENSP00000399797/1-1003 SEGAGTFYIARFLAAVAHSPLAAQLKPMTPFKR-TRITGNPVVTNRIEEGERPDRAKGYD ENSMUSP00000126897/1-1077 AEGAETFYIARFLAAVAHSPLAAQLKPTTPFKRPPRLTRNSVLTNRIEEGERPDRAKGYE ENSRNOP00000018061/1-1004 AEGAETFYIARFLAAVAHSPLAAQLKPTTPFKRPPRLTRNPVSTNRIEEGERPDRAKGYE ENSCPOP00000013099/1-1031 SEGAGTFYIARFLAAVAHSPLATQLKPTTPFKR-SQITRNSVATNQIEEGERPDGAKDYD XP_004853800.1/1-1034 SEGAGTFYIARFLAAVAHSPMATQLKPTAPYKR-IQITRNTMVTNRIEEGERPDRAKGYD :*** ***************:*:**** :*:** ::* *.: **:******** **.*: ENSP00000399797/1-1003 LELSMALGTYYPPPRLRQLLPMLLQGTSIFTAPKEIAEIKAQLETALKWRNYEVKLRLLL ENSMUSP00000126897/1-1077 LELSLALGTYYPPILLRQLLPTLLQGPSIFTAPKEVAEIKAQLETTLKSRNYEVKLRLLL ENSRNOP00000018061/1-1004 LELSLALGTYYPPIRLRQLLPTLLQGPSIFTSPKEVAEIKAQLETTLKSRNYEVKLRLLL ENSCPOP00000013099/1-1031 LELTMPLETYHPPHRLRQLLPVLLQRSNTFAAPKEIAEIKAKLDTSLKWKNYELKFRLLL XP_004853800.1/1-1034 LELSMVLGSYHPPPRLRQLLPILLQRTSTFTAPKEIAEIKAKLETSLKWKNYEVKLRLLL ***:: * :*:** ****** *** .. *::***:*****:*:*:** :***:*:**** ENSP00000399797/1-1003 HLEELQMEHDIRHYDLESVPMTWDPVDQNPRLLTLEVPGVTESRPSVLRGDHLFALLSSE ENSMUSP00000126897/1-1077 HLEELQMEHDIRHYDLDSVPMTWDPVDQNPRLLTLEVPGVAESRPSVLRGDHLFALLSSE ENSRNOP00000018061/1-1004 HLEELQMEHDIRHYDLESVPMTWDPVDQNPRLLTLEVPGVTESRPSVLRGDHLFALLSSE ENSCPOP00000013099/1-1031 HLEELQMEHDIRHYDLESVPMIWDPSAWNPRLLTLQVPGVAESRPSVLRGDHLFALLSSE XP_004853800.1/1-1034 HLEELQMEHDIRHYDLESVPMTWDPTAWNPRLLTLEVPGVTESRPSVLRGDHLFAVLSSE ****************:**** *** *******:****:**************:**** ENSP00000399797/1-1003 THQEDPITYKGFVHKVELDRVKLSFSM-----SLLSRFVDGLTFKVNFTFNRQPLRVQHR ENSMUSP00000126897/1-1077 TQQDDPVTYKGFVHKVELDRVKLSFST-----SLLSRFVDGLTFKVNFTFNRQPLRVQHR ENSRNOP00000018061/1-1004 IQQEDPVTYKGFVHKVELDRVKLSFSP-----SLLSRFVDGLTFKVNFTFNRQPLRVQHR ENSCPOP00000013099/1-1031 AHQENPITYKGFVHKVELDCVKLSFPTILPVQSLLNRFVDGLTFKVNFTFNRQPLRVQHR XP_004853800.1/1-1034 THQENPVTYKGFVHKVELDCVKLSFST-----SLLDRFVDGLTFKVNFTFNRQPLRVQHR :*::*:************ *****. ***.************************ ENSP00000399797/1-1003 ALELTGRWLLWPMLFPVAPRDVPLLPSDVKLKLYDRSLESNPEQLQAMRHIVTGTTRPAP ENSMUSP00000126897/1-1077 ALELTGRWVLWPMLFPVASRGVSLLPSDVKFKLYDRSLESNPEQLQAMKHIVRGTTRPAP ENSRNOP00000018061/1-1004 ALELTGRWVLWPTLFPVASRGVSLLPSDVKFKLYDRSLESNPEQLQAMKHIVRGTTRPAP ENSCPOP00000013099/1-1031 ALELTRRWPLGPLLFPVASRGIPLLPSDVKLKLFDRSLESNPEQMQAMKHIVRGTTRPAP XP_004853800.1/1-1034 ALELTGRWPLGPMLFPVASRGVPLLPSDVKLKLFDRSLESNPEQLQAMKHIVMGTTRPAP ***** ** * * *****.