CLUSTAL W(1.81) multiple sequence alignment ENSMUSP00000121032/1-1369 MAAAAASGAGGVAVAGAGGAGPAGRLLPPPAAGPPAAPAAVPPAAVPARPTAPASRGSMA ENSRNOP00000067534/1-1366 MAAAAASGAGGVAVAGAGGAGPAGRLLPPPAAGPPAAPAAVPPAC-PPRPTAPASQ--MA XP_004856707.1/1-1265 ----------------------------------------------------------MP ENSCPOP00000013014/1-1282 ------------------------------------------------------------ ENSP00000391295/1-1363 ------XGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMP ENSMUSP00000121032/1-1369 ARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKSQLDEENLKKIFREVQIMKML ENSRNOP00000067534/1-1366 ARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKML XP_004856707.1/1-1265 ARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKSQLDEENLKKIFREVQIMKML ENSCPOP00000013014/1-1282 -------------MGFLGVIYFKTDLLFLSKVAIKIIDKSQLDEENLKKIFREVQIMKML ENSP00000391295/1-1363 ARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKML * :.*: *.*: :*********:******************** ENSMUSP00000121032/1-1369 CHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCH ENSRNOP00000067534/1-1366 CHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCH XP_004856707.1/1-1265 CHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCH ENSCPOP00000013014/1-1282 CHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCH ENSP00000391295/1-1363 CHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCH ************************************************************ ENSMUSP00000121032/1-1369 CRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYD ENSRNOP00000067534/1-1366 CRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYD XP_004856707.1/1-1265 CRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYD ENSCPOP00000013014/1-1282 CRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYD ENSP00000391295/1-1363 CRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYD ************************************************************ ENSMUSP00000121032/1-1369 GPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVL ENSRNOP00000067534/1-1366 GPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVL XP_004856707.1/1-1265 GPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVL ENSCPOP00000013014/1-1282 GPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVL ENSP00000391295/1-1363 GPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVL ************************************************************ ENSMUSP00000121032/1-1369 DPNKRLSMEQICRHKWMKLGDADPNFDRLIAECQQLKEERQSDPLNDDVLLAMEDMGLDK ENSRNOP00000067534/1-1366 DPNKRLSMEQICRHRWMKLGDADPNFERLIAECQQLKEERQAEPLNDEVLLAMEDMGLDK XP_004856707.1/1-1265 DPNKRLSMEQICRHKWMKLGDADPNFDRLIAECQQLKEERQTDPLNEDVLLAMEDMGLDK ENSCPOP00000013014/1-1282 DPSKRLSMEQICKHKWMKLGDDDPNFDRLIAECQQLKEDRQTDPLNEDVLLAMEDMGLDK ENSP00000391295/1-1363 DPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDK **.*********:*:****** ****:***********:** :***::************ ENSMUSP00000121032/1-1369 ERTLQSLRSDAYDHYSAIYSLLCDRHKKHKTLRPGALPSMPQAMTFQAPVNLQAEQTGTA ENSRNOP00000067534/1-1366 ERTLQSLRSDAYDHYSAIYSLLCDRHKKNKTLRPGALPSTPQAMTFQAPVNIQAEQTGTA XP_004856707.1/1-1265 ERTL------------------------------------------------QAEQAGTA ENSCPOP00000013014/1-1282 ERTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRAMAFQAPVNIQAEQAGTA ENSP00000391295/1-1363 EQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTA *:** ****:*** ENSMUSP00000121032/1-1369 MNLSVPQVQLINPENQIIEPDGAVNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVM ENSRNOP00000067534/1-1366 MNISVPQVQLINPENQIIEPDGAVNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVM XP_004856707.1/1-1265 MSISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVM ENSCPOP00000013014/1-1282 MNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVM ENSP00000391295/1-1363 MNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVM *.:**************:****::************************************ ENSMUSP00000121032/1-1369 EDLQKLLPGFPGVNPQGPFLQVAPNMNFTHNLLPMQSLQPTGQLEYKEQSLLQPPTLQLL ENSRNOP00000067534/1-1366 DEMQKLLPGFPGANPQTPFLQVAPNMNFMHNLLPMQSLQPTGQLEYKEQSLLQPPTLQLL XP_004856707.1/1-1265 EDLQKLLPGFPGVNPQAPFLQVAPNMNLMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLL ENSCPOP00000013014/1-1282 EDLQKLLPGFPGVNPQAPFLQVAPNVNLMHNLLPMQNLQPTGPLEYKEQSLLQPPTLQLL ENSP00000391295/1-1363 EDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLL :::*********.