*.:.*******:**:**********:***:*** ******* ENSP00000399797/1-1003 YIIFGPPGTGKTVTLVEAIKQVVKHLPKAHILACAPSNSGADLLCQRLRVHLPSSIYRLL ENSMUSP00000126897/1-1077 YIIFGPPGTGKTVTLVEAIKQVVKHLPKAHILACAPSNSGADLLCQRLRVHLPSSIYRLL ENSRNOP00000018061/1-1004 YIIFGPPGTGKTVTLVEAIKQVVKHLPKAHILACTPSNSGADLLCQRLRVHLPSSIYRLL ENSCPOP00000013099/1-1031 YIIFGPPGTGKTVTLVEAIKQVVKHLPKAHILACAPSNSGADLLCQRLRVHLPSSIYRLL XP_004853800.1/1-1034 YIIFGPPGTGKTITLVEAIKQVVKHLPKAHILACTPSNSSADLLCQRLRVHLPSSIYRLL ************:*********************:****.******************** ENSP00000399797/1-1003 APSRDIRMVPEDIKPCCNWDAKKGEYVFPAKKKLQEYRVLITTLITAGRLVSAQFPIDHF ENSMUSP00000126897/1-1077 APSRDIRMVPEDIKTCCNWDAKKGEYVYPAKKHLQQYRVLITTLITASRLVSAQFPIDHF ENSRNOP00000018061/1-1004 APSRDIRMVPEDIKTCCNWDPKKGEYVYPAKKHLQQYRVLITTLITASRLVSAQFPIDHF ENSCPOP00000013099/1-1031 APSRDIRMVPEDIKPCCNWDANKGEYVFPAKKQLQEYRVLITTLITASRLVSAEFPVDHF XP_004853800.1/1-1034 APSRDIRMVPEDIKHCCNWDPKKGEYVFPAKKQLQEYRVLITTLITASRLVSAQFPIDHF ************** *****.:*****:****:**:***********.*****:**:*** ENSP00000399797/1-1003 THIFIDEAGHCMEPESLVAIAGLMEVKETGDPGGQLVLAGDPRQLGPVLRSPLTQKHGLG ENSMUSP00000126897/1-1077 THIFIDEAGHCMEPESLVAIAGLMDVKETGNPGGQLVLAGDPRQLGPVLRSPLALKHGLG ENSRNOP00000018061/1-1004 THIFIDEAGHCMEPESLVAIAGLMDVKETGNPGGQLVLAGDPRQLGPVLRSPLAQKHGLG ENSCPOP00000013099/1-1031 THIFIDEAGHCMEPESLVAIAGLIEVKGTGDPGGQLVLAGDPRQLGPVLRSPLTQKHGLG XP_004853800.1/1-1034 THVFIDEAGHCMEPESLVAIAGLMETKETGNPGGQLVLAGDPRQLGPVLRSPLAQKHGLG **:********************::.* **:**********************: ***** ENSP00000399797/1-1003 YSLLERLLTYNSLYKKGPDGYDPQFITKLLRNYRSHPTILDIPNQLYYEGELQACADVVD ENSMUSP00000126897/1-1077 YSLLERLLAYNSLYKKGPNGYDPQFITKLLRNYRSHPTILDIPNQLYYDGELQACADVVD ENSRNOP00000018061/1-1004 YSLLERLLTYNSLYKKGPNGYDPQFITKLLRNYRSHPTILDIPNQLYYDGELQACADVVD ENSCPOP00000013099/1-1031 YSLLERLLTFNTLYKKGPTGYNPQFITKLLRNYRSHPTILDIPNRLYYDGELQACADVVD XP_004853800.1/1-1034 YSLLERLLTYNTLYKKGPNGYNPQFITKLLRNYRSHPTILDIPNQLYYDGELQACADMMD ********::*:****** **:**********************:***:********::* ENSP00000399797/1-1003 RERFCRWAGLPRQGFPIIFHGVMGKDEREGNSPSFFNPEEAATVTSYLKLLLAPSSKKGK ENSMUSP00000126897/1-1077 RERFCRWEGLPQQGFPIIFHGVMGKDEREGNSPSFFNPEEAATVTSYLKQLLAPSSKKGK ENSRNOP00000018061/1-1004 RERFCRWEGLPQQGFPIIFHGVMGKDEREGNSPSFFNPEEAATVTSYLRQLLAPSSKKGK ENSCPOP00000013099/1-1031 RERFCHWEGLPRKGFPIIFHGVMGKDEREGNSPSFFNPEEAATVTSYLKLLLAPSSKKGK XP_004853800.1/1-1034 RERFCCWEGLPRKGFPIIFHGVMGKDEREGNSPSFFNPEEAATVTSYLKLLLAPSSKKGK ***** * ***::***********************************: ********** ENSP00000399797/1-1003 ARLSPRSVGVISPYRKQVEKIRYCITKLDRELRGLDDIKDLKVGSVEEFQGQERSVILIS ENSMUSP00000126897/1-1077 ARLSPRNVGVISPYRKQVEKIRYCITKLDRELRGLDDIKDLKVGSVEEFQGQERSVILIS ENSRNOP00000018061/1-1004 ARLSPRSVGVISPYRKQVEKIRYCITKLDRELRGLDDIKDLKVGSVEEFQGQERSVILIS ENSCPOP00000013099/1-1031 ARVSPRSVGVISPYRKQVEKIRYCITKLDKELRGLDDIKDLKVGSVEEFQGQERSIILIS XP_004853800.1/1-1034 SRLSPRSVGVISPYRKQVEKIRYCITKLDKELRGLDDIKDLKVGSVEEFQGQERSIILIS :*:***.**********************:*************************:**** ENSP00000399797/1-1003 TVRSSQSFVQLDLDFNLGFLKNPKRFNVAVTRAKALLIIVGNPLLLGHDPDWKVFLEFCK ENSMUSP00000126897/1-1077 TVRSSQSFVQLDLDFNLGFLKNPKRFNVAVTRAKALLIVVGNPLLLGHDPDWKTFLEFCK ENSRNOP00000018061/1-1004 TVRSSQSFVQLDLDFNLGFLKNPKRFNVAVTRAKALLIVVGNPLLLGHDPDWKTFLEFCK ENSCPOP00000013099/1-1031 TVRSSQSFVQLDLDFNLGFLKNPKRFNVAVTRAKALLIVVGNPLLLGHDPDWKAFIEFCK XP_004853800.1/1-1034 TVRSSQSFVQLDLDFNLGFLKNPKRFNVAVTRAKALLIVVGNPLLLGHDPDWKAFLEFCK **************************************:**************.*:**** ENSP00000399797/1-1003 ENGGYTGCPFPAKLDLQQGQNLLQGLSKLSPSTSGPHSHDYLPQEREGEGGLSLQVEPEW ENSMUSP00000126897/1-1077 ENGGYTGCPFPAKLDLQQGQDLLQGLSKLSPSTSGPRRHQNLPQEREGEGGLPLQVEPEW ENSRNOP00000018061/1-1004 ENGGYTGCPFPAKLDLQQGQDLLQGLSKLSPSTSGPRRHQRLPQEREGEEGLPLQVEPEW ENSCPOP00000013099/1-1031 ENGGYTGCPFPAKLDLQQGYNLLQNLSKLSSSTSGACGQDCLPQEQDSEGCLSLQVEPEW XP_004853800.1/1-1034 ENGGYTGCPFPTKLDLQEGQNLLQSLSKLSSSTSGPCGRDCLAQEQEGEGHLSLQVEPEW ***********:*****:* :***.*****.****. :: *.**::.* *.******* ENSP00000399797/1-1003 RNEL ENSMUSP00000126897/1-1077 RNEL ENSRNOP00000018061/1-1004 RNEL ENSCPOP00000013099/1-1031 RNEL XP_004853800.1/1-1034 RNEL ****