*** ********:*: *******.***** ***************** ENSMUSP00000121032/1-1369 NGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEA ENSRNOP00000067534/1-1366 NGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEA XP_004856707.1/1-1265 NGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEA ENSCPOP00000013014/1-1282 NGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEA ENSP00000391295/1-1363 NGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEA ************************************************************ ENSMUSP00000121032/1-1369 VQRYLANRSKRHTLAMTSPTAEIPPDLQRQLGQQSFRSRVWPPHLVPDQHRSTYKDSNTL ENSRNOP00000067534/1-1366 VQRYLANRSKRHTLAMTSPTAEIPPDLQRQLGQQSFRSRVWPPHLVPDQHRSTYKDSNTL XP_004856707.1/1-1265 VQRYLANRSKRHTLAMTNPTAEIPPDLQRQLGQQPFRSRVWPSHLVPDQHRSTYKDSNTL ENSCPOP00000013014/1-1282 VQRYLANRSKRHTLAMTNPTAEIPPDLQRQLGQQPFRARVWPPHLAPDQHRSTYKDSNTL ENSP00000391295/1-1363 VQRYLANRSKRHTLAMTNPTAEIPPDLQRQLGQQPFRSRVWPPHLVPDQHRSTYKDSNTL *****************.****************.**:****.**.************** ENSMUSP00000121032/1-1369 HLPTERFSPVRRFSDGAASIQAFKAHLEKMGNSSSIKQLQQECEQLQKMYGGQVDERTLE ENSRNOP00000067534/1-1366 HLPTERFSPVRRFSDGAASIQAFKAHLERMGNSSSIKQLQQECEQLQKMYGGQVDERTLE XP_004856707.1/1-1265 HLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLE ENSCPOP00000013014/1-1282 HLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLE ENSP00000391295/1-1363 HLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLE ****************************:***.********************:****** ENSMUSP00000121032/1-1369 KTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQVACENQPALLTHQLQRLRIQPSSP ENSRNOP00000067534/1-1366 KTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPTLLTHQLQRLRIQPSSP XP_004856707.1/1-1265 KTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSP ENSCPOP00000013014/1-1282 KTQQQHMLYQQEQHHQILQQQIQDSLCPPQPSPPLQAACENQPALLTHQLQRLRIQPSSP ENSP00000391295/1-1363 KTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSP *************************:**********.******:**************** ENSMUSP00000121032/1-1369 PPNHPSNHLFRQPSNSPPPVSSAMITSHGATSPSQFQGLPSHGAIFQQQPENCSPPPSVA ENSRNOP00000067534/1-1366 PPNHPSNHLFRQPSNSPPPVSSAMISSHGATSPSQFQGLPSHGAIFQQQPENCSPPPSVA XP_004856707.1/1-1265 PPNHPNNHLFRQPSNSPPPMNSAMIQSHGAAASSQFQGLTSRSAVFQQQPENCSPPPNMA ENSCPOP00000013014/1-1282 PPNHPNNHLFRQPSNSPPPMNSAMIQSHGAAAPSQFQGLPSHSAIFQQQPENCSPPPSVA ENSP00000391295/1-1363 PPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVA *****.*************:.**** .***::.******.*:.*:*********.**.:* ENSMUSP00000121032/1-1369 LTCLGLQQASQSQPVTIQLQEPVDMLSNMAGTAAGSAGRSIPISPSASQIQIQHRASLMA ENSRNOP00000067534/1-1366 LTCLGLQQASQSQPVTIQLQEPVDMLSNMAGTTAGSAGRGIPISPSASQIQMQHRTSLMA XP_004856707.1/1-1265 LTCLGIQQPTQSQQVTIQVQEPVDLLSNLPVTAAGSAGRGISISPSANQIQMQHRTNLMA ENSCPOP00000013014/1-1282 LTCLGIQQPTQSQQVTIQVQEPVDLLSNMPGTAVGSTGRGISISPSANQIQMQHRSNLMA ENSP00000391295/1-1363 LTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMA *****:**.:*** ****:*****:***:. *:.**:**.*.*****.*:*:***:.*** ENSMUSP00000121032/1-1369 PFSYGHRPLSKQLSADSAEAHSLNMNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGV ENSRNOP00000067534/1-1366 PFGYGHRPLSKQLSADSAEAHSLSMNRFSPANYDQAHLHPHLFSEQSRGPPSSYSPSTGV XP_004856707.1/1-1265 NFSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSPGV ENSCPOP00000013014/1-1282 TFNYGHRPLSKQLSADNAEAHSLNVNRFSPANYDQPHLHPHLFSDQSQGSPSSYNPSPGV ENSP00000391295/1-1363 TLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGV :.*************.******.:**********.********:**:*.****.**.** ENSMUSP00000121032/1-1369 GFPPTQALKVPPLDQFPTFPPSAQQQPPHYTTSALQQALLSPTPPDYPRHQQVPHILQGL ENSRNOP00000067534/1-1366 GFPPAQALRVPPLDQFPTFPPSAHQQ-PHYTTSALQQALLSPTPPDYTRHQQVPHILQGL XP_004856707.1/1-1265 GFPPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGL ENSCPOP00000013014/1-1282 GFPPTQALKVPPLDQLPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGL ENSP00000391295/1-1363 GFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGL **.*:***:******:*******:** ********************.************ ENSMUSP00000121032/1-1369 LSPRHSLTGHSDIRLPPAEFAQLIKRQQQHR--QQQQQQQQQQEYHELFRHMNQGDAVSL ENSRNOP00000067534/1-1366 LSPRHSLTGHSDIRLPPAEFAQLIKRQQQHRQQQQQQQQQQQQEYHELFRHMNQGDAVSL XP_004856707.1/1-1265 LSPRHSLTGHSDIRLPPAEFAQLMKRQQQQR----QQQQQQQQEYQELFRHMNQGDGGSL ENSCPOP00000013014/1-1282 LSPRHSLTGHSDIRLPPAEFAQLIKK-----------------EYQELFRHMNQGDAGSV ENSP00000391295/1-1363 LSPRHSLTGHSDIRLPPTEFAQLIKRQQQQR--QQQQQQQQQQEYQELFRHMNQGDAGSL *****************:*****:*: **:**********. *: ENSMUSP00000121032/1-1369 APSLGGQNMTEQQALSYQNADSYHRHHTSPQHILQIRAQDCISQGPSPTPTHGYAHQPPL ENSRNOP00000067534/1-1366 APGLGGQNMTEHQALSYQNADSYHRHHTSPQHLLQIRAQDCISQGPLPTPTRGYARQSPL XP_004856707.1/1-1265 APNLGGQSMTEHQALSYQNADSYHHHHTSPQHLLQIRAQECISQVSSPAPTHRYAHQSTL ENSCPOP00000013014/1-1282 VPSLGGQSMTEHQALSYQRSDSYNHHHTSPQHLLQIRAQECISQVSSPAPAHGYAQQPAL ENSP00000391295/1-1363 APSLGGQSMTERQALSYQNADSYH-HHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPAL .*.****.***:******.:***: *******:******:*:** . *:*.: **:*..* ENSMUSP00000121032/1-1369 MHSESMEEDCLCEGLKEGFPD-KSSSTLTKGCHNSPLLLCTSGPGDPEPLLGTVSQAREL ENSRNOP00000067534/1-1366 MHSESMEEDCLCEGVKEGFAD-KSSSTLTKGCHDSPLLLCTSGPGDPEPLLGTVSQAREL XP_004856707.1/1-1265 VHSESMEEDCSCEGAKEGFLDSKSSSSLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQEL ENSCPOP00000013014/1-1282 MHSESMEEDCSCEGAKEGFLDSKSSSSLTKGCHNSPLLLSTGGPGDPESLLGTVSHAQEL ENSP00000391295/1-1363 MHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQEL :********* *** *:** * ****:******:*****.*.******.******:*:** ENSMUSP00000121032/1-1369 GIHPYGHQPTATTFSRNKVPSRESVLGNCLERSSPGQAMELPDHNGLGYPVRPLVSEHLR ENSRNOP00000067534/1-1366 GIHPYGHQPTATTFSRNKVPSRESVIGNCMERSSPGQAMELPDHNGLGYPARPLVSEHLR XP_004856707.1/1-1265 GIHPYGHQSTA-AFNRNKVPSRESVIGNCMDRSSPGQAMELPDHNGLGYPARPSVNEHHR ENSCPOP00000013014/1-1282 GIHPYGHQSTA-AFNRNKAPSRESVIGNCMDRSSPGQAMELPDHNGLGYPTRSSVNEHHR ENSP00000391295/1-1363 GIHPYGHQPTA-AFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHR ********.** :*.:**.****.*:***::*******:***********.*. * ** * ENSMUSP00000121032/1-1369 SRTLQRHHTIQNSDDAYVQLDTLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDEED ENSRNOP00000067534/1-1366 SRTLQRHHTIQNSDDAYVQLDTLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDEED XP_004856707.1/1-1265 SRTLQRHHTIQSSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGEN ENSCPOP00000013014/1-1282 PRTLQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLTGSQQFQDGES ENSP00000391295/1-1363 PRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGEN .*:********.*********.*************************** ******* *. ENSMUSP00000121032/1-1369 EECGVSL-GHEHPGLGDGSQHLNSSRYPATC-VTDIMLSHKHPEV--SFSMEQAGV ENSRNOP00000067534/1-1366 EECGVSL-GHEHPALGDGSQHLN-SRYPATC-VTDIMLNHKHPEV--SFSMEQAGV XP_004856707.1/1-1265 EGKRPYSWGPQRSSWGDSLCLCQGPCTSSMAKIPGEADRTQRPPLMREYAGGMASA ENSCPOP00000013014/1-1282 EECGVSLGGHEHPDLNDGSQHLNSSCYPSTC-ITDILLSYKHPEV--SFSVEQAGV ENSP00000391295/1-1363 EECGASLGGHEHPDLSDGSQHLNSSCYPSTC-ITDILLSYKHPEV--SFSMEQAGV * * ::. .*. : . .: . :.. ::* : .:: *..